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Fetal heart rate complexity measures to detect hypoxia

Oscar Barquero-Perez, Rebeca Goya-Esteban, Antonio Caamano, Carlos Martin-Caballero, Jose Luis Rojo-Alvarez
2015 2015 Computing in Cardiology Conference (CinC)  
Complexity measures of the FHR were different for healthy and hypoxia fetuses. These indices may help to early detect hypoxia with less invasive methods.  ...  When the fetus brain is partially deprived from oxygen, the control of the fetal heart rate (FHR) is affected.  ...  Continuous electronic fetal monitoring, also known as Cardiotocography (CTG), was developed around 1960 [3] and consists of the simultaneous evaluation of the fetal heart rate (FHR) and the uterine activity  ... 
doi:10.1109/cic.2015.7408604 dblp:conf/cinc/Barquero-PerezG15 fatcat:bp4yw2ss55crtplbcck65ptvw4


Oleh Viunytskyi, Vyacheslav Shulgin, Alexander Totsky, Valery Sharonov
One of the ways for detecting symptoms of hypoxia is monitoring of the fetus heart activity.  ...  Fetal hypoxia or distress is a physical stress experienced by a fetus due to a lack of oxygen.  ...  In addition, CTG provides low accuracy in measuring the fetal heart rate. An alternative to current technology is non-invasive fetal ECG (NI-FECG) or abdominal ECG [1] .  ... 
doi:10.36074/grail-of-science.25.06.2021.028 fatcat:ls2ogl35ubdudlzbrd32c5lgjy

Recent Advances in Fetal Electrocardiography

Yoshitaka Kimura
2012 The Open Medical Devices Journal  
A new extraction system based on blind source separation with reference signals (BSSR) was utilized and our detection rates, both off-line (91%) and on-line (60%), in pregnancies of 20 to 41 weeks of gestation  ...  These include three main difficulties for non-invasive measurement of fetal ECG: first, the low signal to noise ratio; second, the lack of a standard lead system for fetal ECG on the maternal abdomen;  ...  Fetal heart rate from fetal ECG clearly had more short term variability (STV) than fetal heart rate from traditional Doppler CTG.  ... 
doi:10.2174/1875181401204010007 fatcat:ujjyao4z5ffqfomnvtu7as6woi

First evidence that intrinsic fetal heart rate variability exists and is affected by chronic hypoxia [article]

Martin G Frasch, Christophe Herry, Youguo Niu, Dino A. Giussani
2018 bioRxiv   pre-print
CONCLUSIONS: The isolated fetal hearts from the hypoxic pregnancy group exhibit a lower complexity in iHRV.  ...  Here, we show iHRV in isolated hearts from fetal sheep in late gestation and significant effects on iHRV of pregnancy complicated by chronic fetal hypoxia.  ...  Acknowledgements Supported by CIHR and The British Heart Foundation  ... 
doi:10.1101/242107 fatcat:hgqn5yq3frg2vogqkwtqrbmdci

Successful Detection of the Fetal Electrocardiogram Waveform Changes during Various States of Singletons

Naoaki Sato, Tetsuro Hoshiai, Takuya Ito, Kazunari Owada, Hiroshi Chisaka, Ayako Aoyagi, Junichi Sugawara, Nobuo Yaegashi, Kunihiro Okamura, Yoshitaka Kimura
2011 Tohoku journal of experimental medicine  
Fetal signals were successfully separated in 163 of 179 subjects at 91.1% success rate regardless of fetal movements. Time intervals of ECG (P, PR and QRS intervals and QTc) were measured.  ...  Accurate assessment of fetal well-being is one of the most important tasks for obstetricians. It is still difficult to measure fetal electrocardiogram (ECG) during fetal movements.  ...  Because a present fetal heart rate monitoring method from 1990's is unreliable, an alternative to or complement to the present monitoring method is needed to be developed.  ... 
doi:10.1620/tjem.225.89 pmid:21908954 fatcat:qncnzfisbnhlldmxjinb2mz63a

