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Extended Lifetime In Vivo Pulse Stimulated Ultrasound Imaging

James Wang, Christopher V. Barback, Casey N. Ta, Joi Weeks, Natalie Gude, Robert F. Mattrey, Sarah L. Blair, William C. Trogler, Hotaik Lee, Andrew C. Kummel
2018 IEEE Transactions on Medical Imaging  
An on-demand long-lived ultrasound contrast agent that can be activated with single pulse stimulated imaging (SPSI) has been developed using hard shell liquid perfluoropentane filled silica 500-nm nanoparticles  ...  for tumor ultrasound imaging.  ...  Acknowledgments This work was supported by National Institute of Health NIH under Grant 1R33CA177449, Grant NIH-NCI-NCTC-R21T, and Grant 1F31CA177199, in part by the T32 Training Grant, and in part by  ... 
doi:10.1109/tmi.2017.2740784 pmid:28829305 pmcid:PMC5868352 fatcat:kvhrv5iigvaubgqecqyqx7l4s4

StimDust: A mm-scale implantable wireless precision neural stimulator with ultrasonic power and communication [article]

David K. Piech, Benjamin C. Johnson, Konlin Shen, M. Meraj Ghanbari, Ka Yiu Li, Ryan M. Neely, Joshua E. Kay, Jose M. Carmena, Michel M. Maharbiz, Rikky Muller
2020 arXiv   pre-print
We demonstrate the in vivo performance of the system with motes acutely implanted with a cuff on the sciatic nerve of anesthetized rats and show highly repeatable stimulation across a wide range of physiological  ...  The IC harvests ultrasonic power with high efficiency, decodes stimulation parameter downlink data, and generates current-controlled stimulation pulses.  ...  pulse repetition frequency in-vivo stimulation.  ... 
arXiv:1807.07590v5 fatcat:o3anqjxuafgizcdrkktmnhmipi

Fiber laser technologies for photoacoustic microscopy

Long Jin, Yizhi Liang
2021 Visual Computing for Industry, Biomedicine, and Art  
A fiber laser can output laser pulses with high energy, a high repetition rate, a controllable wavelength, low noise, and good beam quality, making it applicable in photoacoustic imaging.  ...  Multispectral PAM can be used to image oxygen saturation or lipid-rich biological tissues by applying a Q-switched fiber laser, a stimulated Raman scattering-based laser source, or a fiber-based supercontinuum  ...  SNR Stability Figures 9(a)-(d) show the in vivo PAM images of a mouse ear and brain, using a fiber laser sensor for ultrasound detection [58, 59] .  ... 
doi:10.1186/s42492-021-00076-y pmid:33928461 fatcat:lz54x6zomjg6xnvk2aexbqsfu4

Hollow silica and silica-boron nano/microparticles for contrast-enhanced ultrasound to detect small tumors

Alexander Liberman, H. Paul Martinez, Casey N. Ta, Christopher V. Barback, Robert F. Mattrey, Yuko Kono, Sarah L. Blair, William C. Trogler, Andrew C. Kummel, Zhe Wu
2012 Biomaterials  
In vitro studies have shown that these particles can be continuously imaged by US up to 48 min and their signal lifetime persisted for 5 days.  ...  Studies were performed in phantoms to optimize particle concentration, injection dose, and the ultrasound settings such as pulse frequency and mechanical index.  ...  Acknowledgments This study utilized the Small Animal Imaging Resource supported by the In vivo Cancer and Molecular Imaging Center (ICMIC) P50-CA128346.  ... 
doi:10.1016/j.biomaterials.2012.03.066 pmid:22498299 pmcid:PMC3588157 fatcat:4eg62ftk3zhrbkwt4hqvqft7tq

Stimuli-responsive nanobubbles for biomedical applications

Ranhua Xiong, Ronald X. Xu, Chaobo Huang, Stefaan De Smedt, Kevin Braeckmans
2021 Chemical Society Reviews  
This review presents an overview of the recent advances in the development of stimuli-responsive nanobubbles and their novel biomedical applications including bio-imaging, drug delivery and ablation of  ...  Ultrasound and PA imaging significantly enhanced the detection of tumor xenografts in vivo.  ...  Although most shelled NBs show extended stability in vitro, they do not perform as well when continuously irradiated with ultrasound or used in vivo because UCAs undergo fast and extreme oscillations in  ... 
doi:10.1039/c9cs00839j pmid:33972972 fatcat:j24zr55ptza53fgtqfwf56szom

