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DROPA: DRIP-seq optimized peak annotator

Marco Russo, Bruno De Lucca, Tiziano Flati, Silvia Gioiosa, Giovanni Chillemi, Giovanni Capranico
2019 BMC Bioinformatics  
Its output can easily be integrated into pipelines to perform downstream analyses, while useful and informative summary plots and statistical enrichment tests can be produced.  ...  R-loops are three-stranded nucleic acid structures that usually form during transcription and that may lead to gene regulation or genome instability.  ...  Acknowledgements We wish to thank all the members of the laboratory for the helpful discussion.  ... 
doi:10.1186/s12859-019-3009-9 fatcat:ud6tcyjab5ccnjgc2urab52tki

Multiomic characterization of the effects of G-quadruplex binders on R-loop homeostasis and innate immune response in human cancer cells

Marco Russo
2020
Here, through bioinformatic analysis of genomic R-loop maps and the development of a specific tool to better annotate R-loop regions to gene, we propose that stabilization of G4 structures with specific  ...  ligands leads to accumulation of DNA damage and genome instability in cancer cells and that this process is mediated by R-loop stabilization.  ...  Acknowledgements We wish to thank all the members of the laboratory for the helpful discussion.  ... 
doi:10.6092/unibo/amsdottorato/9253 fatcat:z76mq6kvezhlxovztri7qfvram

Correlative mass spectrometry imaging of animal–microbe symbioses [article]

Benedikt Geier, Universität Bremen, Nicole Dubilier
2020
However, the chemical images generated with this state-of-the-art technique are difficult to analyze and interpret.  ...  Mass spectrometry imaging provides a new frontier in imaging the spatial distribution of molecular species.  ...  helped us collect our extensive sample set of mussel species.  ... 
doi:10.26092/elib/73 fatcat:y4lhjlcybvbmxckaxjhjayqxcy