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Raisonner, raisonnements en géographie scolaire

Pierre Colin, Catherine Heitz, Sophie Gaujal, Florence Giry, Caroline Leininger-Frézal, Xavier Leroux
2019 Géocarrefour  
doi:10.4000/geocarrefour.12524 fatcat:xdorj6tqira3lcg62q24kczpwe

Enjeux, freins et mise en œuvre des programmes de mobilité en Guyane

Florence Ihaddadene, Céline Leroux
2017 Cahiers de l'action  
éducation populaire. Tous droits réservés pour tous pays. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors
more » ... s cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit.
doi:10.3917/cact.049.0057 fatcat:ihy42onlr5gppa55u7m53tvg7a

Supplemental_Material_for_screening_aggresome_by_Lesire,_et_al – Supplemental material for High-Throughput Image-Based Aggresome Quantification

Laetitia Lesire, Ludovic Chaput, Paulina Cruz De Casas, Fanny Rousseau, Catherine Piveteau, Julie Dumont, David Pointu, Benoît Déprez, Florence Leroux
2020 Figshare  
Leroux in SLAS Discovery  ...  et_al for High-Throughput Image-Based Aggresome Quantification by Laetitia Lesire, Ludovic Chaput, Paulina Cruz De Casas, Fanny Rousseau, Catherine Piveteau, Julie Dumont, David Pointu, Benoît Déprez and Florence  ... 
doi:10.25384/sage.12369674.v1 fatcat:3lxwrgizbzcwdokjk4tfo773a4

Riemann Solvers for some Hyperbolic Problems with a Source Term

Alain Yves Leroux, Robert Boyer, Elisabeth Croc, Yves Dermenjian, Florence Hubert, Elaine Pratt
1999 ESAIM: Proceedings and Surveys  
R esum e. Dans de nombreux mod eles de m ecanique des uides, le terme source correspond a u n e i n teraction de l' ecoulement a vec le milieu environnant : la g eom etrie ou certaines forces internes telles que la friction, la gravit e, la force de Coriolis, etc.. Dans les probl emes d'environnement, cette interaction est souvent un terme dominant qui d etermine les equilibres ( etats au repos). Lors des simulations num eriques, il est evidemment t r es important de reproduire parfaitement c e
more » ... s etats d' equilibre et de les maintenir a l ' equilibre au cours du temps. Il est surtout important d ' eviter que la perte de l' equilibre au niveau num erique vienne d estabiliser et modi er de fa con signi cative la simulation. Dans ce papier, cette question est analys ee a partir d'exemples concrets, et des solveurs appropri es, dits solveurs equilibr es, sont propos es Mots cl es. Probl emes d'environnement, stabilit e d e s c h emas num eriques pour les syst emes hyperboliques, solveurs equilibr es, volumes nis (Godunov). Abstract. In many problems of uid dynamics, the source term corresponds to the interaction with the surrounding medium, including the geometry and some internal forces (friction, gravity, Coriolis acceleration, etc..) In environmental problems, this interaction is often a very dominant t e r m w h i c h c haracterizes the well balanced states. I n a n umerical simulation, it is obviously important to be able to reproduce these equilibria and maintain them for a large number of timesteps, or at least, to avoid a stable equilibrium to be disturbed and destabilized by an unsuitable method. This is the matter discussed in the present paper. Keywords. Problems in environmental science, stability o f n umerical schemes for hyperbolic systems, well balanced solvers, nite volumes (Godunov)
doi:10.1051/proc:1999047 fatcat:qenrp3mbqjdcln7mgop3zbvi2u

Effects of fudioxonil on Botrytis cinerea and on grapevine defence response

Anne-Noëlle PETIT, Nathalie VAILLANT-GAVEAU, Anne-Sophie WALKER, Pierre LEROUX, Fabienne BAILLIEUL, Marie-Laure PANON, Christophe CLÉMENT, Florence FONTAINE
2011 Phytopathologia Mediterranea  
Anne-noëlle PETIT 1 , nAthAlie VaILLaNT-GavEau 1 , Anne-SoPhie WaLkER 2 , Pierre LERoux 2 , FAbienne BaILLIEuL 1 , MArie-lAure PaNoN 3 , ChriStoPhe CLéMENT 1 and FlorenCe FoNTaINE 1 trol of B. cinerea  ...  Several classes of fungicides are available (Leroux et al., 2002) .  ... 
doi:10.14601/phytopathol_mediterr-9049 doaj:552b673cf2a840eca349b4ede49d927c fatcat:vyata7jdhzgbvfux2rorhdy3fa

