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Temperature Cycling for Photoresist Processing

Yuheng Wang, HuiTong Chua, Arthur Tay, ZhongPing Fang
2008 IFAC Proceedings Volumes  
A programmable multizone thermal processing module together with a model-based feedback control method are developed to achieve temperature uniformity of a silicon wafer throughout the processing temperature cycle of ramp, hold and quench in post-exposure bake (PEB) step of lithography. The module comprises of numerous small thermoelectric devices (TEDs) capable of precise substrate spatial temperature control. The detailed thermal modeling of the module is presented and the simulation results
more » ... re compared with the experimental results to verify its feasibility. A model-based PID feedback control method is employed to minimize temperature nonuniformity across the wafer. With the method, temperature nonuniformity could be controlled less than 0.1 • C throughout the entire thermal cycle. Advanced applications are enabled due to the proposed system.
doi:10.3182/20080706-5-kr-1001.00162 fatcat:v4f6k3d5kfdndjjnyvjjhtnu5a

Bioanalysis of drug in tissue: current status and challenges

Y-J Xue, Hong Gao, Qin C Ji, Zamas Lam, XinPing Fang, Zhongping Lin, Matthew Hoffman, Daniel Schulz-Jander, Naidong Weng
2012 Bioanalysis  
doi:10.4155/bio.12.252 pmid:23173797 fatcat:phyuodvbibbmvoi65pn7r45hny

Adhesion Control Strategy Based on the Wheel-Rail Adhesion State Observation for High-Speed Trains

Xiaochun Fang, Shuai Lin, Zhongping Yang, Fei Lin, Hu Sun, Liang Hu
2018 Electronics  
In this paper, an adhesion control strategy based on the wheel-rail adhesion state observation is proposed for high-speed trains. First, the high-speed train single axle dynamics model is established. Then, a modified adhesion control method is proposed. The scheme observes the tangential force coefficient between wheel and rail through full dimension observer and forecasts the slope of the adhesion-slip curve by the recursive least squares method with forgetting factor. Meanwhile, a
more » ... analysis of the method and the control parameters tuning is conducted. Afterwards, the experimental study of the proposed adhesion control is carried out based on a 5.5 kW induction motor drag platform using dSPACE simulation technology. The experimental results confirm the feasibility of the adhesion control method proposed in this paper. Using the proposed adhesion control method can achieve high wheel-rail adhesion performance under variable complex road conditions.
doi:10.3390/electronics7050070 fatcat:eyv7svhx75gj7ha4saqsg32qca

"Factual" or "Emotional": Stylized Image Captioning with Adaptive Learning and Attention [chapter]

Tianlang Chen, Zhongping Zhang, Quanzeng You, Chen Fang, Zhaowen Wang, Hailin Jin, Jiebo Luo
2018 Lecture Notes in Computer Science  
Generating stylized captions for an image is an emerging topic in image captioning. Given an image as input, it requires the system to generate a caption that has a specific style (e.g., humorous, romantic, positive, and negative) while describing the image content semantically accurately. In this paper, we propose a novel stylized image captioning model that effectively takes both requirements into consideration. To this end, we first devise a new variant of LSTM, named style-factual LSTM, as
more » ... he building block of our model. It uses two groups of matrices to capture the factual and stylized knowledge, respectively, and automatically learns the word-level weights of the two groups based on previous context. In addition, when we train the model to capture stylized elements, we propose an adaptive learning approach based on a reference factual model, it provides factual knowledge to the model as the model learns from stylized caption labels, and can adaptively compute how much information to supply at each time step. We evaluate our model on two stylized image captioning datasets, which contain humorous/romantic captions and positive/negative captions, respectively. Experiments shows that our proposed model outperforms the state-ofthe-art approaches, without using extra ground truth supervision.
doi:10.1007/978-3-030-01249-6_32 fatcat:wvlyyluijnattm5hkcgs755bje

miR-185 Silencing Promotes the Progression of Atherosclerosis via Targeting Stromal Interaction Molecule 1

