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Malformations of Cortical Development: Diagnostic Accuracy of Fetal MR Imaging

Orit A. Glenn, Addison A. Cuneo, A. James Barkovich, Zary Hashemi, Agnes I. Bartha, Duan Xu
2012 Radiology  
postnatal age (corrected for delivery age , 37 weeks) of 3 days.  ...  In addition, if there is any doubt, follow-up MR imaging at a later gestational age can be helpful. decreased estimation of specificity for cortical malformations (18) .  ... 
doi:10.1148/radiol.12102492 pmid:22495681 pmcid:PMC3359515 fatcat:apaidnm5ezgprkggwe7garixgy

Use of Fetal Magnetic Resonance Image Analysis and Machine Learning to Predict the Need for Postnatal Cerebrospinal Fluid Diversion in Fetal Ventriculomegaly

Jared M. Pisapia, Hamed Akbari, Martin Rozycki, Hannah Goldstein, Spyridon Bakas, Saima Rathore, Julie S. Moldenhauer, Phillip B. Storm, Deborah M. Zarnow, Richard C. E. Anderson, Gregory G. Heuer, Christos Davatzikos
2018 JAMA pediatrics  
OBJECTIVE To determine whether extraction of multiple imaging features from fetal magnetic resonance imaging (MRI) and integration using machine learning techniques can predict which patients require postnatal  ...  no role the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for  ...  All case patients and an equal number of controls were selected and matched by best obstetric estimate of gestational age at the time of diagnostic fetal MRI.  ... 
doi:10.1001/jamapediatrics.2017.3993 pmid:29255892 pmcid:PMC5796744 fatcat:rsswig3xcjbcxbvi4g4hk3rg4i

Regional Gray Matter Growth, Sexual Dimorphism, and Cerebral Asymmetry in the Neonatal Brain

J. H. Gilmore, W. Lin, M. W. Prastawa, C. B. Looney, Y. S. K. Vetsa, R. C. Knickmeyer, D. D. Evans, J. K. Smith, R. M. Hamer, J. A. Lieberman, G. Gerig
2007 Journal of Neuroscience  
We used magnetic resonance imaging and an automatic segmentation methodology to study brain structure in 74 neonates in the first few weeks after birth.  ...  Although there has been recent interest in the study of childhood and adolescent brain development, very little is known about normal brain development in the first few months of life.  ...  The gestational age at MRI was 42.8 Ϯ 1.6 weeks (mean Ϯ SD; range, 38.8 -47.8 weeks).  ... 
doi:10.1523/jneurosci.3339-06.2007 pmid:17287499 pmcid:PMC2886661 fatcat:fwkczp3an5eyjf3f2nfvswdib4

Affinity for risky behaviors following prenatal and early childhood exposure to tetrachloroethylene (PCE)-contaminated drinking water: a retrospective cohort study

Ann Aschengrau, Janice M Weinberg, Patricia A Janulewicz, Megan E Romano, Lisa G Gallagher, Michael R Winter, Brett R Martin, Veronica M Vieira, Thomas F Webster, Roberta F White, David M Ozonoff
2011 Environmental Health  
PCE exposure was estimated using the U.S.  ...  a teenager or as an adult (Relative Risk (RR) for teen use = 1.6, 95% CI: 1.2-2.2; and RR for adult use = 1.5, 95% CI: 1.2-1.9).  ...  Simple percentages were used to account for partial years. We estimated PCE exposure levels only for subjects with complete geocoded residential histories from birth through age five.  ... 
doi:10.1186/1476-069x-10-102 pmid:22136431 pmcid:PMC3268745 fatcat:exmqzoi2pvd6rp3vrbervn6fjy

Transient late gestation prenatal hypoxic insult results in functional deficits but not gross neuroanatomic deficits in mice [article]

Ana G Cristancho, Elyse C Gadra, Ima M Samba, Chenying Zhao, Minhui Ouyang, Sergey Magnitsky, Hao Huang, Angela N Viaene, Stewart A Anderson, Eric D Marsh
2021 bioRxiv   pre-print
Hypoxia did not result in motor or visual learning deficits.  ...  There was no difference in gestational age at birth, litter size at birth, survival, fetal brain cell death, or long-term changes in gray or white matter between offspring after normoxia and hypoxia.  ...  Rui Xiao in the Department of Biostatistics at UPenn for her advice on statistical analysis. We thank Brenna Daugherty for initial studies monitoring pregnant mouse locomotion.  ... 
doi:10.1101/2021.08.04.451528 fatcat:q7pbhl2jffbmdjpqah2dzvfnku

