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Longevity is determined by ETS transcription factors in multiple tissues and diverse species

Adam J. Dobson, Richard Boulton-McDonald, Lara Houchou, Tatiana Svermova, Ziyu Ren, Jeremie Subrini, Mireya Vazquez-Prada, Mimoza Hoti, Maria Rodriguez-Lopez, Rita Ibrahim, Afroditi Gregoriou, Alexis Gkantiragas (+4 others)
2019 PLoS Genetics  
In combination, Aop can both moderate or synergise with Foxo, dependent on promoter context. Moreover, Foxo and Aop oppose the gene-regulatory activity of Pnt, an ETS transcriptional activator.  ...  Directly knocking down Pnt recapitulates aspects of the Aop/Foxo transcriptional programme and is sufficient to extend lifespan.  ...  To assess the interaction of FOXO and AOP with promoters' complements of TF-binding motifs, these normalised data were analysed by fitting a linear model of the form y � FRE � EBM � FOXO � AOP ACT in which  ... 
doi:10.1371/journal.pgen.1008212 pmid:31356597 pmcid:PMC6662994 fatcat:ii623mmly5hijjqdypvg56vcne

A platform-independent UML profile for aspect-oriented development

Joerg Evermann, Adrian Fiech, Farhana Eva Alam
2011 Proceedings of The Fourth International C* Conference on Computer Science and Software Engineering - C3S2E '11  
Aspect Oriented Software Development (AOSD) has its roots in the need to deal with requirements that cut across the primary modularization of a software system.  ...  However, on the modeling level, there is as yet little support for AOSD.  ...  Advice The meta-class Advice extends Class and is associated with AdviceCollection, which extends StructuralFeature (Figure 2 ).  ... 
doi:10.1145/1992896.1992900 dblp:conf/c3s2e/EvermannFA11 fatcat:vh27phnflfghjn5jhl7bcw7eoq

Modeling for dynamic aspect-oriented evelopment

Farhana Eva Alam, Joerg Evermann, Adrian Fiech
2009 Proceedings of the 2009 C3S2E conference on - C3S2E '09  
Aspect Oriented Software Development (AOSD) has its roots in the need to deal with requirements that cut across the primary modularization of a software system.  ...  However, on the modeling level, there is as yet little support for AOSD. Building on previous work, this paper develops UML modeling support for dynamic AOSD, using standard UML extension mechanisms.  ...  Both approaches use standardized mechanisms and are therefore compatible with existing modeling tools.  ... 
doi:10.1145/1557626.1557649 dblp:conf/c3s2e/AlamEF09 fatcat:bsbl4y6cbfbsfacaznmd2y654m

Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster

Nazif Alic, Maria E. Giannakou, Irene Papatheodorou, Matthew P. Hoddinott, T. Daniel Andrews, Ekin Bolukbasi, Linda Partridge, Stuart K. Kim
2014 PLoS Genetics  
At the same time, AOP activity in another fly organ, the fat body, has further beneficial roles, regulating genes in common with dfoxo, such as the secreted, non-sensory, odorant binding protein (Obp99b  ...  ), and robustly extending lifespan.  ...  A Boolean network models of dFOXO-AOP-PNT-lifespan interaction. The linear model is indicated in grey and the feedforward model in red.  ... 
doi:10.1371/journal.pgen.1004619 pmid:25232726 pmcid:PMC4169242 fatcat:rmbon5bpa5amhkvhndafzaiuhu

Components and Aspects Composition Planning for Ubiquitous Adaptive Services

Mourad Alia, Mikael Beauvois, Yann Davin, Romain Rouvoy, Frank Eliassen
2010 2010 36th EUROMICRO Conference on Software Engineering and Advanced Applications  
Basically, this extension specifies an architectural model for defining applications as a composition of aspects and components.  ...  In ubiquitous environments, resources limitations and fluctuations combined with device mobility requires the dynamic adaptation of mobile applications.  ...  ASPECTS AND COMPONENTS PLANNING MODEL The main contribution of this paper is to extend the MUSIC approach with AOP.  ... 
doi:10.1109/seaa.2010.45 dblp:conf/euromicro/AliaBDRE10 fatcat:35k55xrhenf5ljwj2sir3m54b4

Relational Concurrent Refinement with Internal Operations

John Derrick, Eerke Boiten
2007 Electronical Notes in Theoretical Computer Science  
We then extend these results by showing how the effect of internal operations can be incorporated into the relational model.  ...  In this paper we survey recent results linking the relational model of refinement to the process algebraic models.  ...  ] Blocking data ref. with extended finalisations failures-divergences Derrick and Boiten [2, 12] Non-blocking data ref. with extended finalisations but no input/output failures-divergences Derrick and  ... 
doi:10.1016/j.entcs.2006.08.043 fatcat:35ownczwijcobhy3ehrqxyqa7q

AN ASPECT-ORIENTED WITH BIP COMPONENTS FOR BETTER CROSSCUTTING CONCERNS MODERNIZATION IN IOT APPLICATIONS

Anas M. R. AlSobeh, Aws A. Magableh
2018 Figshare  
In this paper, we propose an aggregated model of aspect orientation paradigm and BIP components to provide better means to deal with these complexities.  ...  Our proposed model provides IoT high level abstractions which gathers relevant contextual properties pertaining to the environment of IoT interactions.  ...  BIP-AOP model components are elaborated on AOP processes.  ... 
doi:10.6084/m9.figshare.7222979 fatcat:rznjiji5qfhepd72mcafgyj3dy