Ming Fang, Yanfei Li, Yingbiao Wu, Zhongping Ning, Xuejun Wang, Xinming Li
2019 Cell Cycle  
Atherosclerosis (AS) is a major risk factor for cardiovascular disease. microRNAs play a key role in gene regulation in the formation and development of atherosclerotic plaques. Herein, the role and target gene of miR-185 in AS were explored.
doi:10.1080/15384101.2019.1580493 pmid:30784343 pmcid:PMC6464577 fatcat:occ3ya5xc5fvrfk44cfn77okry

The pseudogene PRELID1P6 promotes glioma progression via the hnHNPH1-Akt/mTOR axis

Shaoyan Xi, Haiping Cai, Jiabin Lu, Yu Zhang, Yanjiao Yu, Furong Chen, Qitao Huang, Fang Wang, Zhongping Chen
2021 Oncogene  
AbstractResearch over the past decade has suggested important roles for pseudogenes in glioma. This study aimed to show that pseudogene PRELI domain-containing 1 pseudogene 6 (PRELID1P6) promotes glioma progression. Aberrant expression of genes was screened using The Cancer Genome Atlas database. We found that mRNA level of PRELID1P6 was highly upregulated in glioma and was associated with a shorter survival time. Functional studies showed that the knockdown of PRELID1P6 decreased cell
more » ... tion, sphere formation, and clone formation ability and blocked the cell cycle transition at G0/G1, while overexpression of PRELID1P6 had the opposite effects. Mechanistically, knockdown of PRELID1P6 changed the cellular localization of heterogeneous nuclear ribonucleoprotein H1 (hnRNPH1) from nucleus to cytoplasm, which promoted ubiquitin-mediated degradation of hnRNPH1. RNA-sequence and gene set enrichment analysis suggested that knockdown of PRELID1P6 regulates the apoptosis signaling pathway. Western blotting showed that PRELID1P6 increased TRF2 expression by hnRNPH1-mediated alternative splicing effect and activated the Akt/mTOR pathway. Furthermore, Akt inhibitor MK2206 treatment reversed the oncogenic function of PRELID1P6. PRELID1P6 was also found to be negatively regulated by miR-1825. Our result showed that PRELID1P6 promotes glioma progression through the hnHNPH1-Akt/mTOR pathway. These findings shed new light on the important role of PRELID1P6 as a novel oncogene for glioma.
doi:10.1038/s41388-021-01854-x pmid:34108621 pmcid:PMC8249232 fatcat:k2tgqoz7h5c35ao5ttfdxa35ye

Simple current control of permanent magnet synchronous machines for railway traction operating in six-steps

Xiaochun Fang, Zhongbei Tian, Zhongping Yang, Fei Lin, Pietro Tricoli
2020 IET electric power applications  
doi:10.1049/iet-epa.2020.0106 fatcat:peqog6snazcq7bskk2df33ao4y

Crystal Chemistry and Electronic Properties of the Al-Rich Compounds, Al2Cu, ω-Al7Cu2Fe and θ-Al13Fe4 with Cu Solution

Changming Fang, Maaouia Souissi, Zhongping Que, Zhongyun Fan
2022 Metals  
In this work, we investigate Cu solution in θ-Al13Fe4 and related Al-rich ω-Al7Cu2Fe and Al2Cu phases in the Al-Cu-Fe system using the first-principles density functional theory (DFT) with on-site Coulomb interaction correction. The results show preference of Cu at Al7, forming a ternary θ-Al76Cu2Fe24 at ambient conditions, and both Al7 and Al9 sites (in Grin's note), forming θ-(Al76−xCu2+x)Fe24 at a high temperature. The relative stability of the Al-rich compounds and their crystal and
more » ... ic properties are investigated. We show the importance of the Hubbard U correction to the standard DFT functionals for Cu-containing metallic materials. This study helps characterize the intermetallic compounds in Cu-containing Al alloys, and helps further control Fe-containing intermetallic compounds in the solidification of Al-based alloys.
doi:10.3390/met12020329 fatcat:qtumf25y6rhpvnxcj4rukmcpya

Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging

Fang Yang, Yixin Li, Zhongping Chen, Yu Zhang, Junru Wu, Ning Gu
2009 Biomaterials  
Fang Yang is also thankful for the Scientific Research Foundation of Graduate School of Southeast University.  ... 
doi:10.1016/j.biomaterials.2009.03.051 pmid:19395082 fatcat:wpxjmewiynfgjilyhsanoibvry

