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Exploring Volatile General Anesthetic Binding to a Closed Membrane-Bound Bacterial Voltage-Gated Sodium Channel via Computation

S. G. Raju, Annika F. Barber, David N. LeBard, Michael L. Klein, Vincenzo Carnevale, Emad Tajkhorshid
<span title="2013-06-13">2013</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ch57atmlprauhhbqdf7x4ytejm" style="color: black;">PLoS Computational Biology</a> </i> &nbsp;
To this end, we have performed a molecular dynamics "flooding" simulation on a membrane-bound structural model of the archetypal bacterial VGSC, NaChBac in a closed pore conformation.  ...  This computation allowed us to identify binding sites and access pathways for the commonly used volatile general anesthetic, isoflurane.  ...  We have performed molecular dynamics simulations on one of these bacterial voltage gated sodium channels, NaChBac, to identify binding sites and access pathways for the volatile general anesthetic isoflurane  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1003090">doi:10.1371/journal.pcbi.1003090</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23785267">pmid:23785267</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3681623/">pmcid:PMC3681623</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xvwsjtykq5exjinuec4gkmndea">fatcat:xvwsjtykq5exjinuec4gkmndea</a> </span>
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Exceptionally Conserved Asparagines in the Pore-Lining Helices of Calcium and Sodium Channels Stabilize the Open State through Interdomain H-Bonds

Denis B. Tikhonov, Iva Bruhova, Daniel P. Garden, Boris S. Zhorov
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dez2wau7t5aqvklzwrcsreuwq4" style="color: black;">Biophysical Journal</a> </i> &nbsp;
Nav1.7 in action potential (AP) generation: when transfected into DRGs, N1455A may attenuate prolonged high-frequency firing, whereas the threshold (thought to be set by Nav1.7) may remain unaffected.  ...  With this mutations we produced a useful molecular tool and approach for elucidating the role and influence of Nav1.6 SI on firing patterns in sensory neurons. 690-Pos Board B459  ...  699-Pos Board B468 Polymodal, High Affinity Actions of m-Conotoxins on a Bacterial Voltage-Gated Sodium Channel Rocio K. Finol-Urdaneta 1 , Robert Glavica 1 , Jeff R. McArthur 2 , Robert J.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2012.11.773">doi:10.1016/j.bpj.2012.11.773</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/obfvbgry55gyjbx74aw3i5p65q">fatcat:obfvbgry55gyjbx74aw3i5p65q</a> </span>
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Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel

C. Boiteux, I. Vorobyov, R. J. French, C. French, V. Yarov-Yarovoy, T. W. Allen
<span title="2014-08-18">2014</span> <i title="Proceedings of the National Academy of Sciences"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nvtuoas5pbdsllkntnhizy4f4q" style="color: black;">Proceedings of the National Academy of Sciences of the United States of America</a> </i> &nbsp;
Voltage-gated sodium (Na v ) channels are important targets in the treatment of a range of pathologies.  ...  Phenytoin exhibits a different binding distribution owing to preferential interactions at the membrane and water-protein interfaces.  ...  Voltage-gated sodium (Na v ) channels are important targets in the treatment of a range of pathologies.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.1408710111">doi:10.1073/pnas.1408710111</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25136136">pmid:25136136</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4246943/">pmcid:PMC4246943</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ueekb5x3djg5tkbhcryhkvzpli">fatcat:ueekb5x3djg5tkbhcryhkvzpli</a> </span>
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Computer Simulations of Voltage-Gated Cation Channels

Werner Treptow, Michael L. Klein
<span title="2012-04-05">2012</span> <i title="American Chemical Society (ACS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/qvqjzqkslzcfresyomjvrcqisq" style="color: black;">Journal of Physical Chemistry Letters</a> </i> &nbsp;
In the case of voltage-gated cation channels (VGCCs) recent computational works have focused on ion-conduction and gating mechanisms, along with their regulation by agonist/antagonist ligands.  ...  sodium channels.  ...  Authors are grateful to Letícia Stock for helpful contribution in preparation of Figures 1 through 4.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1021/jz300089g">doi:10.1021/jz300089g</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22523619">pmid:22523619</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3328965/">pmcid:PMC3328965</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/dzxnwplkgjhz7mikok5ccgb5vi">fatcat:dzxnwplkgjhz7mikok5ccgb5vi</a> </span>
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Characterizing Na+/K+ Permeation Rates through the Bacterial NavAb Sodium Channel

