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Binding properties and evolution of homodimers in protein-protein interaction networks

I. Ispolatov
2005 Nucleic Acids Research  
This points to the conclusion that most of interactions between paralogs are inherited from ancestral homodimeric proteins, rather than established de novo after duplication.  ...  We also show that on average homodimers have twice as many interaction partners than non-self-interacting proteins.  ...  DE-AC02-98CH10886, Division of Material Science, U.S. Department of Energy.  ... 
doi:10.1093/nar/gki678 pmid:15983135 pmcid:PMC1160523 fatcat:dkpz57b7cnggvjpceqi3bvqrea

IL-8 single-chain homodimers and heterodimers: Interactions with the chemokine receptors CXCR1, CXCR2, and DARC

Steven R. Leong, Caroline A. Hebert, Henry B. Lowman, Jun Liu, Steven Shire, Laura E. Deforge, Beth L. Gillece-Castro, Robert Mcdowell
2008 Protein Science  
Physical studies indicated that use of a simple peptide linker to join two subunits, while allowing receptor binding and activation, led to self-association of the tethered dimers.  ...  Crosslinked single-chain dimers bind to both IL-8 neutrophil receptors CXCRl and CXCR2 as well as to DARC, as does a double disulfide-linked dimer with no peptide linker.  ...  subunit might still be capable of receptor binding and activation, and to provide a stable dimeric form of IL-8 in which effects of mutation in only one subunit can be further explored.  ... 
doi:10.1002/pro.5560060310 pmid:9070443 pmcid:PMC2143685 fatcat:obzsvxkvzzd7foadgzcupvwm7i

Probing the Druggablility on the Interface of the Protein–Protein Interaction and Its Allosteric Regulation Mechanism on the Drug Screening for the CXCR4 Homodimer

Liting Shen, Yuan Yuan, Yanzhi Guo, Menglong Li, Chuan Li, Xuemei Pu
2019 Frontiers in Pharmacology  
G protein-coupled receptors (GPCRs) are the largest family of targeted proteins and could form dimers in living biological cells through PPIs.  ...  the PPI molecule and TM4 of the receptor.  ...  Unfortunately, the drugs targeting the PPI interface of the GPCR dimers have not been explored so far.  ... 
doi:10.3389/fphar.2019.01310 pmid:31787895 pmcid:PMC6855241 fatcat:4we6luy5jjfjnoidj4rkrabiti

Mapping Tyrosine Kinase Receptor Dimerization to Receptor Expression and Ligand Affinities

Spencer B. Mamer, Alexandra A. Palasz, P. I. Imoukhuede
2019 Processes  
Accordingly, it will drive the exploration of cross-family interactions and help guide therapeutic developments across processes like cancer and cardiovascular diseases, which depend on RTK-mediated signaling  ...  protein families.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/pr7050288 fatcat:shspthhoavbrld63vibzkdf7um

Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers

B Cheskis, L P Freedman
1994 Molecular and Cellular Biology  
Nuclear hormone receptors, for example, bind either as homodimers or as heterodimers with retinoid X receptors (RXR) to half-site repeats that are stabilized by protein-protein interactions mediated by  ...  In this study, we have begun to explore the role of the ligand in vitamin D3 receptor (VDR) function by examining its effect on receptor homodimer and heterodimer formation.  ...  In vivo, ligand appears to act on steroid receptors principally by stimulating the dissociation of heat shock proteins from the receptors, resulting in the formation of receptor homodimers (47) and subsequent  ... 
doi:10.1128/mcb.14.5.3329 pmid:8164684 pmcid:PMC358699 fatcat:vrwrbjjfmfbq5nftg4dn3vdhsq

Paired Plant Immune Receptors

M. T. Nishimura, J. L. Dangl
2014 Science  
articles ): April 22, 2014 (this information is current as of The following resources related to this article are available online at  ...  you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of  ...  Interaction of these two effectors with RPS4 cannot be excluded, but is thus far elusive.  ... 
doi:10.1126/science.1253849 pmid:24744367 fatcat:jvbd32yjxzcwle2sowqhg6y5c4

Measuring Membrane Receptor Interactions Using Single Quantum Dot Tracking

D. Lidke
2012 Microscopy and Microanalysis  
of receptor interactions.  ...  Using these techniques, we have examined the interaction dynamics of the erbB receptors on living cells, revealing new insights into the roles of receptor dynamics and membrane partitioning in the regulation  ...  The impact of the differential lifetimes of erbB complexes is explored using agent-based stochastic models, where contributions of relative erbB receptor density and expression can be considered.  ... 
doi:10.1017/s1431927612002528 fatcat:6ct3vgf7rrghzdn5nvyx5j5nve

Functional significance of serotonin receptor dimerization

Katharine Herrick-Davis
2013 Experimental Brain Research  
The original model of G protein activation by a single G-protein-coupled receptor (GPCR) is giving way to a new model wherein two protomers of a GPCR dimer interact with a single G protein.  ...  The functional significance will be discussed in terms of G-protein activation following ligand binding to one or two protomers in a dimeric structure, the formation of heterodimers and the development  ...  of but does not demonstrate protein-protein interaction.  ... 
doi:10.1007/s00221-013-3622-1 pmid:23811735 pmcid:PMC3788847 fatcat:wmwtjczsxre3takjfyzpzox6d4

