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2008 Human Heredity  
Available from: ics/ashg06s/index.shtml. 26 Wang H, Segre AM, Huang Y, O'Connell JR, Vieland VJ: Fast computation of human ge- netic linkage.  ...  Presented at the annual meeting of The American Society of Human Genetics; October 9-13, 2006, New Orleans, LA, USA.  ... 
doi:10.1159/000152188 fatcat:6aunb3j44ndfdjyv65reqqytlm

Page 1577 of Genetics Vol. 179, Issue 3 [page]

2008 Genetics  
Human Genetics, University of Chicago, 920 E. 58th St., Chicago, IL 60637.  ...  of Human Genetics, University of Chicago, Chicago, Illinois 60637 Manuscript received April 4, 2008 Accepted for publication May 2, 2008 ABSTRACT Computing identity-by-descent sharing between individuals  ... 

A Genome Scan for Fasting Insulin and Fasting Glucose Identifies a Quantitative Trait Locus on Chromosome 17p: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

S. S. Rich, D. W. Bowden, S. M. Haffner, J. M. Norris, M. F. Saad, B. D. Mitchell, J. I. Rotter, C. D. Langefeld, C. C. Hedrick, L. E. Wagenknecht, R. N. Bergman
2004 Diabetes  
There was significant evidence for linkage of fasting insulin to the short arm of chromosome 17 (logarithm of odds [LOD] ‫؍‬ 3.30; 54 cM between D17S1294 and D17S1299, P ‫؍‬ 1.0 ؋ 10 ؊4 ).  ...  The strongest evidence for linkage over all pedigrees for fasting glucose was also observed in this region (LOD ‫؍‬ 1.44; 58 cM, P ‫؍‬ 9.9 ؋ 10 ؊3 ).  ...  In this study, the primary location for the existence of a putative QTL influencing variation in fasting insulin and fasting glucose occurs on the short arm of human chromosome 17.  ... 
doi:10.2337/diabetes.54.1.290 pmid:15616041 fatcat:glcsmytqrbenfgljhhjunae4yy

Page 2383 of Genetics Vol. 173, Issue 4 [page]

2006 Genetics  
To date, several ‘Corresponding author: Human Genetics Center, School of Public Health, University of Texas, 1200 Herman Pressler, Box 20186, Houston, IX 77030.  ...  * Human Genetics Center, School of Public Health, University of Texas, Houston, Texas 77030 and ‘ Laboratory for Conservation and Utilization of Bioresources, Yunnan University, Kunming Province, Yunnan  ... 

Genetic control of PI and GC variants in the American mink

G P Borodin, A V Perelygin, T I Axenovich, O V Trapezov, O L Serov
1995 Animal Genetics  
Two codominant alleles were identified at each of the two loci. The data ruled out the possibility of any linkage between the PI, GC and the coat colour gene Crystal (Cr).  ...  Genetic polymorphism of the serum alpha-protease inhibitor (PI) and group-specific component (GC) in minks was revealed using one-dimensional polyacrylamide gel electrophoresis and immunoblotting.  ...  Ott J. (1974) Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. American Journal of Human Genetics 26, 588-97.  ... 
pmid:8572367 fatcat:cqwcgs4tzbhq3diukhzx24vwzu

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q

A V Lembertas, L Pérusse, Y C Chagnon, J S Fisler, C H Warden, D A Purcell-Huynh, F T Dionne, J Gagnon, A Nadeau, A J Lusis, C Bouchard
1997 Journal of Clinical Investigation  
Sibpair analysis based on a maximum of 258 sib pairs revealed suggestive linkages between the percentage of body fat ( P Ͻ 0.004), body mass index ( P Ͻ 0.008), and fasting insulin ( P Ͻ 0.0005) and a  ...  Analysis of NZB/BINJ ϫ SM/J intercross mice located a quantitative trait locus (QTL) for obesity on distal mouse chromosome 2, in a region syntenic with a large region of human chromosome 20, showing linkage  ...  This work was supported by grants from the National Institutes of Health (DK-45066 and HL-42488), and from the Medical Research Council of Canada (PG-11811). A.V.  ... 
doi:10.1172/jci119637 pmid:9276742 pmcid:PMC508301 fatcat:5iwuuhqd6fhmhadjekm5ep6oqu

Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7

R Duggirala, M P Stern, B D Mitchell, L J Reinhart, P A Shipman, O C Uresandi, W K Chung, R L Leibel, C N Hales, P O'Connell, J Blangero
1996 American Journal of Human Genetics  
Despite the evidence that human obesity has strong genetic determinants, efforts at identifying specific genes that influence human obesity have largely been unsuccessful.  ...  Weaker evidence for linkage to several other obesity-related traits (e.g., waist circumference, body-mass index, fat mass by bioimpedance, etc.) was observed for a genetic location, which is approximately  ...  Some of the results of this paper were obtained by using the program package SAGE, which is supported by U.S.  ... 
pmid:8751871 pmcid:PMC1914918 fatcat:mavryuqgkvfbtax7b4nlmwtgwm

