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Thus, as a sub-database of H-InvDB, an integrated database of annotated human genes (http://h-invi tational.jp/), we constructed a fully curated database of evolutionary features of human genes, called ... Evola provides amino acid sequence alignments and phylogenetic trees of orthologs and homologs. In 'd N /d S view', natural selection on genes can be analyzed between human and other species. ... ACKNOWLEDGEMENTS We thank the members of Integrated Database Group, Japan Biological Information Research Center for their helpful suggestions. ...doi:10.1093/nar/gkm878 pmid:17982176 pmcid:PMC2238928 fatcat:xteys3cy2bdlvibwufigy7ivxm
ACKNOWLEDGEMENTS We acknowledge all the members of the H-Invitational 2 consortium and Genome Information Integration Project (GIIP), especially the staffs of JBIRC for construction of H-InvDB, Ryo Aono ... Sequence alignments and phylogenetic trees of the orthologous genes and homologous genes are shown in Evola. ... It provides sequence alignments and phylogenetic trees of manually curated orthologous genes among human and 11 model organisms, Pan troglodytes (chimpanzee), Macaca sp. ...doi:10.1093/nar/gkm999 pmid:18089548 pmcid:PMC2238988 fatcat:q4zm6oxqwfgifbvf74ce3543ma
Genetic determinism of cranial morphology is complex and largely unknown in humans. Animal models such as mice may be useful in identifying genes influencing skull morphogenesis. ... Our results show that, besides a strong effect, QTL on chromosome 1 interacts with genes on chromosomes 13 and 18. ... P42 Evola: ORTHOLOG DATABASE OF ALL HUMAN GENES IN H-InvDB WITH MANUAL CURATION OF PHYLOGENETIC TREES Ryuichi Sakate 1 , Akihiro Matsuya 1,2 , Yoshihiro Kawahara 1 , Yoshiharu Sato 1 , Takashi Gojobori ...doi:10.1039/c8sm90107d fatcat:tko5byj5izccvgfzmdsssx4mgm
We further found that PHQ bound to and interfered with the depolymerization of tubulin in vitro and arrested the cell cycle at G1 and G2/M. ... We therefore predicted that NER might be involved in suppression of spontaneous mutations, and analyzed base substitutions occurring spontaneously within the rpoB gene in NER-proficient (wildtype), -deficient ... We surveyed SNPs registered in dbSNP locating on GT-AG sites of all human gene exons, determined by the annotated human transcriptome database, H-InvDB. ...doi:10.1266/ggs.83.479 fatcat:saoqceianzfs7oyepgy7voo2jm
The HUGO Journal
We would like to extend our utmost appreciation to them for all of their support. ... The identification of an EYS mutation in a dog affected with retinal progressive atrophy would provide a useful model for establishing future therapies for retinitis pigmentosa. ... H-InvDB consists of three main views, the Transcript view, the Locus view and the Protein view, and six sub-databases; G-integra, H-ANGEL, DiseaseInfo Viewer, Evola, PPI view and Gene Family/Group view ...doi:10.1007/s11568-010-9143-0 fatcat:oykxd6u7snfi5o7m6tst7wi6yq