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Exploring Distributed Control with the NK Model [article]

Larry Bull
2020 arXiv   pre-print
This paper introduces a modified form of the NK model for exploring distributed control in complex systems such as organisations, social networks, collective robotics, etc.  ...  The NK model has been used widely to explore aspects of natural evolution and complex systems.  ...  The NKD model is introduced as a generalisation of the NKCS model to enable the exploration of distributed control structures within the space of NK models.  ... 
arXiv:2004.10061v1 fatcat:fs76l3rquzgvpdek3aoiib6ena

Hematopoietic-Specific Deletion of Foxo1 Promotes NK Cell Specification and Proliferation

Pei Huang, Fangjie Wang, Yao Yang, Wenjing Lai, Meng Meng, Shuting Wu, Hongyan Peng, Lili Wang, Rixing Zhan, Saber Imani, Jianhua Yu, Bingbo Chen (+2 others)
2019 Frontiers in Immunology  
CD27+CD11b- and CD27+CD11b+ NK cells, consistent with the findings in the murine model of Ncr1-iCre mediated Foxo1 deletion.  ...  In this model, however, the role of Foxo1 in regulating NK cell specification and early development remains exclusive.  ...  This study was also supported by grants from the Army Laboratory animal administration office (SYDW(2017)01 to BC).  ... 
doi:10.3389/fimmu.2019.01016 pmid:31139183 pmcid:PMC6519137 fatcat:rnxgyn3rfjfy5kt4bwaia5ki44

Effects of physical exercise on natural killer cell activity during (neo)adjuvant chemotherapy: A randomized pilot study

Elisa C. Toffoli, Maike G. Sweegers, Hetty J. Bontkes, Teatske M. Altenburg, Henk M.W. Verheul, Hans J. Vliet, Tanja D. Gruijl, Laurien M. Buffart
2021 Physiological Reports  
NK cell degranulation was preserved in the exercise group whereas it decreased in the control group resulting in a between-group difference of 11.4% CD107a+ degranulated NK cells (95%CI = 0.57;22.3, p  ...  In multiple murine models, it was shown that physical exercise had the potential to increase NK cell antitumor activity through their mobilization and tissue redistribution in an interleukin (IL)-6 and  ...  Finally, the IL-6 levels were found slightly increased during exercise, which aligns with published data from mouse models, and may be related to NK cell re-distribution to the tumor microenvironment  ... 
doi:10.14814/phy2.14919 pmid:34110712 pmcid:PMC8191403 fatcat:axqgyg5qvbclxlxe5cqeznvgbm

Frontiers in natural killer cell immunology

2013 Cellular & Molecular Immunology  
feature of NK cell distribution).  ...  They also highlight the finding that these memory NK cells are liver-resident in some models.  ...  NK cells play a critical role in early control of viral infection, not only through directly killing virus-infected host cells, but also through mounting a systemic immune response by interacting with  ... 
doi:10.1038/cmi.2013.5 pmid:23645298 pmcid:PMC4012771 fatcat:2zryhhsnmbacnbsm5it2ccslxa

Dynamic Poisson Factorization

Laurent Charlin, Rajesh Ranganath, James McInerney, David M. Blei
2015 Proceedings of the 9th ACM Conference on Recommender Systems - RecSys '15  
and the actions with Poisson distributions.  ...  To address this, we propose dPF, a dynamic matrix factorization model based on the recent Poisson factorization model for recommendations. dPF models the time evolving latent factors with a Kalman filter  ...  We thank the reviewers for their helpful comments. RR is supported by an NDSEG fellowship. DMB is supported by NSF IIS-0745520, NSF IIS-1247664, ONR N00014-11-1-0651, and DARPA FA8750-14-2-0009.  ... 
doi:10.1145/2792838.2800174 dblp:conf/recsys/CharlinRMB15 fatcat:2is667t2srhnrlausmilvq5hru

