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Evaluation of Hippocampal Segmentation Methods for Healthy and Pathological Subjects [article]

Courtney A. Bishop, Mark Jenkinson, Jerome Declerck, Dorit Merhof
2010 Eurographics Workshop on Visual Computing for Biomedicine  
This work brings to light several strengths and weaknesses of the evaluated hippocampal segmentation methods, of utmost importance for robust and accurate segmentation in the presence of specific and substantial  ...  Here, both current and novel MR hippocampal segmentation methods are presented and evaluated: Two versions of FMRIB's Integrated Registration and Segmentation Tool (FIRST and FIRSTv2), Freesurfer's Aseg  ...  Acknowledgments With thanks to the LSI DTC, EPSRC and BBSRC David Phillips Fellowship for funding this research, David Kennedy and David Glahn for providing MR data and expert manual labels from the Center  ... 
doi:10.2312/vcbm/vcbm10/017-024 fatcat:4likep2ptfckvg2awlkz3vsuca

Automated hippocampal segmentation in patients with epilepsy: Available free online

Gavin P. Winston, M. Jorge Cardoso, Elaine J. Williams, Jane L. Burdett, Philippa A. Bartlett, Miklos Espak, Charles Behr, John S. Duncan, Sebastien Ourselin
2013 Epilepsia  
We validate and make freely available online a novel automated method. Methods: Manual hippocampal segmentation was performed on 876, 3T MRI scans and 202, 1.5T scans.  ...  based on local similarity to ensure accurate segmentation regardless of pathology.  ...  Duncan has served as a consultant for GE Healthcare on the development of PET tracers. The remaining authors have no conflicts of interest.  ... 
doi:10.1111/epi.12408 pmid:24151901 pmcid:PMC3995014 fatcat:3xgbuqhk3zgbzknkbk5ahcv52i

Hippocampal Surface Deformation Accuracy in T1-Weighted Volumetric MRI Sequences in Subjects with Epilepsy

R. Edward Hogan, