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In order to design actionable SARS-CoV-2 strategies, we extended the SEIRS model to support stratified isolation levels for healthy <60 and vulnerable individuals. At first, we forced isolation levels to be uniform, showing that daily deaths curves of all metropolitan areas in the analysis can be fitted using homogeneous Ro=3.3. In the process, we established the possibility that an extremely short infectiousness period of 2 days coupled with 5 days exposure may be responsible for the multipledoi:10.1101/2020.10.09.20210146 fatcat:rqmvoqi5bjghfhyy5l2eycnzom
more »... eaths valleys observed during the weeks following lockdowns. Regardless of the infectiousness period, we realized that is possible to infer non-uniform isolation levels for healthy <60 and vulnerable by forcing the model to match the <60 to >60 age serology ratio reported in seroprevalence studies. Since the serology ratio is more robust than absolute values, we argue immunity level estimations made in this way (Madrid 43%; Catalonia 24%; Brussels 73%; and Stockholm 65%) are closer to reality. In locations where we did not find reliable serology, we performed immunity estimations assuming Spain serology ratio (Paris: 24%; London: 34%). We predict that, with the exception of Brussels, no location can return to normal life without having a second wave (albeit in Stockholm a smaller one). For locations far from the herd immunity threshold (HIT) we searched what isolation values allow to return to normal life in 90 days minimizing final deaths, shockingly all found isolations for healthy <60 were negative (i.e. coronavirus parties minimize final deaths). Then, assuming an ideal 1-day long vaccination campaign with a 77% efficacy vaccine, we compared predicted final deaths of those 90-day strategies for all possible vaccination dates with a 180-day long vaccine waiting strategy that imposes 0.40 mandatory isolation to healthy <60 and results in 0.65 isolation to vulnerable. We found that 180-day of mandatory isolations to healthy <60 (i.e. schools and workplaces closed) produces more final deaths if the vaccination date is later than (Madrid: March 7 2021; Catalonia: Dec 26 2020; Paris: Jan 12 2021; London: Jan 25 2021). We conclude that our 2-stratum SEIRS model is suitable to predict SARS-CoV-2 epidemic behavior and can be used to minimize covid-19 disease and isolations related damages.
Mucous membrane pemphigoid (MMP) is a heterogeneous group of blistering disorders affecting the mucosae with or without skin involvement, characterized by the presence of autoantibodies to components of the basement membrane zone, including the bullous pemphigoid antigen BP180 and β4 integrin. Current literature has shown that a minority of patients present circulating antibodies to laminin-332 and this population seems to be associated with a relatively high risk of malignancy. Objective: Todoi:10.5826/dpc.0902a07 pmid:31106014 pmcid:PMC6502303 fatcat:3fqebrnydrgjfeznzhvfao3thm
more »... esent our personal case series of patients with MMP-associated malignancy from a dermatology university hospital. Methods: Twenty-two patients affected by MMP were seen in the period between 2001 and 2016; in 4 patients (18%) an associated cancer was detected. Results: These patients were 2 men and 2 women, with a mean age of 69.7 years (range, 48-83). The associated malignancies included a breast cancer, a pancreatic adenocarcinoma, a metastatic laryngeal carcinoma, and a hepatic carcinoma. All patients had negative results for both BP180 and laminin-332 autoantibodies. Conclusion: We confirm that MMP patients have a relatively high possibility of developing a solid cancer, but the autoantibody detection is not mandatory and is probably correlated with the severity of the disease.
Naxos in the greenhouse of the University of Naples Federico II. ...doi:10.19263/redia-101.18.08 fatcat:prewr44qebavlkfcrh7trcl4wa
Search is an integral part of a software development process. Developers often use search engines to look for information during development, including reusable code snippets, API understanding, and reference examples. Developers tend to prefer general-purpose search engines like Google, which are often not optimized for code related documents and use search strategies and ranking techniques that are more optimized for generic, non-code related information. In this paper, we explore whether aarXiv:1803.08612v1 fatcat:f4rshpfx4fflnmgimku62r667a
more »... neral purpose search engine like Google is an optimal choice for code-related searches. In particular, we investigate whether the performance of searching with Google varies for code vs. non-code related searches. To analyze this, we collect search logs from 310 developers that contains nearly 150,000 search queries from Google and the associated result clicks. To differentiate between code-related searches and non-code related searches, we build a model which identifies the code intent of queries. Leveraging this model, we build an automatic classifier that detects a code and non-code related query. We confirm the effectiveness of the classifier on manually annotated queries where the classifier achieves a precision of 87%, a recall of 86%, and an F1-score of 87%. We apply this classifier to automatically annotate all the queries in the dataset. Analyzing this dataset, we observe that code related searching often requires more effort (e.g., time, result clicks, and query modifications) than general non-code search, which indicates code search performance with a general search engine is less effective.
