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Examining Sodium and Potassium Channel Conductances Involved in Hyperexcitability of Chemotherapy-Induced Peripheral Neuropathy: A Mathematical and Cell Culture-Based Study

Parul Verma, Muriel Eaton, Achim Kienle, Dietrich Flockerzi, Yang Yang, Doraiswami Ramkrishna
2020 Frontiers in Computational Neuroscience  
Our mathematical investigation of a reductionist DRG neuron model comprised of sodium channel Nav1.7, sodium channel Nav1.8, delayed rectifier potassium channel, A-type transient potassium channel, and  ...  Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent, painful side effect which arises due to a number of chemotherapy agents. CIPN can have a prolonged effect on quality of life.  ...  Haroon Anwar, New Jersey Institute of Technology, USA, for support with model selection and building, and Max Planck Institute for Dynamics of Complex Technical Systems, Germany, for sponsoring trips to  ... 
doi:10.3389/fncom.2020.564980 pmid:33178002 pmcid:PMC7593680 fatcat:xzpbd3y5oraclm3ap5oqzetkhm

A mathematical investigation of chemotherapy-induced peripheral neuropathy [article]

Parul Verma, Muriel Eaton, Achim Kienle, Dietrich Flockerzi, Yang Yang, Doraiswami Ramkrishna
2020 bioRxiv   pre-print
Our mathematical investigation suggests that the sodium channel Nav1.8 and the delayed rectifier potassium channel conductances are the most critical for hyperexcitability in normal firing small DRG neurons  ...  Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent, painful side effect which arises due to a number of chemotherapy agents. CIPN can have a prolonged effect on quality of life.  ...  In this study, we analyze the role of voltage-gated sodium and potassium ion channels in paclitaxel-induced hyperexcitability using mathematical modeling and bifurcation theory, then support our results  ... 
doi:10.1101/2020.04.23.057851 fatcat:gysyxmujpff53mxrmuoos3eh54

Axonal excitability changes and acute symptoms of oxaliplatin treatment: In vivo evidence for slowed sodium channel inactivation

Rikke Heide, Hugh Bostock, Lise Ventzel, Peter Grafe, Joseph Bergmans, Anders Fuglsang-Frederiksen, Nanna B. Finnerup, Hatice Tankisi
2018 Clinical Neurophysiology  
Conclusions: Oxaliplatin induces reversible slowing of sodium channel inactivation in motor axons, and these changes are closely related to the reversible cold allodynia.  ...  The motor nerve excitability changes were well modeled by a slowing of sodium channel inactivation, and were proportional to dose/m 2 with a half-life of about 10d.  ...  that the most pronounced effect of oxaliplatin on dorsal root ganglion (DRG) cells was a slowdown of the inactivation kinetics of sodium channels; Sittl et al. (2012) , recording from cultured mouse  ... 
doi:10.1016/j.clinph.2017.11.015 pmid:29233604 fatcat:wuzmd2hqrjft7j5ntl7jp3536q

Animal Pain Models for Spinal Cord Stimulation [chapter]

Joseph M. Williams, Courtney A. Kelley, Ricardo Vallejo, David C. Platt, David L. Cedeño
2021 Animal Models in Medicine and Biology [Working Title]  
Other neuropathic pain models described are the spinal nerve ligation (SNL) for neuropathic pain of segmental origin, as well as the chemotherapy-induced and diabetes-induced peripheral neuropathy models  ...  The models described include those in which SCS has been coupled to neuropathic pain models in rats and sheep based on peripheral nerve injuries, including the chronic constriction injury (CCI) model and  ...  Tina Billstrom who have provided their help in developing our own SCS animal models.  ... 
doi:10.5772/intechopen.96403 fatcat:ge7764xvl5hp7c7xbwwc7kqhnm

Oral Abstracts

2021 Glia  
CNS, have given us a deeper inside into the variety of cell-types and the molecular mechanisms involved their generation, deployment, and homeostasis.  ...  In this course, we will look into the mechanisms involved in the generation of different neural cell-types focusing on glial cells, including the role of transcription regulators driving commitment toward  ...  Wendy Xin, Simon Pan and Feng Mei.  ... 
doi:10.1002/glia.24035 pmid:34173981 fatcat:q2h3ttvpxnfcxds4p6jy6h7mcq

Abstracts of the XXXVIII Congress of the Spanish Society of Physiological Sciences (SECF), 13-16 September 2016, Zaragoza, Spain

2016 Journal of physiology and biochemistry  
Different studies will be presented in the form of plenary sessions, symposia and posters and will include superb scientific material that was carefully selected by the Scientific Committee.  ...  Topics cover a wide range of subjects, mainly related to Cell and Molecular Physiology, Neurophysiology, Endocrinology, Cardiovascular Physiology, Respiratory Physiology, Gastrointestinal Physiology, Renal  ...  Nutrition, Food Sciences and Physiology. School of Pharmacy and Nutrition. University of Navarra. 2. Center for Nutrition Research.  ... 
doi:10.1007/s13105-016-0508-2 pmid:27524160 fatcat:ifzgptw3nfg3pntly6jsi6b4me