Characterization and Identification of a Ripening-Related Gene AaPG18 in Actinidia arguta

Yukuo Li, Hailei Huang, Muhammad Abid, Hong Gu, Jinbao Fang, Zhongping Cheng, Xiujuan Qi
2022 International Journal of Molecular Sciences  
Actinidia arguta (A. arguta) is a kind of climacteric fruit that quickly softens and limits fruit shelf-life and commercial value. Therefore, it is of great significance to develop kiwifruit genotypes with an extended shelf-life of fruit. However, the ripening and softening mechanisms remain unclear in A. arguta. Here, we demonstrated that a key polygalacturonase (PG)-encoding gene AaPG18 was involved in A. arguta ripening through the degradation of the cell wall. Fruits were harvested at three
more » ... developmental stages (S1, S2, and S3) for high-throughput transcriptome sequencing, based on which two candidate transcripts c109562_g1 and c111961_g1 were screened. The genome-wide identification of the PG gene family assigned c109562_g1 and c111961_g1 to correspond to AaPG4 and AaPG18, respectively. The expression profiles of candidate genes at six preharvest stages of fruit showed significantly higher expression levels of AaPG18 than AaPG4, indicating AaPG18 might be a key gene during fruit ripening processes. The subcellular localization displayed AaPG18 was located at the cytoplasmic membrane. The transient overexpression of AaPG18 in strawberry and the following morphological observation suggested AaPG18 played a key role in maintaining the stability of cell morphology. The homologous transient transformation in A. arguta "RB-4" proved the crucial function of AaPG18 in fruit ripening processes by causing the rapid redness of the fruit, which was an indicator of fruit maturity. All in all, our results identified AaPG18 as a key candidate gene involved in cell wall degeneration, which provides a basis for the subsequent exploration of the molecular mechanisms underlying the ripening and softening of A. arguta fruit.
doi:10.3390/ijms23052597 pmid:35269737 pmcid:PMC8910643 fatcat:hdh6srknz5ey5drhj3vzlvk3hm

Influence of Oilseed Rape Seed Treatment with Imidacloprid on Survival, Feeding Behavior, and Detoxifying Enzymes of Mustard Aphid, Lipaphis erysimi

Fang Huang, Zhongping Hao, Fengming Yan
2019 Insects  
Imidacloprid application, as a seed coating agent on oilseed rape, is recommended to control mustard aphid, Lipaphis erysimi (Kaltenbach) (Hemiptera: Aphididae). In this study, responses of L. erysimi were investigated, including survival, feeding behavior, and detoxifying enzymes, on the oilseed rape seedlings grown from seeds coated with imidacloprid at rates of 6, 12, or 18 g active ingredient (a.i.)/kg seed. The results showed that the aphids' survival rate, together with that of the
more » ... of the survivors, on the seed-treated seedlings significantly decreased. This indicates that the aphid population in fields can be suppressed effectively. The electrical penetration graph (EPG) technique was used to record aphid feeding behaviors on two-, four-, and six-leaf stages of oilseed rape seedlings that had been seed-coated with imidacloprid, and individual responses were revealed during the aphid feeding behavior. On the plants at the two-leaf stage, aphid feeding behaviors were influenced, showing decreased frequency of stylet penetration into the leaf (probe) or into the mesophyll cells (potential drops, pds for short), and shortened duration of stylet event in the leaf (probe) or in the phloem. On the plants at the four- and six-leaf stages, these impacts of imidacloprid were weakened; however, the saliva secretion duration in phloem was shortened to less than 5 min in all imidacloprid treatments. The activity of mixed-function oxidase in aphids maintained on the treated seedlings with imidacloprid was elevated. In conclusion, imidacloprid could be used as a seed coating agent for aphid control, but chemical resistance in aphids should not be ignored.
doi:10.3390/insects10050144 pmid:31137546 pmcid:PMC6572145 fatcat:pw6wauh6cfc67ci4gr7hyscwke

Selective visual detection of trace trinitrotoluene residues based on dual-color fluorescence of graphene oxide–nanocrystals hybrid probe

