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Excitability Constraints on Voltage-Gated Sodium Channels

Elaine Angelino, Michael P. Brenner
2007 PLoS Computational Biology  
Citation: Angelino E, Brenner MP (2007) Excitability constraints on voltage-gated sodium channels. PLoS Comput Biol 3(9): e177.  ...  We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels.  ...  We also thank Olivia White for early collaborations, and Ron Milo and Andrew Murray for helpful comments on this manuscript.  ... 
doi:10.1371/journal.pcbi.0030177 pmid:17892320 pmcid:PMC1988852 fatcat:t4csv6ccizfvfn5pj242uc23p4

Slow Changes in the Availability of Voltage-gated Ion Channels: Effects on the Dynamics of Excitable Membranes

S. Marom
1998 Journal of Membrane Biology  
Effects of Slow Gating Processes on Resting Membrane Potential and its Fluctuations So far we have discussed changes in the threshold, due to slow changes in the availability of voltage-gated sodium and  ...  Cellular Short-term Memory in Experimental Model Systems Lester and his colleagues (Hsu et al., 1993 ) expressed a combination of sodium and potassium voltage-gated ion channels of excitable membranes  ... 
doi:10.1007/s002329900318 pmid:9435267 fatcat:s4vnrnzxgzf2phqibqgnifsbtu

Structural and regulatory evolution of cellular electrophysiological systems

Barbara Rosati, David McKinnon
2009 Evolution & Development  
In this review we will focus on the intrinsic electrophysiological properties of electrically excitable cells, which are largely determined by the voltage-gated ion channels that these cells express.  ...  Precursors of eukaryote calcium and sodium channels are found in prokaryotes in the form of voltage-gated sodium channels (Durell and Guy, 2001; Ren et al, 2001b; Koishi et al, 2004) and possibly calciumselective  ... 
doi:10.1111/j.1525-142x.2009.00367.x pmid:19754717 pmcid:PMC2747049 fatcat:j5szxyhev5axhc3tslzkyiwp64

Collective Equilibrium Behaviour of Ion Channel Gating in Cell Membranes: An Ising Model Formulation

Rıza Erdem
2007 Journal of biological physics (Print)  
A statistical mechanical model for voltage-gated ion channels in cell membranes is proposed using the transfer matrix method. Equilibrium behavior of the system is studied.  ...  In the HH equations, the gating variables that govern the activation and inactivation of the channels and experimentally-determined voltage transition rates are included [4].  ...  They obtained the maximum fractions of open potassium and sodium channels by solving a self-consistent nonlinear algebraic equation under a mean-field approximation (MFA) with the important constraint  ... 
doi:10.1007/s10867-007-9034-3 pmid:19669439 pmcid:PMC2651540 fatcat:gcfflo7ld5fe7ahwdbbon4wtlu

The action potential: From voltage-gated conductances to molecular structures

FRANCISCO BEZANILLA
2006 Biological Research  
BEZANILLA F (1973) Currents related to movement of the gating particles of the sodium channels.  ...  constraints.  ... 
doi:10.4067/s0716-97602006000300005 fatcat:budjhpyihbfmtn43dhllkpqvlu

Expression, Purification, and Preliminary Characterization of a Human Cardiac Sodium Channel Voltage Sensing Domain

Mohammed H. Bhuiyan, Sebastien F. Poget
2015 Biophysical Journal  
and ion conduction in voltage gated sodium channels.  ...  The opening of voltage-gated sodium channels (Na v ) is responsible for the rapid upstroke of action potentials. A key player during myocardial excitation is the cardiac channel isoform Na v 1.5.  ... 
doi:10.1016/j.bpj.2014.11.3145 fatcat:3zyfjirmcjesfamovmdbcdunbq

Coupling of Channel Fluctuations in Ion Permeation and Selectivity in Bacterial Sodium Channel NavAb

Christopher Ing, Nilmadhab Chakrabarti, Ning Zheng, William A. Catterall, Régis Pomès
2015 Biophysical Journal  
and ion conduction in voltage gated sodium channels.  ...  The opening of voltage-gated sodium channels (Na v ) is responsible for the rapid upstroke of action potentials. A key player during myocardial excitation is the cardiac channel isoform Na v 1.5.  ... 
doi:10.1016/j.bpj.2014.11.3144 fatcat:abocfvswkzdxbncu3kz5womu2m

The Voltage Sensor Module in Sodium Channels [chapter]

James R. Groome
2014 Handbook of Experimental Pharmacology  
Sodium Channels and the Action Potential Voltage-gated sodium channels initiate the action potential in excitable tissues such as neurons, cardiac, and skeletal muscle fibers (Armstrong and Hille 1998  ...  The action potential was now described in mathematical terms, computational neuroscience was born, and the search for the basis of voltage gating in excitable cell membranes was on.  ... 
doi:10.1007/978-3-642-41588-3_2 pmid:24737230 fatcat:4liaxbguifanzmuyyz5ctfwy2e

