A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Filters
O038. I.V. methylprednisolone plus diazepam in medication-overuse headache
2015
The Journal of Headache and Pain
Preserved Fulltext
Nonconvulsive Seizures and Dementia: A Case Report
2011
International Journal of Alzheimer's Disease
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Nonconvulsive status epilepticus (NCSE) is a severe medical condition that shows increased incidence in the elderly and is frequently underdiagnosed because of its pleomorphic presentation. We report an NCSE in a 76-year-old woman affected by dementia with acute change of cognitive status and behavior. Intravenous diazepam solved clinical and electroencephalographic manifestations. Neuropsychological assessment after NCSE conclusion showed impairment of several fields that remained unchanged at
doi:10.4061/2011/690305
pmid:21559184
pmcid:PMC3089911
fatcat:psks2oj7e5eptanbbwlrzkvdtm
more »
... 3-month followup. NCSE should be considered when sudden and transient cognitive fluctuations appear in the elderly. Epileptic events in dementia occur frequently and are often underrecognized; this could be a misleading factor when considering a quick progression of mnesic performances. Moreover, recent findings both in animal models and in humans demonstrated the deep link between epilepsy and dementia, also supporting the hypothesis that epileptiform activity could contribute to cognitive impairment.
Patients with migraine with aura have increased flow mediated dilation
2010
BMC Neurology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Endothelium-derived nitric oxide (NO) mediates the arterial dilation following a flow increase (i.e. flow-mediated dilation, FMD), easily assessed in the brachial artery. NO is also involved in cerebral hemodynamics and it is supposed to trigger vascular changes occurring during migraine. This study aimed at investigating whether migraine patients present an altered response to NO also in the peripheral artery system. Methods: We enrolled 21 migraineurs (10 with aura [MwA], 11 without aura
doi:10.1186/1471-2377-10-18
pmid:20219129
pmcid:PMC2848147
fatcat:qab6embqpbc55ngz64b33ue2a4
more »
... ]), and 13 controls. FMD was evaluated with ultrasound in all subjects by measuring the percentage increase of the brachial artery diameter induced by hyperaemia reactive to sustained cuff inflation around the arm above systolic pressure. FMD values were then normalized for shear stress. Results: Normalized FMD values were higher in patients with MwA (28.5 10 -2 %.s) than in controls (9.0 10 -2 %.s) and patients with MwoA (13.7 10 -2 %.s) (p < 0.001). FMD was over the median value (19%) in 23.1% of controls, in 45.5% of the MwoA patients, and in 90% of the MwA patients. Conclusions: Migraineurs with aura present an excessive arterial response to hyperaemia, likely as an effect of an increased sensitivity to endothelium-derived nitric oxide. This phenomenon observed peripherally might reflect similar characteristics in the cerebral circulation.
Commentary: Enhanced Hemodynamic and Clinical Response to αCGRP in Migraine Patients—A TCD Study
2021
Frontiers in Neurology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Copyright © 2021 Altamura and Vernieri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...
doi:10.3389/fneur.2021.663818
pmid:33815263
pmcid:PMC8012904
fatcat:wzdllnxl7zg3xakgkyqsauay3q
Ceruloplasmin/Transferrin Ratio Changes in Alzheimer's Disease
2011
International Journal of Alzheimer's Disease
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
The link between iron and Alzheimer's disease (AD) has been mainly investigated with a focus on the local accumulation of this metal in specific areas of the brain that are critical for AD. In the present study, we have instead looked at systemic variations of markers of iron metabolism. We measured serum levels of iron, ceruloplasmin, and transferrin and calculated the transferrin saturation and the ceruloplasmin to transferrin ratio (Cp/Tf). Cp/Tf and transferrin saturation increased in AD
doi:10.4061/2011/231595
pmid:21234401
pmcid:PMC3014694
fatcat:cz3msmwdlvemfeil5f4xrcqxcy
more »
... ients. Cp/Tf ratios also correlated positively with peroxide levels and negatively with serum iron concentrations. Elevated values of ceruloplasmin, peroxides, and Cp/Tf inversely correlated with MMSE scores. Isolated medial temporal lobe atrophy positively correlated with Cp/Tf and negatively with serum iron. All these findings indicate that the local iron accumulation found in brain areas critical for AD should be viewed in the frame of iron systemic alterations.
