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Evidence of a modality-dependent role of the cerebellum in working memory? An fMRI study comparing verbal and abstract n-back tasks

Hubertus Hautzel, Felix M. Mottaghy, Karsten Specht, Hans-Wilhelm Müller, Bernd J. Krause
2009 NeuroImage  
working memory Cerebellum fMRI In working memory (WM), functional imaging studies demonstrate cerebellar involvement indicating a cognitive role of the cerebellum.  ...  A direct comparison of verbal and abstract visual WM was performed in 17 young volunteers by applying a 2back paradigm and extracting the % change in BOLD signal from the fMRI data.  ...  Discussion The present study revealed an almost identical cerebellar activation pattern when comparing percent change of BOLD signal in a verbal WM task with an abstract WM task on a lobule by lobule basis  ... 
doi:10.1016/j.neuroimage.2009.06.005 pmid:19524048 fatcat:7xfxp2zjfbg7fjrbzhdyp3kp4u

Involvement of the cerebellar cortex and nuclei in verbal and visuospatial working memory: A 7T fMRI study

M. Thürling, H. Hautzel, M. Küper, M.R. Stefanescu, S. Maderwald, M.E. Ladd, D. Timmann
2012 NeuroImage  
One group of subjects (n = 21) performed an abstract and a verbal version of an n-back task contrasting a 2back and 0-back condition.  ...  On the one hand, the lack of difference between abstract and verbal n-back tasks and the lack of significant lateralization suggest a more general contribution of the cerebellum to working memory regardless  ...  Acknowledgments The study was supported by the German Research Foundation (DFG TI 239/9-1) and a grant by the European Union (Marie Curie Initial Training Network "Cerebellar-Cortical Control: Cells, Circuits  ... 
doi:10.1016/j.neuroimage.2012.05.037 pmid:22634219 fatcat:b5jqz7ujnjdhlh3duuorwvsvca

Learning and memory [chapter]

Anna-katharine Brem, Kathy Ran, Alvaro Pascual-leone
2013 Handbook of Clinical Neurology  
INTRODUCTION A fairly large number of studies to date have investigated the nature of learning and memory processes in brain-injured and healthy subjects with noninvasive brain stimulation (NBS) methods  ...  Then we provide a systematic and comprehensive summary of available research that investigates the neurobiological substrates of memory and aims to improve memory functions in patient populations, as well  ...  Work on this study was supported by grants from the National Center for Research Resources: Harvard Clinical and Translational Science Center/Harvard Catalyst (UL1 RR025758), and investigator-initiated  ... 
doi:10.1016/b978-0-444-53497-2.00055-3 pmid:24112934 pmcid:PMC4248571 fatcat:xgnntahdergq7ov3ooj4irjvt4

Working Memory From the Psychological and Neurosciences Perspectives: A Review

Wen Jia Chai, Aini Ismafairus Abd Hamid, Jafri Malin Abdullah
2018 Frontiers in Psychology  
Recent studies have subsequently implicated the roles of subcortical regions (such as the midbrain and cerebellum) in working memory.  ...  In the present article, the authors provide an overview of several working memory-relevant studies in order to harmonize the findings of working memory from the neurosciences and psychological standpoints  ...  As demonstrated in the study using fMRI, the nature of the task (such as verbal or visual-spatial) might have played a role as a higher level of testosterone (in males) correlated with activations of the  ... 
doi:10.3389/fpsyg.2018.00401 pmid:29636715 pmcid:PMC5881171 fatcat:ps2z76pwnnarxp26ltanhbeuba

Maintenance of real objects and their verbal designations in working memory

Stefan Kaiser, Marie-Luise Kopka, Mirjam Rentrop, Stephan Walther, Klaus Kronmüller, Robert Olbrich, Matthias Weisbrod, Christoph Stippich
2010 Neuroscience Letters  
Both of these studies have used n-back tasks that do not allow the separation of maintenance from encoding and retrieval.  ...  Hautzel and colleagues found no difference in prefrontal or posterior brain regions in a blocked n-back task [14] .  ... 
doi:10.1016/j.neulet.2009.11.045 pmid:19932154 fatcat:i5w5qfxmpjdftg7qyuwnyfh2va

