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EXTENSION OF REFRACTORINESS IN A MODEL OF CARDIAC DEFIBRILLATION
1998
Biocomputing '99
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It examines the extension of refractoriness" hypothesis for de brillation which postulates that the shock induces an extension of the refractory period of cardiac cells thus blocking propagating waves ...
The present study uses a model of the de brillation process that represents a sheet of myocardium as a bidomain with unequal anisotropy ratios. ...
Acknowledgments This research is supported by funds from contract LEQSF1998-01-RD-A-30 from the Louisiana Board of Regents through the Board of Regents Support Fund, and by NSF GIG Award DMF-9709754. ...
doi:10.1142/9789814447300_0024
fatcat:6a6bwp3d2rd3zo7swewtd4i7am
Page 4 of None Vol. 41, Issue 2
[page]
1997
None
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Relationship between “extension of refractoriness” and probability of successful defibrillation
OSCAR H. TOVAR AND JANICE L. ...
Relationship between “extension of refractoriness” and probability of suc- cessful defibrillation. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H1011—H1019, 1997. ...
Spatial and temporal organization during cardiac fibrillation
1998
Nature
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Finally, defibrillation at such a time in the cardiac cycle might minimize the chances that VF would reinitiate following defibrillation (cf. refs 7,8). ...
The future Modeling study to optimize criteria of this type in two ways: maximizing the reduction in defibrillation energy and minimizing the expected waiting time until the criterion is met. ...
the great cardiac vein, and a subcutaneous patch in the pectoral region. ...
doi:10.1038/32164
pmid:9510249
fatcat:why3k7bikndarbb2tryvwzoyta
The fine-scale architecture of defibrillation
2004
Cardiovascular Research
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Acknowledgements Research on cardiac virtual tissue engineering in the Computational Biology Laboratory is supported by grants from the British Heart Foundation, Engineering and Physical Sciences Research ...
The bidomain model offers an idealized computational model for cardiac tissue in which the tissue voltage is represented as two co-extensive domains, the intracellular and the extracellular, that differ ...
Since DC cardiac defibrillation/cardioversion was pioneered by Lown [2] in the 1960s, there have been substantial improvements in the engineering of defibrillators, leading to implantable devices for ...
doi:10.1016/j.cardiores.2004.09.015
pmid:15537490
fatcat:s5yfiumerbdwxff6sxevaafsne
Mechanisms of Defibrillation Failure
[chapter]
2011
Cardiac Defibrillation - Mechanisms, Challenges and Implications
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Simulations with this www.intechopen.com Cardiac Defibrillation -Mechanisms, Challenges and Implications 4 model, termed the rabbit bidomain model of defibrillation, have proven invaluable in understanding ...
To test this hypothesis, we analyzed the global three-dimensional activity in ventricles with the use of a recently-developed realistic computer model of stimulation/defibrillation in the rabbit heart ...
Hard cover, 248 pages The only known effective therapy for lethal disturbances in cardiac rhythm is deï¬ brillation, the delivery of a strong electric shock to the heart. ...
doi:10.5772/25279
fatcat:m3o7m7tqbrfiriu2r4vrclwzpi
Association Between Pad Placement and the Return of Spontaneous Circulation for Defibrillation During Ventricular Fibrillation: A Systematic Review
2021
Journal of Innovations in Cardiac Rhythm Management
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The Journal of Innovations in Cardiac Rhythm Management, June 2021 ...
a key objective to improve the prognosis of patients following cardiac arrest. ...
doi:10.19102/icrm.2021.120607
fatcat:bzxk6utcajbefoycxtmemmgkke
Mystery of Biphasic Defibrillation Waveform Efficacy
2008
Journal of the American College of Cardiology
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With optical mapping in a Langendorf model, Efimov et al. ...
The biphasic mystery is part of the larger uncertainty over the mechanism of defibrillation itself, with critical mass (2), upper limit of vulnerability (3, 4) , and refractory period extension and/or ...
doi:10.1016/j.jacc.2008.05.041
pmid:18755346
fatcat:hl2u7p7gdvdtpextfmtunxbxpi
DOuble SEquential External Defibrillation for Refractory Ventricular Fibrillation (DOSE VF): study protocol for a randomized controlled trial
2020
Trials
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Discussion A well-designed randomized controlled trial employing a standardized approach to alternative defibrillation strategies early in the treatment of refractory VF is urgently required to determine ...
Research question Among adult (≥ 18 years) patients presenting in refractory VF or pulseless ventricular tachycardia (pVT) during out-of-hospital cardiac arrest, does DSED or VC defibrillation result in ...
