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O038. I.V. methylprednisolone plus diazepam in medication-overuse headache

Matteo Paolucci, Riccardo Altavilla, Giulia Gambale, Claudia Altamura, Fabrizio Vernieri
2015 The Journal of Headache and Pain  
doi:10.1186/1129-2377-16-s1-a103 pmid:28132285 pmcid:PMC4759341 fatcat:cccykpg4ard6tj4z2v5abe3al4

Nonconvulsive Seizures and Dementia: A Case Report

Campana Chiara, Assenza Giovanni, Pellegrino Giovanni, Benvenga Antonella, Assenza Federica, Ursini Francesca, Vernieri Fabrizio, Tombini Mario
2011 International Journal of Alzheimer's Disease  
Nonconvulsive status epilepticus (NCSE) is a severe medical condition that shows increased incidence in the elderly and is frequently underdiagnosed because of its pleomorphic presentation. We report an NCSE in a 76-year-old woman affected by dementia with acute change of cognitive status and behavior. Intravenous diazepam solved clinical and electroencephalographic manifestations. Neuropsychological assessment after NCSE conclusion showed impairment of several fields that remained unchanged at
more » ... 3-month followup. NCSE should be considered when sudden and transient cognitive fluctuations appear in the elderly. Epileptic events in dementia occur frequently and are often underrecognized; this could be a misleading factor when considering a quick progression of mnesic performances. Moreover, recent findings both in animal models and in humans demonstrated the deep link between epilepsy and dementia, also supporting the hypothesis that epileptiform activity could contribute to cognitive impairment.
doi:10.4061/2011/690305 pmid:21559184 pmcid:PMC3089911 fatcat:psks2oj7e5eptanbbwlrzkvdtm

Patients with migraine with aura have increased flow mediated dilation

Fabrizio Vernieri, Leo Moro, Claudia Altamura, Paola Palazzo, Raffaele Antonelli Incalzi, Paolo Maria Rossini, Claudio Pedone
2010 BMC Neurology  
Endothelium-derived nitric oxide (NO) mediates the arterial dilation following a flow increase (i.e. flow-mediated dilation, FMD), easily assessed in the brachial artery. NO is also involved in cerebral hemodynamics and it is supposed to trigger vascular changes occurring during migraine. This study aimed at investigating whether migraine patients present an altered response to NO also in the peripheral artery system. Methods: We enrolled 21 migraineurs (10 with aura [MwA], 11 without aura
more » ... ]), and 13 controls. FMD was evaluated with ultrasound in all subjects by measuring the percentage increase of the brachial artery diameter induced by hyperaemia reactive to sustained cuff inflation around the arm above systolic pressure. FMD values were then normalized for shear stress. Results: Normalized FMD values were higher in patients with MwA (28.5 10 -2 %.s) than in controls (9.0 10 -2 %.s) and patients with MwoA (13.7 10 -2 %.s) (p < 0.001). FMD was over the median value (19%) in 23.1% of controls, in 45.5% of the MwoA patients, and in 90% of the MwA patients. Conclusions: Migraineurs with aura present an excessive arterial response to hyperaemia, likely as an effect of an increased sensitivity to endothelium-derived nitric oxide. This phenomenon observed peripherally might reflect similar characteristics in the cerebral circulation.
doi:10.1186/1471-2377-10-18 pmid:20219129 pmcid:PMC2848147 fatcat:qab6embqpbc55ngz64b33ue2a4

Commentary: Enhanced Hemodynamic and Clinical Response to αCGRP in Migraine Patients—A TCD Study

Claudia Altamura, Fabrizio Vernieri
2021 Frontiers in Neurology  
Copyright © 2021 Altamura and Vernieri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fneur.2021.663818 pmid:33815263 pmcid:PMC8012904 fatcat:wzdllnxl7zg3xakgkyqsauay3q

