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Excitability Constraints on Voltage-Gated Sodium Channels
2007
PLoS Computational Biology
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Citation: Angelino E, Brenner MP (2007) Excitability constraints on voltage-gated sodium channels. PLoS Comput Biol 3(9): e177. ...
We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. ...
We also thank Olivia White for early collaborations, and Ron Milo and Andrew Murray for helpful comments on this manuscript. ...
doi:10.1371/journal.pcbi.0030177
pmid:17892320
pmcid:PMC1988852
fatcat:t4csv6ccizfvfn5pj242uc23p4
Slow Changes in the Availability of Voltage-gated Ion Channels: Effects on the Dynamics of Excitable Membranes
1998
Journal of Membrane Biology
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Effects of Slow Gating Processes on Resting Membrane Potential and its Fluctuations So far we have discussed changes in the threshold, due to slow changes in the availability of voltage-gated sodium and ...
Cellular Short-term Memory in Experimental Model Systems Lester and his colleagues (Hsu et al., 1993 ) expressed a combination of sodium and potassium voltage-gated ion channels of excitable membranes ...
doi:10.1007/s002329900318
pmid:9435267
fatcat:s4vnrnzxgzf2phqibqgnifsbtu
Structural and regulatory evolution of cellular electrophysiological systems
2009
Evolution & Development
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In this review we will focus on the intrinsic electrophysiological properties of electrically excitable cells, which are largely determined by the voltage-gated ion channels that these cells express. ...
Precursors of eukaryote calcium and sodium channels are found in prokaryotes in the form of voltage-gated sodium channels (Durell and Guy, 2001; Ren et al, 2001b; Koishi et al, 2004) and possibly calciumselective ...
doi:10.1111/j.1525-142x.2009.00367.x
pmid:19754717
pmcid:PMC2747049
fatcat:j5szxyhev5axhc3tslzkyiwp64
Collective Equilibrium Behaviour of Ion Channel Gating in Cell Membranes: An Ising Model Formulation
2007
Journal of biological physics (Print)
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A statistical mechanical model for voltage-gated ion channels in cell membranes is proposed using the transfer matrix method. Equilibrium behavior of the system is studied. ...
In the HH equations, the gating variables that govern the activation and inactivation of the channels and experimentally-determined voltage transition rates are included [4]. ...
They obtained the maximum fractions of open potassium and sodium channels by solving a self-consistent nonlinear algebraic equation under a mean-field approximation (MFA) with the important constraint ...
doi:10.1007/s10867-007-9034-3
pmid:19669439
pmcid:PMC2651540
fatcat:gcfflo7ld5fe7ahwdbbon4wtlu
The action potential: From voltage-gated conductances to molecular structures
2006
Biological Research
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BEZANILLA F (1973) Currents related to movement of the gating particles of the sodium channels. ...
constraints. ...
doi:10.4067/s0716-97602006000300005
fatcat:budjhpyihbfmtn43dhllkpqvlu
Expression, Purification, and Preliminary Characterization of a Human Cardiac Sodium Channel Voltage Sensing Domain
2015
Biophysical Journal
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and ion conduction in voltage gated sodium channels. ...
The opening of voltage-gated sodium channels (Na v ) is responsible for the rapid upstroke of action potentials. A key player during myocardial excitation is the cardiac channel isoform Na v 1.5. ...
doi:10.1016/j.bpj.2014.11.3145
fatcat:3zyfjirmcjesfamovmdbcdunbq
Coupling of Channel Fluctuations in Ion Permeation and Selectivity in Bacterial Sodium Channel NavAb
2015
Biophysical Journal
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and ion conduction in voltage gated sodium channels. ...
The opening of voltage-gated sodium channels (Na v ) is responsible for the rapid upstroke of action potentials. A key player during myocardial excitation is the cardiac channel isoform Na v 1.5. ...
doi:10.1016/j.bpj.2014.11.3144
fatcat:abocfvswkzdxbncu3kz5womu2m
The Voltage Sensor Module in Sodium Channels
[chapter]
2014
Handbook of Experimental Pharmacology
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Sodium Channels and the Action Potential Voltage-gated sodium channels initiate the action potential in excitable tissues such as neurons, cardiac, and skeletal muscle fibers (Armstrong and Hille 1998 ...
