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Extracting relations between outcomes and significance levels in Randomized Controlled Trials (RCTs) publications

Anna Koroleva, Patrick Paroubek
2019 Proceedings of the 18th BioNLP Workshop and Shared Task  
We propose a machine learning approach to automatically extract reported outcomes, significance levels and the relation between them.  ...  Randomized controlled trials assess the effects of an experimental intervention by comparing it to a control intervention with regard to some variables -trial outcomes.  ...  Acknowledgements We thank Sanjay Kamath for his help in conducting experiments with BERT.  ... 
doi:10.18653/v1/w19-5038 dblp:conf/bionlp/KorolevaP19 fatcat:viqrkrhqu5fdzhmbaydkkcwhbi

Annotating Spin in Biomedical Scientific Publications: the case of Randomized Controlled Trials (RCTs)

Koroleva Anna, Paroubek Patrick
2018 Zenodo  
We present the manual annotation model and its annotation guidelines and describe the planned machine learning experiments and evaluations.  ...  In this paper we report on the collection in the context of the MIROR project of a corpus of biomedical articles for the task of automatic detection of inadequate claims (spin), which to our knowledge  ...  This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 676207. Bibliographical References  ... 
doi:10.5281/zenodo.3608721 fatcat:q6p7bsnvwng67aydahj4wconuy

A careful biomedicine? Generalization and abstraction in RCTs

Marsha Rosengarten, Martin Savransky
2018 Critical Public Health  
This article takes up biomedical and public health concerns about the difficulty of generalizing or extrapolating measurements of efficacy produced by the method of the randomized control trial (RCT) to  ...  of care at work in efforts to devise Ebola adaptive trials.  ...  Introduction Across the numerous fields of health and medical inquiry and intervention in evidencebased medicine (EBM), the randomized control trial (RCT) is regarded as the method best designed to statistically  ... 
doi:10.1080/09581596.2018.1431387 fatcat:a372ijv26vgv7nl5esagrr6xte

The pathway to RCTs: how many roads are there? Examining the homogeneity of RCT justification

Jeffrey Tin Yu Chow, Kevin Lam, Abdul Naeem, Zarique Z. Akanda, Francie Fengqin Si, William Hodge
2017 Trials  
Randomized controlled trials (RCTs) form the foundational background of modern medical practice.  ...  For each RCT, we recorded information relating to the justification for conducting RCTs such as average study size cited, number of studies cited, and types of studies cited.  ...  The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.  ... 
doi:10.1186/s13063-017-1804-z pmid:28148278 pmcid:PMC5288880 fatcat:vobymu3gubgzjh5fn3yxmpgwsm

Mixed methods evaluation of targeted case finding for cardiovascular disease prevention using a stepped wedged cluster RCT

Tom Marshall, Michael Caley, Karla Hemming, Paramjit Gill, Nicola Gale, Kate Jolly
2012 BMC Public Health  
This is a stepped wedge randomised controlled trial design.  ...  Discussion: It is possible to design a stepped wedge randomised controlled trial using routine data to determine the primary outcome to evaluate implementation of a cardiovascular prevention programme.  ...  Acknowledgements Thanks are due to the general practices who participated in this project; to Paul Westerby who implemented cardiovascular case finding in Sandwell; and to Manisha Sharma and Ansaf Azhar  ... 
doi:10.1186/1471-2458-12-908 pmid:23101763 pmcid:PMC3505746 fatcat:qah5rcmvhfgiflxwyy2mlx64am

