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Abnormal Asymmetry of Brain Connectivity in Schizophrenia

Michele Ribolsi, Zafiris J. Daskalakis, Alberto Siracusano, Giacomo Koch
2014 Frontiers in Human Neuroscience  
Furthermore, diffusion tensor imaging studies have shown a significant reduction of leftward asymmetry in some key white-matter tracts in SCZ.  ...  Finally, we hypothesize that structural deficits across the corpus callosum may contribute to the abnormal asymmetry of intra-hemispheric connectivity in schizophrenia.  ...  White matter Diffusion tensor imaging investigation has revealed wide whitematter changes in schizophrenia, even at the illness' onset, as well as before (Kubicki and Shenton, 2014) .  ... 
doi:10.3389/fnhum.2014.01010 pmid:25566030 pmcid:PMC4273663 fatcat:eibhflcul5by7pgbd45t6abr6q

Associations between hemispheric asymmetry and schizophrenia-related risk genes in people with schizophrenia and people at a genetic high risk of schizophrenia

Yue Zhu, Shuai Wang, Xiaohong Gong, Elliot K. Edmiston, Suyu Zhong, Chao Li, Pengfei Zhao, Shengnan Wei, Xiaowei Jiang, Yue Qin, Jujiao Kang, Yi Wang (+4 others)
2021 British Journal of Psychiatry  
People with schizophrenia and those with genetic high risk of schizophrenia (GHR) have presented with similar neurodevelopmental deficits in hemispheric asymmetry.  ...  Hemispheric asymmetric deficit of local efficiency was significantly positively correlated with SZ-PRSs in the schizophrenia and GHR groups.  ...  We are grateful to all the members of the Brain Function Research Section in the First Affiliated Hospital of China Medical University and the support of Shenyang Mental Health Center.  ... 
doi:10.1192/bjp.2021.47 pmid:35048853 pmcid:PMC8529637 fatcat:e6xwqhkpqfe2xp7i5hc75ne7zu

Diffusion Tensor Imaging, Structural Connectivity, and Schizophrenia

Thomas J. Whitford, Marek Kubicki, Martha E. Shenton
2011 Schizophrenia Research and Treatment  
existence and nature of white matter abnormalities in schizophrenia.  ...  Given that the white matter fasciculi represent the primary infrastructure for long distance communication in the brain, abnormalities in these fiber bundles have been implicated in the etiology of schizophrenia  ...  in the fibers connecting spatially disparate populations of neurons-that is, the white matter (WM).  ... 
doi:10.1155/2011/709523 pmid:22937272 pmcid:PMC3420716 fatcat:ppkqik4mkrbf3mu5twofkbupki

Asymmetry of the Uncinate Fasciculus: A Post-mortem Study of Normal Subjects and Patients with Schizophrenia

J. R. Highley
2002 Cerebral Cortex  
We conclude that the uncinate fasciculus is larger in the right hemisphere, perhaps indicating greater right-sided fronto-temporal connectivity.  ...  The temporal lobes show a number of anatomical asymmetries, some of which are altered in schizophrenia.  ...  First, it contrasts with studies of inter-hemispheric white matter tracts, which have found differences in their size and/or fibre content.  ... 
doi:10.1093/cercor/12.11.1218 pmid:12379610 fatcat:cncljhh5kfe27izjjxtc2dykra

The Kraepelinian Dichotomy Viewed by Neuroimaging

M.-A. d'Albis, J. Houenou
2014 Schizophrenia Bulletin  
We performed a comparative review of neuroimaging features in both conditions at several scales: whole-brain and regional volumes, brain activity, connectivity, and networks.  ...  all brain networks in SZ and restricted to limbic, paralimbic, and interhemispheric networks in BD.  ...  Acknowledgment The authors have declared that there are no conflicts of interest in relation to the subject of this study.  ... 
doi:10.1093/schbul/sbu174 pmid:25533269 pmcid:PMC4332955 fatcat:kvvvybhwhjaajjkg7dfblixwzm