The action potential was now described in mathematical terms, computational neuroscience was born, and the search for the basis of voltage gating in excitable cell membranes was on. ...
doi:10.1007/978-3-642-41588-3_2
pmid:24737230
fatcat:4liaxbguifanzmuyyz5ctfwy2e
Voltage gating by molecular subunits of Na+ and K+ ion channels: higher-dimensional cubic kinetics, rate constants, and temperature
2015
Journal of Neurophysiology
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VOLTAGE GATING BY CHANNEL MOLECULAR SUBUNITS J Neurophysiol • ...
Channel densities and further details are given in Fohlmeister et al. (2010) . 3760 VOLTAGE GATING BY CHANNEL MOLECULAR SUBUNITS J Neurophysiol • Parameters for equivalent rate constants for sodium and ...
The rate constants for 37°C, and for kinetics m 4 , n 4 , and independent Na-inactivation h, are:
Nerve Model Model excitation is based on the voltage-gated currents I Na (inactivating sodium), I K ( ...
doi:10.1152/jn.00551.2014
pmid:25867741
pmcid:PMC4468971
fatcat:hz3bqbmqsvf4dfbxpozrrvy73i
Molecular Dynamics Study of Ion Conduction and Selectivity in a Prokaryotic Ion Channel
2015
Biophysical Journal
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and ion conduction in voltage gated sodium channels. ...
The opening of voltage-gated sodium channels (Na v ) is responsible for the rapid upstroke of action potentials. A key player during myocardial excitation is the cardiac channel isoform Na v 1.5. ...
doi:10.1016/j.bpj.2014.11.3143
fatcat:pdcc74r5lzcz3fsn5crpa77d7a
A Thermodynamic Analysis of Disease-Causing Mutations in the Nav1.5 C-Terminus
2015
Biophysical Journal
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and ion conduction in voltage gated sodium channels. ...
The opening of voltage-gated sodium channels (Na v ) is responsible for the rapid upstroke of action potentials. A key player during myocardial excitation is the cardiac channel isoform Na v 1.5. ...
doi:10.1016/j.bpj.2014.11.3146
fatcat:mnwxha7kmndwxll2liavcqhizy
Small molecule modulation of voltage gated sodium channels
2017
Current Opinion in Structural Biology
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of voltage-gated sodium channels. ...
Voltage gated sodium channels are fundamental players in animals physiology. By triggering the depolarization of the lipid membrane they enable generation and propagation of the action potential. ...
Pharmacology of VGSCs Many FDA approved drug molecules target voltage gated sodium channels (VGSCs), usually to reduce cell excitability via suppression of VGSCs activity. ...
doi:10.1016/j.sbi.2017.02.002
pmid:28363194
pmcid:PMC5420475
fatcat:udr6jpmoanh6vcmq5vft6wppym
Regulatory Evolution and Voltage-Gated Ion Channel Expression in Squid Axon: Selection-Mutation Balance and Fitness Cliffs
2015
PLoS ONE
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PLOS ONE | ...
Acknowledgments We would like to thank Drs Joshua Rest, Ira Cohen and Paul Adams for their comments on this work.
Author Contributions ...
To convincingly demonstrate that minimization of energy utilization is a critical constraint on the evolution of voltage-gated ion channel expression levels, it is necessary to demonstrate that some other ...
doi:10.1371/journal.pone.0120785
pmid:25875483
pmcid:PMC4395378
fatcat:p7blbjsqnzbrthj4tvuhqs2j44
The contribution of voltage clamp fluorometry to the understanding of channel and transporter mechanisms
2019
The Journal of General Physiology
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One approach that may allow us to bridge this gap between structure and function is voltage clamp fluorometry (VCF). ...
Many of the important papers that have used VCF to probe the gating mechanisms of channels and transporters have been published in the Journal of General Physiology. ...
The faster clamp speed of COVG compared to the TEV enabled studies on fast gating channels such as the voltage-gated sodium channel (Cha et al., 1999) . ...
doi:10.1085/jgp.201912372
pmid:31431491
pmcid:PMC6785729
fatcat:qgymc5hrdzb6dbwr6jqdhbswbq
Ionic Imbalance
[chapter]
2011
Clinical and Genetic Aspects of Epilepsy
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Inward cations 5.1.1 Voltage-gated Na+ channels Many AEDs selectively decrease current through voltage-gated sodium channels. ...
K+ channels While voltage-gated sodium and calcium ion channels have long been targets of AEDs, targeting voltage-gated potassium channels is relatively new. ...
doi:10.5772/19517
fatcat:bctvxyv3pjh7zmpcvdfn25xfyq
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