Fetal Programming and Sexual Dimorphism of Mitochondrial Protein Expression and Activity of Hearts of Prenatally Hypoxic Guinea Pig Offspring

Loren P. Thompson, Hong Song, Brian M. Polster
2019 Oxidative Medicine and Cellular Longevity  
While the fetal heart adapts to the reduced oxygenation, the offspring heart becomes vulnerable to subsequent metabolic challenges as an adult.  ...  Indices of mitochondrial function such as mitochondrial DNA content, Complex (C) I-V expression, and CI/CIV enzyme activity were measured in hearts of male and female offspring at 90 days old exposed to  ...  This project is supported in part by the National Heart, Lung, and Blood Institute Grant HL-126859 (LPT).  ... 
doi:10.1155/2019/7210249 pmid:31249648 pmcid:PMC6589217 fatcat:qvygrrgydjghfamvodcs32pf4u

Heart rate variability code: Does it exist and can we hack it? [article]

Martin G. Frasch
2021 arXiv   pre-print
Heart rate variability (HRV) has been studied for over 50 years, yet an integrative concept is missing on what HRV's mathematical properties represent physiologically.  ...  I review the existing evidence from physiological studies in various species to support this concept and propose experiments to help validate and expand this notion further.  ...  Studies in pregnant sheep demonstrate the potential to detect fetal acidemia and predict cardiovascular decompensation during labor using highprecision ECG recording of fetal heart rate (FHR).  ... 
arXiv:2001.08264v4 fatcat:6mpmlfxgsjdorf2cpsvdxnrh44

ST Analysis of the Fetal ECG, as an Adjunct to Fetal Heart Rate Monitoring in Labour: A Review

Tahira Kazmi, Forough Radfer, Sultana Khan
2011 Oman Medical Journal  
Recordi ng the fetal heart rate has been standard practice for more than 159 years.  ...  Therefore, ST analysis is based on the ability to detect changes in the ST interval when the fetus defends itself from hypoxia during labor.  ...  Recordi ng the fetal heart rate has been standard practice for more than 159 years.  ... 
doi:10.5001/omj.2011.118 pmid:22253962 pmcid:PMC3251207 fatcat:ivfgxkeipjaongcp6kxa2keps4

Intrapartum Fetal Monitoring: Pathophysiology and Evolution of Various Techniques

Myron Godinho, Somsubhra De
2018 Journal of Asian Scientific Research  
Article History Keywords Monitoring Fetal Technique Intrapartum CTG Blood sampling Pulse oximetry.  ...  Contribution/ Originality: The study documents the challenges faced by obstetrician during the intrapartum fetal monitoring (IPFM). Various methods of IPFM have been critically analyzed.  ...  This complex physiology of cardiovascular response to hypoxia warrants the need for fetal heart monitoring during the intrapartum phase.  ... 
doi:10.18488/journal.2.2018.81.30.41 fatcat:dcdbdgfq5nbqtgxsqbiucsikie

Brain Sparing in Fetal Mice: BOLD MRI and Doppler Ultrasound Show Blood Redistribution During Hypoxia

Lindsay S Cahill, Yu-Qing Zhou, Mike Seed, Christopher K Macgowan, John G Sled
2014 Journal of Cerebral Blood Flow and Metabolism  
However, it has not been known whether fetal mice reproduce the physiologic response to hypoxia known as brain sparing, where blood flow is redistributed to preserve oxygenation of the brain at the expense  ...  Using Doppler ultrasound measurements, mean cerebral blood velocity was observed to rise by 15±8% under hypoxic conditions relative to hyperoxia.  ...  that occurs with severe hypoxia. 32 Our data highlight the importance of fetal heart rate monitoring as a measure of fetal well-being.  ... 
doi:10.1038/jcbfm.2014.62 pmid:24714036 pmcid:PMC4050255 fatcat:j4hbjyasgbfuvcntpzjqsqzpty

