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Experimental Validation of Image-Based Modeling of Torso Surface Potentials During Acute Myocardial Ischemia

Brian Zenger, Jake Bergquist, Wilson Good, Jess Tate, Rob MacLeod
2019 2019 Computing in Cardiology Conference (CinC)  
of acute, controlled ischemia.  ...  To resolve this need, we have developed a large-animal experimental model that includes simultaneous recordings within the myocardium, on the epicardial surface, and on the torso surface during episodes  ...  the torso surface of an animal with re-closed chest during controlled episodes of acute myocardial ischemia [11] .  ... 
doi:10.22489/cinc.2019.417 pmid:32190706 pmcid:PMC7079820 fatcat:3av6rien5zdhnagrz7wnbofeue

Ionic mechanisms of ST segment elevation in electrocardiogram during acute myocardial infarction

Jun-ichi Okada, Katsuhiko Fujiu, Kazunori Yoneda, Takashi Iwamura, Takumi Washio, Issei Komuro, Toshiaki Hisada, Seiryo Sugiura
2020 Journal of Physiological Sciences  
ST elevation on an electrocardiogram is a hallmark of acute transmural ischemia. However, the underlying mechanism remains unclear.  ...  Thus, transmural heterogeneities of ion channel properties may contribute to the genesis of ST-T changes during mild or moderate transmural ischemia, while ST elevation may be induced without the contribution  ...  Acknowledgements We thank Edanz Group (https ://en-autho r-servi ces.edanz group .com/) for editing a draft of this manuscript.  ... 
doi:10.1186/s12576-020-00760-3 pmid:32660418 fatcat:qasfomv3fncl3ehicjthjyjfau

In silico evaluation of the acute occlusion effect of coronary artery on cardiac electrophysiology and the body surface potential map

Ah-Jin Ryu, Kyung Eun Lee, Soon-Sung Kwon, Eun-Seok Shin, Eun Bo Shim
2019 Korean Journal of Physiology and Pharmacology  
Body surface potential map, an electric potential distribution on the body torso surface, enables us to infer the electrical activities of the heart.  ...  In the result, in the ventricle model during the stage 1, a wider area of ischemia led to counterclockwise rotation of the bipolar angle; and, during the stage 2, the amplitude increased when the ischemia  ...  CONFLICTS OF INTEREST The authors declare no conflicts of interest.  ... 
doi:10.4196/kjpp.2019.23.1.71 pmid:30627012 pmcid:PMC6315095 fatcat:r46xescu4beyjpswjytndpzq5m

Image-based modeling of acute myocardial ischemia using experimentally derived ischemic zone source representations

B.M. Burton, K.K. Aras, W.W. Good, J.D. Tate, B. Zenger, R.S. MacLeod
2018 Journal of Electrocardiology  
Conclusion: From image-based simulations of myocardial ischemia, we generated subject-specific ischemic sources that accurately replicated epicardial potential distributions.  ...  Such models are essential in understanding the underlying mechanisms of the bioelectric fields that arise during ischemia and are the basis for more sophisticated simulations of body surface ECGs.  ...  Conflicts of interest Declarations of interest: none.  ... 
doi:10.1016/j.jelectrocard.2018.05.005 pmid:29997022 pmcid:PMC6050031 fatcat:mpsli4yigbf5rofafiol5wvvzu

Comparison of Electric- and Magnetic-Cardiograms Produced by Myocardial Ischemia in Models of the Human Ventricle and Torso

Erick A. Perez Alday, Haibo Ni, Chen Zhang, Michael A. Colman, Zizhao Gan, Henggui Zhang, Tomohiko Ai
2016 PLoS ONE  
The aim of this study was to investigate such differences by using 12-, 36-ECG and 36-MCG computed from multi-scale biophysically detailed computational models of the human ventricles and torso in both  ...  of the magnetic field to the chest surface of the subject [18] .  ...  The match between simulation data and experimental data validated the developed heart-torso models and algorithms for simulating ECGs and MCGs.  ... 
doi:10.1371/journal.pone.0160999 pmid:27556808 pmcid:PMC4996509 fatcat:zdi2j6yppzfxroxjlkzpxsg3fe