Genetic control of PI and GC variants in the American Mink

G P Borodin, A V Perelygin, T I Axenovich, O V Trapezov, O L Serov
2009 Animal Genetics  
Ott J. (1974) Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. American Journal of Human Genetics 26, 588-97.  ...  . & Hopkinson D.A. (1976) Handbook of Enzyme Electrophoresis in Human Genetics. North- Holland, Amsterdam.  ... 
doi:10.1111/j.1365-2052.1995.tb02696.x fatcat:dly5kzvuxbau7cryo3iyz4273y

Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans

M P Stern, R Duggirala, B D Mitchell, L J Reinhart, S Shivakumar, P A Shipman, O C Uresandi, E Benavides, J Blangero, P O'Connell
1996 Genome Research  
Evidence for linkage to fasting glucose concentration was also observed for two loci on chromosome 6, one of which is identical to a proposed susceptibility locus for type I diabetes {D6S290).  ...  Evidence for linkage of regions on chromosomes 6 and 11 to References  ...  We next computed lod scores for linkage by comparing the multipoint linkage model with the polygenic model.  ... 
doi:10.1101/gr.6.8.724 pmid:8858347 fatcat:ycdpcrfqsnabjndxbuysje26ii

Finding disease genes: a fast and flexible approach for analyzing high-throughput data

William C L Stewart, Esther N Drill, David A Greenberg
2011 European Journal of Human Genetics  
We have tested our approach extensively, and implemented it in the software package EAGLET (Efficient Analysis of Genetic Linkage: Estimation and Testing).  ...  In particular, computational feasibility is often obtained at the expense of power, precision, and/or accuracy.  ...  ACKNOWLEDGEMENTS We would like to acknowledge the support of the Calderone City Health Award, and of the National Institutes of Health: NLO60056, MH48858, MH65213, DKO31175, DKO31813, DA026983, and NS070323  ... 
doi:10.1038/ejhg.2011.81 pmid:21610749 pmcid:PMC3190261 fatcat:xkcesevb6vh7nnzsg7hbwmzscm

Fasting Insulin and Obesity-Related Phenotypes Are Linked to Chromosome 2p: The Strong Heart Family Study

V. P. Diego, H. H.H. Goring, S. A. Cole, L. Almasy, T. D. Dyer, J. Blangero, R. Duggirala, S. Laston, C. Wenger, T. Cantu, B. Dyke, K. North (+6 others)
2006 Diabetes  
Linkage analyses of fasting insulin and two obesity-related phenotypes, BMI and percent fat mass, were performed independently in each of the three populations.  ...  Study, an investigation of the genetic and environmental determinants of cardiovascular disease in American-Indian populations from Arizona, Oklahoma, and North and South Dakota.  ...  The views expressed in this article are those of the authors and do not necessarily reflect those of the Indian Health Service.  ... 
doi:10.2337/db05-0668 pmid:16731856 fatcat:r53coylowbb4ldn4d7pz3o5kpy

2015 Curt Stern Award 1

Leonid Kruglyak
2016 American Journal of Human Genetics  
By the mid to late 1990s, the field of human genetics was starting to go through the transition of realizing that linkage studies were not going to be sufficiently powered to unravel the genetics of complex  ...  It turned out that this required a fair bit of algorithmic development, and I was finally able to crack the computational complexity of the problem by drawing on ideas used in the fast Fourier transform  ... 
doi:10.1016/j.ajhg.2016.01.002 pmid:26942280 pmcid:PMC4800031 fatcat:pfipziuop5a57nmfg7rrsfdjiq

Page 499 of Genetics Vol. 174, Issue 1 [page]

2006 Genetics  
However, linkage phase information in diploids, such as humans, is usually unknown from genotype data.  ...  HE human genome has been portrayed as a series of high linkage disequilibrium (LD) regions with limited haplotype diversity (PATIL et al. 2001; GABRIEL et al. 2002).  ... 

Page 2071 of Genetics Vol. 171, Issue 4 [page]

2005 Genetics  
TELLER, 1953 Equations of state calculation by fast comput- ing machines. ]. Chem. Phys. 21: 1087-1092. Morris, A. P., J. C. WHITTAKER and D. J.  ...  CRowe 1, 2000 Estimate of the muta- tion rate per nucleotide in humans. Genetics 156: 297-304. SHEEHAN, N. A., A. PossoLo and E. A.  ... 

Pleiotropic QTL on Chromosome 12q23-q24 Influences Triglyceride and High-Density Lipoprotein Cholesterol Levels: The HERITAGE Family Study

Mary. F. Feitosa, Treva Rice, Ingrid B. Borecki, Tuomo Rankinen, Arthur S. Leon, James S. Skinner, Jean-Pierre Després, John Blangero, Claude Bouchard, D. C. (Dabeeru C.) Rao
2006 Human Biology: The Official Publication of the American Association of Anthropological Genetics  
On the allelic spectrum of human disease. 7r. Genet. 17:502 J. Gagnon, Y. C. Chagnon et al. 1999.  ...  Linkage Analysis. Linkage analyses using a variance component approach were implemented in the computer program SOLAR, version 2.1.2 (Almasy and Blangero 1998).  ... 
doi:10.1353/hub.2006.0043 pmid:17216804 fatcat:chzufxki3naxhmqcegi53kzmne
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