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Efficient SIMD Arithmetic Modulo a Mersenne Number

Joppe W. Bos, Thorsten Kleinjung, Arjen K. Lenstra, Peter L. Montgomery
2011 2011 IEEE 20th Symposium on Computer Arithmetic  
Using an implementation on a cluster of PlayStation 3 game consoles a new record was set for the elliptic curve method for integer factorization.  ...  For RSA moduli with two factors of about equal size, NFS is expected to be much faster than ECM.  ...  Although we hope, during our continuing efforts using the faster approach from sections III-F and III-G, not to miss factors up to the 65-digit range, with ECM one can never be sure.  ... 
doi:10.1109/arith.2011.37 dblp:conf/arith/BosKLM10 fatcat:vr2ea4hb3jcj5c5pl4lhukktzi

Proteolytic processing of lysyl oxidase–like-2 in the extracellular matrix is required for crosslinking of basement membrane collagen IV

Alberto J. López-Jiménez, Trayambak Basak, Roberto M. Vanacore
2017 Journal of Biological Chemistry  
B, immunoblotting analysis using an anti-LOXL2 antibody of ECM proteins extracted with urea from wild-type (WT) and LOXL2-null (KO) PFHR9 cells.  ...  Enzymatic digestion of 7S dodecamers Ten micrograms of purified 7S dodecamer from PFHR9 cells, bovine glomerulus or bovine placenta were each mixed with an equal volume of 0.1 M Tris-HCl, pH 7.5, buffer  ... 
doi:10.1074/jbc.m117.798603 pmid:28864775 fatcat:6n55ruiqd5anphqscvcfqt5uze

New and Improved Tissue Engineering Techniques: Production of Exogenous Material-Free Stroma by the Self-Assembly Technique [chapter]

Ingrid Saba, Weronika Jakubowska, Stéphane Chabaud, Stéphane Bolduc
2016 Composition and Function of the Extracellular Matrix in the Human Body  
Tissue engineering results from the use of cells and scaffolds to reproduce structural and spatial organization or function of a tissue.  ...  Moreover, the viability of an implanted tissue is associated with its stability to support vascular networks. This chapter summarizes the theory of the self-assembly approach for tissue engineering.  ...  The reseeding technique offers a remarkable alternative to the classical self-assembly protocol because it is faster and it reduces costs associated with extensive culture medium consumption as well as  ... 
doi:10.5772/62588 fatcat:272h4u7jdzb47ms5vexpor46ju

Subgroup Security in Pairing-Based Cryptography [chapter]

Paulo S. L. M. Barreto, Craig Costello, Rafael Misoczki, Michael Naehrig, Geovandro C. C. F. Pereira, Gustavo Zanon
2015 Lecture Notes in Computer Science  
Pairings are typically implemented using ordinary pairingfriendly elliptic curves.  ...  These curves were chosen to drop into existing libraries with minimal code change, and to sustain state-of-the-art performance numbers.  ...  [26] show that cofactor multiplication with h 2 in G 2 is significantly faster than multiplication by the group order n.  ... 
doi:10.1007/978-3-319-22174-8_14 fatcat:brrljkkor5d53dwgunb2vrxvra

Noninvasive Alternatives for the Assessment of Liver Fibrosis [chapter]

Lungen Lu, Kun Zhou
2011 Liver Biopsy  
Using automated image analysis to assess texture features and shape representation of the fibrosis structural expansion can turn the current semiquantitative methods of liver fibrosis assessment into real  ...  Nor can transient elastography identify cofactors and comorbidities or grade necroinflammation and steatosis.  ... 
doi:10.5772/20167 fatcat:wfdhp4hbovgl3ik3k3hsimmw6a

Application of a three‑dimensional (3D) breast cancer model to study macrophage polarization

Agata Golabek, Mariusz Kaczmarek, Ewelina Dondajewska, Kosma Sakrajda, Andrzej Mackiewicz, Hanna Dams‑kozlowska
2021 Experimental and Therapeutic Medicine  
The expression of macrophage markers was studied using reverse transcription-quantitative PCR and flow cytometry. The activity of nitric oxide synthase and arginase in macrophages was also measured.  ...  Moreover, the present study is an example of the application of silk biomaterial to generate useful tools for in vitro research. Figure 1 . 1 Schematic representation of the experimental protocol.  ...  CD44 is a transmembrane receptor for hyaluronic acid that plays an essential role in cell adhesion, cell interactions with the ECM and lymphocyte activation (48) .  ... 
doi:10.3892/etm.2021.9913 pmid:33790991 pmcid:PMC8005691 fatcat:46csr3jfabg25f3ghc33cc6nom

Functionalized Enzyme-Responsive Biomaterials to Model Tissue Stiffening in vitro

Annalisa Tirella, Giorgio Mattei, Margherita La Marca, Arti Ahluwalia, Nicola Tirelli
2020 Frontiers in Bioengineering and Biotechnology  
ECM-stiffening mechanisms.  ...  Lysyl oxidase (LOx) is one of the enzymes involved in several ECM-stiffening processes.  ...  (B) Representation of in vitro 2D model and 3D model with HepG2. (C) Live/dead assay of HepG2 in 2D and 3D models.  ... 
doi:10.3389/fbioe.2020.00208 pmid:32322576 pmcid:PMC7156543 fatcat:wlvpdmkyibbfxn62krugd7wh2m