Structural brain imaging in schizophrenia: a selective review

Godfrey D Pearlson, Laura Marsh
1999 Biological Psychiatry  
refined characterization of abnormal brain structure in schizophrenia in vivo.  ...  influences, and the timing of neuroanatomic pathology in schizophrenia.  ...  It is unclear whether this also applies to focal abnormalities (Marsh et al 1999a) . Regional Brain Structural Abnormalities in Schizophrenia FOCAL GRAY MATTER ABNORMALITIES.  ... 
doi:10.1016/s0006-3223(99)00071-2 pmid:10472416 fatcat:csxul24yarfazjboehxj6rbntm

Mapping Corticocortical Structural Integrity in Schizophrenia and Effects of Genetic Liability

Owen R. Phillips, Keith H. Nuechterlein, Robert F. Asarnow, Kristi A. Clark, Ryan Cabeen, Yaling Yang, Roger P. Woods, Arthur W. Toga, Katherine L. Narr
2011 Biological Psychiatry  
Background-Structural and diffusion tensor imaging studies implicate gray and white matter (WM) abnormalities and disruptions of neural circuitry in schizophrenia.  ...  Results-Compared with control subjects, patients showed reduced superficial WM fractional anisotropy distributed across each hemisphere, particularly in left temporal and bilateral occipital regions (all  ...  We also thank the The maps that correspond to the statistical maps in Figure 2 showing changes in superficial white matter fractional anisotropy in (A) schizophrenia versus control probands; (B) schizophrenia  ... 
doi:10.1016/j.biopsych.2011.03.039 pmid:21571255 pmcid:PMC3838300 fatcat:hvzg6rbjqjanvh5gks55x6xmjq

Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia

Colleen P. E. Rollins, Jane R. Garrison, Maite Arribas, Aida Seyedsalehi, Zhi Li, Raymond C. K. Chan, Junwei Yang, Duo Wang, Pietro Liò, Chao Yan, Zheng-hui Yi, Arnaud Cachia (+5 others)
2020 Translational Psychiatry  
Reduced PCS length and STS depth corresponded to focal deviations in their geometry and to significantly increased covariance within and between areas of the salience and auditory networks.  ...  We quantified the length, depth, and asymmetry indices of the paracingulate and superior temporal sulci (PCS, STS), which have previously been associated with hallucinations in schizophrenia, and constructed  ...  The funders had no input in study design, data collection, data analysis, data interpretation, writing of the report, or the decision to submit for publication.  ... 
doi:10.1038/s41398-020-01075-y pmid:33159044 fatcat:25uba3kntbcjdpzxzhvsxnfsim

White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs

Paul Klauser, Simon T. Baker, Vanessa L. Cropley, Chad Bousman, Alex Fornito, Luca Cocchi, Janice M. Fullerton, Paul Rasser, Ulrich Schall, Frans Henskens, Patricia T. Michie, Carmel Loughland (+8 others)
2016 Schizophrenia Bulletin  
In this study, neuroimaging was used to investigate white matter pathology and its impact on whole-brain white matter connectivity in one of the largest samples of patients with schizophrenia.  ...  In conclusion, although connectivity between cerebral hubs is most extensively disturbed in schizophrenia, white matter pathology is widespread, affecting all cerebral lobes and the cerebellum, leading  ...  The authors have declared that there are no conflicts of interest in relation to the subject of this study.  ... 
doi:10.1093/schbul/sbw100 pmid:27535082 pmcid:PMC5605265 fatcat:r2ioz6mklzfalesiahxvu35jbe

Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study

Lena Palaniyappan, Peter Liddle
2012 Journal of Psychiatry & Neuroscience  
In the insula, a reduction in gyrification was related to reduced cortical thickness in patients with schizophrenia.  ...  Schizophrenia is considered to be a disorder of cerebral connectivity associated with disturbances of cortical development.  ...  [13] [14] [15] As a result, unlike the robust evidence localizing volumetric changes in patients with schizophrenia to the insula, the spatial distribution of focal gyrification abnormalities in these  ... 
doi:10.1503/jpn.110119 pmid:22640702 pmcid:PMC3493098 fatcat:dxfnxviuvzbpfh45yru2o5ewrm