Ceruloplasmin/Transferrin Ratio Changes in Alzheimer's Disease

Rosanna Squitti, Carlo Salustri, Mariacristina Siotto, Mariacarla Ventriglia, Fabrizio Vernieri, Domenico Lupoi, Emanuele Cassetta, Paolo M. Rossini
2011 International Journal of Alzheimer's Disease  
The link between iron and Alzheimer's disease (AD) has been mainly investigated with a focus on the local accumulation of this metal in specific areas of the brain that are critical for AD. In the present study, we have instead looked at systemic variations of markers of iron metabolism. We measured serum levels of iron, ceruloplasmin, and transferrin and calculated the transferrin saturation and the ceruloplasmin to transferrin ratio (Cp/Tf). Cp/Tf and transferrin saturation increased in AD
more » ... ients. Cp/Tf ratios also correlated positively with peroxide levels and negatively with serum iron concentrations. Elevated values of ceruloplasmin, peroxides, and Cp/Tf inversely correlated with MMSE scores. Isolated medial temporal lobe atrophy positively correlated with Cp/Tf and negatively with serum iron. All these findings indicate that the local iron accumulation found in brain areas critical for AD should be viewed in the frame of iron systemic alterations.
doi:10.4061/2011/231595 pmid:21234401 pmcid:PMC3014694 fatcat:cz3msmwdlvemfeil5f4xrcqxcy

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

Stefano Santaguida, Claudio Vernieri, Fabrizio Villa, Andrea Ciliberto, Andrea Musacchio
2011 EMBO Journal  
doi:10.1038/emboj.2011.70 pmid:21407176 pmcid:PMC3102279 fatcat:7e6hi4aftjgsffpmkxkh2ycyky

Daith Piercing in a Case of Chronic Migraine: A Possible Vagal Modulation

Angelo Cascio Rizzo, Matteo Paolucci, Riccardo Altavilla, Nicoletta Brunelli, Federica Assenza, Claudia Altamura, Fabrizio Vernieri
2017 Frontiers in Neurology  
Daith piercing is an ear piercing located at the crus of the helix, bilaterally. It is getting great consent on social media as alternative treatment in chronic migraine. No data about its efficacy and action are available in scientific literature so far. We present the case of a 54-year-old male patient suffering from refractory chronic migraine with medication-overuse, who substantially improved after bilateral ear daith piercing. His migraine was refractory to symptomatic as well as
more » ... tic therapies. He used to treat headaches with up to five symptomatic drugs per attack and had attempted several pharmacological preventive therapies, including Onabotulinumtoxin A. He also underwent detoxification treatments with intravenous steroids and diazepam, without durable benefit. At the time of daith piercing, the headache-related disability measures showed a HIT-6 score of 64, a MIDAS-score of 70, and a 11-point Box scale of 5. On his own free will, he decided to get a "daith piercing." After that, he experienced a reduction of migraine attacks, which became very rare, and infrequent, less disabling episodes of tension-type headache (HIT-6 score of 56; MIDAS score of 27, 11-point Box scale of 3). Painkiller assumption has much decreased: he takes only one tablet of indomethacin 50 mg to treat tensive headaches, about four times per month. Beyond a placebo effect, we can speculate a vagal modulation as the action mechanism of daith piercing: a nociceptive sensory stimulus applied to trigeminal and vagal areas of the ear can activate ear vagal afferents, which can modulate pain pathways by means of projections to the caudal trigeminal nucleus, to the locus coeruleus and to the nucleus raphe magnus. Currently, daith piercing cannot be recommended as migraine treatment because of the lack of scientific evidence, the unquantified rate of failure and the associated risks with insertion. However, given the increasing but anecdotal evidence, we think that the mechanism needs testing by means of a controlled clinical trial in a population of chronic migraineurs.
doi:10.3389/fneur.2017.00624 pmid:29230190 pmcid:PMC5711775 fatcat:3znehibyozdjxiocdhf77s6mya

