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Event-Based Modeling with High-Dimensional Imaging Biomarkers for Estimating Spatial Progression of Dementia [article]

Vikram Venkatraghavan and Florian Dubost and Esther E. Bron and Wiro J. Niessen and Marleen de Bruijne and Stefan Klein
<span title="2019-03-08">2019</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Event-based models (EBM) are a class of disease progression models that can be used to estimate temporal ordering of neuropathological changes from cross-sectional data.  ...  Therefore, we propose a novel method that exploits high-dimensional voxel-wise imaging biomarkers: n-dimensional discriminative EBM (nDEBM). nDEBM is based on an insight that mixture modeling, which is  ...  Discussions We proposed a novel method (nDEBM) that exploits high-dimensional voxelwise imaging biomarkers for event-based modeling using semi-supervised SVM.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1903.03386v1">arXiv:1903.03386v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ydxme6q4zbfybd37p2h2vtndre">fatcat:ydxme6q4zbfybd37p2h2vtndre</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191020205229/https://arxiv.org/pdf/1903.03386v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0e/3a/0e3a5731073ad8725788b9ca1c704d60669949d5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1903.03386v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Editorial: Predictive Intelligence in Biomedical and Health Informatics

E. Adeli, S. H. Rekik, S. H. Park, D. Shen
<span title="">2020</span> <i title="Institute of Electrical and Electronics Engineers (IEEE)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/q2z26obphvchndqieqd65vltle" style="color: black;">IEEE journal of biomedical and health informatics</a> </i> &nbsp;
Using predictive analytics based on electronic health record (EHR) for hospital readmission is faced with multiple challenges such as high dimensionality and event sparsity of medical codes and the class  ...  and high-dimensional medical data into the future with high precision.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/jbhi.2019.2962852">doi:10.1109/jbhi.2019.2962852</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mp2kymg7yjb7ziukia7kjgjula">fatcat:mp2kymg7yjb7ziukia7kjgjula</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201108140235/https://ieeexplore.ieee.org/ielx7/6221020/8984617/08984668.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/92/f4/92f4c067f001b3e821dc4d287ac64d64d71f7636.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/jbhi.2019.2962852"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia

Jessica L Panman, Vikram Venkatraghavan, Emma L van der Ende, Rebecca M E Steketee, Lize C Jiskoot, Jackie M Poos, Elise G P Dopper, Lieke H H Meeter, Laura Donker Kaat, Serge A R B Rombouts, Meike W Vernooij, Anneke J A Kievit (+11 others)
<span title="2021-01-15">2021</span> <i title="BMJ"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hy257cksnngbdoh3z3erevh7h4" style="color: black;">Journal of Neurology, Neurosurgery and Psychiatry</a> </i> &nbsp;
We used discriminative event-based modelling to infer the cascade of biomarker changes in FTD-GRN and estimated individual disease severity through cross-validation.  ...  ObjectiveProgranulin-related frontotemporal dementia (FTD-GRN) is a fast progressive disease.  ...  Recently, novel data-driven methods for disease progression modelling have emerged, focusing on the cascade of biomarker changes. 12 13 Event-based models are a class of disease progression models that  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/jnnp-2020-323541">doi:10.1136/jnnp-2020-323541</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33452053">pmid:33452053</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8053353/">pmcid:PMC8053353</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/v4cox5wi5ncsrif5kmdqnpdvnu">fatcat:v4cox5wi5ncsrif5kmdqnpdvnu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210716085748/https://jnnp.bmj.com/content/jnnp/92/5/494.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/59/b6/59b6db02eefbc63c516531743e9d23d8cf788220.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/jnnp-2020-323541"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> bmj.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053353" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Imaging plus X

Neil P. Oxtoby, Daniel C. Alexander
<span title="">2017</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mvqxlm5kejeaxffyrgyswferqu" style="color: black;">Current Opinion in Neurology</a> </i> &nbsp;
For example, event-based models have revealed finer graded understanding of progression patterns; self-modelling regression and differential equation models have provided data-driven biomarker trajectories  ...  Summary The emerging field of disease progression modelling provides a natural mechanism to integrate different kinds of information, for example from imaging, serum and cerebrospinal fluid markers and  ...  disease progression modelling.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1097/wco.0000000000000460">doi:10.1097/wco.0000000000000460</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28520598">pmid:28520598</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5491241/">pmcid:PMC5491241</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yxaqza7tl5cezch5kdzcpfhreq">fatcat:yxaqza7tl5cezch5kdzcpfhreq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190224044448/http://pdfs.semanticscholar.org/52af/a1ff8e5b72d0e1e6fd909f08caf56d3d2ba4.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/52/af/52afa1ff8e5b72d0e1e6fd909f08caf56d3d2ba4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1097/wco.0000000000000460"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491241" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Modelling the Neuroanatomical Progression of Alzheimer's Disease and Posterior Cortical Atrophy [article]