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction
2011
EMBO Journal
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Daith Piercing in a Case of Chronic Migraine: A Possible Vagal Modulation
2017
Frontiers in Neurology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Daith piercing is an ear piercing located at the crus of the helix, bilaterally. It is getting great consent on social media as alternative treatment in chronic migraine. No data about its efficacy and action are available in scientific literature so far. We present the case of a 54-year-old male patient suffering from refractory chronic migraine with medication-overuse, who substantially improved after bilateral ear daith piercing. His migraine was refractory to symptomatic as well as
doi:10.3389/fneur.2017.00624
pmid:29230190
pmcid:PMC5711775
fatcat:3znehibyozdjxiocdhf77s6mya
more »
... tic therapies. He used to treat headaches with up to five symptomatic drugs per attack and had attempted several pharmacological preventive therapies, including Onabotulinumtoxin A. He also underwent detoxification treatments with intravenous steroids and diazepam, without durable benefit. At the time of daith piercing, the headache-related disability measures showed a HIT-6 score of 64, a MIDAS-score of 70, and a 11-point Box scale of 5. On his own free will, he decided to get a "daith piercing." After that, he experienced a reduction of migraine attacks, which became very rare, and infrequent, less disabling episodes of tension-type headache (HIT-6 score of 56; MIDAS score of 27, 11-point Box scale of 3). Painkiller assumption has much decreased: he takes only one tablet of indomethacin 50 mg to treat tensive headaches, about four times per month. Beyond a placebo effect, we can speculate a vagal modulation as the action mechanism of daith piercing: a nociceptive sensory stimulus applied to trigeminal and vagal areas of the ear can activate ear vagal afferents, which can modulate pain pathways by means of projections to the caudal trigeminal nucleus, to the locus coeruleus and to the nucleus raphe magnus. Currently, daith piercing cannot be recommended as migraine treatment because of the lack of scientific evidence, the unquantified rate of failure and the associated risks with insertion. However, given the increasing but anecdotal evidence, we think that the mechanism needs testing by means of a controlled clinical trial in a population of chronic migraineurs.
The Healthy Eating Plate Advice for Migraine Prevention: An Interventional Study
2020
Nutrients
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
We aimed at evaluating the effect of the Healthy Eating Plate (HEP) education on migraine frequency and disability. At three evaluation times (T-12 = screening, 12 weeks before the intervention; T0 = time of the educational HEP intervention; and T12 = 12-week follow-up), the enrolled subjects underwent assessment of anthropometric and dietary patterns, monthly migraine days (MMDs), and disability scales (Migraine Disability Assessment score (MIDAS), MIDAS A, MIDAS B). The HEP score estimated
doi:10.3390/nu12061579
pmid:32481555
pmcid:PMC7352548
fatcat:4clapghpf5fcnhzmhn4skka3ye
more »
... erence to dietary advice. We enrolled 204 out of 240 screened migraineurs, of these, 97 patients completed the follow-up. We defined ADHERENTS as patients presenting an increase in HEP scores from T0 to T12 and RESPONDERS as those with a reduction of at least 30% in MMDs. ADHERENTS presented a significant decrease in MMDs from T0 to T12. In particular, RESPONDERS reduced red, processed meat and carb intake compared to NON-RESPONDERS. Reduction in carb consumption also related to a decrease in perceived disability (MIDAS) and headache pain intensity (MIDAS B). Logistic regression confirmed that the HEP score increase and total carb decrease were related to a reduction in MMDs. This study showed that adherence to the HEP advice, particularly the reduction in carb, red and processed meat consumption, is useful in migraine management, reducing migraine frequency and disability. Trial registration: ISRCTN14092914.