Fetal Hippocampal Development: Analysis by Magnetic Resonance Imaging Volumetry

2011 Pediatric Research  
Total hippocampal volume was calculated for each subject and compared against gestational age. There was a linear increase in total hippocampal volume with increasing gestational age (P<0.001).  ...  A cohort of 20 healthy pregnant women underwent prenatal MRI at a median gestational age of 24.9 weeks (range 21.3-31.9 weeks); 6 of the women also had a second fetal MRI performed at a 6 week interval  ...  Addison Cuneo for her logistical help, as well as the volunteers who participated in this study.  ... 
doi:10.1203/pdr.0b013e318211dd7f pmid:21270675 pmcid:PMC3132078 fatcat:dchpsh7v4ffd7gazvl3lwhgy6a

Synchronous Aberrant Cerebellar and Opercular Development in Fetuses and Neonates with Congenital Heart Disease: Correlation with Early Communicative Neurodevelopmental Outcomes, Initial Experience

A. Wong, T. Chavez, S. O'Neil, J. Votava-Smith, D. Miller, S. delCastillo, A. Panigrahy, L. Paquette
2017 American Journal of Perinatology Reports  
Neurodevelopment was assessed with Battelle Developmental Inventory, 2nd ed. between 9 and 36 months of age.  ...  Comparable fetal and neonatal T2 contrast was used for manual linear cross-sectional measurement. Multivariable analysis was used for adjustments and curve fitting.  ...  for making sure the patients are enrolled and studied safely.  ... 
doi:10.1055/s-0036-1597934 pmid:28210520 pmcid:PMC5305423 fatcat:jyx3l35s5zgufdndmlwbwjo2eu

Apparent diffusion coefficient of different areas of brain in foetuses with intrauterine growth restriction

Behnaz Moradi, Zohreh Alibeigi Nezhad, Nazanin Seyed Saadat, Mahboobeh Shirazi, Ali Borhani, Mohammad Ali Kazemi
2020 Polish Journal of Radiology  
A total of 38 foetuses with IUGR and 18 normal control foetuses with similar gestational age were compared using a 3T magnetic resonance scanner.  ...  IUGR was defined as a foetal estimated weight less than the10 th percentile for gestational age according to the reference data and based on ultrasound measurement [13] .  ...  The control group was selected from non-IUGR foetuses with similar gestational age, referred for foetal MRI for suspected ventriculomegaly (n = 2), duodenal atresia (n = 2), oesophageal atresia (n = 1)  ... 
doi:10.5114/pjr.2020.96950 pmid:32685065 pmcid:PMC7361370 fatcat:2sej5p7l3jfppdiy36midej46i

Mediterranean diet based intervention in pregnancy to improve maternal and fetal outcomes: Methodological challenges and lessons learned from the multicentre ESTEEM study

Bassel H. Al Wattar, Julie Dodds, Anna Placzek, Eleni Spyreli, Sally Higgins, Amanda Moore, Richard Hooper, Lee Beresford, Tessa J. Roseboom, Maira Bes-Rastrollo, Graham Hitman, Khalid S. Khan (+1 others)
2017 Contemporary Clinical Trials Communications  
for the ESTEEM study group, Mediterranean diet based intervention in pregnancy to improve maternal and fetal outcomes: Methodological challenges and lessons learned from the multicentre ESTEEM study, Abstract  ...  We present the challenges and the 35 lessons learned from a multicentre randomised trial (ESTEEM) on Mediterranean-based 36 dietary intervention in pregnancy. 37 Methods: We recruited pregnant women who  ...  Our panel of 241 experts identified stillbirth, small for gestational age fetus (birth weight less than 10th centile) 242and admission to the neonatal intensive care unit to be the most clinically important  ... 
doi:10.1016/j.conctc.2017.02.012 pmid:29740638 pmcid:PMC5936842 fatcat:uaserhufevdyfaeetwxy46u2hq

Is fetal MRI ready for neuroimaging prime time? An examination of progress and remaining areas for development

Vidya Rajagopalan, Sean Deoni, Ashok Panigrahy, Moriah E. Thomason
2021 Developmental Cognitive Neuroscience  
We will compare and contrast various design considerations for both normative and high-risk populations, in the setting of the post-COVID era.  ...  In the development of a common Healthy Brain and Child Development (HBCD) protocol, one of the chief questions is "is fetal MRI ready for prime-time?"  ...  AP is supported by Department of Defense (W81XWH-16-1-0613), National Heart, Lung and Blood Institute (HL152740, HL128818), National Institute of Aging (R01HL128818-05 S1) and DA050290.  ... 
doi:10.1016/j.dcn.2021.100999 pmid:34391003 pmcid:PMC8365463 fatcat:o7mcpiwc6jehvnd2mmhlzncr6y