Acknowledgements We would like to acknowledge the incredible dedication and hard work of all paramedics who have worked tirelessly over the duration of the study to enroll patients in the DOSE VF study ...
doi:10.1186/s13063-020-04904-z
pmid:33243277
fatcat:v7peixnrtnbvfhd7azxpuxdx6a
Role of KATP Channels in the Maintenance of Ventricular Fibrillation in Cardiomyopathic Human Hearts
2011
Circulation Research
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Methods and Results: In a human Langendorff model, electric mapping of 6 control and 9 treatment (10 mol/L glibenclamide) isolated cardiomyopathic hearts was performed. ...
In an ischemic rat heart model, transmural dispersion of refractoriness (⌬ERP Transmural ؍ERP Epicardium ؊ERP Endocardium ) was verified with pacing protocols. ...
A. Coetzee for his expert advice and for kindly providing cell lysates from HEK cells stably expressing K ATP subunits.
Disclosures None. ...
doi:10.1161/circresaha.110.232918
pmid:21980123
fatcat:mcoknyuiwfgyxaqb47maiofxn4
Theory and practice of defibrillation: (2) defibrillation for ventricular fibrillation
2005
Heart
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. w4 In theory, extension of the refractory period of a sufficient number of cells will cause fibrillatory activation fronts to encounter refractory tissue and thus die out. ...
of refractory myocardium in our previous article in this series. ...
doi:10.1136/hrt.2003.019927
pmid:15604356
pmcid:PMC1768652
fatcat:r36rsttpkjf67hql26ohxqzizy
Imaging of Ventricular Fibrillation and Defibrillation: The Virtual Electrode Hypothesis
[chapter]
2015
Advances in Experimental Medicine and Biology
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Ventricular fibrillation is the major underlying cause of sudden cardiac death. ...
Therefore, the current challenge is to use the knowledge provided by optical mapping to develop a low energy approach of defibrillation, which may lead to more successful defibrillation. ...
[2] Extensive research over the past decades have resulted in the development of internal and external cardiac defibrillators, which have contributed to a significant reduction of the number of SCD ...
doi:10.1007/978-3-319-17641-3_14
pmid:26238060
pmcid:PMC4729445
fatcat:l2pywhnhqzei5dbatddmnpzdty
Milrinone Facilitates Resuscitation From Cardiac Arrest and Attenuates Postresuscitation Myocardial Dysfunction
2003
Circulation
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All animals were defibrillated; 6 of 16 control animals developed refractory postcountershock pulseless electrical activity compared with 0 of 16 treated animals (Pϭ0.018). ...
Background-Left ventricular (LV) dysfunction with a low cardiac index after successful CPR contributes to early death attributable to multiorgan failure, and an effective treatment has not been identified ...
Acknowledgments This study was supported in part by a Directed Research in Cardiac Arrest Survival Award from the Emergency Medicine Foundation, Dallas, Tex, in partnership with Wyeth Pharmaceuticals. ...
doi:10.1161/01.cir.0000101925.37174.85
pmid:14638547
fatcat:eilahwg2bragtcm3v36y2ngote
Mechanical Cardiopulmonary Resuscitation In and On the Way to the Cardiac Catheterization Laboratory
2016
Circulation Journal
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This article summarizes the epidemiology, pathophysiology and nature of cardiac arrest in the cardiac cath lab and discusses the mechanics of CPR and defibrillation in that setting. ...
Mechanical cardiopulmonary resuscitation (CPR) provides unique advantages over manual performance of chest compression for treating cardiac arrest in the cardiac cath lab. ...
From those data, a risk prediction model was developed. ...
doi:10.1253/circj.cj-16-0330
pmid:27180892
fatcat:thatxwvb6na3fnjewya3ocaso4
Comparing Drugs for Out-of-hospital, Shock-refractory Cardiac Arrest: Systematic Review and Network Meta-analysis of Randomized Controlled Trials
2021
Western Journal of Emergency Medicine
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The benefit of medications used in out-of-hospital, shock-refractory cardiac arrest remains controversial. ...
Conclusion: No medication was associated with improved survival to hospital discharge from out-of-hospital, shock-refractory cardiac arrest. ...
Thanchanok Srisawang for her comments in editing the manuscript. ...
doi:10.5811/westjem.2021.2.49590
pmid:35354019
pmcid:PMC8328185
fatcat:34wpaut4pnf3rferd6cymwyddy
Tedisamil increases coherence during ventricular fibrillation and decreases defibrillation energy requirements
1997
Cardiovascular Research
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Drugs which primarily prolong cardiac refractoriness decrease defibrillation voltage and energy requirements in animals and man. ...
Ž . coherence, a measure of spatial organization, and ventricular fibrillation VF cycle length, ventricular effective refractory period VERP , Ž . ...
in preparation of this manuscript. ...
doi:10.1016/s0008-6363(96)00214-3
pmid:9074714
fatcat:3w3hy5tedbc67ov54f6ru6z2bu
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