Natural Killer Cell (NK-92MI)-Based Therapy for Pulmonary Metastasis of Anaplastic Thyroid Cancer in a Nude Mouse Model

Liya Zhu, Xiu Juan Li, Senthilkumar Kalimuthu, Prakash Gangadaran, Ho Won Lee, Ji Min Oh, Se Hwan Baek, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
2017 Frontiers in Immunology  
The NK/F cells exhibited targetability to the pulmonary metastasis and tumor xenograft in the mouse model. conclusion: The results of present study suggest that NK cells are able to target ATC tumors and  ...  An ATC pulmonary metastasis mouse model was successfully generated, and NK cells significantly inhibited the growth of the metastasis (p < 0.01).  ...  The cytotoxic mechanism of NK-92MI in ATC has yet to be clearly explored.  ... 
doi:10.3389/fimmu.2017.00816 pmid:28785259 pmcid:PMC5519537 fatcat:buk4ozwtdrbzrobqwhefrvaddm

IFN type III: in vivo NK cell response

Fernando Souza-Fonseca-Guimaraes, Arabella Young, Mark J. Smyth
2015 OncoTarget  
Smyth Despite extensive studies over the last decade reinforcing the role of the immune system in controlling cancer progression and inflammatory disorders, our knowledge of the innate immune system remains  ...  Each of these stages display receptor expression variance associated with their tissue distribution, regulation, survival, cytotoxicity and cytokine/chemokine producing capacity.  ... 
doi:10.18632/oncotarget.4758 pmid:26343521 pmcid:PMC4652976 fatcat:hofjbou6tzamdbsgf7k3se35um

An Empirical Study of Neural Kernel Bandits [article]

Michal Lisicki, Arash Afkanpour, Graham W. Taylor
2021 arXiv   pre-print
We show that NK bandits achieve state-of-the-art performance on highly non-linear structured data. Furthermore, we analyze practical considerations such as training frequency and model partitioning.  ...  We propose to directly apply NK-induced distributions to guide an upper confidence bound or Thompson sampling-based policy.  ...  The authors thank the Canada Foundation for Innovation and Compute Canada for computing resources.  ... 
arXiv:2111.03543v1 fatcat:lmewgppoxzelxenjr2hk3itxym

KLRG1+natural killer cells protect against pulmonary metastatic disease by immunosurveillance

Philipp Renner, Jordi Rovira, Christoph Klein, Hans-Jürgen Schlitt, Edward K Geissler, Alexander Kroemer
2014 Oncoimmunology  
we discuss the role of intrinsic master transcription factors and extrinsic iL-15 signaling on NK cell-mediated immune protection against murine pulmonary metastasis.  ...  Natural killer cells (NK cells) play a key role in cancer immunosurveillance. however, their activity is highly dependent upon their maturation stage, which in turn relates to organ distribution. here,  ...  Distribution of natural killer (NK) cell subsets with distinct anticancer properties in a metastatic disease model.  ... 
doi:10.4161/onci.28328 pmid:25050205 pmcid:PMC4063134 fatcat:34jvlazegffnxd3xsmaznfaunq

The prognostic landscape of tumor-infiltrating immune cells in lung squamous cell carcinoma

Liang Guo, Jiaoyu Yi, Ming Liu, Juanjuan Li
2021 Annals of Translational Medicine  
Exploring novel biomarkers and developing effective therapeutic strategies can improve the prognosis of lung squamous cell carcinoma (LUSC) in the future.  ...  Using the CIBERSORT method, TICs were evaluated and examined for their association with overall survival (OS) in LUSC. Out of the 27 TICs, 14 were correlated with prognosis in LUSC.  ...  Acknowledgments Funding: This study was supported by the National Natural Science Foundation of China (No. 81800491).  ... 
doi:10.21037/atm-21-1852 pmid:34268412 pmcid:PMC8246229 fatcat:mykkgpksdjak7h6qrflddaju5e