Novel Porcine Models of Myocardial Ischemia/Infarction – Technical Progress, Modified Electrocardiograms Validating, and Future Application [chapter]

Jianxun Liu, Xinzhi Li
2012 Advances in Electrocardiograms - Clinical Applications  
Computer-based simulation of ischemia and reperfusion model Experimental models, however, have their own set of limitations that hamper the comprehensive evaluation of heart functional mechanisms.  ...  For researchers involving in basic science of Novel Porcine Models of Myocardial Ischemia/Infarction -Technical Progress, Modified Electrocardiograms Validating, and Future Application  ...  Novel Porcine Models of Myocardial Ischemia/Infarction -Technical Progress, Modified Electrocardiograms Validating, and Future Application, Advances in Electrocardiograms -Clinical Applications, PhD.  ... 
doi:10.5772/23818 fatcat:gahtef3cobej5mtuu56nh5mxl4

Body Surface Potential Mapping: Contemporary Applications and Future Perspectives

Jake Bergquist, Lindsay Rupp, Brian Zenger, James Brundage, Anna Busatto, Rob S. MacLeod
2021 Hearts  
Body surface potential mapping (BSPM) is a noninvasive modality to assess cardiac bioelectric activity with a rich history of practical applications for both research and clinical investigation.  ...  We assess the state of the art of BSPM implementations and explore modern applications of advanced modeling and statistical analysis of BSPM data.  ...  to create controlled acute myocardial ischemia.  ... 
doi:10.3390/hearts2040040 pmid:35665072 pmcid:PMC9164986 fatcat:sgzzoo76b5f3fgewfklu6wzdei

Report of the first virtual visualization of the reconstructed electrocardiographic display symposium

Rob MacLeod, Fred Kornreich, Adriaan van Oosterom, Pentti Rautaharju, Ron Selvester, Galen Wagner, Christoph Zywietz
2005 Journal of Electrocardiology  
We conclude with a summary of the needs that we feel must be addressed to achieve the full potential of electrically based imaging of the heart. D  ...  Following this introduction are overviews of the present state of the inverse problem of electrocardiography and the underlying assumptions of this form of simulation and modeling.  ...  of transient ischemia, for example, from stress tests or during anesthesia.  ... 
doi:10.1016/j.jelectrocard.2005.06.002 pmid:16216618 fatcat:xw6oe76de5dsjdu6uawy4c3omu

ECG Imaging to Detect the Site of Ventricular Ischemia Using Torso Electrodes: A Computational Study

Vinay Kara, Haibo Ni, Erick Andres Perez Alday, Henggui Zhang
2019 Frontiers in Physiology  
Most inverse studies use the full resolution of the body surface potential (BSP) to reconstruct the epicardial potentials, however using a limited number of torso electrodes to interpolate the BSP is more  ...  However, more recently there has been substantial growth in the area of ECG imaging, which by solving the inverse problem of electrocardiography aims to produce high-resolution mapping of the electrical  ...  Comparison of electric- and magnetic- cardiograms produced by myocardial ischemia in models of the human ventricle and torso. Comput.  ... 
doi:10.3389/fphys.2019.00050 pmid:30804799 pmcid:PMC6378918 fatcat:fubx6nvcbjbn5autepk2b3ni7i

Noninvasive Electrocardiographic Imaging of Arrhythmogenic Substrates in Humans

Y. Rudy
2013 Circulation Research  
T he process of cardiac excitation involves generation of the action potential (AP) by ionic membrane currents and propagation of the AP through the multicellular structure of cardiac tissue. 1 The properties  ...  Most studies of arrhythmia mechanisms and arrhythmogenic substrates have been conducted in animal models.  ...  Sources of Funding Studies presented in this article were supported by grants R01-HL33343 and R01-HL49054 from the National Institute of Health-National Heart, Lung, and Blood Institute (to Y.  ... 
doi:10.1161/circresaha.112.279315 pmid:23449548 pmcid:PMC3596167 fatcat:q777x4cqnncale5cs4sxf7l5wu

