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1998 Biocomputing '99  
It examines the extension of refractoriness" hypothesis for de brillation which postulates that the shock induces an extension of the refractory period of cardiac cells thus blocking propagating waves  ...  The present study uses a model of the de brillation process that represents a sheet of myocardium as a bidomain with unequal anisotropy ratios.  ...  Acknowledgments This research is supported by funds from contract LEQSF1998-01-RD-A-30 from the Louisiana Board of Regents through the Board of Regents Support Fund, and by NSF GIG Award DMF-9709754.  ... 
doi:10.1142/9789814447300_0024 fatcat:6a6bwp3d2rd3zo7swewtd4i7am

Page 4 of None Vol. 41, Issue 2 [page]

1997 None  
Relationship between “extension of refractoriness” and probability of successful defibrillation OSCAR H. TOVAR AND JANICE L.  ...  Relationship between “extension of refractoriness” and probability of suc- cessful defibrillation. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H1011—H1019, 1997.  ... 

Spatial and temporal organization during cardiac fibrillation

Richard A. Gray, Arkady M. Pertsov, José Jalife
1998 Nature  
Finally, defibrillation at such a time in the cardiac cycle might minimize the chances that VF would reinitiate following defibrillation (cf. refs 7,8).  ...  The future Modeling study to optimize criteria of this type in two ways: maximizing the reduction in defibrillation energy and minimizing the expected waiting time until the criterion is met.  ...  the great cardiac vein, and a subcutaneous patch in the pectoral region.  ... 
doi:10.1038/32164 pmid:9510249 fatcat:why3k7bikndarbb2tryvwzoyta

The fine-scale architecture of defibrillation

2004 Cardiovascular Research  
Acknowledgements Research on cardiac virtual tissue engineering in the Computational Biology Laboratory is supported by grants from the British Heart Foundation, Engineering and Physical Sciences Research  ...  The bidomain model offers an idealized computational model for cardiac tissue in which the tissue voltage is represented as two co-extensive domains, the intracellular and the extracellular, that differ  ...  Since DC cardiac defibrillation/cardioversion was pioneered by Lown [2] in the 1960s, there have been substantial improvements in the engineering of defibrillators, leading to implantable devices for  ... 
doi:10.1016/j.cardiores.2004.09.015 pmid:15537490 fatcat:s5yfiumerbdwxff6sxevaafsne

Mechanisms of Defibrillation Failure [chapter]

Takashi Ashihara, Jason Constantino, Natalia A.
2011 Cardiac Defibrillation - Mechanisms, Challenges and Implications  
Simulations with this Cardiac Defibrillation -Mechanisms, Challenges and Implications 4 model, termed the rabbit bidomain model of defibrillation, have proven invaluable in understanding  ...  To test this hypothesis, we analyzed the global three-dimensional activity in ventricles with the use of a recently-developed realistic computer model of stimulation/defibrillation in the rabbit heart  ...  Hard cover, 248 pages The only known effective therapy for lethal disturbances in cardiac rhythm is deï¬ brillation, the delivery of a strong electric shock to the heart.  ... 
doi:10.5772/25279 fatcat:m3o7m7tqbrfiriu2r4vrclwzpi

Association Between Pad Placement and the Return of Spontaneous Circulation for Defibrillation During Ventricular Fibrillation: A Systematic Review

2021 Journal of Innovations in Cardiac Rhythm Management  
The Journal of Innovations in Cardiac Rhythm Management, June 2021  ...  a key objective to improve the prognosis of patients following cardiac arrest.  ... 
doi:10.19102/icrm.2021.120607 fatcat:bzxk6utcajbefoycxtmemmgkke

Mystery of Biphasic Defibrillation Waveform Efficacy

James P. Daubert, Shey-Shing Sheu
2008 Journal of the American College of Cardiology  
With optical mapping in a Langendorf model, Efimov et al.  ...  The biphasic mystery is part of the larger uncertainty over the mechanism of defibrillation itself, with critical mass (2), upper limit of vulnerability (3, 4) , and refractory period extension and/or  ... 
doi:10.1016/j.jacc.2008.05.041 pmid:18755346 fatcat:hl2u7p7gdvdtpextfmtunxbxpi

DOuble SEquential External Defibrillation for Refractory Ventricular Fibrillation (DOSE VF): study protocol for a randomized controlled trial

Ian R. Drennan, Paul Dorian, Shelley McLeod, Ruxandra Pinto, Damon C. Scales, Linda Turner, Michael Feldman, P. Richard Verbeek, Laurie J. Morrison, Sheldon Cheskes
2020 Trials  
Discussion A well-designed randomized controlled trial employing a standardized approach to alternative defibrillation strategies early in the treatment of refractory VF is urgently required to determine  ...  Research question Among adult (≥ 18 years) patients presenting in refractory VF or pulseless ventricular tachycardia (pVT) during out-of-hospital cardiac arrest, does DSED or VC defibrillation result in  ...  Acknowledgements We would like to acknowledge the incredible dedication and hard work of all paramedics who have worked tirelessly over the duration of the study to enroll patients in the DOSE VF study  ... 
doi:10.1186/s13063-020-04904-z pmid:33243277 fatcat:v7peixnrtnbvfhd7azxpuxdx6a

Role of KATP Channels in the Maintenance of Ventricular Fibrillation in Cardiomyopathic Human Hearts