Psychopathological Comorbidities and Clinical Variables in Patients With Medication Overuse Headache
2020
Frontiers in Human Neuroscience
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Copyright © 2020 Migliore, Paolucci, Quintiliani, Altamura, Maffi, D'Aurizio, Curcio and Vernieri. ...
doi:10.3389/fnhum.2020.571035
pmid:33328928
pmcid:PMC7728851
fatcat:4aii3vccgnc33p6w6ggoax6t54
P054. Chronic migraine and onabotulinumtoxinA: results from clinical practice
2015
The Journal of Headache and Pain
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
The Role of Endothelial Dysfunction in the Pathophysiology and Cerebrovascular Effects of Migraine: A Narrative Review
2021
Journal of Clinical Neurology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Investigation: Matteo Paolucci, Claudia Altamura, Fabrizio Vernieri. Methodology: Matteo Paolucci, Claudia Altamura, Fabrizio Vernieri. Project administration: Fabrizio Vernieri. ...
Supervision: Fabrizio Vernieri. Validation: Fabrizio Vernieri. Visualization: Matteo Paolucci. Writing-original draft: Matteo Paolucci. ...
doi:10.3988/jcn.2021.17.2.164
pmid:33835736
pmcid:PMC8053543
fatcat:a2ewgkgvkzcqlmlwb6rkjf75uy
The Genetic Landscape of Patent Foramen Ovale: A Systematic Review
2021
Genes
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf.
(Fabrizio Vernieri)., F.V (Franco Valzania) .; writing neuroradiological topics and selecting the images, R.P.; supervision, M.Z. ...
doi:10.3390/genes12121953
pmid:34946902
pmcid:PMC8700998
fatcat:5aykq2t2gfgrhhnu4yjydayg2q
Copper Perturbation in 2 Monozygotic Twins Discordant for Degree of Cognitive Impairment
2004
Archives of Neurology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
, and Rossini); study supervision (Drs Squitti, Dal Forno, and Rossini); radiological expertise (Dr Lupoi); neuropsychological expertise (Drs Lippolis and Cappa); technical expertise (Dr Vernieri). ...
of data (Drs Squitti, Dal Forno, and Rossini); drafting of the manuscript (Drs Squitti, Dal Forno, Lupoi, Vernieri, and Rossini); critical revision of the manuscript for important intellectual content ...
doi:10.1001/archneur.61.5.738
pmid:15148152
fatcat:v4faqz36lzecpnjibpa3esnyju
P030. Global postural rehabilitation and migraine: a pilot-study
2015
The Journal of Headache and Pain
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Linkage Disequilibrium and Haplotype Analysis of the ATP7B Gene in Alzheimer's Disease
2013
Rejuvenation Research
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Copper dyshomeostasis leading to a labile Cu 2 + not bound to ceruloplasmin ("free" copper) may influence Alzheimer's disease (AD) onset or progression. To investigate this hypothesis, we investigated ATP7B, the gene that controls copper excretion through the bile and concentrations of free copper in systemic circulation. Our study analyzed informative ATP7B single-nucleotide polymorphisms (SNPs) in a case-control population (n = 515). In particular, we evaluated the genetic structure of the
doi:10.1089/rej.2012.1357
pmid:22950421
pmcid:PMC3582274
fatcat:fpcpouzzvnbkpf7frh3fqqcyva
more »
... 7B gene using the HapMap database and carried out a genetic association investigation. Linkage disequilibrium (LD) analysis highlighted that our informative SNPs and their LD SNPs covered 96% of the ATP7B gene sequence, distinguishing two "strong LD" blocks. The first LD block contains the gene region encoding for transmembrane and copper-binding, whereas the second LD block encodes for copper-binding domains. The genetic association analysis showed significant results after multiple testing correction for all investigated variants (rs1801243, odds ratio [OR] = 1.52, 95% confidence interval [CI] = 1.10-2.09, p = 0.010; rs2147363, OR = 1.58, 95% CI = 1.11-2.25, p = 0.010; rs1061472, OR = 1.73, 95% CI = 1.23-2.43, p = 0.002; rs732774, OR = 2.31, 95% CI = 1.41-3.77, p < 0.001), indicating that SNPs in transmembrane domains may have a stronger association with AD risk than variants in copper-binding domains. Our study provides novel insights that confirm the role of ATP7B as a potential genetic risk factor for AD. The analysis of ATP7B informative SNPs confirms our previous hypothesis about the absence of ATP7B in the significant loci of genome-wide association studies of AD and the genetic association study suggests that transmembrane and adenosine triphosphate (ATP) domains in the ATP7B gene may harbor variants/haplotypes associated with AD risk.
« Previous
Showing results 1 — 15 out of 517 results