Poster Sessions Monday/Tuesday

2017 Journal of Neurochemistry  
Since little is known about BDNF action in astrocytes, we examined the effect of BDNF on astrocyte viability and the involvement of TrkB in this action.  ...  In order to identify which TrkB isoform is involved in BDNF protective effect we analyzed mRNA expression levels of TrkB-FL and TrkB-T1 by RT-qPCR, both isoforms TrkB-FL and TrkB-T1 are expressed in cultured  ...  Moreover, the proper clustering of voltage sodium channels (Nav) at the node and potassium channels (Kv1.2) at the juxtaparanode is crucial for correct conduction.  ... 
doi:10.1111/jnc.14093 fatcat:2ms572hs7jfj7apydnl2urupsq

ePresentation Sessions

2018 European Journal of Neurology  
SCN4A gene, that encodes the a-subunit of the voltage-gated sodium channel.  ...  The neurotransmitter GABA and sodium channels are suspected to be involved because SNHL is also described in carbamazepine, gabapentin and vigabatrin.  ...  QOL was evaluated using the Norfolk QOL-DN questionnaire and the SF-36v2 Health Survey (SF-36v2 Background and aims: Chemotherapy-induced peripheral neuropathy (CIPN) represents one of the most worrisome  ... 
doi:10.1111/ene.13700 fatcat:xk5co6xixzbs3n7wnhc5xjkpv4

Review on the Third International Neuroinflammation Congress and Student Festival of Neuroscience in Mashhad University of Medical Sciences

Mostafa Modarres Mousavi, Sajad Sahab Negah, Ali Gorji, Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran, a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Epilepsy Research Center, Department of Neurology and Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany
2019 The Neuroscience Journal of Shefaye Khatam  
Neuroinflammation congress was the third in a series of annual events aimed to facilitate the inves tigative and analytical discussions on a range of neuroinflammatory diseases.  ...  Conclusion: Through a comprehensive scientific program with a broad basic and clinical aspects, we discussed the basic aspects of neuroinflammation and neurodegeneration up to the s tate-of-the-art treatments  ...  1 The Study of How to Articulate the Expression of Key Genes in Alzheimer،s Disease (AD) Bioinformatics Approaches and Analyzing Pathways Involved in Them  ... 
doi:10.29252/shefa.7.3.111 fatcat:zh35i4tf7jc55bzs53kz3tiine

XXVIIth Meeting of the Canadian Congress of Neurological Sciences -corrected - Program and Abstracts

1992 Canadian Journal of Neurological Sciences  
Patients with ZS had a cavum septum pellucidum and vergae evident on US (2), CT (5), and MRI (2); subependymal cysts on US (6), CT (2), and MRI (1).  ...  Abnormal white matter was present on MRI (1 IRD, 2 ZS), and CT (6 ZS, 2 IRD), of whom 3 had normal US.  ...  In physical trauma, rapid changes in extracellular ionic composition (a rise in potassium ([K + ] e ) and a fall in sodium concentrations) activates calcium channels, and is thought to cause a deleterious  ... 
doi:10.1017/s0317167100042359 fatcat:b2dhx6n4vzg2bpgohz6gojyhca

20th European Students' Conference. Promising medical scientists willing to look beyond

2009 European Journal of Medical Research  
Anaes thes i o l o g y Local versus systemic endomorphin 2 in a carrageenan model of inflammatory hyperalgesia  ...  So adipocyte stem cell application can be a benefit way for regeneration of non spacing making bone defects.  ...  Conclusion: There is no doubt that suicide is a multi-casual phenomenon, therapy and prevention should be complex and gender differences should be considered in developing of the efficient strategies to  ... 
doi:10.1186/2047-783x-14-s2-1 fatcat:md6csyjj3ra7xcwspqubslpgne

The 9th International Child Neurology Congress The 7th Asian and Oceanian Congress of Child Neurology

2002 Brain & development (Tokyo. 1979)  
Similarly, potassium channel genes are mutated in benign familial neonatal convulsions and sodium channel genes in GEFS 1 .  ...  Conclusion: CJ LPS could induce peripheral neuropathy, result in more expression of specific antibody and TNF-a on pathological fibers.  ...  Methods: We conducted a 1 year prospective therapeutic study with idebenone (5 mg/kg per day) in seven FRDA patients (age 8.5-27 years).  ... 
doi:10.1016/s0387-7604(02)00091-8 fatcat:oq3u62bpkfewhjytujmpwqqgiu

Poster Sessions

2011 Epilepsia  
In a prospective study we investigated hypovitaminosis-D and its risk factors.  ...  Method: This is a retrospective study, involving 67 patients admitted for SE at our institution from January 2003 to September 2010.  ...  Acknowledgments: Thanks to the University of Ngaoundere for its support.  ... 
doi:10.1111/j.1528-1167.2011.03207.x fatcat:77ayxa5tcbannis7zksyeo57ju


Srijit Das, Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
2019 Medicine & Health  
This study aimed to determine the involvement of KCNQ1 and KCNN4 K+ channels in epithelial wound healing in colorectal cancer (CRC).  ...  In this study, the anti-inflammatory role of 6TG and 6H2MP were evaluated in LPS-induced RAW264.7 cells and PMA-induced HIG-82 cell.  ... 
doi:10.17576/mh.2018.s1302 fatcat:bw564emkujdajmltgtdh5inkfu

Abstracts of Posters Presented at the International Anesthesia Research Society 80th Clinical and Scientific Congress San Francisco, California March 24-28, 2006

2006 Anesthesia and Analgesia  
sodium (Na + ); serum potassium (K + ); lactate and osmolarity.  ...  To investigate APC induced changes at the ion channel level, in the present study, we investigated the effects of APC on the cardiac sodium current (INa), a major depolarizing current in the heart responsible  ...  Methods: We examined the degree of neuroprotection at various concentrations (0-50 µM) of ketamine and TPS, alone and in combination in cortical cultures 24 hr exposed to NMDA or NOC.  ... 
doi:10.1213/01.ane.0000408553.72871.92 fatcat:tp4izd456rafdagsdswfkp2wya
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