Apelin receptor homodimer inhibits apoptosis in vascular dementia

Dexiu Wang, Yuliang Wang, Meiyan Shan, Jing Chen, Huannan Wang, Baoqi Sun, Chengwen Jin, Xin Li, Yue Yin, Chao Song, Changhao Xiao, Jianshe Li (+2 others)
2021 Experimental Cell Research  
Apelin receptor (APJ), a member of family A of the G protein-coupled receptors (GPCRs), is a potential pharmaceutical target for diseases of the nervous system.  ...  After apelin-13 stimulation in the VD rat, the level of APJ and APJ homodimer were elevated.  ...  To explore the signaling pathway of APJ homodimer in vitro, we performed BiFC-BRET in living cells.  ... 
doi:10.1016/j.yexcr.2021.112739 pmid:34343559 fatcat:m7qfhparizaz3ogymutiphadwq

Receptor–Receptor Interactions of G Protein-Coupled Receptors in the Carotid Body: A Working Hypothesis

Andrea Porzionato, Elena Stocco, Diego Guidolin, Luigi Agnati, Veronica Macchi, Raffaele De Caro
2018 Frontiers in Physiology  
Most metabotropic receptors are G protein-coupled receptors (GPCRs).  ...  In other transfected or native cells, GPCRs have been demonstrated to establish physical receptor-receptor interactions (RRIs) with formation of homo/heterocomplexes (dimers or receptor mosaics) in a dynamic  ...  It is noteworthy that D 1 receptors can regulate the function of the NMDA receptor by means of direct protein-protein interactions between the carboxyl terminals of D 1 receptor and NMDA 1 and NMDA 2A  ... 
doi:10.3389/fphys.2018.00697 pmid:29930516 pmcid:PMC6000251 fatcat:4yv2p33sfbc2hgjpv6kftysex4

Novel homodimer model of the ß-adrenergic receptor in complex with free fatty acids and cholesterol: first-principles calculation studies

Yuka Nakano, Yasuo Watanabe, Yoshihiko Ito, Shizuo Yamada, Hiroaki Tokiwa
2012 Bioinformation  
We propose a theoretical novel homodimer model of the β-adrenergic receptor (βAR) in complex with a heterogeneous mixture of free fatty acids (FFAs) and cholesterol based on first-principles calculations  ...  The stable van der Waals interactions propagate from one of the AR to the other through the cholesterol and FFAs in the homodimer complex.  ...  The authors thank the president of the RICOM Corporation, Tadao Hamaya, and the general manager of research and development at the RICOM Corporation, Shouich Kurihama, for their helpful encouragement.  ... 
doi:10.6026/97320630081245 pmid:23275728 pmcid:PMC3532008 fatcat:5u4bxagqebhernpu3e42gwse6y

Dimerization of G protein-coupled receptors: New avenues for somatostatin receptor signalling, control and functioning

Mario Durán-Prado, María M. Malagón, F. Gracia-Navarro, Justo P. Castaño
2008 Molecular and Cellular Endocrinology  
Somatostatin acts through binding and activation of five G protein coupled receptors (GPCRs) termed somatostatin receptors or ssts (sst1-sst5).  ...  The present review summarizes the current knowledge on ssts homodimerization, heterodimerization, and interaction with other GPCRs, as well as how interactions affect different aspects of the normal functioning  ...  Page 13 of 16 A c c e p t e d M a n u s c r i p t  ... 
doi:10.1016/j.mce.2007.12.006 pmid:18242821 fatcat:ikrhe47d7ng5fosj4zzw6twj6e

Intermolecular interactions identify ligand-selective activity of estrogen receptor / dimers

E. Powell, W. Xu
2008 Proceedings of the National Academy of Sciences of the United States of America  
Estrogen receptor (ER) dimerization is prerequisite for its activation of target gene transcription.  ...  Because the two forms of ER, ER␣ and ER␤, exhibit opposing functions in cell proliferation, the ability of ligands to induce ER␣/␤ heterodimers vs. their respective homodimers is expected to have profound  ...  Sugden for the critical reading of this manuscript. This work was supported by National Institutes of Health Grants T32 CA009135 (to E.P.) and R01CA125387 (to W.X.).  ... 
doi:10.1073/pnas.0807274105 pmid:19022902 pmcid:PMC2596243 fatcat:egcfqin7ungxlcl7alr6ojfoyu

A shift in the ligand responsiveness of thyroid hormone receptor alpha induced by heterodimerization with retinoid X receptor alpha

F X Claret, T Antakly, M Karin, F Saatcioglu
1996 Molecular and Cellular Biology  
In vitro, the binding of T3 decreases the DNA-binding activity of T3R alpha homodimers but does not affect DNA binding by T3R alpha:RXR alpha heterodimers.  ...  T3Rs were recently shown to form heterodimers with retinoid X receptors (RXRs), leading to increased binding to T3REs in vitro and potentiation of transcriptional responses in vivo.  ...  The activity of T3R␣ is modulated by interactions with other proteins.  ... 
doi:10.1128/mcb.16.1.219 pmid:8524299 pmcid:PMC230995 fatcat:ypj325x73besfccokdk2ff36iu

Androgen and Glucocorticoid Receptor Heterodimer Formation

Sei-yu Chen, Jian Wang, Gui-qiu Yu, Weihong Liu, David Pearce
1997 Journal of Biological Chemistry  
These observations provide the first evidence that the opposing physiological effects of the androgen and glucocorticoid hormones are due to the direct physical interaction between their receptors at the  ...  A wide range of physiological and molecular biological evidence suggests that the receptors that mediate these effects, the androgen and glucocorticoid receptors (AR and GR, respectively), influence each  ...  While the physiological implications and mechanistic basis of these observations remain to be explored, they clearly challenge the paradigm of a static interaction that merely stabilizes receptor occupancy  ... 
doi:10.1074/jbc.272.22.14087 pmid:9162033 fatcat:k7iyad7hlzblxhhfkri66lm2ei
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