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Validation of the flash-evoked response from fetal MEG

J McCubbin, P Murphy, H Eswaran, H Preissl, T Yee, S E Robinson, J Vrba
2007 Physics in Medicine and Biology  
However, a standard analysis approach based on orthogonal projection (OP) to attenuate maternal and fetal cardiac signals leads to a spatial redistribution of the signal.  ...  These results confirm that the combined application of a beamformer model search and bootstrap significance test provides a validation of the flash-evoked response observed in OP processed fetal MEG channels  ...  Acknowledgements The work was supported by the US National Institutes of Health under grants 1R01NS367704A1 and 1R33EB00978-01.  ... 
doi:10.1088/0031-9155/52/19/005 pmid:17881801 pmcid:PMC2600492 fatcat:3rlumkhntnfozntpinzsy3cgze

Removal of interference from fetal MEG by frequency dependent subtraction

J. Vrba, J. McCubbin, R.B. Govindan, S. Vairavan, P. Murphy, H. Preissl, C.L. Lowery, H. Eswaran
2012 NeuroImage  
Fetal magnetoencephalography (fMEG) recordings are contaminated by maternal and fetal magnetocardiography (MCG) signals and by other biological and environmental interference.  ...  Keywords Magnetoencephalography; interference cancellation; frequency dependent subtraction; orthogonal projection; spontaneous fetal brain signals  ...  Acknowledgments The work was supported by NIH grants R01NS036277 and R01EB007826. APPENDIX A: Simulation parameters Maternal body model:  ... 
doi:10.1016/j.neuroimage.2011.08.103 pmid:21930216 pmcid:PMC3254788 fatcat:uri23nymefei3gdcf5wjwsmu6u

Localization of spontaneous magnetoencephalographic activity of neonates and fetuses using independent component and Hilbert phase analysis

Srinivasan Vairavan, Hari Eswaran, Hubert Preissl, James D Wilson, Naim Haddad, Curtis L Lowery, Rathinaswamy B Govindan
2010 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology  
These cardiac interferences can be attenuated by orthogonal projection (OP) technique of the corresponding spatial vectors.  ...  In this paper, we propose a novel way to extract and localize the neonatal and fetal spontaneous brain activity by using independent component analysis (ICA) technique.  ...  Acknowledgments This work was supported by the U.S. National Institute of Health (NIH) under Grant NIBIB/1R01EB07826-01A1. The authors wish to thank Pam Murphy for useful discussions.  ... 
doi:10.1109/iembs.2010.5626753 pmid:21096327 pmcid:PMC3102006 fatcat:ld3mmfuxwfau5l4kvci5fxlxxe

Separation of Physiological Signals Using Minimum Norm Projection Operators

James D. Wilson, Jens Haueisen
2017 IEEE Transactions on Biomedical Engineering  
Results- We present examples that demonstrate the utility of our projection operators when applied to maternal and fetal magneto-cardiograms.  ...  Methods-Projection operators based upon both the weighted and un-weighted minimum norm equations are presented.  ...  Acknowledgments This work was sponsored in part by NIH grant R01EB007826-04A1 NIBIB/NIH.  ... 
doi:10.1109/tbme.2016.2582643 pmid:27337708 pmcid:PMC5486981 fatcat:yxje4ttxd5h25p5z5ge73pkk5q

Delayed maturation of auditory-evoked responses in growth-restricted fetuses revealed by magnetoencephalographic recordings

Isabelle Kiefer, Eric Siegel, Hubert Preissl, Maureen Ware, Burkhard Schauf, Curtis Lowery, Hari Eswaran
2008 American Journal of Obstetrics and Gynecology  
Objective-To investigate fetal brain development of growth-restricted fetuses by using Auditory Evoked Responses (AER) recorded using the non-invasive magnetoencephalographic technique.  ...  Methods-Serial fetal recordings starting at 27 weeks of gestation were conducted on a fetal magnetoencephalographic device (fMEG) specially designed for obstetrical assessment.  ...  Acknowledgments We thank Pam Murphy , R.N. at the SARA Research Center at UAMS, for her great help to conduct the MEG recordings and Harald Abele, MD, from the Department of Gynaecology and Obstetrics  ... 
doi:10.1016/j.ajog.2008.04.014 pmid:18533116 pmcid:PMC2954061 fatcat:bibfa7eukbgabjy2vxibyd26tu