The Biology of YAP/TAZ: Hippo Signaling and Beyond

Stefano Piccolo, Sirio Dupont, Michelangelo Cordenonsi
2014 Physiological Reviews  
At the same time, YAP/TAZ entertain relationships with morphogenetic signals, such as Wnt growth factors, and are also regulated by Rho, GPCRs and mevalonate metabolism.  ...  YAP/TAZ activation also reflects the cell "social" behavior, including cell adhesion and the mechanical signals that the cell receives from tissue architecture and surrounding extracellular matrix (ECM  ...  In all cases, with age, hepatomegaly is followed by development of tumors of mixed characteristics, resembling both hepatocellular carcinomas and cholangiocarcinomas, in keeping with aberrant mobilization  ... 
doi:10.1152/physrev.00005.2014 pmid:25287865 fatcat:nrpvvfpihzcj3hpl3hlm6gziai

Advances in Engineered Human Liver Platforms for Drug Metabolism Studies

Gregory H Underhill, Salman R Khetani
2018 Drug Metabolism And Disposition  
of drug development with continued commercialization and validation for routine screening use.  ...  Of these models, PHHs provide a balance of high-throughput testing capabilities together with a physiologically relevant cell type that exhibits all the characteristic enzymes, cofactors, and transporters  ...  These droplet generators typically use fluorocarbon oil with surfactant to create aqueous emulsions containing unpolymerized ECM mixed with cells.  ... 
doi:10.1124/dmd.118.083295 pmid:30135245 pmcid:PMC6199629 fatcat:hj4t7impvjbx5gcydb4fcdug6i

3D printed tricalcium phosphate bone tissue engineering scaffolds: effect of SrO and MgO doping on in vivo osteogenesis in a rat distal femoral defect model

Solaiman Tarafder, Neal M. Davies, Amit Bandyopadhyay, Susmita Bose
2013 Biomaterials Science  
We have used direct three dimensional printing (3DP) technology for scaffold fabrication followed by microwave sintering.  ...  noticeable attention from the scientific community in bone tissue engineering due to its enormous role in human physiology such as structure stabilization of many proteins, nucleic acids, acting as a cofactor  ...  Acknowledgments The authors would like to thank Valerie Lynch-Holm and Christine Davitt from Franceschi Microscopy and Imaging Center at Washington State University for their technical assistance with  ... 
doi:10.1039/c3bm60132c pmid:24729867 pmcid:PMC3979641 fatcat:ymo22m6kifdulgkmxya5xrsf24

The Diverse AAA+ Machines that Repair Inhibited Rubisco Active Sites

Oliver Mueller-Cajar
2017 Frontiers in Molecular Biosciences  
In diverse autotrophic organisms this tendency has been counteracted by the recruitment of dedicated AAA+ (ATPases associated with various cellular activities) proteins that all use the energy of ATP hydrolysis  ...  Approaches aiming to replace Rubisco in plants with improved enzymes will need to ensure the presence of a compatible Rca protein.  ...  to ECM.  ... 
doi:10.3389/fmolb.2017.00031 pmid:28580359 pmcid:PMC5437159 fatcat:z2eb77gya5dhtcv2ryed4h3yby

Faster individual discrete logarithms in finite fields of composite extension degree

Aurore Guillevic
2018 Mathematics of Computation  
( 1 ) 1 L Q [1/3, c = (3e) 1/3 ] with ECM to perform the smoothness tests; (2) L Q [1/3, c = (3e) 1/3 (23/27) 2/3 ] with ECM and EAS; (3) L Q [1/3, c = (3e) 1/3 ((15 + 4(2/3) 3k )/19) 2/3 ] with ECM  ...  We will mix Pomerance' strategy with our new initial splitting step to improve its running time. LLL algorithm.  ... 
doi:10.1090/mcom/3376 fatcat:3bles5ordbdmpn53j6gxfuz5w4

Monitoring Sinew Contraction During Formation of Tissue-Engineered Fibrin-Based Ligament Constructs

Jennifer Z. Paxton, Uchena N.G. Wudebwe, Anqi Wang, Daniel Woods, Liam M. Grover
2012 Tissue Engineering. Part A  
The powder mixture was suspended in absolute ethanol and mixed for 12 h.  ...  Another research group has used immunohistochemical techniques to investigate the deposition of extracellular matrix (ECM) using ACL cells in this fibrin gel system. 37 Interestingly, they showed that  ... 
doi:10.1089/ten.tea.2011.0535 pmid:22439983 fatcat:pzz6uzuofrenbmryrvu22rrhva

Elastic materials for tissue engineering applications: Natural, synthetic, and hybrid polymers

Anna M.J. Coenen, Katrien V. Bernaerts, Jules A.W. Harings, Stefan Jockenhoevel, Samaneh Ghazanfari
2018 Acta Biomaterialia  
these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for  ...  accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with  ...  POC was also mixed with a poly(L-lactic acid) (PLLA) nanofiber network to provide reinforcement to the scaffold.  ... 
doi:10.1016/j.actbio.2018.08.027 pmid:30165203 fatcat:4vyddksckjej5nhzbb4cfboew4

Single-cell transcriptomics allows novel insights into aging and circadian processes

Sara S Fonseca Costa, Marc Robinson-Rechavi, Jürgen A Ripperger
2020 Briefings in Functional Genomics  
Nevertheless, due to the overlap of their actions, it was speculated that both interfere or interact with each other.  ...  Figure 1 . 1 Schematic representation of scRNA-Seq.  ...  These effects of aging generate cells with mixed insulin and glucagon secretory phenotypes, correlating with the decline of endocrine functions of the gland.  ... 
doi:10.1093/bfgp/elaa014 pmid:32633783 pmcid:PMC7716582 fatcat:y5chnhqhrncyfj3ggpfzxevham
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