Integrative mapping analysis of chicken microchromosome 16 organization

Romain Solinhac, Sophie Leroux, Svetlana Galkina, Olympe Chazara, Katia Feve, Florence Vignoles, Mireille Morisson, Svetlana Derjusheva, Bertrand Bed'hom, Alain Vignal, Valérie Fillon, Frédérique Pitel
2010 BMC Genomics  
The chicken karyotype is composed of 39 chromosome pairs, of which 9 still remain totally absent from the current genome sequence assembly, despite international efforts towards complete coverage. Some others are only very partially sequenced, amongst which microchromosome 16 (GGA16), particularly underrepresented, with only 433 kb assembled for a full estimated size of 9 to 11 Mb. Besides the obvious need of full genome coverage with genetic markers for QTL (Quantitative Trait Loci) mapping
more » ... major genes identification studies, there is a major interest in the detailed study of this chromosome because it carries the two genetically independent MHC complexes B and Y. In addition, GGA16 carries the ribosomal RNA (rRNA) genes cluster, also known as the NOR (nucleolus organizer region). The purpose of the present study is to construct and present high resolution integrated maps of GGA16 to refine its organization and improve its coverage with genetic markers. Results: We developed 79 STS (Sequence Tagged Site) markers to build a physical RH (radiation hybrid) map and 34 genetic markers to extend the genetic map of GGA16. We screened a BAC (Bacterial Artificial Chromosome) library with markers for the MHC-B, MHC-Y and rRNA complexes. Selected clones were used to perform high resolution FISH (Fluorescent In Situ Hybridization) mapping on giant meiotic lampbrush chromosomes, allowing meiotic mapping in addition to the confirmation of the order of the three clusters along the chromosome. A region with high recombination rates and containing PO41 repeated elements separates the two MHC complexes. Conclusions: The three complementary mapping strategies used refine greatly our knowledge of chicken microchromosome 16 organisation. The characterisation of the recombination hotspots separating the two MHC complexes demonstrates the presence of PO41 repetitive sequences both in tandem and inverted orientation. However, this region still needs to be studied in more detail.
doi:10.1186/1471-2164-11-616 pmid:21050458 pmcid:PMC3091757 fatcat:g34b75dderdfboxq5w4nyqloqm

Décès d'un "raveur" pouvant être imputé à un nouveau produit : la 4-Méthylthioamphétamine