Editorial: Molecular and Cellular Pathways in NK Cell Development

Ewa Sitnicka, Yenan Bryceson, Aharon G. Freud, Emily M. Mace
2020 Frontiers in Immunology  
Cichocki et al. discuss two potential hierarchical models of human NK cell development: (1) a linear model where the lineage commitment occurs stepwise from hematopoietic stem cells, through the lymphoid-primed  ...  multilineage progenitors, the common-lymphoid progenitors, to NK cell-restricted progenitors and CD56 dim NK cells; and (2) a branched model where different NK cell populations, CD56 dim , CD56 bright  ...  AUTHOR CONTRIBUTIONS All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.  ... 
doi:10.3389/fimmu.2020.01448 pmid:32760398 pmcid:PMC7371939 fatcat:as4qwmcfznfalndl35p5pinwtq

A Practical Model Evaluating Antiviral Cytokines by Natural Killer Cells in Treatment Naïve Patients with Chronic Hepatitis B Virus Infection

Xiaoyan Li, Yurong Gu, Xiaobo Guo, Lin Gu, Liang Zhou, Xiaojuan Wu, Xueqin Wang, Zania Stamataki, Yuehua Huang
2017 Scientific Reports  
control.  ...  However, there is lack of a quantifiable model to evaluate cytokine responses by NK cells.  ...  We also thanks those grant support: the National Natural Science  ... 
doi:10.1038/s41598-017-06192-1 pmid:28725030 pmcid:PMC5517634 fatcat:c2fipg2ijnbovhdalfufm2ax4u

Quantification of the Relative Importance of CTL, B Cell, NK Cell, and Target Cell Limitation in the Control of Primary SIV-Infection

Marjet Elemans, Rodolphe Thiébaut, Amitinder Kaur, Becca Asquith, Rob J. De Boer
2011 PLoS Computational Biology  
Here we quantify the relative importance of CTLs, NK cells, B cells and target cell limitation in controlling acute SIV infection in rhesus macaques.  ...  CD8 + cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, B cells and target cell limitation have all been suggested to play a role in the control of SIV and HIV-1 infection.  ...  Wrote the paper: ME BA.  ... 
doi:10.1371/journal.pcbi.1001103 pmid:21408213 pmcid:PMC3048377 fatcat:os336il2tncbhdkbtbhocnasiq

Southern Tibetan Plateau ice core δ18O reflects abrupt shifts in atmospheric circulation in the late 1970s

Jing Gao, Camille Risi, Valerie Masson-Delmotte, You He, Baiqing Xu
2015 Climate Dynamics  
The comparison with regional meteorological data and with a simulation performed with the LMDZiso general circulation model leads to the attribution of the abrupt shift in the late 1970s predominantly  ...  The NK δ 18 O minimum at the end of the 1970s coincides with a PDO phase shift, an inflexion point of the zonal index (representing the overall intensity of the surface westerly anomalies over middle latitudes  ...  Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution  ... 
doi:10.1007/s00382-015-2584-3 fatcat:ssnaon7gezaudkolab37pjeyx4

Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese

Hiroki Furue, Keitaro Matsuo, Hiroshi Kumimoto, Akio Hiraki, Takeshi Suzuki, Yasushi Yatabe, Koji Komori, Yukihide Kanemitsu, Takashi Hirai, Tomoyuki Kato, Minoru Ueda, Kanji Ishizaki (+1 others)
2008 Carcinogenesis  
Conclusion: We found that the HNK1 genotype, associated with high NK cell activity, might be an independent protective factor for CRC among the Japanese population.  ...  To elucidate its impact on colorectal cancer (CRC), we conducted the present case-control study. Method: The subjects were 379 CRC patients and 1137 sex-age-matched non-cancer controls.  ...  We explored three models and found consistent results.  ... 
doi:10.1093/carcin/bgm260 pmid:18174257 fatcat:d3c4tzowgba4xb4rkvxagpxoni
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