The Healthy Eating Plate Advice for Migraine Prevention: An Interventional Study

Claudia Altamura, Gianluca Cecchi, Maria Bravo, Nicoletta Brunelli, Alice Laudisio, Paola Di Caprio, Giorgia Botti, Matteo Paolucci, Yeganeh Manon Khazrai, Fabrizio Vernieri
2020 Nutrients  
We aimed at evaluating the effect of the Healthy Eating Plate (HEP) education on migraine frequency and disability. At three evaluation times (T-12 = screening, 12 weeks before the intervention; T0 = time of the educational HEP intervention; and T12 = 12-week follow-up), the enrolled subjects underwent assessment of anthropometric and dietary patterns, monthly migraine days (MMDs), and disability scales (Migraine Disability Assessment score (MIDAS), MIDAS A, MIDAS B). The HEP score estimated
more » ... erence to dietary advice. We enrolled 204 out of 240 screened migraineurs, of these, 97 patients completed the follow-up. We defined ADHERENTS as patients presenting an increase in HEP scores from T0 to T12 and RESPONDERS as those with a reduction of at least 30% in MMDs. ADHERENTS presented a significant decrease in MMDs from T0 to T12. In particular, RESPONDERS reduced red, processed meat and carb intake compared to NON-RESPONDERS. Reduction in carb consumption also related to a decrease in perceived disability (MIDAS) and headache pain intensity (MIDAS B). Logistic regression confirmed that the HEP score increase and total carb decrease were related to a reduction in MMDs. This study showed that adherence to the HEP advice, particularly the reduction in carb, red and processed meat consumption, is useful in migraine management, reducing migraine frequency and disability. Trial registration: ISRCTN14092914.
doi:10.3390/nu12061579 pmid:32481555 pmcid:PMC7352548 fatcat:4clapghpf5fcnhzmhn4skka3ye

Psychopathological Comorbidities and Clinical Variables in Patients With Medication Overuse Headache

Simone Migliore, Matteo Paolucci, Livia Quintiliani, Claudia Altamura, Sabrina Maffi, Giulia D'Aurizio, Giuseppe Curcio, Fabrizio Vernieri
2020 Frontiers in Human Neuroscience  
Copyright © 2020 Migliore, Paolucci, Quintiliani, Altamura, Maffi, D'Aurizio, Curcio and Vernieri.  ... 
doi:10.3389/fnhum.2020.571035 pmid:33328928 pmcid:PMC7728851 fatcat:4aii3vccgnc33p6w6ggoax6t54

P054. Chronic migraine and onabotulinumtoxinA: results from clinical practice

Matteo Paolucci, Riccardo Altavilla, Giulia Gambale, Claudio Altamura, Giovanna Viticchi, Marco Bartolini, Mauro Silvestrini, Fabrizio Vernieri
2015 The Journal of Headache and Pain  
doi:10.1186/1129-2377-16-s1-a117 pmid:28132271 pmcid:PMC4759296 fatcat:bagpebl36jcgxlcvk2t43zwjlu

The Role of Endothelial Dysfunction in the Pathophysiology and Cerebrovascular Effects of Migraine: A Narrative Review

Matteo Paolucci, Claudia Altamura, Fabrizio Vernieri
2021 Journal of Clinical Neurology  
Investigation: Matteo Paolucci, Claudia Altamura, Fabrizio Vernieri. Methodology: Matteo Paolucci, Claudia Altamura, Fabrizio Vernieri. Project administration: Fabrizio Vernieri.  ...  Supervision: Fabrizio Vernieri. Validation: Fabrizio Vernieri. Visualization: Matteo Paolucci. Writing-original draft: Matteo Paolucci.  ... 
doi:10.3988/jcn.2021.17.2.164 pmid:33835736 pmcid:PMC8053543 fatcat:a2ewgkgvkzcqlmlwb6rkjf75uy

The Genetic Landscape of Patent Foramen Ovale: A Systematic Review

Matteo Paolucci, Chiara Vincenzi, Michele Romoli, Giulia Amico, Isabella Ceccherini, Simona Lattanzi, Anna Bersano, Marco Longoni, Simona Sacco, Fabrizio Vernieri, Rosario Pascarella, Franco Valzania (+1 others)
2021 Genes  
(Fabrizio Vernieri)., F.V (Franco Valzania) .; writing neuroradiological topics and selecting the images, R.P.; supervision, M.Z.  ... 
doi:10.3390/genes12121953 pmid:34946902 pmcid:PMC8700998 fatcat:5aykq2t2gfgrhhnu4yjydayg2q