Leticia Stock, Vincenzo Carnevale, Werner Treptow, Michael L. Klein
<span title="">2014</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dez2wau7t5aqvklzwrcsreuwq4" style="color: black;">Biophysical Journal</a> </i> &nbsp;
resolution structural data on human sodium channels, the publication of a number of crystal structures of related, bacterial voltage-gated sodium channel in the last 2 years has offered the opportunity  ...  to explore the mechanism of entry and location of binding sodium channel blockers.  ...  Voltage-gated ion channels open a gate in response to membrane depolarization which allows ions to pass through the transmembrane pore of the channel.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2013.11.774">doi:10.1016/j.bpj.2013.11.774</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3ar2sq7jonccbpagth24uvtb74">fatcat:3ar2sq7jonccbpagth24uvtb74</a> </span>
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Sodium Channel Peptide Neurotoxin Studies Using a High Throughput Electrophysiology Platform and Very Long Assay Windows

Xin Jiang, Jeffrey Webber, Trisha Mitlo, Edward Verdonk, James Costantin
<span title="">2014</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dez2wau7t5aqvklzwrcsreuwq4" style="color: black;">Biophysical Journal</a> </i> &nbsp;
The bacterial sodium channel NaChBac is a prokaryotic ancestor of eukaryotic voltage-gated sodium channels (Nav), which are critical for action potential generation and propagation in nervous and cardiac  ...  Voltage-gated sodium channels (Nav) are fundamental for the generation and the propagation of action potentials.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2013.11.779">doi:10.1016/j.bpj.2013.11.779</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/sdoqldnkifftbmbta3rb4iri2q">fatcat:sdoqldnkifftbmbta3rb4iri2q</a> </span>
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Binding of the general anesthetic sevoflurane to ion channels

Letícia Stock, Juliana Hosoume, Leonardo Cirqueira, Werner Treptow
<span title="2018-11-26">2018</span> <i title="Public Library of Science"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ch57atmlprauhhbqdf7x4ytejm" style="color: black;">PLoS Computational Biology</a> </i> &nbsp;
The direct-site hypothesis assumes general anesthetics bind ion channels to impact protein equilibrium and function, inducing anesthesia.  ...  We focus on the clinically used sevoflurane interaction to anesthetic-sensitive Kv1.2 mammalian channel to resolve if sevoflurane binds protein's well-characterized open and closed structures in a conformation-dependent  ...  Binding interactions have been evidenced in anesthetic containing systems of mammalian voltage and ligand-gated channels, as well as bacterial channel analogs.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1006605">doi:10.1371/journal.pcbi.1006605</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30475796">pmid:30475796</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6283617/">pmcid:PMC6283617</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wekwziiofbfkdcayynqkdqphay">fatcat:wekwziiofbfkdcayynqkdqphay</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190506044637/https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006605&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/48/5e/485ead46e75df2903b111e97f0cf38082f8d440a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1006605"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283617" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Stability And Conductance Assessment Of A Putative Low-k+ Inactivated State Of The Kcsa Channel

Celine Boiteux, Simon Bernérche
<span title="">2009</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dez2wau7t5aqvklzwrcsreuwq4" style="color: black;">Biophysical Journal</a> </i> &nbsp;
The potassium ion channel, KcsA, gates the passage of ions through cell membranes in response to a change in pH.  ...  We also provide a molecular rationalization for the coupling between the opening and closing of the lower gate and the inactivation of the selectivity filter.  ...  Therefore, a higher proportion of toxin-bound Kv4.1 channels are in the closed pre-open state, compared to toxinbound Kv4.3 channels.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2008.12.3474">doi:10.1016/j.bpj.2008.12.3474</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/w2zlabvmwfdozngpsyjw4l42qu">fatcat:w2zlabvmwfdozngpsyjw4l42qu</a> </span>
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Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites

Yali Wang, Elaine Yang, Marta M. Wells, Vasyl Bondarenko, Kellie Woll, Vincenzo Carnevale, Daniele Granata, Michael L. Klein, Roderic G. Eckenhoff, William P. Dailey, Manuel Covarrubias, Pei Tang (+1 others)
<span title="2018-07-17">2018</span> <i title="Rockefeller University Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2yuph7umhbeorelyupdudpow5y" style="color: black;">The Journal of General Physiology</a> </i> &nbsp;
Voltage-gated sodium (NaV) channels are important targets of general anesthetics, including the intravenous anesthetic propofol.  ...  Unlike volatile anesthetics, 4-fluoropropofol does not bind to the extracellular interface of the pore domain.  ...  The bacterial sodium channel from Bacillus halodurans (Na-ChBac) is a structural homologue of eukaryotic Na V channels (Ren et al., 2001) that provides a convenient model to study the anesthetic interactions  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1085/jgp.201811993">doi:10.1085/jgp.201811993</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30018039">pmid:30018039</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/p7ncxc2fi5c2hezwzzxunmrhge">fatcat:p7ncxc2fi5c2hezwzzxunmrhge</a> </span>
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Binding of general anesthetics to ion channels [article]

Letícia Stock, Juliana Hosoume, Leonardo Cirqueira, Werner Treptow
<span title="2018-02-19">2018</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
The direct-site hypothesis assumes general anesthetics bind ion channels to impact protein equilibrium and function, inducing anesthesia.  ...  We focus on clinically used sevoflurane interaction to anesthetic-sensitive Kv1.2 mammalian channel to resolve if sevoflurane binds the protein's well-characterized open and closed structures in a conformation-dependent  ...  WT thanks CNPq for doctoral fellowship to LS (140845/20143).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/266809">doi:10.1101/266809</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nxfmhmxierhapjehbei76ilwyu">fatcat:nxfmhmxierhapjehbei76ilwyu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180723182533/https://www.biorxiv.org/content/biorxiv/early/2018/02/19/266809.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a4/5d/a45d6b5339acc9b7e85befdc5b3f97663786274f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/266809"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane

Cheng Zhou, Kenneth W Johnson, Karl F Herold, Hugh C Hemmings
<span title="2019-02-21">2019</span> <i title="American Society for Pharmacology &amp; Experimental Therapeutics (ASPET)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gt5uiqzlxvgxndcyllrzj6rxvi" style="color: black;">Journal of Pharmacology and Experimental Therapeutics</a> </i> &nbsp;
Voltage-gated sodium channels (Navs), which are coupled to synaptic vesicle exocytosis, are inhibited by volatile anesthetics through reduction of peak current and modulation of gating.  ...  Volatile anesthetics depress neurotransmitter release in a brain region- and neurotransmitter-selective manner by unclear mechanisms.  ...  Raju SG, Barber AF, LeBard DN, Klein ML, and Carnevale V (2013) Exploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computation.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1124/jpet.118.254938">doi:10.1124/jpet.118.254938</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30792243">pmid:30792243</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6439525/">pmcid:PMC6439525</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gwkjoekqtrfjbgay2apvhvppyi">fatcat:gwkjoekqtrfjbgay2apvhvppyi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200320053603/http://jpet.aspetjournals.org/content/jpet/early/2019/02/21/jpet.118.254938.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ea/7a/ea7ae99f39de8f534a79db4ff912b9426c9160a1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1124/jpet.118.254938"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439525" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Functional Validation of Virtual Screening for Novel Agents with General Anesthetic Action at Ligand-Gated Ion Channels