The graft was tunneled proximally posterior to the inferior vena cava and brought up to Federico Rea, MD, Abdel-Mohsen Hamad, MD, Monica Loy, MD, Cristiano Breda, MD, Marco Schiavon, MD, and Giuseppe Marulli ...doi:10.1016/j.jtcvs.2009.04.008 pmid:19660405 fatcat:ytswyo4r7ngvpdoxxav7bwacpe
VLSI design (Print)
Networks-on-Chip (NoCs) are emerging as scalable interconnection architectures, designed to support the increasing amount of cores that are integrated onto a silicon die. Compared to traditional interconnects, however, NoCs still lack well established CAD deployment tools to tackle the large amount of available degrees of freedom, starting from the choice of a network topology. "Silicon-aware" optimization tools are now emerging in literature; they select an NoC topology taking into account thedoi:10.1155/2007/50285 fatcat:iynxzgm44jcahkfmyqpahfww3y
more »... tradeoff between performance and hardware cost, that is, area and power consumption. A key requirement for the effectiveness of these tools, however, is the availability of accurate analytical models for power and area. Such models are unfortunately not as available and well understood as those for traditional communication fabrics. Further, simplistic models may turn out to be totally inaccurate when applied to wire dominated architectures; this observation demands at least for a model validation step against placed and routed devices. In this work, given an NoC reference architecture, we present a flow to devise analytical models of area occupation and power consumption of NoC switches, and propose strategies for coefficient characterization which have different tradeoffs in terms of accuracy and of modeling activity effort. The models are parameterized on several architectural, synthesis-related, and traffic variables, resulting in maximum flexibility. We finally assess the accuracy of the models, checking whether they can also be applied to placed and routed NoC blocks.
Apoptosis has recently been proposed to contribute to the pathogenesis of emphysema. Methods: In order to establish if cell fate plays a role even in end-stage disease we studied 16 lungs (9 smoking-associated and 7 α1antitrypsin (AAT)-deficiency emphysema) from patients who had undergone lung transplantations. Six unused donor lungs served as controls. Apoptosis was evaluated by TUNEL analysis, single-stranded DNA laddering, electron microscopy and cell proliferation by an immunohistochemicaldoi:10.1186/1465-9921-6-14 pmid:15705190 pmcid:PMC549521 fatcat:nwxvvzvesvgzplpqmsp5tbqudm
more »... ethod (MIB1). The role of the transforming growth factor (TGF)-β1 pathway was also investigated and correlated with epithelial cell turnover and with the severity of inflammatory cell infiltrate. Results: The apoptotic index (AI) was significantly higher in emphysematous lungs compared to the control group (p ≤ 0.01), particularly if only lungs with AAT-deficiency emphysema were considered (p ≤ 0.01 vs p = 0.09). The proliferation index was similar in patients and controls (1.9 ± 2.2 vs 1.7 ± 1.1). An increased number of T lymphocytes was observed in AAT-deficiency lungs than smoking-related cases (p ≤ 0.05). TGF-β1 expression in the alveolar wall was higher in patients with smoking-associated emphysema than in cases with AAT-deficiency emphysema (p ≤ 0.05). A positive correlation between TGF-βRII and AI was observed only in the control group (p ≤ 0.005, r 2 = 0.8). A negative correlation was found between the TGF-β pathway (particularly TGF-βRII) and T lymphocytes infiltrate in smoking-related cases (p ≤ 0.05, r 2 = 0.99) Conclusion: Our findings suggest that apoptosis of alveolar epithelial cells plays an important role even in end-stage emphysema particularly in AAT-deficiency disease. The TGFβ-1 pathway does not seem to directly influence epithelial turnover in end-stage disease. Inflammatory cytokine different from TGF-β1 may differently orchestrate cell fate in AAT and smoking-related emphysema types.
Proceedings of the conference on Design, automation and test in Europe - DATE '08
The NETWORK-ON-CHIP (NOC) interconnection paradigm has been gaining momentum thanks to its flexibility, scalability and suitability to deep submicron technology processes. The next challenge is to use NoCs as the backbones of the upcoming generation of 3D chips, assembled by stacking multiple silicon layers. Multiple technical issues have to be tackled in this respect. One of the foremost is the unsuitability of a purely synchronous design style, as it is not straightforward to impose a strictdoi:10.1145/1403375.1403717 fatcat:62onfdatcfbtpa77kytqfb2qve
more »... ound on the clock skew among multiple clock trees across different layers. In this paper, we present a scheme to handle mesochronous communication in 3D NoCs and analyze (i) the circuit design, (ii) the timing properties, (iii) the requirements to support flow control across mesochronous links, (iv) the implementation cost of such a scheme after placement and routing.