Marie-Hélène Ghysel, Véronique Dupont, Florence Descamps, Claire Leroux, Ornella Salvadore
2000 Annales de Toxicologie Analytique  
Auteur à qui adresser la correspondance : Marie-Hélène GHYSEL, Laboratoire de Police Scientifique, 7, boulevard Vauban -59800 LILLE -Tel : 33 (0)3 20 12 89 79 -Fax : 33 (0) 3 20 12 89 99 RÉSUMÉ En avril 1999 le corps sans vie d'un homme de 26 ans, adepte des soirées "raves" est découvert à son domicile. Des cactus coupés sont retrouvés dans l'appartement. Le cadavre est en état de putréfaction avancée. Le médecin légiste conclut que la mort est en rapport avec un oedème pulmonaire. Le cactus
more » ... pé, a l'aspect d'un Trichocereus. Après extraction par le chloroforme en milieu alcalin et une analyse par chromatographic en phase gazeuse couplée à un spectromètre de masse (CG-SM), de la mescaline est mise en évidence dans le cactus. Le sang prélevé à l'autopsie est analysé par "Espace de tête" CG-DIF, ainsi que, après extraction par Toxi-Tube® A, par CG-SM et par chromatographic liquide couplée à un détecteur Ultraviolet à Barrette de Diodes (CLHP/BD). Des extractions et dérivations spécifiques de la recherche des opiacés, de la cocaïne, du cannabis, de l'amphétamine et des dérivés apparentés à 1'ecstasy, de la buprénorphine sont également réalisées sur ce sang. Un nouveau produit, la 4-méihylthioamphétamine, absent des bibliothèques de spectres vendues par les constructeurs est retrouvé dans ce sang. Sa quantification est réalisée par CLHP à 220 nm après extraction liquide à pH alcalin par un mélange dichlorométhane-hexane-acétate d'éthyle(50,40,10). La colonne est une C8 Symmetry® de chez WATERS, la phase mobile est composée d'un mélange d'acétonitrile et de dihydrogénophosphate de sodium. Les analyses toxicologiques mettent en évidence dans le sang, de la mescaline (0,1 pg/ml) et de la 4méthylthioamphétamine au taux de 2,11 pg/ml. L'alcoolémie est insignifiante (0,1 g/l). Les recherches d'autres produits toxiques d'origine organique sont négatives, notamment en ce qui concerne les autres produits stupéfiants ou l'éphédrine. Ce type d'intoxication serait le premier rapporté en France. SUMMARY We report here a case of intoxication concerning a 26 yearold man who was found dead at home, near sliced cactus. The cactus (Trichocereus) was analyzed and revealed mescaline. Toxicological screening was performed on blood, after extraction using Toxi-Tube®A, and specific extraction for drugs of abuse, followed by identification by gas chromatography coupled with mass spectrometric detection (GC-MS) and high performance liquid chromatography with diode array detection (HPLC-DAD). Mescaline and 4-methylthioamphetamine, a new designer drug, were found in blood. Quantitation was performed by HPLC at 220 nm after liquid extraction at pH 9 by dichloromethane-hexane-ethyl acetate (50,40, 10) . The column used was a C8 Symmetry® WATERS, mobile phase is acetonitrile and sodium dihydrogenophosphate. Blood concentration of mescaline and 4-MTA were respectively 0.1 and 2.1 lmg/l. To our knowledge, this case is the first one described in France.
doi:10.1051/ata/2000012 fatcat:thd545t7jbad7hjzcyb3coawvq

Evolutionary breakpoints through a high-resolution comparative map between porcine chromosomes 2 and 16 and human chromosomes

Yvette Lahbib-Mansais, Florence Mompart, Denis Milan, Sophie Leroux, Thomas Faraut, Chantal Delcros, Martine Yerle
2006 Genomics  
This study reports a high-resolution comparative map between human chromosomes and porcine chromosomes 2 (SSC2) and 16 (SSC16), pointing out new homologies and evolutionary breakpoints. SSC2 is of particular interest because of the presence of several important QTLs. Among 226 porcine ESTs selected according to their expected localization, 151 were RH mapped and ordered on SSC2. This study confirmed the extensive conservation between SSC2 and HSA11 and HSA19 and refined the homology with HSA5
more » ... hree blocks defined). Furthermore the SSC2q pericentromeric region was shown to be homologous to another human chromosome (HSA1). A complex organization of these syntenies was demonstrated on SSC2q. Our strategy led us to improve also the SSC16 RH map by adding 45 markers. Two-color fluorescence in situ hybridization of markers representative of each synteny confirmed block order. Finally, 29 breakpoints were identified in both species, and porcine BACs containing two breakpoints were isolated.
doi:10.1016/j.ygeno.2006.04.010 pmid:16765019 fatcat:c7dfga47wzfitjyork5cjum2c4

Hemispherical–directional reflectance measurements of natural snow in the 0.9–1.45 μm spectral range: comparison with adding–doubling modelling

Claude Sergent, Catherine Leroux, Evelyne Pougatch, Florence Guirado
1998 Annals of Glaciology  
spherical or hemispherical-directional reflectances a re investigated, approximation of spherical particles can be made but is no longer suitable for snow bidirectional applications in the middle infra red (Leroux  ... 
doi:10.3189/1998aog26-1-59-63 fatcat:cydblrwgq5ghvhl6karnqbn4mm

Hemispherical–directional reflectance measurements of natural snow in the 0.9–1.45 μm spectral range: comparison with adding–doubling modelling

Claude Sergent, Catherine Leroux, Evelyne Pougatch, Florence Guirado
1998 Annals of Glaciology  
spherical or hemispherical-directional reflectances a re investigated, approximation of spherical particles can be made but is no longer suitable for snow bidirectional applications in the middle infra red (Leroux  ... 
doi:10.1017/s0260305500014567 fatcat:uelhgmovtbfdjoqbunsey7jw34