Razvan V. Marinescu
<span title="2020-02-29">2020</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
My first contribution is a study on the progression of Posterior Cortical Atrophy, using models already developed: the Event-based Model (EBM) and the Differential Equation Model (DEM).  ...  My second contribution is the development of DIVE, a novel spatio-temporal model of disease progression that estimates fine-grained spatial patterns of pathology, potentially enabling us to understand  ...  Secondly, I'd also like to thank Alexandra Young and Neil Oxtoby for teaching me disease progression modelling, especially in the early years of my PhD.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2003.04805v1">arXiv:2003.04805v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/a5gmy75lvnfnhbtvztqoxikukm">fatcat:a5gmy75lvnfnhbtvztqoxikukm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200320204619/https://arxiv.org/pdf/2003.04805v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2003.04805v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Predicting progression from mild cognitive impairment to Alzheimer's disease on an individual subject basis by applying the CARE index across different independent cohorts

Jiu Chen, Gang Chen, Hao Shu, Guangyu Chen, B. Douglas Ward, Zan Wang, Duan Liu, Piero G. Antuono, Shi-Jiang Li, Zhijun Zhang
<span title="2019-04-30">2019</span> <i title="Impact Journals, LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vjgpqrqckbe5xfxuw2ce3r5nfa" style="color: black;">Aging</a> </i> &nbsp;
Using an event-based probabilistic model approach to integrate widely available biomarkers from behavioral data and brain structural and functional imaging, we calculated the CARE index.  ...  The purposes of this study are to investigate whether the Characterizing Alzheimer's disease Risk Events (CARE) index can accurately predict progression from mild cognitive impairment (MCI) to Alzheimer's  ...  The CARE index estimates the probabilities of occurrence and nonoccurrence of a series of biomarkers by using an event-based probabilistic model [16] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/aging.101883">doi:10.18632/aging.101883</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31078129">pmid:31078129</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6520016/">pmcid:PMC6520016</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fmitkvqxszb7xoa6eub2k4tnzy">fatcat:fmitkvqxszb7xoa6eub2k4tnzy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200508235755/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6520016&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/92/42/9242cf463fd495c63575c522ecb9d95fe3e4c432.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/aging.101883"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520016" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Alliance for Aging Research AD Biomarkers Work Group: structural MRI

Clifford R. Jack
<span title="">2011</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/h77v7bacwjdqjifp5ymnikreee" style="color: black;">Neurobiology of Aging</a> </i> &nbsp;
Finally, the place of MRI in a hypothetical model of temporal ordering of AD biomarkers is reviewed.  ...  Biomarkers serve as proxies for specific pathophysiological features of disease.  ...  Acknowledgments The Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation, USA, and the Robert H. and Clarice Smith Alzheimer's Disease Research Program of the Mayo Foundation  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neurobiolaging.2011.09.011">doi:10.1016/j.neurobiolaging.2011.09.011</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22078173">pmid:22078173</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3661287/">pmcid:PMC3661287</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kyu6vx6a6rezlb4j6laq5emgte">fatcat:kyu6vx6a6rezlb4j6laq5emgte</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211101711/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3661287&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/64/b9/64b997ec8f4a392558b235e061d9d732f6b99fef.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neurobiolaging.2011.09.011"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661287" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Functional MRI Biomarkers Predicting Cognitive Progression in Parkinson's Disease: Protocol for a Prospective Longitudinal Cohort Study (Preprint)

Brenda Hanna-Pladdy, Rao Gullapalli, Hegang Chen
<span title="2018-11-20">2018</span> <i title="JMIR Publications Inc."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vl2vw6ob4raljjnl7vi26tsnsi" style="color: black;">JMIR Research Protocols</a> </i> &nbsp;
Identification of biomarkers with sensitivity for early prediction and estimation of risk for conversion to dementia in PD will pave the way for effective intervention with neuroprotective therapies during  ...  The primary pathological substrate for cognitive decline in PD is unclear, and there are no reliable biomarkers predicting the risk of conversion to dementia.  ...  and funding provided by the National Institute of Aging.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2196/12870">doi:10.2196/12870</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31033450">pmid:31033450</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6660119/">pmcid:PMC6660119</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nrcnwkqtifcf3htjcrz6q3ewee">fatcat:nrcnwkqtifcf3htjcrz6q3ewee</a> </span>
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Challenges of Integrative Disease Modeling in Alzheimer's Disease