A loyalty scheme to encourage physical activity in office workers: a cluster RCT

Ruth F Hunter, Aisling Gough, Jennifer M Murray, Jianjun Tang, Sarah F Brennan, Oliver J Chrzanowski-Smith, Angela Carlin, Chris Patterson, Alberto Longo, George Hutchinson, Lindsay Prior, Mark A Tully (+5 others)
2019 Public Health Research  
Trial registration Current Controlled Trials ISRCTN17975376.  ...  Setting Office-based employees from public sector organisations in Belfast and Lisburn city centres in Northern Ireland.  ...  , assisted with recruitment and data collection of the main trial, led the behavioural economic analyses and publications and contributed to others, led the preparation of the behavioural economic analyses  ... 
doi:10.3310/phr07150 fatcat:cfnafo2linhvvbu6bupvg4jrsq

Form follows function: pragmatic controlled trials (PCTs) have to answer different questions and require different designs than randomized controlled trials (RCTs)

Franz Porzsolt, Martin Eisemann, Michael Habs, Peter Wyer
2012 Journal of Public Health  
Subjects and methods The PCT design meets four requirements of public health and of effectiveness research. It  ...  Pragmatic trials investigate whether the efficacy, presumed or found in explanatory trials under ideal conditions, can also be detected under real world conditions, i.e. effectiveness.  ...  Keywords Randomized controlled trial (RCT) . Pragmatic controlled trial (PCT) . Public health research . Comparative effectiveness research . Internal validity .  ... 
doi:10.1007/s10389-012-0544-5 pmid:23687408 pmcid:PMC3655212 fatcat:snk75n53pbhopaiuftvgdrr4ii

Internet-based interventions for pain management: A systematic review of randomised controlled trial (RCTs) conducted from 2010 to 2014

El Metwally Ashraf
2015 Journal of Public Health and Epidemiology  
A PubMed electronic search was used to identify a systematic randomized controlled trail (RCTs) that examined the effectiveness of internet-based pain management programs.  ...  Out of the 20 RCTs, 5 were on chronic pain, 2 were on acute non-specific pain, while 13 were on disease related pain (rheumatological and neurological diseases, burns, post-operative and cancerrelated)  ...  Inclusion criteria were publications in English language; publication in a peer reviewed journal; clinical trials published from 1 January, 2010 to 4 November, 2014.  ... 
doi:10.5897/jphe2014.0702 fatcat:htgx37fxb5gnhf7vru36pss6ju

Efficacy of Integrated Traditional Chinese and Western Medicine for Treating COVID-19: A Systematic Review and Meta-Analysis of RCTs

Bei Yin, Yi-Ming Bi, Lu Sun, Jin-Zhu Huang, Jia Zhao, Jia Yao, An-Xiang Li, Xian-Zhe Wang, Guan-Jie Fan
2021 Frontiers in Public Health  
In this study, we undertook a systematic review and meta-analysis of published randomized controlled trials (RCTs) to evaluate the efficacy of integrated medicine therapy for patients with COVID-19.Methods  ...  , and cough), the CRP level, and WBC count compared with that of the CWM treatment.  ...  National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), and Wanfang Databases from inception to April 12, 2021, for randomized controlled trials (RCTs) investigating the role of integrated medicine  ... 
doi:10.3389/fpubh.2021.622707 fatcat:rgufcharhfcujbqmtfv7zumsya

Attachment- and Relationship-Based Interventions during NICU Hospitalization for Families with Preterm/Low-Birth Weight Infants: A Systematic Review of RCT Data

Soo-Yeon Kim, Ah Rim Kim
2022 International Journal of Environmental Research and Public Health  
This study conducts a systematic review and meta-analysis of the randomized-controlled clinical trials (RCTs) of attachment- and relationship-based interventions in the NICU.  ...  Tailored, staged interventions may contribute to better health outcomes in preterm infants and their families.  ...  Data Availability Statement: No new data were created or analyzed in this study. Data sharing is not applicable to this article.  ... 
doi:10.3390/ijerph19031126 pmid:35162150 pmcid:PMC8834457 fatcat:tnj7zxx2efcx3o6zi5dkboyd34

Early Enteral Nutrition within 24 Hours or between 24 and 72 Hours for Acute Pancreatitis: Evidence Based on 12 RCTs