Kui Zhang, Lei Yang, Houjuan Zhu, Fang Ma, Zhongping Zhang, Suhua Wang
2014 The Analyst  
The dual-color fluorescence nanohybrid probe comprising blue emissive fluorescent graphene oxide and red emissive nanocrystals has been developed for the visual detection of TNT residues in solution and on various surfaces.
doi:10.1039/c3an02380j pmid:24667778 fatcat:a5gjtjhynrhgbo3gj3ifo4bemu

Elevated Interleukin-6 Levels within 72 Hours Post Admission Are Associated with Disease Progression in Nonseptic Critically Ill Children

Lingfang Tan, Jianzhong Dang, Zhongping Liu, Fang Zheng
2020 BioMed Research International  
It has been established that the innate and adaptive immune suppression was heterogeneous in septic and nonseptic critically ill patients, while the value of immune function in pediatric patients with nonseptic critical illness is limited. We conducted a single-center retrospective study to explore this issue. A total of 65 children with nonseptic illnesses were studied for lymphocyte subpopulations, immunoglobulin concentrations, complement concentrations, and cytokines in peripheral blood in
more » ... he next 72 hours after admission to our Pediatric Intensive Care Unit (PICU). When compared to clinically recovered patients, patients with disease progression had a numerically lower but not significantly different median pediatric critical illness score and longer PICU median stays. The analysis of serum immunoglobulin (IgG, IgM, and IgA), serum complement (C3, C4) concentrations, and lymphocyte subpopulations showed no significantly difference between patients with and without relieved clinical symptoms by day 4. For the cytokine analysis, the level of IL-6 was significantly higher in patients with disease progression than that in patients who clinically recovered (p=0.046). In the univariate Cox regression analysis, plasma IL-6 levels were associated with outcome. Multivariate analysis evidenced that the level of plasma IL-6 was one of the factors determining the length of hospital stays. In conclusions, our results demonstrate that increased IL-6 levels in the initial 72 hours post admission are associated with prolonged stays and disease progression in nonseptic critically ill children in the PICU.
doi:10.1155/2020/4596851 pmid:32695814 pmcid:PMC7368930 fatcat:ck2fjydh6razjgsdhm5hmywqti

"Factual" or "Emotional": Stylized Image Captioning with Adaptive Learning and Attention [article]

Tianlang Chen, Zhongping Zhang, Quanzeng You, Chen Fang, Zhaowen Wang, Hailin Jin, Jiebo Luo
2018 arXiv   pre-print
Generating stylized captions for an image is an emerging topic in image captioning. Given an image as input, it requires the system to generate a caption that has a specific style (e.g., humorous, romantic, positive, and negative) while describing the image content semantically accurately. In this paper, we propose a novel stylized image captioning model that effectively takes both requirements into consideration. To this end, we first devise a new variant of LSTM, named style-factual LSTM, as
more » ... he building block of our model. It uses two groups of matrices to capture the factual and stylized knowledge, respectively, and automatically learns the word-level weights of the two groups based on previous context. In addition, when we train the model to capture stylized elements, we propose an adaptive learning approach based on a reference factual model, it provides factual knowledge to the model as the model learns from stylized caption labels, and can adaptively compute how much information to supply at each time step. We evaluate our model on two stylized image captioning datasets, which contain humorous/romantic captions and positive/negative captions, respectively. Experiments shows that our proposed model outperforms the state-of-the-art approaches, without using extra ground truth supervision.
arXiv:1807.03871v3 fatcat:dxma7gh3qfhvziaub4fcgel4ge

Understanding the Thermodynamics and Crystal Structure of Complex Fe Containing Intermetallic Phases Formed on Solidification of Aluminium Alloys

Alan Dinsdale, Changming Fang, Zhongping Que, Zhongyun Fan
2019 JOM: The Member Journal of TMS  
Ab initio density-functional theory calculations were carried out to investigate the energetics and structure of key Fe-containing intermetallic phases that precipitate from cast Al-Si alloys. These results were compared with published experimental information and used to provide insight into developing improved models to describe the thermodynamic properties of these phases.
doi:10.1007/s11837-019-03380-4 fatcat:mysffnvybbgmfkzswo2hvsmlsq
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