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Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis

S. N. Yazbek, D. A. Buchner, J. M. Geisinger, L. C. Burrage, S. H. Spiezio, G. E. Zentner, C.-W. Hsieh, P. C. Scacheri, C. M. Croniger, J. H. Nadeau
2011 Genome Research  
Although central to many studies of phenotypic variation and disease susceptibility, characterizing the genetic architecture of complex traits has been unexpectedly difficult.  ...  Although fine-mapping reduced the genomic intervals and gene content of these QTLs over 3000-fold, the average phenotypic effect on body weight was reduced less than threefold, highlighting the "fractal  ...  The genetic architecture of complex traits and discovery of the underlying genes is fundamental to studies of phenotypic variation and disease risk.  ... 
doi:10.1101/gr.120741.111 pmid:21507882 pmcid:PMC3129249 fatcat:dsyjnrtnczc53pzxa7ba3cukhm

Genetic control of obesity, glucose homeostasis, dyslipidemia and fatty liver in a mouse model of diet-induced metabolic syndrome

D S Sinasac, J D Riordan, S H Spiezio, B S Yandell, C M Croniger, J H Nadeau
2015 International Journal of Obesity  
characterized strain-specific combinations of MetS conditions, and tested genetic and phenotypic complexity on a single substituted chromosome.  ...  By studying phenotypic responsiveness to high-risk versus control diet in two inbred mouse strains and their derivatives, we estimated the relative contributions of diet and genetic background to MetS,  ...  This work was supported by NIH grants RR12305 (JHN) and AA017837 (CMC).  ... 
doi:10.1038/ijo.2015.184 pmid:26381349 fatcat:wvnhokb4cbdwnhwxrepi6fmvie

Non-invasive biomarkers of fetal brain development reflecting prenatal stress: An integrative multi-scale multi-species perspective on data collection and analysis

Martin G. Frasch, Silvia M. Lobmaier, Tamara Stampalija, Paula Desplats, María Eugenia Pallarés, Verónica Pastor, Marcela A. Brocco, Hau-tieng Wu, Jay Schulkin, Christophe L. Herry, Andrew J.E. Seely, Gerlinde A.S. Metz (+2 others)
2018 Neuroscience and Biobehavioral Reviews  
We review the evidence for the effects of PS on fetal programming of the HPA axis and the ANS.  ...  This process of 'fetal programming' is mediated by the effects of the prenatal experience on the developing hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS).  ...  Many studies showed detrimental acute and transgenerational effects on neurodevelopment and HPA axis responsiveness to stress.  ... 
doi:10.1016/j.neubiorev.2018.05.026 pmid:29859198 fatcat:xrv7db7mrfaxzhsyubexd7o5qi

A Unifying Theory of Evolution Generated by Means of Information Modelling

Jytte Brender McNair
2016 Studies in Health Technology and Informatics  
one integrated world of information and communication media.  ...  of the EC programmes' Advanced Informatics in Medicine (AIM) and Biomedical and Health Research (BHR) bioengineering branch.  ...  For instance, "A large number of environmental factors from nutrition to toxicants have been shown to induce the transgenerational inheritance of disease and phenotypic variation (ref)." ( [36] page  ... 
pmid:27580093 fatcat:ggnzcgvswfcu3nobkuxol5jb6i

Homeostasis as the Mechanism of Evolution

John Torday
2015 Biology  
of physiologic structure and function.  ...  Starting with the inception of life itself, with the advent of reproduction during meiosis and mitosis, moving forward both ontogenetically and phylogenetically through the evolutionary steps involved  ...  Our laboratory has been studying the effect of maternal nicotine exposure on the transgenerational inheritance of the asthma phenotype [45] .  ... 
doi:10.3390/biology4030573 pmid:26389962 pmcid:PMC4588151 fatcat:ewcnaot2jzcxnkpbmt2q4hdebm

Homeostasis as the Mechanism of Evolution [chapter]

2017 Evolution, the Logic of Biology  
of physiologic structure and function.  ...  Starting with the inception of life itself, with the advent of reproduction during meiosis and mitosis, moving forward both ontogenetically and phylogenetically through the evolutionary steps involved  ...  Our laboratory has been studying the effect of maternal nicotine exposure on the transgenerational inheritance of the asthma phenotype [45] .  ... 
doi:10.1002/9781118729403.ch15 fatcat:hyx4mwmzofbddo6yuazhvjw3oe

Unveiling Human Non-Random Genome Editing Mechanisms Activated in Response to Chronic Environmental Changes: I. Where Might These Mechanisms Come from and What Might They Have Led To?