Distinct functional and structural neural underpinnings of working memory

Max M. Owens, Bryant Duda, Lawrence H. Sweet, James MacKillop
2018 NeuroImage  
Participants were a large sample of adults from the Human Connectome Project (N = 1064; 54% female) who completed an in-scanner visual N-back WM task.  ...  Working memory (WM), the short-term abstraction and manipulation of information, is an essential neurocognitive process in daily functioning.  ...  No funding sources were involved in study design or collection, analysis, and interpretation of the data. These findings do not reflect the official position of the National Institutes of Health.  ... 
doi:10.1016/j.neuroimage.2018.03.022 pmid:29551458 pmcid:PMC6908808 fatcat:udgv6wuaibhphhapjj3cikttmi

Working Memory: A View from Neuroimaging

Edward E. Smith, John Jonides
1997 Cognitive Psychology  
In our second kind of experiment we have focused on verbal working memory and incrementally varied one task parameter-memory load-in an effort to obtain a more fine-grained analysis of the system's operations  ...  These studies indicate that: (a) there are different working-memory systems for spatial, object, and verbal information (with the spatial system localized more in the right hemisphere, and the verbal system  ...  We employed it in the experiments described in this section. Effects of Continuous Variations in Verbal Working-Memory Load An n-back experiment.  ... 
doi:10.1006/cogp.1997.0658 pmid:9212720 fatcat:xduerdlkdzbupfa7nvm76vxpd4

Neural and Behavioral Effects of an Adaptive Online Verbal Working Memory Training in Healthy Middle-Aged Adults

Mónica Emch, Isabelle Ripp, Qiong Wu, Igor Yakushev, Kathrin Koch
2019 Frontiers in Aging Neuroscience  
Neural correlates of working memory (WM) training remain a matter of debate, especially in older adults.  ...  We used functional magnetic resonance imaging (fMRI) together with an n-back task to measure brain plasticity in healthy middle-aged adults following an 8-week adaptive online verbal WM training.  ...  ACKNOWLEDGMENTS The authors wish to thank the scanner technicians: Sylvia Schachoff, Claudia Meisinger, Anna Winter, Brigitte Mackert, and all the participants.  ... 
doi:10.3389/fnagi.2019.00300 pmid:31736741 pmcid:PMC6838657 fatcat:a757rrtsqbhmxloccmjtoduqke

Early 'visual' cortex activation correlates with superior verbal memory performance in the blind

Amir Amedi, Noa Raz, Pazit Pianka, Rafael Malach, Ehud Zohary
2003 Nature Neuroscience  
Using functional magnetic resonance imaging (fMRI) in ten congenitally blind human participants, we found robust occipital activation during a verbal-memory task (in the absence of any sensory input),  ...  No such occipital activation was found in sighted subjects. This difference between the groups was mirrored by superior performance of the blind in various verbal-memory tasks.  ...  No correlation was found between V1 activation during the auditory noise one-back task (which required the use of nonverbal working memory) and per-formance in the Wechsler memory tests (Pearson's r <  ... 
doi:10.1038/nn1072 pmid:12808458 fatcat:3gs4ufebnbbvvk56rr22s76xm4

Selective transfer of visual working memory training on Chinese character learning

Bertram Opitz, Julia A. Schneiders, Christoph M. Krick, Axel Mecklinger
2014 Neuropsychologia  
This issue was explored in the present experiment by comparing visual working memory training with an active (auditory working memory training) control condition and a passive, no training control condition  ...  We, therefore, suggest that the conjoint activity of the mid-fusiform gyrus and the precuneus after visual working memory training reflects an interaction of working memory and imagery processes with complex  ...  We observed training gains in the n-back working memory tasks for the visual working memory training group that allowed us to compare the transfer effects on performance and neural activation changes in  ... 
doi:10.1016/j.neuropsychologia.2013.10.017 pmid:24184440 fatcat:assijbfbvjdmvnxtzhiojrn6t4