La fuerza de un mito: la presencia del paisaje "nacional" en la publicidad turística gallega en España A força de um mito: a presença da paisagem "nacional" na publicidade turística galega na Espanha Resumen En el mundo contemporáneo se da una coincidencia llamativa entre los métodos seguidos por los nacionalismos para fomentar la identificación de la imagen de sus pueblos a través del paisaje propio y las prácticas de marketing aplicadas por las instituciones públicas y privadas paradoi:10.5216/ag.v1i1.2371 fatcat:xm3pd6c6erca3jegz5azdwfuc4
more »... r determinados "productos turísticos de masas" a través de rasgos fácilmente identificables de los paisajes que quieren vender. En ambos casos se trata de subrayar la diferencia mediante la exaltación esencialista o caricaturesca de ciertos elementos del paisaje. Se puede mostrar la validez de esta teoría mediante el estudio del caso gallego en España. Del mismo modo que existe una "identidad paisajística castellana" o "andaluza", sin duda existe una "identidad paisajística gallega": ciertos elementos topográficos, climáticos, botánicos y culturales que dan forma a nuestro paisaje y lo distinguen de los demás. Sin embargo, desde que en el siglo XIX el regionalismo y el nacionalismo se fijaron por primera vez en el territorio, se ha insistido hasta la saciedad en algunos motivos del mismo. Los elementos iconográficos que ayudaron a definir la identidad nacional gallega a través del paisaje se han mantenido vivos a lo largo del siglo XX mediante una publicidad turística. ¿Encontramos todavía esos elementos en la publicidad actual? ¿Son tan distintas la imaginería nacionalista y la iconografía turística? En la presente comunicación comprobaremos la insistencia de los publicistas de la televisión que trabajan para la Xunta de Galicia -el gobierno autonómico o regional-en la "galleguidad" del paisaje, "galleguidad" que se exalta mediante el uso de una serie de elementos de fuerte carga simbólica. Ateliê Geográfico Goiânia-GO v. 1, n. 1 set/2007 p.1-24 página 1 Resumo No mundo contemporâneo há uma semelhança entre os métodos adotados pelos nacionalistas para fomentar a identificação da imagem de seus lugares através de uma paisagem singular, e as práticas de marketing aplicadas pelas instituições para promoverem determinados "produtos turísticos de massa", pelos sinais facilmente identificáveis das paisagens que querem vender. Em ambos os casos, trata-se de destacar a exaltação essencialista ou caricatural de determinados elementos paisagísticos. Esta hipótese é ilustrada com este estudo de caso sobre a Galicia. Assim como existe um "identidade paisagística catalana" ou "andaluza", também existe uma "identidade paisagística galega": certos elementos topográficos, climáticos, botânicos e culturais que dão forma a nossa paisagem e a distingue das demais. Todavia, desde que o regionalismo e o nacionalismo no século XIX se atentaram para o território, tem se servido insaciavelmente do mesmo. Os elementos iconográficos que contribuíram na definição na identidade nacional galega na paisagem se mantiveram ao longo do século XX com a publicidade turística. Estariam esses elementos presente na atual publicidade? Há diferença entre o imaginário nacionalista e a iconografia turística? No presente artigo comprova-se a insistência da publicidade televisiva que, para a Junta de Galicia -governo autônomo ou regional -, enfoca a "galleguidad" da paisagem, "galleguidad" que se exalta mediante o uso de uma série de elementos de forte carga simbólica. Abstract The national landscape and the tourism advertising in Galicia (Spain): In the contemporary world the methods used by nationalisms to foster the identification of the image of their peoples through their own landscape finds a peculiar parallel in the marketing practices used by public and private institutions to foster
In this report we present a successful clamshell approach for lung harvest, with subsequent two single lung transplantations in two different patients, from a donor who had previous median sternotomy for aortic valve substitution. #doi:10.1016/j.ejcts.2008.09.029 pmid:18996707 fatcat:r6aylpmvpjesbh4z4lz6ha6ybq
Coronavirus disease 2019 (COVID-19) has been declared pandemic since March 2020. In Europe, Italy has been the first nation affected by this infection. In this paper we report anamnestic data, clinical features and therapeutic management of two lung transplant recipients with confirmed COVID-19 pneumonia. Both patients were in good clinical conditions prior to the infection and were on immunosuppression with calcineurin inhibitors (CNI), mycophenolate mofetil and corticosteroids. Whilstdoi:10.1111/ajt.15993 pmid:32400074 pmcid:PMC7273094 fatcat:wr67sydibzh5hjqltle3nqeegi
more »... olate mofetil was withdrawn in both cases, CNI were suspended only in the second patient. The first patient always maintained excellent oxygen saturation throughout hospitalization with no need for additional oxygen therapy. He was discharged with a satisfactory pulmonary function and a complete resolution of radiological and clinical findings. However, at discharge SARS-CoV-2 RNA could still be detected in the nasopharyngeal swab and in the stools. The second patient required mechanical ventilation, had a progressive deterioration of his clinical conditions and had a fatal outcome. Further insight into SARS-CoV-2 infection is eagerly awaited to improve the outcome transplant recipients affected by COVID-19 pneumonia.