An algorithm for imaging isochrones of ventricular activation on patient-specific epicardial surface

Shijie Zhou, John Sapp, Amir AbdelWahab, Milan Horacek
2018 2018 Computing in Cardiology Conference (CinC)  
The methodology involves reconstruction of unipolar electrograms (EGMs) and isochronal maps on the epicardial surface from noninvasively acquired body-surface potentials.  ...  Electrocardiographic imaging has been shown to provide useful information for pre-procedure planning of catheter-ablation procedures.  ...  Graduate Scholarship, the Heart & Stroke Foundation of Nova Scotia, and the Cardiac Arrhythmia Network of Canada (CANet).  ... 
doi:10.22489/cinc.2018.343 dblp:conf/cinc/ZhouSAH18 fatcat:enmtvbfnnbgerph66qmgp6znze

Multiscale Modeling of Myocardial Electrical Activity: From Cell to Organ [chapter]

Beatriz Trenor, Lucia Romero, Karen Cardona, Julio Gomis, Javier Saiz, Jose Maria Ferrero Jr.
2011 Applied Biomedical Engineering  
during myocardial ischemia and drug treatment.  ...  However, the rapid changes arising during acute myocardial ischemia and the limitations in experimental techniques hamper the complete understanding of this pathology.  ... 
doi:10.5772/22907 fatcat:mg4lpv5utnbihkrcihfnuadmwa

Effect of cardiac ventricular mechanical contraction on the characteristics of the ECG: A simulation study

Ismail Adeniran, Jules C. Hancox, Henggui Zhang
2013 Journal of Biomedical Science and Engineering  
The 12-lead electrocardiogram (ECG) is the most widely-used tool for the detection and diagnosis of cardiac conditions including myocardial infarction and ischemia.  ...  within a human torso, from which 12-lead ECGs were computed at a stimulation rate of 1 Hz.  ...  change and acute myocardial infarction [5] .  ... 
doi:10.4236/jbise.2013.612a007 fatcat:mzfuscm2gbbhhmnvjo5zpjt4au

Inverse electrocardiographic source localization of ischemia: An optimization framework and finite element solution

Dafang Wang, Robert M. Kirby, Rob S. MacLeod, Chris R. Johnson
2013 Journal of Computational Physics  
With the goal of non-invasively localizing cardiac ischemic disease using body-surface potential recordings, we attempted to reconstruct the transmembrane potential (TMP) throughout the myocardium with  ...  While precisely estimating the TMP in general cases remains an open problem, our study shows the feasibility of reconstructing TMP during the ST interval as a means of ischemia localization.  ...  We acknowledge the Treadwell Foundation and the Cardiovascular Research and Training Institute at the University of Utah for their support of acquiring the experimental data.  ... 
doi:10.1016/ pmid:23913980 pmcid:PMC3727301 fatcat:7dy4dwdgizbbff3qs5vjdnj3r4

Source of Electrocardiographic ST Changes in Subendocardial Ischemia

Danshi Li, Chuan Yong Li, Ah Chot Yong, David Kilpatrick
1998 Circulation Research  
Key Words: ST depression Ⅲ potential mapping Ⅲ bidomain model Ⅲ subendocardial ischemia Ⅲ regional myocardial blood flow  ...  To clarify the source of electrocardiographic ST depression associated with ischemia, a sheep model of subendocardial ischemia was developed in which simultaneous epicardial and endocardial ST potentials  ...  Clive and Vera Ramaciotti Foundation of New South Wales.  ... 
doi:10.1161/01.res.82.9.957 pmid:9598593 fatcat:2mbsmkegqzcunm4lelfrjwhmum
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