T. A. Farid, K. Nair, S. Masse, M. A. Azam, A. Maguy, P. F. H. Lai, K. Umapathy, P. Dorian, V. Chauhan, A. Varro, A. Al-Hesayen, M. Waxman (+2 others)
2011 Circulation Research  
Methods and Results: In a human Langendorff model, electric mapping of 6 control and 9 treatment (10 mol/L glibenclamide) isolated cardiomyopathic hearts was performed.  ...  In an ischemic rat heart model, transmural dispersion of refractoriness (⌬ERP Transmural ‫؍‬ERP Epicardium ؊ERP Endocardium ) was verified with pacing protocols.  ...  A. Coetzee for his expert advice and for kindly providing cell lysates from HEK cells stably expressing K ATP subunits. Disclosures None.  ... 
doi:10.1161/circresaha.110.232918 pmid:21980123 fatcat:mcoknyuiwfgyxaqb47maiofxn4

Theory and practice of defibrillation: (2) defibrillation for ventricular fibrillation

A A J Adgey
2005 Heart  
. w4 In theory, extension of the refractory period of a sufficient number of cells will cause fibrillatory activation fronts to encounter refractory tissue and thus die out.  ...  of refractory myocardium in our previous article in this series.  ... 
doi:10.1136/hrt.2003.019927 pmid:15604356 pmcid:PMC1768652 fatcat:r36rsttpkjf67hql26ohxqzizy

Imaging of Ventricular Fibrillation and Defibrillation: The Virtual Electrode Hypothesis [chapter]

Bastiaan J. Boukens, Sarah R. Gutbrod, Igor R. Efimov
2015 Advances in Experimental Medicine and Biology  
Ventricular fibrillation is the major underlying cause of sudden cardiac death.  ...  Therefore, the current challenge is to use the knowledge provided by optical mapping to develop a low energy approach of defibrillation, which may lead to more successful defibrillation.  ...  [2] Extensive research over the past decades have resulted in the development of internal and external cardiac defibrillators, which have contributed to a significant reduction of the number of SCD  ... 
doi:10.1007/978-3-319-17641-3_14 pmid:26238060 pmcid:PMC4729445 fatcat:l2pywhnhqzei5dbatddmnpzdty

Milrinone Facilitates Resuscitation From Cardiac Arrest and Attenuates Postresuscitation Myocardial Dysfunction

J. T. Niemann
2003 Circulation  
All animals were defibrillated; 6 of 16 control animals developed refractory postcountershock pulseless electrical activity compared with 0 of 16 treated animals (Pϭ0.018).  ...  Background-Left ventricular (LV) dysfunction with a low cardiac index after successful CPR contributes to early death attributable to multiorgan failure, and an effective treatment has not been identified  ...  Acknowledgments This study was supported in part by a Directed Research in Cardiac Arrest Survival Award from the Emergency Medicine Foundation, Dallas, Tex, in partnership with Wyeth Pharmaceuticals.  ... 
doi:10.1161/01.cir.0000101925.37174.85 pmid:14638547 fatcat:eilahwg2bragtcm3v36y2ngote

Mechanical Cardiopulmonary Resuscitation In and On the Way to the Cardiac Catheterization Laboratory

Preethi William, Prashant Rao, Uday B. Kanakadandi, Alejandro Asencio, Karl B. Kern
2016 Circulation Journal  
This article summarizes the epidemiology, pathophysiology and nature of cardiac arrest in the cardiac cath lab and discusses the mechanics of CPR and defibrillation in that setting.  ...  Mechanical cardiopulmonary resuscitation (CPR) provides unique advantages over manual performance of chest compression for treating cardiac arrest in the cardiac cath lab.  ...  From those data, a risk prediction model was developed.  ... 
doi:10.1253/circj.cj-16-0330 pmid:27180892 fatcat:thatxwvb6na3fnjewya3ocaso4

Comparing Drugs for Out-of-hospital, Shock-refractory Cardiac Arrest: Systematic Review and Network Meta-analysis of Randomized Controlled Trials

Karan Srisurapanont, Thachapon Thepchinda, Siriaran Kwangsukstith, Suchada Saetiao, Chayada Kasirawat, Worawan Janmayka, Wachira Wongtanasarasin
2021 Western Journal of Emergency Medicine  
The benefit of medications used in out-of-hospital, shock-refractory cardiac arrest remains controversial.  ...  Conclusion: No medication was associated with improved survival to hospital discharge from out-of-hospital, shock-refractory cardiac arrest.  ...  Thanchanok Srisawang for her comments in editing the manuscript.  ... 
doi:10.5811/westjem.2021.2.49590 pmid:35354019 pmcid:PMC8328185 fatcat:34wpaut4pnf3rferd6cymwyddy

Tedisamil increases coherence during ventricular fibrillation and decreases defibrillation energy requirements

Paul Dorian, David Newman
1997 Cardiovascular Research  
Drugs which primarily prolong cardiac refractoriness decrease defibrillation voltage and energy requirements in animals and man.  ...  Ž . coherence, a measure of spatial organization, and ventricular fibrillation VF cycle length, ventricular effective refractory period VERP , Ž .  ...  in preparation of this manuscript.  ... 
doi:10.1016/s0008-6363(96)00214-3 pmid:9074714 fatcat:3w3hy5tedbc67ov54f6ru6z2bu
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