Integration of dynamic AOP into the OSGi service platform

Florian Irmert, Frank Lauterwald, Matthias Bott, Thomas Fischer, Klaus Meyer-Wegener
2008 Proceedings of the 2nd workshop on Middleware-application interaction affiliated with the DisCoTec federated conferences 2008 - MAI '08  
Dynamic aspect-oriented programming (d-AOP) in conjunction with service oriented programming is well suited to face this demand.  ...  This paper introduces our approach to combine an OSGi Framework with d-AOP to establish dynamic adaptation of core concerns as well as crosscutting concerns.  ...  Dynamic AOP (d-AOP) extends the original notion of AOP by allowing the integration of aspects at runtime [15, 2, 17] .  ... 
doi:10.1145/1394272.1394279 fatcat:lvysqtjvvbhbjngxvltbzwcz6m

Chemical hazard prediction and hypothesis testing using quantitative adverse outcome pathways

Edward Perkins
2019 ALTEX: Alternatives to Animal Experimentation  
Briefly, we extended a hypothalamus-pituitary-ovary model of 17β-estradiol synthesis for fathead minnow (Pimephales promelas) by Shoemaker et al. (2010) with a liver component that mathematically described  ...  The development of AOP-based quantitative models is likely to face similar challenges to those found with biologically-based dose-response models where extensive data and long development times have limited  ... 
doi:10.14573/altex.1808241 pmid:30332685 fatcat:ddgfenvywzcifgso2uqnch5kma

Spoon

Renaud Pawlak
2005 Proceedings of the 1st workshop on Aspect oriented middleware development - AOMD '05  
With Spoon, it is possible to do comprehensive and efficient AOP in pure Java, without relying on any specific language or IDE support.  ...  In particular, Spoon provides an AOP extension under the form of a set of annotation processors.  ...  We have shown how to do AOP with Spoon and compared our approach with other AOP tools.  ... 
doi:10.1145/1101560.1101566 fatcat:sv44dfwzerhozcxtu36w6rpsbq

Architectural Aspect-Aware Design for IoT Applications: Conceptual Proposal

Anas M. R. AlSobeh, Aws A. Magableh
2018 International Journal of Computer Science & Information Technology (IJCSIT)  
Aspect-Oriented Programming (AOP) provides new constructs and concepts to handle secondary requirements in applications.  ...  BIP-AOP model components are elaborated on AOP processes.  ...  Behaviour is defined as a transition system extended with data and functions.  ... 
doi:10.5121/ijcsit.2018.10601 fatcat:g7kv63znpnbshjc4jhymwxz4tm

A Versatile Kernel for Distributed AOP [chapter]

Éric Tanter, Rodolfo Toledo
2006 Lecture Notes in Computer Science  
To date, very few AOP proposals take distribution into account.  ...  Aspect-Oriented Programming (AOP) promotes better separation of concerns in software systems by introducing aspects for the modular implementation of crosscutting concerns.  ...  All other entities of the reflective model are augmented with the information of the host in which they are defined. Hookset Extended.  ... 
doi:10.1007/11773887_25 fatcat:5gq6tkheznagfkrs3ydjknga5a

Extended depth of focus contact lenses vs. two commercial multifocals: Part 2. Visual performance after 1 week of lens wear

Ravi C. Bakaraju, Daniel Tilia, Jennifer Sha, Jennie Diec, Jiyoon Chung, Danny Kho, Shona Delaney, Anna Munro, Varghese Thomas
2018 Journal of Optometry  
Purpose: To compare the visual performance of prototype contact lenses designed via deliberate manipulation of higher-order spherical aberrations to extend-depth-of-focus with two commercial multifocals  ...  ) and extended-depth-of-focus prototypes (EDOF) appropriate to their add requirements.  ...  The authors would like to extend sincere gratitude to the late Professor Holden, whose inspirational leadership and foresight made this project possible.  ... 
doi:10.1016/j.optom.2017.04.001 pmid:28619486 pmcid:PMC5777928 fatcat:neibjsyczfheziyv2ajhaahtvq

An approach to implementation of aspect-oriented programming for C

E. M. Novikov
2013 Programming and computer software  
features of C and a build process of C programs affect AOP implementations.  ...  This paper describes an approach to implementation of aspect oriented programming (AOP) frameworks for C, outlines traditional AOP facilities for different programming languages, and shows how specific  ...  AOP extends the capabilities of the existing programming languages and smoothly complements them.  ... 
doi:10.1134/s0361768813040051 fatcat:ja3svydj7fbsrprou6psacfjpi

Computational simulation of human perception of spatially dependent patterns modulated by degree and angle of linear polarization

Gary P. Misson, Shelby E. Temple, Stephen J. Anderson
2019 Optical Society of America. Journal A: Optics, Image Science, and Vision  
Our model indicates: (i) edge boundaries between two adjacent areas of different linear polarization are preserved for both AoP and DoP modulated stimuli; and (ii) compared with DoP stimuli, AoP stimuli  ...  The computational model was supported experimentally with an optical test of the model comprising a radial diattenuating polarizing filter and modified liquid crystal displays (LCD) generating DoP and  ...  se pattern, wher both AoP and Do thus extending a Edge preservatio e pattern AoP stim modeling revea imuli is twice tha at, for a given b er physiological s t potential role fo lient, they may  ... 
doi:10.1364/josaa.36.000b65 fatcat:oe7h6qzbrnbjvi4kdebpgaqtia
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