Imaging chromophores with undetectable fluorescence by stimulated emission microscopy

Wei Min, Sijia Lu, Shasha Chong, Rahul Roy, Gary R. Holtom, X. Sunney Xie
2009 Nature  
In a pump-probe experiment, upon photoexcitation by a pump pulse, the sample is stimulated down to the ground state by a time-delayed probe pulse, whose intensity is concurrently increased.  ...  ., spontaneous emission, is generally more sensitive than absorption measurement, and is widely used in optical imaging 1, 2 .  ...  Stimulated emission microscopy allows imaging of nonfluorescent chromophores with 3D optical sectioning and high sensitivity, and extends the repertoire of reporters for biological imaging beyond fluorophores  ... 
doi:10.1038/nature08438 pmid:19847261 fatcat:ye347mkgwjcvngwgrpaexoizmm

Biomolecular Ultrasound and Sonogenetics

David Maresca, Anupama Lakshmanan, Mohamad Abedi, Avinoam Bar-Zion, Arash Farhadi,, George J. Lu, Jerzy O. Szablowski, Di Wu, Sangjin Yoo, Mikhail G. Shapiro
2018 Annual Review of Chemical and Biomolecular Engineering  
In contrast, ultrasound is a widely used medical imaging and therapeutic modality that enables the observation and perturbation of internal anatomy and physiology but has historically had limited ability  ...  Driven by the discovery and engineering of new contrast agents, reporter genes, and bioswitches, the nascent field of biomolecular ultrasound carries a wave of exciting opportunities.  ...  Related work in the LITERATURE CITED  ... 
doi:10.1146/annurev-chembioeng-060817-084034 pmid:29579400 pmcid:PMC6086606 fatcat:rarfxqdklbhbfe3iqfkm2voaoa

Acoustic and Photoacoustic Molecular Imaging of Cancer

K. E. Wilson, T. Y. Wang, J. K. Willmann
2013 Journal of Nuclear Medicine  
Ultrasound and combined optical and ultrasonic (photoacoustic) molecular imaging have shown great promise in the visualization and monitoring of cancer through imaging of vascular and extravascular molecular  ...  In this review, recent developments in acoustic and photoacoustic molecular imaging of cancer are discussed.  ...  (Middle) Next, ultrasound pulses are applied to destroy microbubbles within imaging plane.  ... 
doi:10.2967/jnumed.112.115568 pmid:24187042 pmcid:PMC4084699 fatcat:52j5okyitba3rkzjr5g25susqq

High-resolution fluorescence-guided transcranial ultrasound mapping in the live mouse brain

Hector Estrada, Justine Robin, Ali Özbek, Zhenyue Chen, Anne Marowsky, Quanyu Zhou, Daniel Beck, Beau le Roy, Michael Arand, Shy Shoham, Daniel Razansky
2021 Science Advances  
in vivo.  ...  In contrast to MRI, the time resolution of fluorescence imaging is determined by the fluorescence lifetime in the nanosecond range (38) .  ...  Use of think article is subject to the Terms of service High-resolution fluorescence-guided transcranial ultrasound mapping in the live mouse brain  ... 
doi:10.1126/sciadv.abi5464 pmid:34878843 pmcid:PMC8654306 fatcat:yqf3npbnyrckhnqnkqry4jm4du

Targeted imaging using ultrasound contrast agents

S.H. Bloch, P.A. Dayton, K.W. Ferrara
2004 IEEE Engineering in Medicine and Biology Magazine  
In this case, a sequence of pulses is transmitted with a single set of high-amplitude destructive pulses preceding a train of nondestructive imaging pulses.  ...  [104] and in stimulating arteriogenesis [105] .  ... 
doi:10.1109/memb.2004.1360405 pmid:15565796 fatcat:rgsz6pnftbe6vdyztjpr7v6oqq

Effects of low intensity pulsed ultrasound with and without increased cortical porosity on structural bone allograft incorporation