Construction of a radiation hybrid map of chicken chromosome 2 and alignment to the chicken draft sequence

Sophie Leroux, Mélanie Dottax, Suzanne Bardes, Florence Vignoles, Katia Fève, Frédérique Pitel, Mireille Morisson, Alain Vignal
2005 BMC Genomics  
The ChickRH6 whole chicken genome radiation hybrid (RH) panel recently produced has already been used to build radiation hybrid maps for several chromosomes, generating comparative maps with the human and mouse genomes and suggesting improvements to the chicken draft sequence assembly. Here we present the construction of a RH map of chicken chromosome 2. Markers from the genetic map were used for alignment to the existing GGA2 (Gallus gallus chromosome 2) linkage group and EST were used to
more » ... de valuable comparative mapping information. Finally, all markers from the RH map were localised on the chicken draft sequence assembly to check for eventual discordances. Eighty eight microsatellite markers, 10 genes and 219 EST were selected from the genetic map or on the basis of available comparative mapping information. Out of these 317 markers, 270 gave reliable amplifications on the radiation hybrid panel and 198 were effectively assigned to GGA2. The final RH map is 2794 cR6000 long and is composed of 86 framework markers distributed in 5 groups. Conservation of synteny was found between GGA2 and eight human chromosomes, with segments of conserved gene order of varying lengths. We obtained a radiation hybrid map of chicken chromosome 2. Comparison to the human genome indicated that most of the 8 groups of conserved synteny studied underwent internal rearrangements. The alignment of our RH map to the first draft of the chicken genome sequence assembly revealed a good agreement between both sets of data, indicative of a low error rate.
doi:10.1186/1471-2164-6-12 pmid:15693999 pmcid:PMC548691 fatcat:7vob4agqj5fanox7lw2vmq5yaq

Differential Gene Expression Profiling of Dystrophic Dog Muscle after MuStem Cell Transplantation

Florence Robriquet, Aurélie Lardenois, Candice Babarit, Thibaut Larcher, Laurence Dubreil, Isabelle Leroux, Céline Zuber, Mireille Ledevin, Jack-Yves Deschamps, Yves Fromes, Yan Cherel, Laetitia Guevel (+2 others)
2015 PLoS ONE  
Several adult stem cell populations exhibit myogenic regenerative potential, thus representing attractive candidates for therapeutic approaches of neuromuscular diseases such as Duchenne Muscular Dystrophy (DMD). We have recently shown that systemic delivery of MuStem cells, skeletal muscle-resident stem cells isolated in healthy dog, generates the remodelling of muscle tissue and gives rise to striking clinical benefits in Golden Retriever Muscular Dystrophy (GRMD) dog. This global effect,
more » ... h is observed in the clinically relevant DMD animal model, leads us to question here the molecular pathways that are impacted by MuStem cell transplantation. To address this issue, we compare the global gene expression profile between healthy, GRMD and MuStem cell treated GRMD dog muscle, four months after allogenic MuStem cell transplantation. the Pays de la Loire Region. ubiquitin-mediated protein degradation is highly enhanced in GRMD dog muscle after systemic delivery of MuStem cells. Conclusions Overall, our results provide the first high-throughput characterization of GRMD dog muscle and throw new light on the complex molecular/cellular effects associated with muscle repair and the clinical efficacy of MuStem cell-based therapy.
doi:10.1371/journal.pone.0123336 pmid:25955839 pmcid:PMC4425432 fatcat:wfcvmwkgrnbkneat7f3vm242wm

Large-scale study reveals regional fungicide applications as a major determinant of resistance evolution in the wheat pathogen Zymoseptoria tritici in France [article]

Maxime Garnault, Clementine Duplaix, Pierre Leroux, Gilles Couleaud, Olivier David, Anne-Sophie Walker, Florence Carpentier
2020 bioRxiv   pre-print
Indeed,Leroux & Walker, 2011; Huf et al., 2018).  ...  strains in these conditions; Leroux & Walker, 2011). Bayesian framework, with the rjags package (Plummer, 2013). parameter estimation.  ... 
doi:10.1101/2020.07.17.208728 fatcat:juxjcii3gvcfjhkczwdmvzzeqe