Detection and response to acute systemic hypoxia

A.D. Kane, E. Kothmann, D.A. Giussani
2020 BJA Education  
Interruptions in this flow can rapidly lead to a state of tissue hypoxia. Therefore, mammals have evolved a complex multisystem response to hypoxia.  ...  We will then consider how the fetus withstands such insults and consider the transition in the response to hypoxia from fetal to postnatal life.  ...  Detection and response to acute systemic hypoxia BJA Education -Volume 20, Number 2, 2020  ... 
doi:10.1016/j.bjae.2019.10.004 pmid:33456931 pmcid:PMC7807956 fatcat:64vwbwfw2zgv5os2no4jencnbi

ST waveform analysis for monitoring hypoxic distress in fetal sheep after prolonged umbilical cord occlusion

Peter Andriessen, Alex Zwanenburg, Judith O. E. H. van Laar, Rik Vullings, Ben J. M. Hermans, Hendrik J. Niemarkt, Reint K. Jellema, Daan R. M. G. Ophelders, Tim G. A. M. Wolfs, Boris W. Kramer, Tammo Delhaas, Martin Gerbert Frasch
2018 PLoS ONE  
The STAN device produced high false positive event rates during baseline and did not detect T/QRS changes adequately after prolonged fetal hypoxemia.  ...  Conclusions The STAN device showed limitations in detecting hypoxemia in fetal sheep after prolonged UCO.  ...  Acknowledgments The authors would like to thank Jeroen Hameleers for technical assistance during the study. Author Contributions  ... 
doi:10.1371/journal.pone.0195978 pmid:29659625 pmcid:PMC5901956 fatcat:uvnfxcsldjgafopwntgjx62wiq

A contribution to the monitoring of fetal arrhythmias

R. Boos, L. Auer, H. Rüttgers, F. Kubli
1982 Journal of Perinatal Medicine  
Since the CTG cannot be interpreted äs usual during fetal arrhythmia, frequent scalp pH measurements must be performed to detect hypoxia äs a possible cause or consequence of the bradyarrhythmia.  ...  Here the arrhythmia present is clearly detected. C simultaneously with fetal heart rate, the maternal heart rate was also registered.  ... 
doi:10.1515/jpme.1982.10.2.85 pmid:7097470 fatcat:ywsq33kutfakzlkhd3nomoomie

Role of Prostanoids in the Regulation of Cerebral Blood Flow During Normoxia and Hypoxia in the Fetal Sheep

Naoko Nishida, Arlin B Blood, Christian J Hunter, Shannon Bragg, James Williams, William J Pearce, Gordon G Power
2006 Pediatric Research  
The fetal cardiovascular responses to hypoxia include decreased peripheral blood flow and increased cerebral, cardiac, and adrenal blood flow.  ...  In the control experiments, CBF, measured continuously with laser Doppler flowmetry, increased to 148% of baseline values (p Ͻ 0.01) and cerebral vascular resistance decreased to 70% of baseline values  ...  Figure 2 shows mean arterial blood pressure and heart rate for both experimental groups.  ... 
doi:10.1203/01.pdr.0000242268.99726.53 pmid:16988195 fatcat:4w7hutgb2rfcph2e5nbkm2ijra

Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development

Martin G. Frasch, Dino A. Giussani
2020 Cells  
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease.  ...  Here, we review the current evidence and novel avenues of bench-to-bed research in this field of perinatal cardiogenesis as well as its translational significance for early detection of future risk for  ...  The analysis of fetal heart rate variability (HRV) has been the mainstay of noninvasive fetal health monitoring for decades, yet its utility to identify endangered fetuses has remained limited [7, 8]  ... 
doi:10.3390/cells9030733 pmid:32192015 pmcid:PMC7140710 fatcat:myfadsbmofaexe5c7kgoeqd3qi
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