Multiple interactive memory representations underlie the induction of false memory

Bi Zhu, Chuansheng Chen, Xuhao Shao, Wenzhi Liu, Zhifang Ye, Liping Zhuang, Li Zheng, Elizabeth F. Loftus, Gui Xue
2019 Proceedings of the National Academy of Sciences of the United States of America  
By manipulating the sensory modalities (visual and auditory) at different processing stages (learning and test) in the Deese–Roediger–McDermott task, we found that the auditory-learning visual-test (AV  ...  pole as a result of auditory learning.  ...  Craig Stark for helpful comments on an early version of the manuscript.  ... 
doi:10.1073/pnas.1817925116 fatcat:fw4kb6ifejdivetov3d2chskxu

Working memory circuit as a function of increasing age in healthy adolescence: A systematic review and meta-analyses

Julia Andre, Marco Picchioni, Ruibin Zhang, Timothea Toulopoulou
2016 NeuroImage: Clinical  
Deficits in working memory are linked to the risk of onset of neurodevelopmental disorders such as schizophrenia, and there is a significant temporal overlap between the peak of first episode psychosis  ...  of all the available primary functional magnetic resonance imaging studies (n = 382) that mapped WM function in healthy adolescents (10-17 years) and young adults (18-30 years).  ...  These differed according to task subtype, control task, memory modality and stimulus types.  ... 
doi:10.1016/j.nicl.2015.12.002 pmid:27995059 pmcid:PMC5153561 fatcat:ihvmz67jenbqbnkkd4yqiypnv4

Modelling neural correlates of working memory: A coordinate-based meta-analysis

C. Rottschy, R. Langner, I. Dogan, K. Reetz, A.R. Laird, J.B. Schulz, P.T. Fox, S.B. Eickhoff
2012 NeuroImage  
Moreover, impairments of working memory functions may be found in nearly all neurological and psychiatric diseases.  ...  Moreover, the lateral prefrontal cortex showed a division in a rostral and a caudal part based on differential involvement in task set and load effects.  ...  Acknowledgments This work was partly funded by the Human Brain Project (R01-MH074457-01A1), the Helmholtz Alliance on Systems Biology (Human Brain Model), the DFG (IRTG 1328) and the medical faculty of  ... 
doi:10.1016/j.neuroimage.2011.11.050 pmid:22178808 pmcid:PMC3288533 fatcat:54b2zwpqm5esfpog6zmbe2xsuu

The Functional Organization of Auditory Working Memory as Revealed by fMRI

Stephen R. Arnott, Cheryl L. Grady, Stephanie J. Hevenor, Simon Graham, Claude Alain
2005 Journal of Cognitive Neuroscience  
, consistent with results from visual working memory studies. & D  ...  In the present functional magnetic resonance imaging experiment, participants encoded and maintained either the location or the identity of a sound for a delay period of several seconds and then subsequently  ...  The data reported in this experiment have been deposited in the fMRI Data Center ( The accession number is 2-2005-118HA.  ... 
doi:10.1162/0898929053747612 pmid:15904548 fatcat:5whpayom5baxvmj4qa34c6ljym

N-back working memory paradigm: A meta-analysis of normative functional neuroimaging studies

Adrian M. Owen, Kathryn M. McMillan, Angela R. Laird, Ed Bullmore
2005 Human Brain Mapping  
One of the most popular experimental paradigms for functional neuroimaging studies of working memory has been the n-back task, in which subjects are asked to monitor the identity or location of a series  ...  Here, it provides evidence both for broadly consistent activation of frontal and parietal cortical regions by various versions of the n-back working memory paradigm, and for process-and content-specific  ...  Because of its widespread usage in a number of domains, the n-back task is an ideal candidate for such an approach and a wealth of relevant data already exists in the published literature.  ... 
doi:10.1002/hbm.20131 pmid:15846822 fatcat:tc25d2jivvcx5aztr733tw6wze
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