S. A. Heusser, R. J. Howard, C. M. Borghese, M. A. Cullins, T. Broemstrup, U. S. Lee, E. Lindahl, J. Carlsson, R. A. Harris
<span title="2013-08-15">2013</span> <i title="American Society for Pharmacology &amp; Experimental Therapeutics (ASPET)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6xwvu5novbc6pd2bib5sr3ptvi" style="color: black;">Molecular Pharmacology</a> </i> &nbsp;
The recently published crystal structure of the general anesthetic propofol bound to Gloeobacter violaceus ligand-gated ion channel (GLIC), a bacterial homolog of GABA A receptors, provided an opportunity  ...  to explore structure-based ligand discovery for pentameric ligand-gated ion channels (pLGICs).  ...  Wrote or contributed to the writing of the manuscript: Heusser, Howard, Borghese, Lindahl, Carlsson, Harris.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1124/mol.113.087692">doi:10.1124/mol.113.087692</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23950219">pmid:23950219</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3807073/">pmcid:PMC3807073</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fcashwhhsnhutdcs6w7xprlnsy">fatcat:fcashwhhsnhutdcs6w7xprlnsy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171007021831/http://molpharm.aspetjournals.org/content/molpharm/84/5/670.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c3/04/c304976a0db42117ddd21d2aa35288279119d52b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1124/mol.113.087692"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807073" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Thirty-Fifth Annual Meeting February 24–28, 1991 Moscone Center San Francisco, California

<span title="">1991</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dez2wau7t5aqvklzwrcsreuwq4" style="color: black;">Biophysical Journal</a> </i> &nbsp;
Voltage-activated, sodium selective currents of more than 2 nA were reliably obtained in a very high percentage of the cells in culture.  ...  We report reliable transient expression in a mammalian cell line of the RI skeletal muscle sodium channel.  ...  Acknowledgements: A.S. is a postdoctoral fellow of CHF. We wish to thank Dr. M. Morton for providing the cell cultures.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0006-3495(91)82247-0">doi:10.1016/s0006-3495(91)82247-0</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/djohf6aqpfg2javuqzjlbynctq">fatcat:djohf6aqpfg2javuqzjlbynctq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171005095621/http://publisher-connector.core.ac.uk/resourcesync/data/elsevier/pdf/f14/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS9zMDAwNjM0OTU5MTgyMjQ3MA%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/46/08/4608e6b8f8d26e19a0045ee264c6739c3912feb6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0006-3495(91)82247-0"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Forty-First Annual Meeting March 2-6, 1997 Ernest N. Morial Convention Center New Orleans, Louisiana. Wednesday Symposia and Posters, Part III

<span title="">1997</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dez2wau7t5aqvklzwrcsreuwq4" style="color: black;">Biophysical Journal</a> </i> &nbsp;
bind PIP2, and using liposomes to modify membrane composition.  ...  The second type had a KATP channel with normal y but an altered selectivity to K' ion. Both types of channels partially lost the sensitivity to both MgATP and MgADP.  ...  General anesthetics decrease the excitability of nerves and mscles by affecting the function of ligand-gated and voltage-gated ion channels. 2,6-Diisopropylphenol, mRNA's encoding for the al main conducting  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0006-3495(97)78742-3">doi:10.1016/s0006-3495(97)78742-3</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vp7keofm5nhklmqi2ul4lum75a">fatcat:vp7keofm5nhklmqi2ul4lum75a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171004003848/http://publisher-connector.core.ac.uk/resourcesync/data/elsevier/pdf/d58/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS9zMDAwNjM0OTU5Nzc4NzQyMw%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/db/9d/db9d06b274cfa9be92ce36b3d8bc5d25a1ccea7c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0006-3495(97)78742-3"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Twenty-Seventh Annual Meeting February 13–16, 1983 Town & Country Hotel, San Diego, California

<span title="">1983</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dez2wau7t5aqvklzwrcsreuwq4" style="color: black;">Biophysical Journal</a> </i> &nbsp;
The thermodynamics of the phase change as detected with this probe were closely comparable to the results from DPH.  ...  The cation to lipid ratio must be close to or greater than 0.5:1 in order to induce the stable phase, suggesting that the lipid head groups must be completely neutralized.  ...  To test these assumptions experiments were designed to compare hyperbaric nitrogen with other anesthetic agents, and to explore the basis for pressure antagonism to anesthetic block of sodium channels.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0006-3495(83)84426-9">doi:10.1016/s0006-3495(83)84426-9</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xe4oxz6ozbg3dg3sy3olcsane4">fatcat:xe4oxz6ozbg3dg3sy3olcsane4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190323031456/https://core.ac.uk/download/pdf/82233051.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/70/a9/70a90fead70523342fec4676bf72a0d20c4d3428.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0006-3495(83)84426-9"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>
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