Verification of fetal brain responses by coregistration of fetal ultrasound and fetal magnetoencephalography data

C. Micheli, J. McCubbin, P. Murphy, H. Eswaran, C.L. Lowery, E. Ortiz, H. Preissl
2010 NeuroImage  
Fetal magnetoencephalography (fMEG) is used to study neurological functions of the developing fetus by measuring magnetic signals generated by electrical sources within the fetal brain.  ...  In the second step we compared the results gained by the model search approach to the exact location of the fetal head determined on pregnant mothers by ultrasound.  ...  Acknowledgments This study was supported by NIBIB-National Institutes of Health grant R01EB007826-01A1.  ... 
doi:10.1016/j.neuroimage.2009.09.025 pmid:19778620 pmcid:PMC2948237 fatcat:7cfevyvrevhu5lddinio7ryxti

Exploring early human brain development with structural and physiological neuroimaging

Lana Vasung, Esra Abaci Turk, Silvina L. Ferradal, Jason Sutin, Jeffrey N. Stout, Banu Ahtam, Pei-Yi Lin, P. Ellen Grant
2018 NeuroImage  
Early brain development, from the embryonic period to infancy, is characterized by rapid structural and functional changes.  ...  The complementary roles of magnetic resonance imaging (MRI), electroencephalography (EEG), magnetoencephalography (MEG), and near-infrared spectroscopy (NIRS) are discussed.  ...  Acknowledgements This work was been supported by the National Institutes of Health U01NS082320 (Sahin), R01MH097979 (Rathi), R01HD076258 (Grant), R01EB017337 (Grant, Wald, Adalsteinsson), R01HD078561 (  ... 
doi:10.1016/j.neuroimage.2018.07.041 pmid:30041061 pmcid:PMC6537870 fatcat:nzxrgiebqbdhledw5ierh3arc4

Ellipsoidal head model for fetal magnetoencephalography: forward and inverse solutions

David Gutiérrez, Arye Nehorai, Hubert Preissl
2005 Physics in Medicine and Biology  
SARA is an MEG system especially designed for fetal assessment and is currently used for heart and brain studies.  ...  There are a number of aspects related to fMEG modelling that must be addressed, such as the conductor volume, fetal position and orientation, gestation period, etc.  ...  Acknowledgments This work was supported by NIN/NINDS Grant 2 R01 NS36277-04A1 and NSF Grant CCR-0105334.  ... 
doi:10.1088/0031-9155/50/9/015 pmid:15843742 fatcat:rpunaxclgfbnvi3uxdrcy3uwne

Green Tea (Camellia sinensis) Extract Induces p53-Mediated Cytotoxicity and Inhibits Migration of Breast Cancer Cells

Ronimara A. Santos, Emmanuele D. S. Andrade, Mariana Monteiro, Eliane Fialho, Jerson L. Silva, Julio B. Daleprane, Danielly C. Ferraz da Costa
2021 Foods  
An increment in p53 and p21 expression stimulated by GTE was observed in MCF-7, and the opposite phenomenon was found in MDA-MB-231 cells, with a redistribution of mutant-p53 from the nucleus and no differences  ...  GTE was also effective in reducing MCF-7 and MDA-MD-231 cell migration by 30 and 50%, respectively.  ...  Dimethyl sulfoxide (DMSO), trypsin, antibiotics (peni-cillin, streptomycin), fetal bovine serum, Mammary Epithelial Growth Supplement (MEGS), Dulbecco's Modified Eagle's Medium (DMEM) media were purchased  ... 
doi:10.3390/foods10123154 pmid:34945706 pmcid:PMC8701076 fatcat:iym5vtr4uff4boaq4ijjvzjyny

Redistribution of Nucleoside Transporters to the Cell Membrane Provides a Novel Approach for Imaging Thymidylate Synthase Inhibition by Positron Emission Tomography