Transcultural psychiatry and schizophrenia [chapter]

2009 Schizophrenia  
Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity. Neuroimage 2004 Jan; 21(1): 27-35. 15. Wood SJ, Pantelis C, Velakoulis D et al.  ...  Focal gray matter density changes in schizophrenia. Arch Gen Psychiatry 2001 Dec; 58(12): 1118-25. 14. Hulshoff Pol HE, Schnack HG, Mandl RC et al.  ... 
doi:10.3109/9781420080063-24 fatcat:g3viiksvhrdkri2hj4tdy4az2m

A Review of Impaired Neuroplasticity in Schizophrenia Investigated with Non-invasive Brain Stimulation

Apoorva Bhandari, Daphne Voineskos, Zafiris J. Daskalakis, Tarek K. Rajji, Daniel M. Blumberger
2016 Frontiers in Psychiatry  
Several lines of evidence implicate dysfunctional neuronal plasticity in the pathophysiology of schizophrenia (SCZ).  ...  Conclusion: Our review of the literature reveals evidence for disrupted neuroplasticity in SCZ and its close association to alterations in cortical inhibition and dysfunctional intracortical connectivity  ...  In one such study, a subset of SCZ patients showed a progressive postonset reduction in several gray and white matter regions, with greatest severity in the frontal lobes and a concomitant increase in  ... 
doi:10.3389/fpsyt.2016.00045 pmid:27065890 pmcid:PMC4810231 fatcat:r5aixvazjnfvpp2digrnnqtruq

A review of structural neuroimaging in schizophrenia: from connectivity to connectomics

Anne L. Wheeler, Aristotle N. Voineskos
2014 Frontiers in Human Neuroscience  
In patients with schizophrenia neuroimaging studies have revealed global differences with some brain regions showing focal abnormalities.  ...  Examining neurocircuitry, diffusion-weighted imaging studies have identified altered structural integrity of white matter in frontal and temporal brain regions and tracts such as the cingulum bundles,  ...  The corpus callosum is the largest white matter structure in the brain and is the main commissural tract as it connects the two hemispheres.  ... 
doi:10.3389/fnhum.2014.00653 pmid:25202257 pmcid:PMC4142355 fatcat:tdcsuyufgzgwflmwrcokyxg7ki

Callosal and subcortical white matter alterations in schizophrenia: A diffusion tensor imaging study at multiple levels

Wei Zhao, Shuixia Guo, Ningning He, Albert C. Yang, Ching-Po Lin, Shih-Jen Tsai
2018 NeuroImage: Clinical  
Diffusion tensor imaging and its distinct capability to detect micro-structural changes in vivo allows the exploration of white matter (WM) abnormalities in patients who have been diagnosed with schizophrenia  ...  These disruptions were evident in both voxel and connectivity levels and further supported by associations between FA values and illness duration.  ...  The number of voxels for each white matter tract is shown in Table 2 .  ... 
doi:10.1016/j.nicl.2018.08.027 pmid:30186763 pmcid:PMC6120601 fatcat:r3p3is7vzbfhvdqt2zvgqs35ua

Abnormalities in structural covariance of cortical gyrification in schizophrenia

Lena Palaniyappan, Bert Park, Vijender Balain, Raj Dangi, Peter Liddle
2014 Brain Structure and Function  
Disrupted gyrification of focal brain regions is a consistent feature of schizophrenia.  ...  We found that several key regions including anterior insula and dorsolateral prefrontal cortex show increased segregation in schizophrenia, alongside reduced segregation in somato-sensory and occipital  ...  Palaniyappan received a travel fellowship sponsored by Eli Lilly in 2011. In the past 5 years, P. F.  ... 
doi:10.1007/s00429-014-0772-2 pmid:24771247 pmcid:PMC4481329 fatcat:jtda3jyayjgpfoj5f6xwtiv65m
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