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Exploring Distributed Control with the NK Model
[article]
2020
arXiv
pre-print
This paper introduces a modified form of the NK model for exploring distributed control in complex systems such as organisations, social networks, collective robotics, etc. ...
The NK model has been used widely to explore aspects of natural evolution and complex systems. ...
The NKD model is introduced as a generalisation of the NKCS model to enable the exploration of distributed control structures within the space of NK models. ...
arXiv:2004.10061v1
fatcat:fs76l3rquzgvpdek3aoiib6ena
Hematopoietic-Specific Deletion of Foxo1 Promotes NK Cell Specification and Proliferation
2019
Frontiers in Immunology
CD27+CD11b- and CD27+CD11b+ NK cells, consistent with the findings in the murine model of Ncr1-iCre mediated Foxo1 deletion. ...
In this model, however, the role of Foxo1 in regulating NK cell specification and early development remains exclusive. ...
This study was also supported by grants from the Army Laboratory animal administration office (SYDW(2017)01 to BC). ...
doi:10.3389/fimmu.2019.01016
pmid:31139183
pmcid:PMC6519137
fatcat:rnxgyn3rfjfy5kt4bwaia5ki44
Effects of physical exercise on natural killer cell activity during (neo)adjuvant chemotherapy: A randomized pilot study
2021
Physiological Reports
NK cell degranulation was preserved in the exercise group whereas it decreased in the control group resulting in a between-group difference of 11.4% CD107a+ degranulated NK cells (95%CI = 0.57;22.3, p ...
In multiple murine models, it was shown that physical exercise had the potential to increase NK cell antitumor activity through their mobilization and tissue redistribution in an interleukin (IL)-6 and ...
Finally, the IL-6 levels were found slightly increased during exercise, which aligns with published data from mouse models, and may be related to NK cell re-distribution to the tumor microenvironment ...
doi:10.14814/phy2.14919
pmid:34110712
pmcid:PMC8191403
fatcat:axqgyg5qvbclxlxe5cqeznvgbm
Frontiers in natural killer cell immunology
2013
Cellular & Molecular Immunology
feature of NK cell distribution). ...
They also highlight the finding that these memory NK cells are liver-resident in some models. ...
NK cells play a critical role in early control of viral infection, not only through directly killing virus-infected host cells, but also through mounting a systemic immune response by interacting with ...
doi:10.1038/cmi.2013.5
pmid:23645298
pmcid:PMC4012771
fatcat:2zryhhsnmbacnbsm5it2ccslxa
Dynamic Poisson Factorization
2015
Proceedings of the 9th ACM Conference on Recommender Systems - RecSys '15
and the actions with Poisson distributions. ...
To address this, we propose dPF, a dynamic matrix factorization model based on the recent Poisson factorization model for recommendations. dPF models the time evolving latent factors with a Kalman filter ...
We thank the reviewers for their helpful comments. RR is supported by an NDSEG fellowship. DMB is supported by NSF IIS-0745520, NSF IIS-1247664, ONR N00014-11-1-0651, and DARPA FA8750-14-2-0009. ...
doi:10.1145/2792838.2800174
dblp:conf/recsys/CharlinRMB15
fatcat:2is667t2srhnrlausmilvq5hru
Natural Killer Cell (NK-92MI)-Based Therapy for Pulmonary Metastasis of Anaplastic Thyroid Cancer in a Nude Mouse Model
2017
Frontiers in Immunology
The NK/F cells exhibited targetability to the pulmonary metastasis and tumor xenograft in the mouse model. conclusion: The results of present study suggest that NK cells are able to target ATC tumors and ...
An ATC pulmonary metastasis mouse model was successfully generated, and NK cells significantly inhibited the growth of the metastasis (p < 0.01). ...
The cytotoxic mechanism of NK-92MI in ATC has yet to be clearly explored. ...
doi:10.3389/fimmu.2017.00816
pmid:28785259
pmcid:PMC5519537
fatcat:buk4ozwtdrbzrobqwhefrvaddm
IFN type III: in vivo NK cell response
2015
OncoTarget
Smyth Despite extensive studies over the last decade reinforcing the role of the immune system in controlling cancer progression and inflammatory disorders, our knowledge of the innate immune system remains ...
Each of these stages display receptor expression variance associated with their tissue distribution, regulation, survival, cytotoxicity and cytokine/chemokine producing capacity. ...
doi:10.18632/oncotarget.4758
pmid:26343521
pmcid:PMC4652976
fatcat:hofjbou6tzamdbsgf7k3se35um
An Empirical Study of Neural Kernel Bandits
[article]
2021
arXiv
pre-print
We show that NK bandits achieve state-of-the-art performance on highly non-linear structured data. Furthermore, we analyze practical considerations such as training frequency and model partitioning. ...