Meg Perumal, Radhakrishna G. Pillai, Henryk Barthel, Julius Leyton, John R. Latigo, Martin Forster, Fraser Mitchell, Ann L. Jackman, Eric O. Aboagye
2006 Cancer Research  
We conclude that [ 18 F]FLT-PET can be used to measure thymidylate synthase inhibition as early as 1 to 2 hours after treatment with 5-FU by a mechanism involving redistribution of nucleoside transporters  ...  Radiation-induced fibrosarcoma-1 tumor-bearing mice were injected with a single i.p. dose of the thymidylate synthase inhibitor 5-fluorouracil (5-FU; 165 mg/kg) and imaged by [ 18 F]FLT-PET at 1 to 2 hours  ...  Acknowledgments The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be marked advertisement in accordance with 18 U.S.C.  ... 
doi:10.1158/0008-5472.can-06-0898 pmid:16951168 fatcat:6cwx75mt35fxhizoptc3utcjg4

Glucose Metabolism Measured by [18F]Fluorodeoxyglucose Positron Emission Tomography Is Independent of PTEN/AKT Status in Human Colon Carcinoma Cells

Quang-Dé Nguyen, Meg Perumal, Todd A. Waldman, Eric O. Aboagye
2011 Translational Oncology  
Acute inhibition of PI3K activity by LY294002, and hence decreased activated AKT expression, led to a significant reduction in tumor [ 18 F]FDG uptake that could be explained at least in part by decreased  ...  Stimulation of the PI3K pathway can be initiated by alterations at different levels of the signaling cascade including growth factor receptor activation, as well as mutations in PIK3CA, PTEN, and AKT genes  ...  projection using a two-dimensional Hamming filter (cutoff, 0.6).  ... 
doi:10.1593/tlo.11118 pmid:21804920 pmcid:PMC3140012 fatcat:nm3ppskph5dfpawdy7gu3yxtoa

Anti-tumour effects by a trimodal combination of temozolomide, meloxicam and X-rays in cultures of human glioma cells

Krista A. Van Nifterik, Jaap Van Den Berg, Ben J. Slotman, Johannes Van Rijn
2010 International Journal of Radiation Biology  
Long-term observations of D384 cells demonstrated that the repopulation rates of the surviving cells are far less affected by the various treatment protocols than those from the non-surviving cells.  ...  K.A. van Nifterik was supported in part by the Dutch Cancer Society project #VU 2000-2149. The authors would like to thank Dr. M.V.M.  ...  Incorporation of O 6 -MeG adducts into the DNA can result in futile repair attempts by the mismatch repair system; leading to base/base mismatches and eventually cell death [5, 12, 15] .  ... 
doi:10.3109/09553002.2010.519423 pmid:21067299 fatcat:no5llzqttvhktg3qcuu347qyzm

Innovative Processing Algorithms for Fetal Magnetoencephalographic Data [article]

Katrin Sippel, Universitaet Tuebingen, Rosenstiel, Wolfgang (Prof. Dr.)
2020
Furthermore, signal redistribution is a problem with the current methods, which makes later detection of the fetal brain activity challenging.  ...  Important questions concerning the developmental process of the fetal brain, as well as the maternal influence on the metabolic and cognitive state of the newborn, can be clarified by the analysis of fMEG  ...  The removal of heart activity until now has been done by orthogonal projection (OP) [98] . This method worked reliable but had the problem of redistributing the signal [100] .  ... 
doi:10.15496/publikation-47450 fatcat:ilgpigr2gbdajbphdsbcxrantm

An Overview of Empathy

James Hardee
2003 The Permanente Journal  
This support was embodied by the OOPS project being part of the strategic plan, by carefully allocating key people's time, and by intervening with regard to key issues to help project teams move forward  ...  Meg Graue: Patient-centered care truly acknowledges the patient as an individual.  ...  KP Southern California was one of four health plans in the country chosen by Medicare to participate in the three-year demonstration project.  ... 
doi:10.7812/tpp/03-072 fatcat:nju7jrduqzf3xaljlgskymtcei

Disruption of Network Synchrony and Cognitive Dysfunction After Traumatic Brain Injury

John A. Wolf, Paul F. Koch
2016 Frontiers in Systems Neuroscience  
Unlike focal injury to a discrete brain region, axonal injury is fundamentally an injury to the substrate by which networks of the brain communicate with one another.  ...  to impairment of memory redistribution.  ...  reciprocal projections.  ... 
doi:10.3389/fnsys.2016.00043 pmid:27242454 pmcid:PMC4868948 fatcat:hqxcbi7hljgg7h7ttrdbqzf2ey
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