Kezhi Jia
2014 Medical Science Monitor  
EEN within 24 h of admission presented significantly better outcome in morality than EEN between 24 and 72 h.  ...  However, no significant heterogeneity was observed in the risk of pancreatic infection, organ failure, hyperglycemia, and catheter-related septic complications between the 2 subgroups.  ...  The following terms and strategy were applied for searching in the databases: ("enteral nutrition" OR "nasojejunal" OR "nasogastric") AND ("acute pancreatitis) AND ("randomized controlled trial" OR "RCT  ... 
doi:10.12659/msm.892770 pmid:25399541 pmcid:PMC4247233 fatcat:copc2cl7orbfjl2hdzz55otp3a

Lifestyle Interventions to Improve Glycemic Control in Adults with Type 2 Diabetes Living in Low-and-Middle Income Countries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (RCTs)

Grainne O'Donoghue, Cliona O'Sullivan, Isabelle Corridan, Jennifer Daly, Ronan Finn, Kathryn Melvin, Casey Peiris
2021 International Journal of Environmental Research and Public Health  
Four electronic databases were searched for RCTs published between 1990 and 2020. T2DM, lifestyle interventions, LMICs and their synonyms were used as search terms.  ...  Data codebooks were developed and data were extracted.  ...  Acknowledgments: The authors would like to acknowledge Diarmuid Stokes, Liaison Librarian for Health and Science in University College Dublin, for his advice and assistance regarding electronic literatures  ... 
doi:10.3390/ijerph18126273 fatcat:chhqeznzofg4zm3j2lds7tfez4

Empathy promoting interventions for health professionals: a systematic review of RCTs

Vassilios N. Kiosses, Vassilios T. Karathanos, Athina Tatsioni
2016 Journal of Compassionate Health Care  
Method: Authors searched Pubmed, Cochrane Database of Clinical Trials, Scopus, and PsycInfo for randomized controlled trials (RCTs) (latest search on November 2012).  ...  There were only two studies that evaluated interventions specifically aiming at promoting empathy; one of these trials reported significant increase in residents' empathy related knowledge, skills, and  ...  Dr AT agrees to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.  ... 
doi:10.1186/s40639-016-0024-9 fatcat:3dbopauy2bb65o4rks3s3iahpm

A Systematic Review of RCTs and quasi-RCTs on Traditional Chinese Patent Medicines for Treatment of Chronic Hepatitis B

Tao ZHAN, Xing WEI, Ze-qi CHEN, Dong-sheng WANG, Xing-ping DAI
2011 Journal of Traditional Chinese Medicine  
The OR and 95% CI were 0.37 [0.15, 0.88] between the experimental and control groups.  ...  Three reported that Dan Shen agents improved HBV serum markers or HBV DNA levels, while the other four trials claimed no significant difference compared to controls.  ... 
doi:10.1016/s0254-6272(12)60006-5 fatcat:hblqw7mawzdrfac7fcr2aqlmde

Physical Activity Change in an RCT: Comparison of Measurement Methods

Sandahl H. Nelson, Loki Natarajan, Ruth E. Patterson, Sheri J. Hartman, Caroline A. Thompson, Suneeta V. Godbole, Eileen Johnson, Catherine R. Marinac, Jacqueline Kerr
2019 American Journal of Health Behavior  
Methods: Data were from a randomized weight loss trial that encouraged increased PA among 333 postmenopausal breast cancer survivors.  ...  Objectives: We aimed to quantify the agreement between self-report, standard cut-point accelerometer, and machine learning accelerometer estimates of physical activity (PA), and exam- ine how agreement  ...  Acknowledgements This study was funded in part by the National Institutes of Health U54 CA155435, F32 CA220859.  ... 
doi:10.5993/ajhb.43.3.9 pmid:31046885 pmcid:PMC6812571 fatcat:4frezejbajgczbnd5lju7z4tzi
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