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Evaluation of geometric features as biomarkers of diabetic retinopathy for characterizing the retinal vascular changes during the progression of diabetes

Georgios Leontidis, Bashir Al-Diri, Jeffrey Wigdahl, Andrew Hunter
2015 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)  
However, until now, it is unclear how different features, extracted from the retinal vasculature, can be associated with the progression of diabetes and therefore become biomarkers of DR.  ...  Diabetic retinopathy (DR) has been widely studied and characterized.  ...  This feature could possibly identify changes in the vessels' junctions as a whole, giving us an indication of the adaptation of the junctions during the progression of diabetes.  ... 
doi:10.1109/embc.2015.7319577 pmid:26737477 dblp:conf/embc/LeontidisAWH15 fatcat:yiy7s2wsybbujpkvcw7gne6bsu

Spectropathology-corroborated multimodal quantitative imaging biomarkers for neuroretinal degeneration in diabetic retinopathy

Arpan Guha Mazumder, Swarnadip Chatterjee, Saunak Chatterjee, Juan Jose Gonzalez, Swarnendu Bag, Sambuddha Ghosh, Anirban Mukherjee, Jyotirmoy Chatterjee
2017 Clinical Ophthalmology  
Image-based early detection for diabetic retinopathy (DR) needs value addition due to lack of well-defined disease-specific quantitative imaging biomarkers (QIBs) for neuroretinal degeneration and spectropathological  ...  OCT, fundoscopy, and FA provided geometrical as well as optical features.  ...  The authors also acknowledge the Fulbright Foreign Scholarship Board (FFSB), Washington, DC, USA, as well as the United States-India Educational Foundation (USIEF) (grantee ID 15141659), India, for providing  ... 
doi:10.2147/opth.s140110 pmid:29200821 pmcid:PMC5703157 fatcat:g4bexr6c6zc3fekrt3cc3pwjtu

Retinal Vascular Caliber as a Biomarker for Diabetes Microvascular Complications

M. K. Ikram, C. Y. Cheung, M. Lorenzi, R. Klein, T. L. Z. Jones, T. Y. Wong
2013 Diabetes Care  
., and T.Y.W. reviewed and edited the manuscript. All authors and collaborators approved the final version of the manuscript. APPENDIXdCollaborators  ...  AcknowledgmentsdNo potential conflicts of interest relevant to this article were reported. M.K.I., C.Y.C., and M.L. wrote the manuscript.  ...  NEWER METHODS FOR DYNAMIC STUDIES OF RETINAL VESSELSdFurther, the development of retinal vascular caliber changes as a robust biomarker of risk for retinopathy and other microvascular complications of  ... 
doi:10.2337/dc12-1554 pmid:23431093 pmcid:PMC3579354 fatcat:jgnxzyp76neyfkau5yjlvdgwri

Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside

Søren Leer Blindbæk, Thomas Lee Torp, Kristian Lundberg, Kerstin Soelberg, Anna Stage Vergmann, Christina Døfler Poulsen, Ulrik Frydkjaer-Olsen, Rebecca Broe, Malin Lundberg Rasmussen, Jimmi Wied, Majbrit Lind, Anders Højslet Vestergaard (+2 others)
2017 Journal of Diabetes Research  
The retinal vascular system is the only part of the human body available for direct, in vivo inspection.  ...  Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy.  ...  Acknowledgments The authors thank the VELUX Foundation, the Danish Diabetes Academy supported by the Novo Nordisk Foundation, the University of Southern Denmark, the Region of Southern Denmark, Odense  ... 
doi:10.1155/2017/2562759 pmid:28491870 pmcid:PMC5406729 fatcat:pe7qx23mijgbhcjzzmnx7hhjae

Exploiting the Retinal Vascular Geometry in Identifying the Progression to Diabetic Retinopathy Using Penalized Logistic Regression and Random Forests [chapter]

Georgios Leontidis, Bashir Al-Diri, Andrew Hunter
2016 Studies in Computational Intelligence  
A statistical mixed model design was used to evaluate the significance of the changes between two periods: three years before the onset of diabetic retinopathy and the first year of diabetic retinopathy  ...  Identifying and quantifying the retinal vascular changes remains a very challenging task, due to the heterogeneity of the retina.  ...  Acknowledgements This research study was supported by a Marie Sklodowska-Curie grant from the European Commission in the framework of the REVAMMAD ITN (Initial Training Research network), Project number  ... 
doi:10.1007/978-3-319-33353-3_20 fatcat:ijru3wvc7vb7dn3fty3mb2palu

Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?