Sepehr Golriz Khatami, Christine Robinson, Colin Birkenbihl, Daniel Domingo-Fernández, Charles Tapley Hoyt, Martin Hofmann-Apitius
<span title="2020-01-14">2020</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zqzewb742bdglfxhkef3ke6cla" style="color: black;">Frontiers in Molecular Biosciences</a> </i> &nbsp;
Previous approaches for characterizing AD were targeted at single aspects of the disease. Yet, due to the complex nature of AD, the success of these approaches was limited.  ...  However, in recent years, advancements in integrative disease modeling, built on a wide range of AD biomarkers, have taken a global view on the disease, facilitating more comprehensive analysis and interpretation  ...  Event-based models estimate the most probable sequence of events based on the assessment of a probability density function for a particular event order.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fmolb.2019.00158">doi:10.3389/fmolb.2019.00158</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31993440">pmid:31993440</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6971060/">pmcid:PMC6971060</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5uizjucmbrfxzhvmp7kh6dk4sm">fatcat:5uizjucmbrfxzhvmp7kh6dk4sm</a> </span>
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Cascading network failure across the Alzheimer's disease spectrum

David T. Jones, David S. Knopman, Jeffrey L. Gunter, Jonathan Graff-Radford, Prashanthi Vemuri, Bradley F. Boeve, Ronald C. Petersen, Michael W. Weiner, Clifford R. Jack
<span title="2015-11-19">2015</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3yly6om4ynhcta4fdjenhrdk5y" style="color: black;">Brain</a> </i> &nbsp;
spectrum; and (ii) high connectivity between the posterior default mode network and hubs of high connectivity (many located in the frontal lobe) is associated with amyloid accumulation.  ...  This model predicts a connectivity 'overload' that precedes structural and functional declines and recasts the interpretation of high connectivity from that of a positive compensatory phenomenon to that  ...  We would also like to thank Joe Fleming of Joe Motion (www.joemotion.tv) for invaluable assistance with thumbnails and cover art.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awv338">doi:10.1093/brain/awv338</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26586695">pmid:26586695</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4805086/">pmcid:PMC4805086</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kg4cu4jwavg7ldapbme54uteau">fatcat:kg4cu4jwavg7ldapbme54uteau</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190228012933/http://pdfs.semanticscholar.org/89d1/9a1db4137d7ef15ab6508d4df54d610bdda8.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/89/d1/89d19a1db4137d7ef15ab6508d4df54d610bdda8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awv338"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805086" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Sino Longitudinal Study on Cognitive Decline (SILCODE): protocol for a Chinese longitudinal observational study to develop risk prediction models of conversion to mild cognitive impairment in individuals with subjective cognitive decline

Xuanyu Li, Xiaoni Wang, Li Su, Xiaochen Hu, Ying Han
<span title="2019-07-26">2019</span> <i title="BMJ"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/cadiaxy7y5alle7oylyd7rqmnu" style="color: black;">BMJ Open</a> </i> &nbsp;
The least absolute shrinkage and selection operator logistic regression model followed by the sub-distribution hazard function model with death as a competing risk will be constructed to establish risk  ...  Subjects will be contacted by telephone every 3 months and interviewed, on average, every 15 months for 5 years. The study endpoint is the development of mild cognitive impairment or dementia.  ...  It is a data mining method for shrinkage estimation and dimensionality reduction, overcoming processing difficulties caused by high-dimensional data, and estimating the parameters more accurately.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/bmjopen-2018-028188">doi:10.1136/bmjopen-2018-028188</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31350244">pmid:31350244</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6661672/">pmcid:PMC6661672</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kj2usy3f2fer3anx67p7tgkwwu">fatcat:kj2usy3f2fer3anx67p7tgkwwu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200213083950/https://bmjopen.bmj.com/content/bmjopen/9/7/e028188.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/68/8e/688edf744bcb875484f88fac61bc80fa583c78b9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/bmjopen-2018-028188"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> bmj.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661672" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

DIVE: A spatiotemporal progression model of brain pathology in neurodegenerative disorders

Răzvan V. Marinescu, Arman Eshaghi, Marco Lorenzi, Alexandra L. Young, Neil P. Oxtoby, Sara Garbarino, Sebastian J. Crutch, Daniel C. Alexander
<span title="2019-03-04">2019</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
DIVE is an image-based disease progression model with single-vertex resolution, designed to reconstruct long-term patterns of brain pathology from short-term longitudinal data sets.  ...  DIVE further estimates the disease stage and progression speed for every visit of every subject, potentially enhancing stratification for clinical trials or management.  ...  Acknowledgements This work was supported by the EPSRC Centre for Doctoral Training in Medical Imaging with grant EP/L016478/1. A.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2019.02.053">doi:10.1016/j.neuroimage.2019.02.053</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30844504">pmid:30844504</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gxq53thcfjhm3ohvggrdbaxway">fatcat:gxq53thcfjhm3ohvggrdbaxway</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190429123432/http://discovery.ucl.ac.uk/10070052/1/1-s2.0-S1053811919301491-main%20%281%29.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a9/7f/a97fc7bbb4b76f2c46ec91b9b99b8eb8dc7ed945.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2019.02.053"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a>

A Non Invasive Biomarkers for Alzheimer's disease Detection

<span title="2019-08-29">2019</span> <i title="Blue Eyes Intelligence Engineering and Sciences Engineering and Sciences Publication - BEIESP"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3sfifsouvjgadp4gfj54u3z2ku" style="color: black;">International journal of recent technology and engineering</a> </i> &nbsp;
Objective of this survey is to review the non-invasive biomarkers that could be used to predict early onset of AD and delay cognitive impairment.  ...  Present need demands the discovery of diagnostic and prognostic patient specific effective biomarkers to improve patient's life quality and avoid big healthcare costs.  ...  A diffusion model with impulsive sources over the brain connectivity network was suggested to model the progress of brain atrophy.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.35940/ijrte.b1001.0782s519">doi:10.35940/ijrte.b1001.0782s519</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/af6kyeyxknalvj2vkwxtbwg3oe">fatcat:af6kyeyxknalvj2vkwxtbwg3oe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209081959/https://www.ijrte.org/wp-content/uploads/papers/v8i2S5/B10010682S519.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e3/34/e3347390cec1e11670d902b2cd6b9c89d635eb13.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.35940/ijrte.b1001.0782s519"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

The Road to Personalized Medicine in Alzheimer's Disease: The Use of Artificial Intelligence

Anuschka Silva-Spínola, Inês Baldeiras, Joel P. Arrais, Isabel Santana
<span title="2022-01-29">2022</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jgmgd4z6dzhzziggcczoforhve" style="color: black;">Biomedicines</a> </i> &nbsp;
Alzheimer's disease (AD) accounts for the majority of dementia cases and stands as the most common neurodegenerative disease.  ...  In this review, we present an overview of relevant topics regarding the application of AI in AD, detailing the algorithms and their applications in the fields of drug discovery, and biomarkers.  ...  Acknowledgments: The authors want to acknowledge and thank the support given by the multidisciplinary teams that are part of the affiliated institutions.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/biomedicines10020315">doi:10.3390/biomedicines10020315</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35203524">pmid:35203524</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8869403/">pmcid:PMC8869403</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/axujetc3fbfglezmd4nbkwh2yu">fatcat:axujetc3fbfglezmd4nbkwh2yu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220130050705/https://mdpi-res.com/d_attachment/biomedicines/biomedicines-10-00315/article_deploy/biomedicines-10-00315.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1e/aa/1eaa3efeafa3dafbf908a579a784f43a3fd0b5b0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/biomedicines10020315"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869403" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Five-year biomarker progression variability for Alzheimer's disease dementia prediction: Can a complex instrumental activities of daily living marker fill in the gaps?

Ioannis Tarnanas, Anthoula Tsolaki, Mark Wiederhold, Brenda Wiederhold, Magda Tsolaki
<span title="">2015</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/y5b3apqmfve23ds3kch2bvmcxa" style="color: black;">Alzheimer&#39;s and Dementia: Diagnosis, Assessment and Disease Monitoring</a> </i> &nbsp;
This study examines progressions of established biomarkers along with a novel marker in a longitudinal cognitive decline.  ...  We calculated standardized biomarker progression rates and used them as predictors of outcome within 5 years.  ...  The authors state that no conflicts of interest exist for this study.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.dadm.2015.10.005">doi:10.1016/j.dadm.2015.10.005</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27239530">pmid:27239530</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4879487/">pmcid:PMC4879487</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vi2hn5nfxrds3omgqngce3aafu">fatcat:vi2hn5nfxrds3omgqngce3aafu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170927114321/http://publisher-connector.core.ac.uk/resourcesync/data/elsevier/pdf/51f/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS9zMjM1Mjg3MjkxNTAwMDg0Ng%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/90/23/90232d406d69d31744beee5094fa5988103e85a8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.dadm.2015.10.005"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879487" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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