We propose to directly apply NK-induced distributions to guide an upper confidence bound or Thompson sampling-based policy. ...
The authors thank the Canada Foundation for Innovation and Compute Canada for computing resources. ...
arXiv:2111.03543v1
fatcat:lmewgppoxzelxenjr2hk3itxym
KLRG1+natural killer cells protect against pulmonary metastatic disease by immunosurveillance
2014
Oncoimmunology
we discuss the role of intrinsic master transcription factors and extrinsic iL-15 signaling on NK cell-mediated immune protection against murine pulmonary metastasis. ...
Natural killer cells (NK cells) play a key role in cancer immunosurveillance. however, their activity is highly dependent upon their maturation stage, which in turn relates to organ distribution. here, ...
Distribution of natural killer (NK) cell subsets with distinct anticancer properties in a metastatic disease model. ...
doi:10.4161/onci.28328
pmid:25050205
pmcid:PMC4063134
fatcat:34jvlazegffnxd3xsmaznfaunq
The prognostic landscape of tumor-infiltrating immune cells in lung squamous cell carcinoma
2021
Annals of Translational Medicine
Exploring novel biomarkers and developing effective therapeutic strategies can improve the prognosis of lung squamous cell carcinoma (LUSC) in the future. ...
Using the CIBERSORT method, TICs were evaluated and examined for their association with overall survival (OS) in LUSC. Out of the 27 TICs, 14 were correlated with prognosis in LUSC. ...
Acknowledgments Funding: This study was supported by the National Natural Science Foundation of China (No. 81800491). ...
doi:10.21037/atm-21-1852
pmid:34268412
pmcid:PMC8246229
fatcat:mykkgpksdjak7h6qrflddaju5e
Editorial: Molecular and Cellular Pathways in NK Cell Development
2020
Frontiers in Immunology
Cichocki et al. discuss two potential hierarchical models of human NK cell development: (1) a linear model where the lineage commitment occurs stepwise from hematopoietic stem cells, through the lymphoid-primed ...
multilineage progenitors, the common-lymphoid progenitors, to NK cell-restricted progenitors and CD56 dim NK cells; and (2) a branched model where different NK cell populations, CD56 dim , CD56 bright ...
AUTHOR CONTRIBUTIONS All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication. ...
doi:10.3389/fimmu.2020.01448
pmid:32760398
pmcid:PMC7371939
fatcat:as4qwmcfznfalndl35p5pinwtq
A Practical Model Evaluating Antiviral Cytokines by Natural Killer Cells in Treatment Naïve Patients with Chronic Hepatitis B Virus Infection
2017
Scientific Reports
control. ...
However, there is lack of a quantifiable model to evaluate cytokine responses by NK cells. ...
We also thanks those grant support: the National Natural Science ...
doi:10.1038/s41598-017-06192-1
pmid:28725030
pmcid:PMC5517634
fatcat:c2fipg2ijnbovhdalfufm2ax4u
Quantification of the Relative Importance of CTL, B Cell, NK Cell, and Target Cell Limitation in the Control of Primary SIV-Infection
2011
PLoS Computational Biology
Here we quantify the relative importance of CTLs, NK cells, B cells and target cell limitation in controlling acute SIV infection in rhesus macaques. ...
CD8 + cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, B cells and target cell limitation have all been suggested to play a role in the control of SIV and HIV-1 infection. ...
Wrote the paper: ME BA. ...
doi:10.1371/journal.pcbi.1001103
pmid:21408213
pmcid:PMC3048377
fatcat:os336il2tncbhdkbtbhocnasiq
Southern Tibetan Plateau ice core δ18O reflects abrupt shifts in atmospheric circulation in the late 1970s
2015
Climate Dynamics
The comparison with regional meteorological data and with a simulation performed with the LMDZiso general circulation model leads to the attribution of the abrupt shift in the late 1970s predominantly ...
The NK δ 18 O minimum at the end of the 1970s coincides with a PDO phase shift, an inflexion point of the zonal index (representing the overall intensity of the surface westerly anomalies over middle latitudes ...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution ...
doi:10.1007/s00382-015-2584-3
fatcat:ssnaon7gezaudkolab37pjeyx4
Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese
2008
Carcinogenesis
Conclusion: We found that the HNK1 genotype, associated with high NK cell activity, might be an independent protective factor for CRC among the Japanese population. ...
To elucidate its impact on colorectal cancer (CRC), we conducted the present case-control study. Method: The subjects were 379 CRC patients and 1137 sex-age-matched non-cancer controls. ...
We explored three models and found consistent results. ...
doi:10.1093/carcin/bgm260
pmid:18174257
fatcat:d3c4tzowgba4xb4rkvxagpxoni
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