Akanksha Gupta, Sonika Bhatnagar
2015 Omics  
We argue here that there is a parallel between characteristic features of vasoregression in the ocular microvessels and atherosclerosis in the larger vessels.  ...  Shared molecular pathways and molecular effectors in the two conditions are outlined, thus highlighting the possible systemic causes of local vascular diseases.  ...  Acknowledgment AG acknowledges financial support from Netaji Subhas Institute of Technology.  ... 
doi:10.1089/omi.2015.0128 pmid:26669709 pmcid:PMC4684001 fatcat:rraemqs2ozhg3c2q2mdjlgbciu

Retinal biomarkers for Alzheimer's disease and vascular cognitive impairment and dementia (VCID): implication for early diagnosis and prognosis

Cecilia Czakó, Tibor Kovács, Zoltan Ungvari, Anna Csiszar, Andriy Yabluchanskiy, Shannon Conley, Tamas Csipo, Agnes Lipecz, Hajnalka Horváth, Gábor László Sándor, Lilla István, Trevor Logan (+2 others)
2020 GeroScience  
as thickness of the inner retinal layers, retinal vessel density, foveal avascular zone area, tortuosity and fractal dimension of retinal vessels, and microvascular dysfunction—for cognitive impairment  ...  Should further studies need to be conducted, these retinal alterations may prove to be useful biomarkers for screening and monitoring dementia progression in clinical routine.  ...  Being a public health concern worldwide, identifying retinal biomarkers of dementia is crucial for early diagnosis as well as evaluating the efficacy of novel therapies.  ... 
doi:10.1007/s11357-020-00252-7 pmid:33011937 fatcat:fba57lp3bfe2ff6cg2kqf6vcaq

Investigating Vascular Complexity and Neurogenic Alterations in Sectoral Regions of the Retina in Patients With Cognitive Impairment

Delia Cabrera DeBuc, William J. Feuer, Patrice J. Persad, Gabor Mark Somfai, Maja Kostic, Susel Oropesa, Carlos Mendoza Santiesteban
2020 Frontiers in Physiology  
Analysis of combined structural-functional parameters in sectoral regions of the retina, instead of individual retinal biomarkers, may provide a useful clinical marker of CI.  ...  Quantification of the retinal structure was performed in retinal fundus images [45 o field of view (FOV), optic disk centered] with excellent quality for all individuals [19 healthy controls (HC) and 20  ...  Still, they couldn't find significant differences in the retinal vascular network for either diabetic patients, with or without non-proliferative diabetic retinopathy when comparing the generalized dimensions  ... 
doi:10.3389/fphys.2020.570412 pmid:33240097 pmcid:PMC7680898 fatcat:x32ninltenhyplsyemgon2wkty

Automated Diabetic Retinopathy Screening and Monitoring Using Retinal Fundus Image Analysis

Malavika Bhaskaranand, Chaithanya Ramachandra, Sandeep Bhat, Jorge Cuadros, Muneeswar Gupta Nittala, SriniVas Sadda, Kaushal Solanki
2016 Journal of Diabetes Science and Technology  
Diabetic retinopathy (DR) is a common microvascular complication of diabetes that affects nearly all the type 1 diabetes patients and >60% of type 2 diabetes patients 1 and is the leading cause of new-onset  ...  Diabetic retinopathy (DR)-a common complication of diabetes-is the leading cause of vision loss among the working-age population in the western world.  ...  Abbreviations AUROC, area under receiver operating characteristic curve; DR, diabetic retinopathy; HOG, histogram of gradients; ICDR, International Clinical Diabetic Retinopathy; MA, microaneurysm; ME,  ... 
doi:10.1177/1932296816628546 pmid:26888972 pmcid:PMC4773978 fatcat:phjb52pxbzfojh5vy6ir3g7eyi

Investigating Multimodal Diagnostic Eye Biomarkers of Cognitive Impairment by Measuring Vascular and Neurogenic Changes in the Retina

Delia Cabrera DeBuc, Gabor Mark Somfai, Edmund Arthur, Maja Kostic, Susel Oropesa, Carlos Mendoza Santiesteban
2018 Frontiers in Physiology  
neuronal dysfunction and microvasculature changes suggesting that retinal geometric vascular and functional parameters might be associated with physiological changes in the retina due to CI.  ...  for the differential diagnosis of CI.  ...  Moreover, the resulting geometric vascular parameters of the retina were obtained and used for further analysis: retinal vascular caliber, summarized as central retinal artery/vein equivalent (CRAE, CRVE  ... 
doi:10.3389/fphys.2018.01721 pmid:30574092 pmcid:PMC6291749 fatcat:uv3mhe3if5cllekjvijbigcmoq

