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FANGMING ZHONG received the Ph.D. degree in software engineering from the Dalian University of Technology, Dalian, China, in 2018. ...doi:10.1109/access.2020.2967594 fatcat:nr4ghjvhi5c3vpg2ml4eq7x3ga
Rationale: Spontaneous spinal epidural hematoma (SSEH) is a rare but highly disabling neurological emergency. The initial presentations are variable. Most patients of SSEH present with paraplegia or tetraplegia clinically, but recurrent hemiparesis with complete spontaneous recovery, mimicking transient ischemic attack (TIA), is a very rare initial presentation of SSEH. Patient concerns: A 71-year-old female presented to the emergency department with 2 episodes of transient right hemiparesis indoi:10.1097/md.0000000000009007 pmid:29245281 pmcid:PMC5728896 fatcat:ltwc3hpzgjdmtmxmaoeqzh7yba
more »... 5 hours. Two days later, above symptom reappeared and progressed to quadriplegia, dyspnea, and uroschesis quickly. The neurological examination showed tetraplegia and hypalgesia below the C2 level, but neither facial palsy nor aphasia was found. Diagnosis: The patient was initially misdiagnosed as TIA and treated with antiplatelet therapy. But during the hospital day, the cervical magnetic resonance imaging showed a dorsal epidural hematoma extending from C2 to C6 level and she was diagnosed as SSEH. Interventions: She underwent surgical decompression and hematoma removal 1 week later. Outcomes: One week after operation, the sensory deficit above C6 level improved, but there was no improvement in her muscle strength and dyspnea. Unfortunately, she died 1 month later. Lessons: Our case highlights recurrent hemiparesis with complete spontaneous recovery mimicking TIA is a rare initial presentation of SSEH. It is important to perform careful clinical assessments and neuroimaging investigations for correct diagnosis. Neck pain and hemiparesis sparing cranial nerve are important signs for distinction of SSEH from acute ischemic cerebrovascular diseases. Abbreviations: MRI = magnetic resonance imaging, SSEH = spontaneous spinal epidural hematoma, TIA = transient ischemic attack.
Hashing based methods for cross-modal retrieval has been widely explored in recent years. However, most of them mainly focus on the preservation of neighborhood relationship and label consistency, while ignore the proximity of neighbors and proximity of classes, which degrades the discrimination of hash codes. And most of them learn hash codes and hashing functions simultaneously, which limits the flexibility of algorithms. To address these issues, in this article, we propose a two-stepdoi:10.1109/access.2020.3015528 fatcat:k42zalqde5afbk5hlw3sj736im
more »... dal retrieval method named Manifold-Embedded Semantic Hashing (MESH). It exploits Local Linear Embedding to model the neighborhood proximity and uses class semantic embeddings to consider the proximity of classes. By so doing, MESH can not only extract the manifold structure in different modalities, but also can embed the class semantic information into hash codes to further improve the discrimination of learned hash codes. Moreover, the two-step scheme makes MESH flexible to various hashing functions. Extensive experimental results on three datasets show that MESH is superior to 10 state-of-the-art cross-modal hashing methods. Moreover, MESH also demonstrates superiority on deep features compared with the deep cross-modal hashing method. INDEX TERMS Cross-modal hashing, manifold embedding, semantic, discrete optimization.
2009 17th International Packet Video Workshop
Peer-to-Peer (P2P) live video streaming systems have recently received significant attention, with commercial deployment gaining increased popularity in the Internet. It is evident from our experiences with real-world systems that, it is not uncommon to have hundreds of thousands of users trying to join a program in the first few minutes of a live broadcast. This phenomenon, unique in live streaming systems, referred to as the flash crowd, poses significant challenges in the system design. Indoi:10.1109/packet.2009.5152154 fatcat:rgk7thj42rcevffnr7ock2oxya
more »... is paper, we develop a mathematical model to capture the inherent relationship between time and scale in P2P streaming systems under the flash crowd. Specifically, we show that there is an upper bound on the system scale with respect to a time constraint. In addition, our analysis has brought forth an in-depth understanding on the effect from the Gossip protocol and churn effects.
