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A magneto-motive ultrasound platform designed for pre-clinical and clinical applications

Diego Ronaldo Thomaz Sampaio, Felipe Wilker Grillo, Alexandre Colello Bruno, Theo Zeferino Pavan, Antonio Adilton Oliveira Carneiro
2017 Research on Biomedical Engineering  
Magneto-motive ultrasound (MMUS) combines magnetism and ultrasound (US) to detect magnetic nanoparticles in soft tissues. One type of MMUS called shear-wave dispersion magneto-motive ultrasound (SDMMUS) analyzes magnetically induced shear waves (SW) to quantify the elasticity and viscosity of the medium. The lack of an established presets or protocols for pre-clinical and clinical studies currently limits the use of MMUS techniques in the clinical setting. Methods: This paper proposes a
more » ... to acquire, process, and analyze MMUS and SDMMUS data integrated with a clinical ultrasound equipment. For this purpose, we developed an easy-to-use graphical user interface, written in C++/Qt4, to create an MMUS pulse sequence and collect the ultrasonic data. We designed a graphic interface written in MATLAB to process, display, and analyze the MMUS images. To exemplify how useful the platform is, we conducted two experiments, namely (i) MMUS imaging to detect magnetic particles in the stomach of a rat, and (ii) SDMMUS to estimate the viscoelasticity of a tissue-mimicking phantom containing a spherical target of ferrite. Results: The developed software proved to be an easy-to-use platform to automate the acquisition of MMUS/SDMMUS data and image processing. In an in vivo experiment, the MMUS technique detected an area of 6.32 ± 1.32 mm 2 where magnetic particles were heterogeneously distributed in the stomach of the rat. The SDMMUS method gave elasticity and viscosity values of 5.05 ± 0.18 kPa and 2.01 ± 0.09 Pa.s, respectively, for a tissue-mimicking phantom. Conclusion: Implementation of an MMUS platform with addressed presets and protocols provides a step toward the clinical implementation of MMUS imaging equipment. This platform may help to localize magnetic particles and quantify the elasticity and viscosity of soft tissues, paving a way for its use in pre-clinical and clinical studies.
doi:10.1590/2446-4740.03116 fatcat:ojg4cd3jc5bx7ipjff74ci7gny

Patient-specific neurosurgical phantom: assessment of visual quality, accuracy, and scaling effects

Felipe Wilker Grillo, Victor Hugo Souza, Renan Hiroshi Matsuda, Carlo Rondinoni, Theo Zeferino Pavan, Oswaldo Baffa, Helio Rubens Machado, Antonio Adilton Oliveira Carneiro
2018 3D Printing in Medicine  
Training in medical education depends on the availability of standardized materials that can reliably mimic the human anatomy and physiology. One alternative to using cadavers or animal bodies is to employ phantoms or mimicking devices. Styrene-ethylene/butylene-styrene (SEBS) gels are biologically inert and present tunable properties, including mechanical properties that resemble the soft tissue. Therefore, SEBS is an alternative to develop a patient-specific phantom, that provides real visual
more » ... and morphological experience during simulationbased neurosurgical training. Results: A 3D model was reconstructed and printed based on patient-specific magnetic resonance images. The fused deposition of polyactic acid (PLA) filament and selective laser sintering of polyamid were used for 3D printing. Silicone and SEBS materials were employed to mimic soft tissues. A neuronavigation protocol was performed on the 3D-printed models scaled to three different sizes, 100%, 50%, and 25% of the original dimensions. A neurosurgery team (17 individuals) evaluated the phantom realism as "very good" and "perfect" in 49% and 31% of the cases, respectively, and rated phantom utility as "very good" and "perfect" in 61% and 32% of the cases, respectively. Models in original size (100%) and scaled to 50% provided a quantitative and realistic visual analysis of the patient's cortical anatomy without distortion. However, reduction to one quarter of the original size (25%) hindered visualization of surface details and identification of anatomical landmarks. Conclusions: A patient-specific phantom was developed with anatomically and spatially accurate shapes, that can be used as an alternative for surgical planning. Printed models scaled to sizes that avoided quality loss might save time and reduce medical training costs.
doi:10.1186/s41205-018-0025-8 pmid:29782617 pmcid:PMC5954795 fatcat:t2ykrgjcdrcmdnfwrscwfpunuy

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Avenida Lucio, Martins Rodrigues, -Travessa -Bloco, Abner Morilha, Adalgiso Silveira, Each Adilson, Marcos Montefusco, Adriana Takimoto, Adriane Jacinto, Salustiano Fmrp, Adriano Bonfim, Carregaro Fzea (+46 others)
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Wilker Grillo FFCLRP Fellipe de Almeida Pasin EEL Fernanda Alves Fahl FAU Fernanda Beatrice Conceição Nonato I P E N Fernanda Conforto de Oliveira IRI Fernanda Cristina Sales Salineiro  ...  Felipe Coro Ghiro ICMC Felipe Diniz Brunini EESC e ICMC Felipe Freitas Gargiulo PROLAM Felipe Medeiros Gracio I P E N Felipe Palma Cardozo Garcia IGc Felipe Peres Fernandes ECA Felipe  ...