Loris Zamai
2020 Cells  
RNA-guided mutagenic enzymes may therefore "Lamarkianly" generate single nucleotide polymorphisms (SNP) and gene copy number variations (CNV), as well as transposon transposition and chromosomal translocations  ...  Non-random genome editing mechanisms represent tools of evolvability leading to organismal adaptation including transgenerational non-Mendelian gene transmission or to death of environmentally inadequate  ...  Altogether, these mechanisms produce both epigenetic and genetic variations that yield a range of environmentally induced phenotypes (phenotypic plasticity).  ... 
doi:10.3390/cells9112362 pmid:33121045 pmcid:PMC7693803 fatcat:fjvpr54rnnbjlp3t33rdnuwlmq

9th World Congress on Developmental Origins of Health and Disease

2015 Journal of Developmental Origins of Health and Disease  
from transitioning societies points to life-course influences on disease risk.  ...  The well-known associations of kidney measures in early life with kidney disease in later life may be partly explained by common genetic variants. 4628 Prenatal nutritional supplementation effects on  ...  Conclusion: There was no effect of HIV exposure on the growth of children in mid childhood. 4819 Effect of Preterm birth and intrauterine life on adulthood lung function: A clinical follow-up of births  ... 
doi:10.1017/s2040174415002329 fatcat:27qnex5ma5fijoxq4bejdxw2eq

8th World Congress on Developmental Origins of Health and Disease

2013 Journal of Developmental Origins of Health and Disease  
Changes in growth and metabolism had no impact on glucose tolerance of the offspring at 6 months.  ...  As observed in other models of programming, (e.g. maternal low protein), investigation of late adult stages may uncover more direct metabolic consequences indicative of disease.  ...  Results: The variation in the daughters and grand daughters milk ability due to transgenerational maternal effects (m2) were similar, with between 0.9 and 1.5% (depending on the dam/daughter/grand daughter  ... 
doi:10.1017/s2040174413000421 fatcat:3pcc3kcvlzbibkgpu57vldg37u

Supplement 1

2010 Norsk Epidemiologi  
The 16th Norwegian Conference on Epidemiology  ...  The economic upturn in the last decade did not appear to weaken the association between maternal social disadvantage and decreased fetal growth.  ...  More importantly, these effects are linked to a phenotype with increased cardiovascular risk.  ... 
doi:10.5324/nje.v18i0.614 fatcat:qwnbkwayvbcvjml7h57huwimma

Cell sensitivity, non-linearity and inverse effects

Paolo Bellavite, Andrea Signorini, Marta Marzotto, Elisabetta Moratti, Clara Bonafini, Debora Olioso
2015 Homeopathy  
on the basis of recent scientific advances.  ...  underlying the inversion of drug effects.  ...  Acknowledgements Experimental work was supported by grants from Boiron Laboratoires to Verona University e Department of Pathology and Diagnostics and from Italian Research Ministry.  ... 
doi:10.1016/j.homp.2015.02.002 pmid:25869978 fatcat:kbvpe2mhabeylg2nejepe35nj4

SUPPLEMENT: ABSTRACTS FROM RAMBAM RESEARCH DAY

Research Day
2012 Rambam Maimonides Medical Journal  
We show the advantages to either scheme depending on the stimulus properties.  ...  We show that individual neurons and networks display a very complex, history dependent response patterns that pose constraints on possible representation schemes.  ...  QA study assessed for accuracy and effectiveness of FNA with emphasis on the impact on diagnosis and case management.  ... 
doi:10.5041/rmmj.10071 pmid:35606991 pmcid:PMC3707411 fatcat:pdsxzjee6zemhnsam2deaqwdmq

Proceedings Book - Luso-Brazilian Meeting of Physiology, 2020

Luis Monteiro Rodrigues et Al
2020 Journal Biomedical and Biopharmaceutical Research (BBR)  
Objective: The aim of this study was to evaluate the influence of P. albidus hydroalcoholic extract supplementation for 20 days on body weight, food intake, blood glucose, triglycerides, total cholesterol  ...  During this period, all animals received food and water ad libitum and had their food intake and body weight monitored daily.  ...  risk for cardiometabolic diseases later in life.  ... 
doi:10.19277/bbr.17.2.243 fatcat:sb2aqticcjchzajikmgpjzlk7y

Neurological and mental disorders [chapter]

Tarakad S. Ramachandran
2013 Alcohol  
She has taught Medical and Biological Sciences in various universities in Australia, USA, UAE, Bahrain, Pakistan and Brunei.  ...  and other vascular disorders such as schizophrenia.  ...  Ana Garcia for assistance in analysis of the data and Psy. Aloysio Campos da Paz Neto for the protocol design and the Laboratory of Neuroscience and Behavior at the University of Brasília, Brazil.  ... 
doi:10.1093/acprof:oso/9780199655786.003.0036 fatcat:s4tdazxlxzfnldqys522y4zqvm

23rd Conference for Microcirculation of the European Society

2004 Journal of Vascular Research  
for each drug for any change in indications and dosage and for added warnings and precautions.  ...  Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of  ...  between LBW and increased risk of cardiovascular disease in adults.  ... 
doi:10.1159/000081024 fatcat:qdkyi4ufdbfovet6gejsbiscdm
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