Three-dimensional (3D) manufacturing technologies are viewed as promising solutions to the bandwidth bottlenecks in VLSI communication. At the architectural level, Networkson-chip (NoCs) have been proposed to address the complexity of interconnecting an ever-growing number of cores, memories and peripherals. NoCs are a promising choice for implementing scalable 3D interconnect architectures. However, the development of 3D NoCs is still at an early development stage. In this paper, we present adoi:10.4108/icst.nanonet2007.2033 dblp:conf/nanonet/LoiAB07 fatcat:xrmlgkcfa5awlk6enj7afwhgw4
more »... emi-automated design flow for 3D NoCs. Starting from an accurate physical and geometric model of Through-Silicon Vias (TSVs), we extract a circuit-level model for vertical interconnections, and we use it to evaluate the design implications of extending switch architectures with ports in the vertical direction. In addition, we present a design flow allowing for post-layout simulation of NoCs with links in all three physical dimensions.
Finally, Federico Giri thanks the Dipartamento Scienze e Tecnologie per l'Ambiente e il Territorio (Universita del Molise) for providing a working place in their laboratory. ... areola 15 centre-posterior extremes of the cephalothorax Relative warp analysis (1 and 2) between A. neuquensis (squares), A. riolimayana (circles) and the intermediate specimens (triangles). 39 GIRI AND LOY ...doi:10.1651/07-2824r.1 fatcat:yh3izclkhfeslf4ybehokkusve
Objective: The aim of the study is to analyse long-term results of patients with small cell lung cancer (SCLC) treated at the same institution according to a prospective study including surgery, chemotherapy, and radiotherapy. Methods: From 1981 to 1995, 104 patients with a proven histology of SCLC underwent surgery, chemotherapy, and radiotherapy. Fifty-one patients with operable stage I or II lesion received surgical resection followed by adjuvant chemotherapy and radiotherapy. Fifty-threedoi:10.1016/s1010-7940(98)00203-6 pmid:9845145 fatcat:ckcseui6pbadbf4dci7s4xkcpq
more »... ients with proved SCLC and clinical stage III received induction chemotherapy followed by surgery and radiotherapy. All patients received from four to six courses of chemotherapy and 36 had prophylactic cranial irradiation (PCI). All patients had follow-up for at least 1 year, and survival time was calculated from the date of the diagnosis until death or most recent follow-up. Results: Ninety-six patients were male and eight female. We performed 29 pneumonectomies, eight bilobectomies, 66 lobectomies and one no resection. Regarding the clinical stage, 35 patients (33.6%) had stage I, 16 patients (15.4%) had stage II and 53 (51%) had stage III. Post-operative pathologic staging revealed stage I in 37 patients (35.6%), stage II in nine patients (8.6%), stage III in 45 patients (43.3%), and in 13 patients (12.5%) there was no more tumor. The 30-day mortality was 2% (two patients). Fourteen patients (13.4%) had post-operative complications. Fifty-one patients (49%) had a relapse. The median followup was 55 months. Twenty-six patients remain alive and 78 patients have died. The overall 5-year survival rate was 32%, with an estimate median survival time of 28 months; according to the pathologic stage, the survival data were 52.2%, 30% and 15.3% for stage I, II and III, respectively (P Ͻ 0.001). The 5-year survival was 41% in patients without SCLC after chemotherapy. Conclusion: As with non-small cell lung cancer, survival following surgery and chemotherapy clearly correlates with the stage. At present, it is not clear whether surgery is truly effective for patients with SCLC. In our experience, the complete elimination of small cell lung cancer is associated with an improvement in survival (41% at 5 years).
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