Zhong et al 128 also discussed the concentration effects on ECR performance. ...doi:10.1002/ese3.935 fatcat:4yd25nkosnevbn5mlwjm6wsdvq
The activation of telomerase in unstable plaques is an important factor in atherosclerosis, and may be predictive of the risk of cerebrovascular diseases. Human telomerase reverse transcriptase (hTERT) is a subunit of telomerase that is essential for telomerase activation. The aim of the present study was to investigate whether aspirin inhibits the activation of telomerase and hTERT in unstable carotid plaques. Polymorphonuclear neutrophils (PMNs) derived from carotid plaques were isolated fromdoi:10.3892/etm.2013.1082 pmid:23935747 pmcid:PMC3735718 fatcat:zmvnz232fnfkbaxox6comayrce
more »... the washing medium of angioplasty balloons, while circulating PMNs, isolated from arterial blood, served as the controls. A polymerase chain reaction-based telomeric repeat amplification protocol (TRAP) enzyme-linked immunosorbent assay (ELISA) was used to measure the telomerase activity in the cells following treatment with aspirin. The mRNA and protein expression of hTERT were detected by a reverse transcription-polymerase chain reaction (RT-PCR) and western blot analysis, respectively. The results revealed that the atherosclerotic plaques were positive for telomerase activity, and that aspirin inhibited the telomerase activity of the PMNs derived from the plaques. In addition, aspirin was demonstrated to inhibit the mRNA and protein expression of hTERT through the suppression of hTERT transcriptional activity; however, it had no inhibitory effect on the telomerase activity of the circulating PMNs. Thus, the activation of telomerase in resident PMNs is critical in the instability of carotid plaques. The upregulation of telomerase and hTERT during the progression of atherosclerosis may indicate a role for telomerase in the vascular remodeling that occurs during atherogenesis. Aspirin was demonstrated to inhibit the activation of telomerase via an hTERT-dependent manner in the PMN cells of unstable carotid plaques, and thus hTERT may be considered as a target in the treatment of cerebrovascular diseases.
Writing -original draft: Guocan Yu, Yanqin Shen, Fangming Zhong. Writing -review & editing: Guocan Yu, Fangming Zhong. ... Discrepancies were settled through a discussion with a third investigator (Fangming Zhong). ...doi:10.1371/journal.pone.0242982 pmid:33253313 fatcat:yasqtl63tjc4fevjrnkqtxwzve
The introduction of deep transfer learning (DTL) further reduces the requirement of data and expert knowledge in various uses of applications, helping DNN-based models effectively reuse information. However, it often transfers all parameters from the source network that might be useful to the task. The redundant trainable parameters restrict DTL in low-computing-power devices and edge computing, while small effective networks with fewer parameters have difficulty transferring knowledge due todoi:10.1155/2021/9957067 fatcat:wjowimah2zhmbnavz5vj6racny
more »... ructural differences in design. For the challenge of how to transfer a simplified model from a complex network, in this paper, an algorithm is proposed to realize a sparse DTL, which only transfers and retains the most necessary structure to reduce the parameters of the final model. Sparse transfer hypothesis is introduced, in which a compressing strategy is designed to construct deep sparse networks that distill useful information in the auxiliary domain, improving the transfer efficiency. The proposed method is evaluated on representative datasets and applied for smart agriculture to train deep identification models that can effectively detect new pests using few data samples.
Background It is unclear about the duration of anti-tuberculous therapy before pericardiectomy (DATT) in the patients with constrictive tuberculous pericarditis. This study aims to explore the optimal DATT and its impact on surgical outcomes in these patients. Methods We retrospectively enrolled 93 patients with constrictive tuberculous pericarditis undergoing pericardiectomy and divided them into two groups according to the optimal cutoff value of DATT which was determined by the receiverdoi:10.1186/s13019-021-01691-9 pmid:34702309 fatcat:q5eqrdnotzfzjbzjhgc5pfxnza
more »... ting characteristic (ROC) curve and Youden Index. Postoperative and survival outcomes were compared between the two groups. Results The optimal cutoff value of DATT was 1.05 (months). The enrolled patients were divided into the DATT ≤ 1.05 group and the DATT > 1.05 group, with 24 (25.8%) and 69 (74.2%) cases, respectively. Comparing with the DATT ≤ 1.05 group, the DATT > 1.05 group had shorter postoperative ICU stay (P = 0.023), duration of chest drainage (P = 0.002), postoperative hospital stay (P = 0.001) and lower incidence of postoperative complications (P < 0.001). There were no statistical differences between the two groups in recurrence and survival outcomes. Conclusions It would be of potential benefit to enhance recovery after pericardiectomy if DATT lasted for at least 1 month in the patients with constrictive tuberculous pericarditis.