Voltage gating by molecular subunits of Na+ and K+ ion channels: higher-dimensional cubic kinetics, rate constants, and temperature

Jürgen F. Fohlmeister
2015 Journal of Neurophysiology  
VOLTAGE GATING BY CHANNEL MOLECULAR SUBUNITS J Neurophysiol •  ...  Channel densities and further details are given in Fohlmeister et al. (2010) . 3760 VOLTAGE GATING BY CHANNEL MOLECULAR SUBUNITS J Neurophysiol • Parameters for equivalent rate constants for sodium and  ...  The rate constants for 37°C, and for kinetics m 4 , n 4 , and independent Na-inactivation h, are: Nerve Model Model excitation is based on the voltage-gated currents I Na (inactivating sodium), I K (  ... 
doi:10.1152/jn.00551.2014 pmid:25867741 pmcid:PMC4468971 fatcat:hz3bqbmqsvf4dfbxpozrrvy73i

Molecular Dynamics Study of Ion Conduction and Selectivity in a Prokaryotic Ion Channel

Karen M. Callahan, Benoît Roux
2015 Biophysical Journal  
and ion conduction in voltage gated sodium channels.  ...  The opening of voltage-gated sodium channels (Na v ) is responsible for the rapid upstroke of action potentials. A key player during myocardial excitation is the cardiac channel isoform Na v 1.5.  ... 
doi:10.1016/j.bpj.2014.11.3143 fatcat:pdcc74r5lzcz3fsn5crpa77d7a

A Thermodynamic Analysis of Disease-Causing Mutations in the Nav1.5 C-Terminus

Ching-Chieh Tung, Ricardo E. Rivera-Acevedo, Bernd R. Gardill, Filip Van Petegem
2015 Biophysical Journal  
and ion conduction in voltage gated sodium channels.  ...  The opening of voltage-gated sodium channels (Na v ) is responsible for the rapid upstroke of action potentials. A key player during myocardial excitation is the cardiac channel isoform Na v 1.5.  ... 
doi:10.1016/j.bpj.2014.11.3146 fatcat:mnwxha7kmndwxll2liavcqhizy

Small molecule modulation of voltage gated sodium channels

Vincenzo Carnevale, Michael L Klein
2017 Current Opinion in Structural Biology  
of voltage-gated sodium channels.  ...  Voltage gated sodium channels are fundamental players in animals physiology. By triggering the depolarization of the lipid membrane they enable generation and propagation of the action potential.  ...  Pharmacology of VGSCs Many FDA approved drug molecules target voltage gated sodium channels (VGSCs), usually to reduce cell excitability via suppression of VGSCs activity.  ... 
doi:10.1016/j.sbi.2017.02.002 pmid:28363194 pmcid:PMC5420475 fatcat:udr6jpmoanh6vcmq5vft6wppym

Regulatory Evolution and Voltage-Gated Ion Channel Expression in Squid Axon: Selection-Mutation Balance and Fitness Cliffs

Min Kim, Don McKinnon, Thomas MacCarthy, Barbara Rosati, David McKinnon, Steven Barnes
2015 PLoS ONE  
PLOS ONE |  ...  Acknowledgments We would like to thank Drs Joshua Rest, Ira Cohen and Paul Adams for their comments on this work. Author Contributions  ...  To convincingly demonstrate that minimization of energy utilization is a critical constraint on the evolution of voltage-gated ion channel expression levels, it is necessary to demonstrate that some other  ... 
doi:10.1371/journal.pone.0120785 pmid:25875483 pmcid:PMC4395378 fatcat:p7blbjsqnzbrthj4tvuhqs2j44

The contribution of voltage clamp fluorometry to the understanding of channel and transporter mechanisms

John Cowgill, Baron Chanda
2019 The Journal of General Physiology  
One approach that may allow us to bridge this gap between structure and function is voltage clamp fluorometry (VCF).  ...  Many of the important papers that have used VCF to probe the gating mechanisms of channels and transporters have been published in the Journal of General Physiology.  ...  The faster clamp speed of COVG compared to the TEV enabled studies on fast gating channels such as the voltage-gated sodium channel (Cha et al., 1999) .  ... 
doi:10.1085/jgp.201912372 pmid:31431491 pmcid:PMC6785729 fatcat:qgymc5hrdzb6dbwr6jqdhbswbq

Ionic Imbalance [chapter]

John Robert, Christine Drown, Monica Gertz
2011 Clinical and Genetic Aspects of Epilepsy  
Inward cations 5.1.1 Voltage-gated Na+ channels Many AEDs selectively decrease current through voltage-gated sodium channels.  ...  K+ channels While voltage-gated sodium and calcium ion channels have long been targets of AEDs, targeting voltage-gated potassium channels is relatively new.  ... 
doi:10.5772/19517 fatcat:bctvxyv3pjh7zmpcvdfn25xfyq
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