Papillary Trunk Bifurcation Angles as Major Determinants of Ocular Perfusion: A Cross-Sectional Study

2020 Journal of Clinical Review & Case Reports  
This study has elucidated retinal vascular geometrics of healthy and diseased Indians, a knowledge that can improve our understanding of 'abnormal features' and 'natural variants' in retinal vascular architecture  ...  In the theoretical analysis of arterial networks, the existence of geometric optimisation for enabling functional adequacy has long been suggested, but observational studies have not yet fully corroborated  ...  during qualitative inspection of diabetic retinopathy fundus of our study.  ... 
doi:10.33140/jcrc.05.06.03 fatcat:lpyw7c2vq5hnxjvzzzxtqpvjma

A Review on the Extraction of Quantitative Retinal Microvascular Image Feature

Kuryati Kipli, Mohammed Enamul Hoque, Lik Thai Lim, Muhammad Hamdi Mahmood, Siti Kudnie Sahari, Rohana Sapawi, Nordiana Rajaee, Annie Joseph
2018 Computational and Mathematical Methods in Medicine  
These extracted markers or characterized fundus digital image features provide insights and relates quantitative retinal vascular topography abnormalities to various pathologies such as diabetic retinopathy  ...  This paper will also review recent research on the image processing-based extraction techniques of the quantitative retinal microvascular feature.  ...  Acknowledgments The authors would like also to acknowledge Universiti Malaysia Sarawak (UNIMAS). This work has been supported in part by Special Short Term Grant (SpSTG) MyRA F02/SpSTG/1374/16/16.  ... 
doi:10.1155/2018/4019538 pmid:30065780 pmcid:PMC6051289 fatcat:cdobi3d3vjgp5atzuponk7xgre

The application of retinal fundus camera imaging in dementia: A systematic review

Sarah McGrory, James R. Cameron, Enrico Pellegrini, Claire Warren, Fergus N. Doubal, Ian J. Deary, Baljean Dhillon, Joanna M. Wardlaw, Emanuele Trucco, Thomas J. MacGillivray
2017 Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring  
Discussion: Inconsistent findings across studies provide tentative support for the application of fundus camera imaging as a means of identifying changes associated with dementia.  ...  The potential of fundus image analysis in differentiating between dementia subtypes should be investigated using larger well-characterized samples.  ...  Acknowledgments This work was supported by the Engineering and Physical Sciences Research Council (EPSRC) grant "Multi-modal retinal biomarkers for vascular dementia" (EP/M005976/1).  ... 
doi:10.1016/j.dadm.2016.11.001 pmid:28229127 pmcid:PMC5312461 fatcat:3whwhprqdvg6fezxlbxgcyr5si

Thermography and the Eye: A Look at Ocular Surface Temperature [chapter]

2014 Ophthalmological Imaging and Applications  
12 Chapter 12: Corneal Topography and Tomography: The Orbscan II  ...  The relation of retinal vessel caliber to the incidence and progression of diabetic retinopathy: XIX: The Wisconsin Epidemiologic Study of Diabetic Retinopathy. Arch Ophthalmol 122:76-83.  ...  The relation of retinal vessel caliber to the incidence and progression of diabetic retinopathy: XIX: The Wisconsin Epidemiologic Study of Diabetic Retinopathy. Arch Ophthalmol 122:76-83. 118.  ... 
doi:10.1201/b17026-28 fatcat:3gs6tfry6fhm7kzbaejq7w5hdq

Retinal oxidative stress at the onset of diabetes determined by synchrotron FTIR widefield imaging: towards diabetes pathogenesis

Ebrahim Aboualizadeh, Mahsa Ranji, Christine M. Sorenson, Reyhaneh Sepehr, Nader Sheibani, Carol J. Hirschmugl
2017 The Analyst  
A mechanistic understanding of oxidative damage in the retina and the significance of photoreceptors at the onset of diabetic retinopathy are reported.  ...  Introduction Diabetic retinopathy (DR), a progressive disease affecting the integrity and function of retinal circulation, is the leading cause of blindness in adults 1 .  ...  Ins2 Akita -C57BL/6 diabetic mice develop retinal vascular pathology characteristic of the early stages of DR.  ... 
doi:10.1039/c6an02603f pmid:28210739 pmcid:PMC5388248 fatcat:e2p45kg2yzbytehqmpjbo3rqn4
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