Copper Perturbation in 2 Monozygotic Twins Discordant for Degree of Cognitive Impairment

Rosanna Squitti, Emanuele Cassetta, Gloria Dal Forno, Domenico Lupoi, Giulia Lippolis, Flavia Pauri, Fabrizio Vernieri, Antonella Cappa, Paolo M. Rossini
2004 Archives of Neurology  
, and Rossini); study supervision (Drs Squitti, Dal Forno, and Rossini); radiological expertise (Dr Lupoi); neuropsychological expertise (Drs Lippolis and Cappa); technical expertise (Dr Vernieri).  ...  of data (Drs Squitti, Dal Forno, and Rossini); drafting of the manuscript (Drs Squitti, Dal Forno, Lupoi, Vernieri, and Rossini); critical revision of the manuscript for important intellectual content  ... 
doi:10.1001/archneur.61.5.738 pmid:15148152 fatcat:v4faqz36lzecpnjibpa3esnyju

P030. Global postural rehabilitation and migraine: a pilot-study

Camilla Refice, Rita Loriga, Maria Novella Pompa, Giulia Gambale, Riccardo Altavilla, Matteo Paolucci, Claudia Altamura, Philippe Souchard, Fabrizio Vernieri
2015 The Journal of Headache and Pain  
doi:10.1186/1129-2377-16-s1-a116 pmid:28132272 pmcid:PMC4759348 fatcat:3jhauwefpnb6hpijvimmrxlnym

Linkage Disequilibrium and Haplotype Analysis of the ATP7B Gene in Alzheimer's Disease

Rosanna Squitti, Renato Polimanti, Serena Bucossi, Mariacarla Ventriglia, Stefania Mariani, Dario Manfellotto, Fabrizio Vernieri, Emanuele Cassetta, Francesca Ursini, Paolo Maria Rossini
2013 Rejuvenation Research  
Copper dyshomeostasis leading to a labile Cu 2 + not bound to ceruloplasmin ("free" copper) may influence Alzheimer's disease (AD) onset or progression. To investigate this hypothesis, we investigated ATP7B, the gene that controls copper excretion through the bile and concentrations of free copper in systemic circulation. Our study analyzed informative ATP7B single-nucleotide polymorphisms (SNPs) in a case-control population (n = 515). In particular, we evaluated the genetic structure of the
more » ... 7B gene using the HapMap database and carried out a genetic association investigation. Linkage disequilibrium (LD) analysis highlighted that our informative SNPs and their LD SNPs covered 96% of the ATP7B gene sequence, distinguishing two "strong LD" blocks. The first LD block contains the gene region encoding for transmembrane and copper-binding, whereas the second LD block encodes for copper-binding domains. The genetic association analysis showed significant results after multiple testing correction for all investigated variants (rs1801243, odds ratio [OR] = 1.52, 95% confidence interval [CI] = 1.10-2.09, p = 0.010; rs2147363, OR = 1.58, 95% CI = 1.11-2.25, p = 0.010; rs1061472, OR = 1.73, 95% CI = 1.23-2.43, p = 0.002; rs732774, OR = 2.31, 95% CI = 1.41-3.77, p < 0.001), indicating that SNPs in transmembrane domains may have a stronger association with AD risk than variants in copper-binding domains. Our study provides novel insights that confirm the role of ATP7B as a potential genetic risk factor for AD. The analysis of ATP7B informative SNPs confirms our previous hypothesis about the absence of ATP7B in the significant loci of genome-wide association studies of AD and the genetic association study suggests that transmembrane and adenosine triphosphate (ATP) domains in the ATP7B gene may harbor variants/haplotypes associated with AD risk.
doi:10.1089/rej.2012.1357 pmid:22950421 pmcid:PMC3582274 fatcat:fpcpouzzvnbkpf7frh3fqqcyva
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