Correspondence: Ye Chen (firstname.lastname@example.org) Calcium/calmodulin-dependent protein kinase (CAMK) kinase1 (CAMKK1) could specifically recognize and activate CAMK I and IV. Furthermore, the activation of CAMK showed positive correlation in proliferation of lung cancer (LC). In addition, a genome-wide association study (GWAS) has identified rs7214723 (E375G) in the CAMKK1 gene as a susceptibility locus for LC in the U.K. population. Therefore, we conducted a case-control study involving 320 LCdoi:10.1042/bsr20170762 pmid:28739589 pmcid:PMC5554780 fatcat:pz5nm3hbwzdbzaprydem42o4da
more »... nts and 320 controls to validate this conclusion in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan TM Kit. Our results indicated that the individuals with CC genotype of rs7214723 polymorphism had the higher risk of LC than those who carried TT genotype. Moreover, CAMKK1 rs7214723 polymorphism showed positive correlation with the elevated risk of LC in the allelic model and recessive model, but not in the dominant model. Stratified analysis further confirmed this significant association in male groups and smokers. In conclusion, CAMKK1 rs7214723 polymorphism may be associated with the increased risk of LC. However, larger studies with more diverse ethnic populations are needed to confirm these results.
This study aimed to evaluate the accuracy of the Xpert MTB/RIF assay for the diagnosis of bone and joint tuberculosis.doi:10.1371/journal.pone.0221427 pmid:31437232 pmcid:PMC6705841 fatcat:z2cdufpgbfdwfcj4i3ad4e2ux4
Artificial photosynthesis, specifically H 2 O dissociation for CO 2 reduction with solar energy, is regarded as one of the most promising methods for sustainable energy and utilisation of environmental resources. However, a highly efficient conversion still remains extremely challenging. The hydrogenation of CO 2 is regarded as the most commercially feasible method, but this method requires either exotic catalysts or high-purity hydrogen and hydrogen storage, which are regarded as andoi:10.1038/srep04503 pmid:24675820 pmcid:PMC3968486 fatcat:ria3ojifh5adtbyo6t5v6zgetu
more »... nsive process. Here we report a highly efficient method of H 2 O dissociation for reducing CO 2 into chemicals with Zn powder that produces formic acid with a high yield of approximately 80%, and this reaction is revealed for the first time as an autocatalytic process in which an active intermediate, ZnH 2 complex, serves as the active hydrogen. The proposed process can assist in developing a new concept for improving artificial photosynthetic efficiency by coupling geochemistry, specifically the metal-based reduction of H 2 O and CO 2 , with solar-driven thermochemistry for reducing metal oxide into metal. OPEN SUBJECT AREAS: ENERGY RENEWABLE ENERGY
Two investigators (Guocan Yu and Fangming Zhong) independently assessed the candidate articles by reviewing their titles and abstracts, followed by the full text, for inclusion. ... The same two investigators (Guocan Yu and Fangming Zhong) independently extracted the necessary information from each of the included articles; We cross-checked the data that we have obtained. ...doi:10.1371/journal.pone.0257220 pmid:34506587 pmcid:PMC8432788 fatcat:btbsrd6gjzbsjkqlli3cmqp4xy
Direct reduction of bicarbonate, a typical product of CO2 captured in alkaline solution, into value-added organics is one promising way to achieve a simplified and green CO2 capture and utilization...doi:10.1039/d0gc02785e fatcat:3eepigzanjaehmjb5uxtsiedjy
Circular RNAs (circRNAs), formed from pre-messenger RNAs by back-splicing, are a novel class of evolutionarily-conserved endogenous non-coding RNAs. While circRNAs are involved in various diseases, the role of circRNAs in intracerebral hemorrhage (ICH) remains unknown. In the present study, we performed high-throughput sequencing to profile the expression of circRNAs in the rat brain at 24 and 48 hours after ICH onset, and utilized bioinformatics methods to make predictions about the functionpmid:32913495 pmcid:PMC7476132 fatcat:lsfb3ion3bfjpi72gesfdhht34
more »... dysregulated circRNAs. Compared with the sham group, 346 and 389 circRNAs changed significantly (|log2 (fold change)| > 1 and P < 0.05) at 24 and 48 hours after ICH, respectively. Bioinformatics analyses indicated that parent genes of dysregulated circRNAs were involved in biological processes, cellular component, and molecular function following ICH, and that they were enriched in the dopaminergic synapses, glutamatergic synapses, endocytosis, regulation of actin cytoskeleton, the mitogen-activated protein kinase signaling pathway, and the retrograde endocannabinoid signaling pathway. Enrichment analyses of target mRNAs showed that these mRNAs were enriched in synaptic plasticity, ion channel activity, and pathways including the phospholipase D signaling and the cGMP-PKG signaling. Our study indicates that the expression profile of circRNAs changes significantly after ICH in rat brains, and suggests that circRNAs may be crucial for the pathophysiological process following ICH.
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