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Design matters in patient-level prediction: evaluation of a cohort vs. case-control design when developing predictive models in observational healthcare datasets

Jenna M. Reps, Patrick B. Ryan, Peter R. Rijnbeek, Martijn J. Schuemie
2021 Journal of Big Data  
Methods Using a US claims database, we replicated two published prediction models (dementia and type 2 diabetes) which were developed using a case-control design, and trained models for the same prediction  ...  Background The design used to create labelled data for training prediction models from observational healthcare databases (e.g., case-control and cohort) may impact the clinical usefulness.  ...  For this evaluation we used a 'temporal' validation set: visits post December 31 2014 for Alzheimer's and post November 30 2012 for type 2 diabetes.  ... 
doi:10.1186/s40537-021-00501-2 fatcat:q4l6dpy4kjgi7a6ajkzxhjddxm

Validity of Claims Diagnosis Codes for Cardiovascular Diseases in Diabetes Patients in Japanese Administrative Database

Yasuhisa Ono, Yusuke Taneda, Tomomi Takeshima, Kosuke Iwasaki, Atsutaka Yasui
2020 Clinical Epidemiology  
We examined the positive predictive value (PPV) of outcomes that often develop in type 2 diabetes patients: cardiovascular outcomes including congestive heart failure (CHF), myocardial infarction (MI),  ...  Observational studies using large claims databases for diabetes patients have been increasingly conducted.  ...  Acknowledgments We thank Health, Clinic, and Education Information Evaluation Institute (HCEI: Kyoto, Japan) and Real World Data Co, Ltd (Kyoto, Japan) for providing the dataset and critical scientific  ... 
doi:10.2147/clep.s245555 pmid:32308492 pmcid:PMC7152547 fatcat:7nmee2iu7nbpxn7uu5mpgcwliu

Prescribing Quality and Prediction of Clinical Outcomes in Patients With Type 2 Diabetes: A Prospective Cohort Study

Kirsten P.J. Smits, Grigory Sidorenkov, Gerjan Navis, Margriet Bouma, Marianne A. Meulepas, Henk J.G. Bilo, Petra Denig
2017 Diabetes Care  
This is a first study testing the predictive validity of a set of clinical action indicators that were developed using a systematic structured approach (4).  ...  A cohort study was conducted using data from the Groningen Initiative to Analyze Type 2 Diabetes Treatment (GIANTT) database, including medical records data of 26,321 patients with type 2 diabetes in primary  ... 
doi:10.2337/dc17-0236 pmid:28473336 fatcat:o2un466ikrcm5opzjxpnzhivre

Personalized Diabetes Management Using Electronic Medical Records

Dimitris Bertsimas, Nathan Kallus, Alexander M. Weinstein, Ying Daisy Zhuo
2016 Diabetes Care  
We present a data-driven algorithm for personalized diabetes management that improves health outcomes relative to the standard of care.  ...  We evaluated the effect of recommendations on matched patient outcomes from unseen data.  ...  Michael Kane, Massachusetts Institute of Technology, for sharing clinical expertise in the progression and treatment of diabetes and Dr.  ... 
doi:10.2337/dc16-0826 pmid:27920019 fatcat:2crwfu4aqng6nn3gx7iiti4s5m

A call for wider use of ambulatory blood pressure monitoring in patients with diabetes

Kazuo Eguchi
2011 Hypertension Research  
of a composite outcome of fatal and non-fatal major cardiovascular events in type 2 diabetics with at high risk for cardiovascular events. 2 As a secondary outcome, intensive BP lowering was effective  ...  For the assessment and management of BP, ABPM is better than clinic BP. 5 ABPM can more reliably and easily assess actual BP levels than clinic BP and is helpful for predicting cardiovascular events, target  ...  For the assessment and management of BP, ABPM is better than clinic BP. 5 ABPM can more reliably and easily assess actual BP levels than clinic BP and is helpful for predicting cardiovascular events, target  ... 
doi:10.1038/hr.2011.123 pmid:21833003 fatcat:npzwspeo7jcw7nbominsogmtfa

Validity of Canadian discharge abstract data for hypertension and diabetes from 2002 to 2013

J. Jiang, D. Southern, C. A. Beck, M. James, M. Lu, H. Quan
2016 CMAJ Open  
Methods: We used the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) database, a clinical registry, as the reference standard to evaluate the validity of the Discharge  ...  The validity of the Discharge Abstract Database for hypertension and diabetes remained mostly consistent over time.  ...  We used a prospective clinical registry, the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) database, as the reference standard.  ... 
doi:10.9778/cmajo.20160128 pmid:28018877 pmcid:PMC5173472 fatcat:7umdgfknbfha3awtgke65fq2ke

Existing predictive methods applied to gait analysis of patients with diabetes: study protocol for a systematic review

Patrícia Mayara Moura da Silva, Ana Beatriz Oliveira Bezerra, Luanna Barbara Araújo Farias, Tatiana Souza Ribeiro, Edgard Morya, Fabrícia Azevêdo da Costa Cavalcanti
2022 BMJ Open  
Risk of bias and quality of evidence will be assessed using the Prediction Model Risk of Bias Assessment Tool and the Transparent Reporting of a multivariable prediction model for Individual Prognosis  ...  Quantitative data from objective methods for evaluating gait patterns are accurate and cost-effective.  ...  Acknowledgements The authors thank CAPES Foundation, an agency under the Ministry of Education (MEC) of Brazil for their assistance during the research.  ... 
doi:10.1136/bmjopen-2021-051981 pmid:35190422 pmcid:PMC8862448 fatcat:fo7jlqz2wvhs3jtk4ijqwezovm

