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Executive control function, brain activation and white matter hyperintensities in older adults

Vijay K. Venkatraman, Howard Aizenstein, Jack Guralnik, Anne B. Newman, Nancy W. Glynn, Christopher Taylor, Stephanie Studenski, Lenore Launer, Marco Pahor, Jeff Williamson, Caterina Rosano
2010 NeuroImage  
Context-Older adults responding to executive control function (ECF) tasks show greater brain activation on functional MRI (fMRI).  ...  Main variables of interest: fMRI activation, accuracy while performing an ECF task (Digit Symbol Substitution Test), volume of white matter hyperintensities and of total brain atrophy.  ...  Varlashkin and S. Urda, for assistance in obtaining the data necessary for this analysis. Supported in part by Intramural Research Program, National Institute of Aging (NIA 263-MA-706016).  ... 
doi:10.1016/j.neuroimage.2009.11.019 pmid:19922803 pmcid:PMC2818521 fatcat:ctdo7s2znngk5dgy2p7en4yyqy

Master Athletes and cognitive performance: What are the potential explanatory neurophysiological mechanisms?

Olivier Dupuy, Roman Goenarjo, Sarah Anne Fraser, Louis Bherer, Laurent Bosquet
2019 Movement & sport sciences  
This is partly because the prefrontal cortex, which governs these functions, seems to be very sensitive to physical activity levels.  ...  The aim of this review is to identify studies assessing the cognitive performance of Master Athletes and report on the probable neurophysiological mechanisms that explain the cognitive benefits in this  ...  White matter hyperintensities / hypointensities White matter hyperintensities in the brain can be detected on MRI.  ... 
doi:10.1051/sm/2019023 fatcat:pbeqxfroe5hsvai6p6ya3wc3ky


R Holtzer, M Lucas, M Wagshul, M Izzetoglu
2018 Innovation in aging  
The dopaminergic system may be an intervention target for increasing brain resilience and enhancing functional outcomes in older adults.  ...  We examined the influence of pre-fall executive function, attention, and visuospatial skill on change in gait speed and instrumental activities of daily living (IADL) between the assessment before, and  ...  In this talk, a multi-modal imaging (DTI and fNIRS) study implemented in a cohort of 55 non-demented older adults, will be used to propose white matter integrity as moderator of (in)efficient prefrontal  ... 
doi:10.1093/geroni/igy023.203 fatcat:6uqlkiiwxfd4fkzw62z2wti6ne

White Matter Hyperintensities, Exercise, and Improvement in Gait Speed: Does Type of Gait Rehabilitation Matter?

Neelesh K. Nadkarni, Stephanie A. Studenski, Subashan Perera, Caterina Rosano, Howard J. Aizenstein, Jennifer S. Brach, Jessie M. Van Swearingen
2013 Journal of The American Geriatrics Society  
and Objectives-White matter hyperintensities (WMH) on brain MRI are associated with cognitive and mobility impairment in older adults.  ...  Task-oriented therapy that targets timing and coordination of gait may particularly benefit older adults with WMH in brain tracts that influence gait and cognition.  ...  Pepper Older American's Independence Center grant (P30 AG024827). We appreciate the assistance of Rebecca L. MacCloud for providing the figure-inserts for the brain tracts.  ... 
doi:10.1111/jgs.12211 pmid:23590257 pmcid:PMC3874589 fatcat:dlbxyuzndngwhmmry4z7rk6tse

Applications of magnetic resonance imaging for treatment-resistant late-life depression

Christian Agudelo, Howard J Aizenstein, Jordan F Karp, Charles F Reynolds
2015 Dialogues in Clinical Neuroscience  
This literature review summarizes neuroimaging findings associated with depression in older adults and treatment-response variability.  ...  These associations help explain the depression-executive dysfunction syndrome observed in LLD, and support cerebrovascular burden as a pathogenic mechanism.  ...  Acknowledgments: Supported in part by P30 MH90333, R01 MH076079, R34 MH101371, T32 MH19986, UL1 TR000005, and the UPMC Endowment in Geriatric Psychiatry.  ... 
pmid:26246790 pmcid:PMC4518699 fatcat:6mgpwl3jojgkhhu6q37g3otfiq

Neuropsychological mechanisms of falls in older adults

Yu Liu, John S. Y. Chan, Jin H. Yan
2014 Frontiers in Aging Neuroscience  
Older adults may shift from unconscious movement control to more conscious or attentive motor control.  ...  By integrating the existing evidence, we propose that brain aging is an important precursor of the increased risk of falls in older adults.  ...  Longitudinal results indicate that older adults with moderate to severe brain abnormalities (ventricular enlargement, white matter hyperintensities, subcortical and basal ganglia small brain infarcts)  ... 
doi:10.3389/fnagi.2014.00064 pmid:24782761 pmcid:PMC3988382 fatcat:ksrjagyhsfe5tamerg7zh4pexi

Sleep Duration and White Matter Quality in Middle-Aged Adults

Kristine Yaffe, Ilya Nasrallah, Tina D. Hoang, Diane S. Lauderdale, Kristen L. Knutson, Mercedes R. Carnethon, Lenore J. Launer, Cora E. Lewis, Stephen Sidney
2016 Sleep  
Five years later, we obtained brain MRI markers of white matter including fractional anisotropy, mean diffusivity, and white matter hyperintensities.  ...  Methods: In a prospective cohort of 613 black and white adults (mean age = 45.4 years) enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study, participants reported typical sleep  ...  [11] [12] [13] [14] [15] In one cross-sectional study of older adults, long sleep was associated with worse cognitive function, and among participants with diabetes, increased white matter hyperintensities  ... 
doi:10.5665/sleep.6104 pmid:27397561 pmcid:PMC4989263 fatcat:hrbgjkhbebglri42c3hv5jeaaq

Compromised prefrontal structure and function are associated with slower walking in older adults

Victoria N. Poole, Thomas Wooten, Ikechukwu Iloputaife, William Milberg, Michael Esterman, Lewis A. Lipsitz
2018 NeuroImage: Clinical  
These findings suggest that subtle damage to frontal white matter may contribute to altered executive network activation and slower walking in older adults.  ...  Our previous work demonstrates that reduced activation of the executive network is associated with slow walking speed in a cohort of older adults from the MOBILIZE Boston Study.  ...  in the brains of older adults.  ... 
doi:10.1016/j.nicl.2018.08.017 pmid:30191124 pmcid:PMC6125763 fatcat:ix2mxkcamja6rfgvswbw73y6aq

How Late-Life Depression Affects Cognition: Neural Mechanisms

Elizabeth A. Crocco, Kenia Castro, David A. Loewenstein
2010 Current Psychiatry Reports  
In contrast to younger depressed patients, most depressed older adults suffer more severe variants of the disorder, including significant cognitive impairments.  ...  Studies examining clinical correlates, neuropsychological testing, and functional and anatomic imaging have yielded a clearer understanding of the neural mechanisms underlying cognitive deficits in late-life  ...  In addition, executive function and cognitive processing speed were associated with reductions in whole brain gray matter and white matter.  ... 
doi:10.1007/s11920-009-0081-2 pmid:20425308 fatcat:l6lemirmyvfmzh4l3iedooth4m

The association between cognitive function and white matter lesion location in older adults: a systematic review

Niousha Bolandzadeh, Jennifer C Davis, Roger Tam, Todd C Handy, Teresa Liu-Ambrose
2012 BMC Neurology  
Maintaining cognitive function is essential for healthy aging and to function autonomously within society. White matter lesions (WMLs) are associated with reduced cognitive function in older adults.  ...  We limited our search results to adults aged 60 years and older, and studies published in the English language from 2000 to 2011.  ...  [30] studied a sample of 95 older adults. White matter lesions were defined as FLAIR and T2 hyperintensities, and were categorized into frontal and posterior regions.  ... 
doi:10.1186/1471-2377-12-126 pmid:23110387 pmcid:PMC3522005 fatcat:rzfczqzxzzedxatkh6aap5mksm

The association between cognitive function and white matter lesion location in older adults: A systematic review

Niousha Bolandzadeh, Jennifer C. Davis, Roger Tam, Todd Handy, Teresa Liu-Ambrose
2012 Alzheimer's & Dementia  
Maintaining cognitive function is essential for healthy aging and to function autonomously within society. White matter lesions (WMLs) are associated with reduced cognitive function in older adults.  ...  We limited our search results to adults aged 60 years and older, and studies published in the English language from 2000 to 2011.  ...  [30] studied a sample of 95 older adults. White matter lesions were defined as FLAIR and T2 hyperintensities, and were categorized into frontal and posterior regions.  ... 
doi:10.1016/j.jalz.2012.05.2162 fatcat:py5ugztvo5depgrgoibii7kqdi

Structural neuroimaging in Altheimer's disease: do white matter hyperintensities matter?

Adam M Brickman, Jordan Muraskin, Molly E Zimmerman
2009 Dialogues in Clinical Neuroscience  
White matter hyperintensities (WMH), which are distributed patches of increased hyperintense signal on T2-weighted MRI, are among the most common structural neuroimaging findings in older adults.  ...  A significant proportion of older adults experience precipitous cognitive decline that negatively impacts functional activities.  ...  Acknowledgments: This work was supported in part by NIH grants AG029949, AG024708, AG007232, and Alzheimer's Association grant 05-14586 awarded to AMB and a Clinical and Translational Science Award Imaging  ... 
pmid:19585953 pmcid:PMC2864151 fatcat:u6uy2r2obzganp65wlwcay3cqe

Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression

B S Diniz, E Sibille, Y Ding, G Tseng, H J Aizenstein, F Lotrich, J T Becker, O L Lopez, M T Lotze, W E Klunk, C F Reynolds, M A Butters
2014 Molecular Psychiatry  
We analyzed data from 80 older adults with remitted major depression (36 with mild cognitive impairment (LLD+MCI) and 44 with normal cognitive (LLD+NC)) function.  ...  Individuals with LLD+MCI also showed greater white matter hyperintensity burden compared with LLD+NC (P = 0.015).  ...  during a depressive episode in older adults and most commonly involves impairments in information processing speed, executive functioning and episodic memory. 3 When cognitive impairment co-occurs with  ... 
doi:10.1038/mp.2014.76 pmid:25092249 pmcid:PMC4494754 fatcat:mck76qpevvg5plrfpplwpm4a7m

Longer lithium exposure is associated with better white matter integrity in older adults with bipolar disorder

Ariel G Gildengers, Meryl A Butters, Howard J Aizenstein, Megan M Marron, James Emanuel, Stewart J Anderson, Lisa A Weissfeld, James T Becker, Oscar L Lopez, Benoit H Mulsant, Charles F Reynolds
2014 Bipolar Disorders  
We explored whether lithium treatment is related to better brain integrity and cognitive function in older adults with BD.  ...  Results-In comparison to controls, subjects with BD had worse overall cognitive performance, lower total gray matter volume, and lower white matter integrity.  ...  Michelle Zmuda for the recruitment of control subjects and coordination of all neuropsychological assessments as well as Ms.  ... 
doi:10.1111/bdi.12260 pmid:25257942 pmcid:PMC4374042 fatcat:u5ynjhyuc5cmpcyq75ebuxr7lq

Pathways linking regional hyperintensities in the brain and slower gait

Niousha Bolandzadeh, Teresa Liu-Ambrose, Howard Aizenstein, Tamara Harris, Lenore Launer, Kristine Yaffe, Stephen B. Kritchevsky, Anne Newman, Caterina Rosano
2014 NeuroImage  
Importance-Cerebral white matter hyperintensities (WMHs) are involved in the evolution of impaired mobility and executive functions. Executive functions and mobility are also associated.  ...  Results-In older adults with an average gait speed of 0.91 m/sec, total WMH volume, WMHs located in the right anterior thalamic radiation (ATRR) and frontal corpus callosum (CCF) were most associated with  ...  N.B. was supported by Heart and Stroke Foundation of Canada for her PhD studies. T.L.A. is a Canada Research Chair in Physical Activity, Mobility and Cognitive Neuroscience.  ... 
doi:10.1016/j.neuroimage.2014.05.017 pmid:24841418 pmcid:PMC4508128 fatcat:xkksf5u225ew7moomnkautijqy
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