Clusthaplo: a plug-in for MCQTL to enhance QTL detection using ancestral alleles in multi-cross design

Damien Leroux, Abdelaziz Rahmani, Sylvain Jasson, Marjolaine Ventelon, Florence Louis, Laurence Moreau, Brigitte Mangin
2014 Theoretical and Applied Genetics  
of MCQTl parameters and thus boost the QTl discovery. We developed clusthaplo, an r package (http://cran.rproject.org/web/packages/clusthaplo/index.html), which aims to cluster haplotypes using a genomic similarity that reflects the probability of sharing the same ancestral allele. Computed in a sliding window along the genome and followed by a clustering method, the genomic similarity allows the local clustering of the parent haplotypes. Our assumption is that the haplotypes belonging to the
more » ... me class transmit the same ancestral allele. So their putative QTl allelic effects can be modeled with the same parameter, leading to a parsimonious model, that is plugged in MCQTl. Intensive simulations using three maize data sets showed the significant gain in power and in accuracy of the QTl mapping with the ancestral allele model compared to the classical MCQTl model. MCQTl_lD (clusthaplo outputs plug in MCQTl) is a versatile and powerful tool for QTl mapping in multiple related families that makes use of linkage and linkage disequilibrium (web site http://carlit.toulouse.inra.fr/MCQTl/). Abstract Key message We enhance power and accuracy of QTL mapping in multiple related families, by clustering the founders of the families on their local genomic similarity. Abstract MCQTl is a linkage mapping software application that allows the joint QTl mapping of multiple related families. In its current implementation, QTls are modeled with one or two parameters for each parent that is a founder of the multi-cross design. The higher the number of parents, the higher the number of model parameters which can impact the power and the accuracy of the mapping. We propose to make use of the availability of denser and denser genotyping information on the founders to lessen the number Communicated by e. A. Carbonell. Electronic supplementary material The online version of this article (
doi:10.1007/s00122-014-2267-1 pmid:24482114 pmcid:PMC3964294 fatcat:blvcm2xmurfijbitp35bklnvse

Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods

Christelle Reynès, Hélène Host, Anne-Claude Camproux, Guillaume Laconde, Florence Leroux, Anne Mazars, Benoit Deprez, Robin Fahraeus, Bruno O. Villoutreix, Olivier Sperandio, Philip E. Bourne
2010 PLoS Computational Biology  
Protein-protein interactions (PPIs) may represent one of the next major classes of therapeutic targets. So far, only a minute fraction of the estimated 650,000 PPIs that comprise the human interactome are known with a tiny number of complexes being drugged. Such intricate biological systems cannot be cost-efficiently tackled using conventional high-throughput screening methods. Rather, time has come for designing new strategies that will maximize the chance for hit identification through a
more » ... nalization of the PPI inhibitor chemical space and the design of PPI-focused compound libraries (global or target-specific). Here, we train machine-learning-based models, mainly decision trees, using a dataset of known PPI inhibitors and of regular drugs in order to determine a global physico-chemical profile for putative PPI inhibitors. This statistical analysis unravels two important molecular descriptors for PPI inhibitors characterizing specific molecular shapes and the presence of a privileged number of aromatic bonds. The best model has been transposed into a computer program, PPI-HitProfiler, that can output from any drug-like compound collection a focused chemical library enriched in putative PPI inhibitors. Our PPI inhibitor profiler is challenged on the experimental screening results of 11 different PPIs among which the p53/MDM2 interaction screened within our own CDithem platform, that in addition to the validation of our concept led to the identification of 4 novel p53/MDM2 inhibitors. Collectively, our tool shows a robust behavior on the 11 experimental datasets by correctly profiling 70% of the experimentally identified hits while removing 52% of the inactive compounds from the initial compound collections. We strongly believe that this new tool can be used as a global PPI inhibitor profiler prior to screening assays to reduce the size of the compound collections to be experimentally screened while keeping most of the true PPI inhibitors. PPI-HitProfiler is freely available on request from our CDithem platform website, www.CDithem.com.
doi:10.1371/journal.pcbi.1000695 pmid:20221258 pmcid:PMC2832677 fatcat:dwi7e2ndmfcublzqxiyfeogq6e
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