Language function following preterm birth: prediction using machine learning

Evdoxia Valavani, Manuel Blesa, Paola Galdi, Gemma Sullivan, Bethan Dean, Hilary Cruickshank, Magdalena Sitko-Rudnicka, Mark E. Bastin, Richard F. M. Chin, Donald J. MacIntyre, Sue Fletcher-Watson, James P. Boardman (+1 others)
2021 Pediatric Research  
This study aimed to predict language outcomes at 2 years corrected gestational age (CGA) for children born preterm.  ...  Impact A combination of clinical perinatal factors and neonatal DTI measures of white matter microstructure leads to accurate prediction of language outcome at 2 years corrected gestational age following  ...  All authors have drafted the article or revised it critically for important intellectual content and have approved the final version to be considered for publication. FUNDING INFORMATION  ... 
doi:10.1038/s41390-021-01779-x pmid:34635792 fatcat:qkgtsxcpnnb2dnub4usop44lt4

Association of Prenatal Sugar Consumption with Newborn Brain Tissue Organization

Paige K. Berger, Catherine Monk, Ravi Bansal, Siddhant Sawardekar, Michael I. Goran, Bradley S. Peterson
2021 Nutrients  
Adjusting for postmenstrual age, sex, birth weight, and total energy intake revealed that maternal total and added sugar consumption were associated inversely and diffusely with infant MD values, not FA  ...  Animal studies have shown that exposure to excess sugar during the prenatal and postnatal periods may alter early brain structure in rat pups. However, evidence in humans is lacking.  ...  Postmenstrual age at the time of MRI scan is defined as the time that elapsed between the mother's last menstrual period and birth of the infant, also known as gestational age at birth, plus chronological  ... 
doi:10.3390/nu13072435 pmid:34371944 pmcid:PMC8308814 fatcat:oixj52ysine6lhfuwrfmz7ofc4

Prenatal Exposure to Paint Thinner Alters Postnatal Development and Behavior in Mice

Hanaa Malloul, Ferdaousse M. Mahdani, Mohammed Bennis, Saadia Ba-M'hamed
2017 Frontiers in Behavioral Neuroscience  
At PND5, the pups were assessed for their postnatal growth, physical maturation, reflex development, neuromotor abilities, sensory function, activity level, anxiety, depression, learning and memory functions  ...  At adulthood, structural changes of the hippocampus were examined by estimating the total volume of the dentate gyrus.  ...  REGRAGUI for his support by providing us experimental animals.  ... 
doi:10.3389/fnbeh.2017.00171 pmid:28959195 pmcid:PMC5604056 fatcat:h3nstz6ajfhxthedrmgawagndy

Association of Prenatal Maternal Anxiety With Fetal Regional Brain Connectivity

Josepheen De Asis-Cruz, Dhineshvikram Krishnamurthy, Li Zhao, Kushal Kapse, Gilbert Vezina, Nickie Andescavage, Jessica Quistorff, Catherine Lopez, Catherine Limperopoulos
2020 JAMA Network Open  
This study analyzed 59 resting-state functional connectivity magnetic resonance image data sets from the fetuses (mean [SD] gestational age, 33.52 [4 weeks]) of 50 healthy pregnant women (mean [SD] age  ...  Early onset of functional deviations suggests the need for more widespread screening of pregnant women for symptoms of anxiety.  ...  This analysis included 59 resting-state MRI scans performed on 50 fetuses between 24.71 and 39.43 gestational weeks (mean [SD] gestational age, 33.52 [4.00] weeks).  ... 
doi:10.1001/jamanetworkopen.2020.22349 pmid:33284334 fatcat:zz5l37e5off4baeumgv6gykyyi

Relationship between fetal pulmonary artery blood flow velocity waveform and fetal lung length in pregnancies complicated by oligohydramnios

Krysztof Blaszczyk, M. Wojcieszyn, A. Lukasik, K. Swadzba, M. Stokowacka, R. Poreba
2001 Ultrasound in Obstetrics and Gynecology  
Methodology: Over a 4-year period, a transabdominal echocardiography was performed in 912 high risk pregnancies for congenital heart disease at 18-38 weeks of gestation.  ...  Objective: To estimate the effectiveness of the three vessels view in prenatal diagnosis of congenital heart defects (CHD).  ...  Mean gestational age at delivery was 35 weeks and 5 days. Eighteen (64%) delivered prematurely. The mean birth weight was 2562 g. Four infants (14%) were small for gestational age.  ... 
doi:10.1046/j.1469-0705.2001.0180s1027.x fatcat:5mscwstpxzbgti4qgcwtinzxrq
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