Brandon G Santoni, Nicole Ehrhart, A Simon Turner, Donna L Wheeler
2008 Journal of Orthopaedic Surgery and Research  
Though used for over a century, structural bone allografts suffer from a high rate of mechanical failure due to limited graft revitalization even after extended periods in vivo.  ...  The current study evaluated the effect of low-intensity pulsed ultrasound (LIPUS), a potent exogenous biophysical stimulus used clinically to accelerate the course of fresh fracture healing, and longitudinal  ...  The ultrasound devices were graciously provided by Smith & Nephew. The technical input of Dr. Hans Burchardt, Dr. Travis Heare as well as the members of the administrative,  ... 
doi:10.1186/1749-799x-3-20 pmid:18505579 pmcid:PMC2414658 fatcat:lzf7um3fx5hohhy5zvvk6z2tyi

Ingestible transiently anchoring electronics for microstimulation and conductive signaling

Alex Abramson, David Dellal, Yong Lin Kong, Jianlin Zhou, Yuan Gao, Joy Collins, Siddartha Tamang, Jacob Wainer, Rebecca McManus, Alison Hayward, Morten Revsgaard Frederiksen, Jorrit J. Water (+4 others)
2020 Science Advances  
Here, we report the development of an orally administered electrical stimulation device characterized in ex vivo human tissue and in in vivo swine models, which transiently anchored itself to the stomach  ...  The probes provided stimulation to the tissue via timed electrical pulses that could be used as a treatment for gastric motility disorders.  ...  Jamiel for help with the in vivo porcine work. We thank the Koch Institute for Integrative Cancer Research at MIT's histology core.  ... 
doi:10.1126/sciadv.aaz0127 pmid:32923616 pmcid:PMC7455191 fatcat:typkbwnuy5dara4yu2y3a7sri4

Emerging imaging methods to study whole-brain function in rodent models

Marija Markicevic, Iurii Savvateev, Christina Grimm, Valerio Zerbi
2021 Translational Psychiatry  
In parallel, innovation in brain imaging techniques has led to the availability of a broad set of imaging tools to characterize the functional organization of complex networks.  ...  This review aims to give an overview of currently available preclinical imaging methods and an outlook on future developments.  ...  Therefore, they have a speed acquisition limit, which is set by the fluorescence lifetime of the fluorophore and the pulse of the laser.  ... 
doi:10.1038/s41398-021-01575-5 pmid:34482367 pmcid:PMC8418612 fatcat:2ecb2lzmrndgzp2po7skzlte34

Factors Affecting the Endothelial Retention of Targeted Microbubbles: Influence of Microbubble Shell Design and Cell Surface Projection of the Endothelial Target Molecule

Elham Khanicheh, Martina Mitterhuber, Katharina Kinslechner, Lifen Xu, Jonathan R. Lindner, Beat A. Kaufmann
2012 Journal of the American Society of Echocardiography  
To assess in vivo attachment efficiency to endothelial counterligands that vary in their distance from the endothelial cell surface, contrast-enhanced ultrasound (CEU) molecular imaging of tumor necrosis  ...  Conclusions-Microbubble targeting to endothelial ligands is influenced by Keywords Molecular imaging; Microbubbles; Contrast ultrasound; Microbubble design Contrast-enhanced ultrasound (CEU) molecular  ...  In vivo circulation half-life of microbubble preparations with different length PEG spacer moieties were compared using low-mechanical index ultrasound imaging.  ... 
doi:10.1016/j.echo.2011.12.016 pmid:22266330 pmcid:PMC3941177 fatcat:nmzyxzwpm5folox7v6ikp6g6pu

International Society for Therapeutic Ultrasound Conference 2016

Brian Fowlkes, Pejman Ghanouni, Narendra Sanghvi, Constantin Coussios, Paul C. Lyon, Michael Gray, Christophoros Mannaris, Marie de Saint Victor, Eleanor Stride, Robin Cleveland, Robert Carlisle, Feng Wu (+723 others)
2017 Journal of Therapeutic Ultrasound  
O21 Tests of thermal ablation with a 230 kHz transcranial MRI-guided focused ultrasound system in a large animal model Nathan McDannold 1 , Jonathan Sutton 1 , Natalia Vykhodtseva 1 , Margaret Livingstone  ...  Another challenge stems from the need for a high rate of image acquisition. This may be currently associated with a high radiation dose.  ...  Tissue samples of stimulated heart (N=40) as well as control regions (N=24) were collected in 4 ex vivo and 4 in vivo hearts.  ... 
doi:10.1186/s40349-016-0079-2 fatcat:wjrvxyhd5bappjipymenn5swwq
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