Surrogate End Points for the Treatment of Diabetic Neuropathic Foot Ulcers

D. J. Margolis, J. M. Gelfand, O. Hoffstad, J. A. Berlin
2003 Diabetes Care  
RESEARCH DESIGN AND METHODS -This is a retrospective cohort study using the Curative Health Services database. As many as 39,918 neuropathic wounds on 20,213 individuals with diabetes were evaluated.  ...  OBJECTIVE -The goal of this study was to determine whether surrogate markers based primarily on changes in the size of a wound can be used to correctly predict which individuals with diabetic neuropathic  ...  Acknowledgments -Funds for this study were provided by Grant DK59154 from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health.  ... 
doi:10.2337/diacare.26.6.1696 pmid:12766096 fatcat:zetvxwl57navdp3rwnbe4bk4o4

Development and validation of a Bayesian index for predicting major adverse cardiac events with percutaneous transluminal coronary angioplasty

A J de Belder
2001 Heart  
Objective-To create a risk model for predicting major adverse complicating events of percutaneous transluminal coronary angioplasty (PTCA), and to test the accuracy of the model on a prospective cohort  ...  To establish the accuracy of these predictive tools, a Bayes table was created to evaluate major adverse complicating events (MACE)-death, emergency coronary artery bypass grafting (CABG), or Q wave infarct  ...  The clinical characteristics for multiple relevant clinical variables were entered onto the database at the time of the procedure.  ... 
doi:10.1136/heart.85.1.69 pmid:11119467 pmcid:PMC1729571 fatcat:phntmaxvxjeovaj3mckkxbgk6a

Predicting Clinical Outcomes and Response to Thrombolysis in Acute Stroke Patients With Diabetes

D. Nikneshan, R. Raptis, J. Pongmoragot, L. Zhou, S. C. Johnston, G. Saposnik
2013 Diabetes Care  
Few tools are available to evaluate clinical outcomes and response to thrombolysis (tPA) in stroke patients with diabetes.  ...  We explored how the iScore (, a validated risk score, predicts clinical outcomes in stroke patients with and without diabetes.  ...  The authors thank the investigators of the RCSN, Dr. M. Kapral, and Dr. F. Silver for providing access to the data.  ... 
doi:10.2337/dc12-2095 pmid:23359359 pmcid:PMC3687301 fatcat:uthvqm4xj5as5bixhhjwxvhw5i

Gestational diabetes in young women predicts future risk of serious liver disease

Ravi Retnakaran, Jin Luo, Baiju R Shah
2018 Diabetologia  
We hypothesised that GDM predicts future lifetime risk of serious liver-disease outcomes, such as cirrhosis, liver failure and need for transplantation.  ...  In common with type 2 diabetes, gestational diabetes mellitus (GDM) is associated with a propensity for hepatic fat deposition.  ...  The Institute for Clinical Evaluative Sciences (ICES) is a not-for-profit research institute funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC).  ... 
doi:10.1007/s00125-018-4775-z pmid:30426169 fatcat:yss3wushoza2dcjxgpnyunbzkq

Can data extraction from general practitioners' electronic records be used to predict clinical outcomes for patients with type 2 diabetes?

Michael Staff
2013 Journal of Innovation in Health Informatics  
Objective To assess the feasibility of extracting data from a general practice medical record software package to predict clinically significant outcomes for patients with T2DM.  ...  Type 2 diabetes (T2DM) is a chronic condition cared for primarily in the general practice setting that lends itself to the application of tools in this area.  ...  I would also like to thank Professor Lyn March for her kind comments on a draft of this article.  ... 
doi:10.14236/jhi.v20i2.30 pmid:23710774 fatcat:tvfaqxpf4nflri2ramuozbuhfi

Quality of care: assessment

Allam Rao, Gumpeny Sridhar
2007 Lipids in Health and Disease  
A similar exercise in India is necessary to improve the quality of diabetes care.  ...  To translate science into clinical practice we must first assess the quality of care that is being delivered.  ...  Application to clinical care Outcomes can be predicted on the basis of biographical and clinical variables.  ... 
doi:10.1186/1476-511x-6-12 pmid:17442124 pmcid:PMC1858695 fatcat:6jv6kq7wpzaaxe2mgu62eojrry


SD Ramsey, L Clarke, B Donato, SD Sullivan, C Varela, N Hermans, D Boudreau
2003 Value in Health  
RESULTS: Over the study period, DEA identified a total of four teams on the frontier for clinical tests and ten teams for patient care time.  ...  When adjusting for clinical outcomes, RA identified an excess use of resources among the same teams operating below frontier in DEA.  ...  Abstracts care integrating multiple measures of both resource use and clinical outcomes.  ... 
doi:10.1016/s1098-3015(10)62019-0 fatcat:pbi5ol26gfhtlcwdcq5uahfbva

Diabetes Mellitus and Cardiovascular Events in Older Patients With Myocardial Infarction Prescribed Intensive-Dose and Moderate-Dose Statins

D. T. Ko, H. C. Wijeysundera, C. A. Jackevicius, A. Yousef, J. Wang, J. V. Tu
2013 Circulation. Cardiovascular Quality and Outcomes  
No endorsement by the Institute for Clinical Evaluative Sciences or the Ontario Ministry of Health and Long-term Care is intended or should be inferred. Sources of Funding Disclosures None.  ...  Acknowledgments This study was supported by the Institute for Clinical Evaluative Sciences, which is funded by an annual grant from the Ontario Ministry of Health and Long-Term Care.  ...  using all the clinically relevant variables that would predict the development of diabetes mellitus and adverse cardiovascular outcomes.  ... 
doi:10.1161/circoutcomes.111.000015 pmid:23674307 fatcat:4pis5hiy2bgdtakuzdpiowx4e4
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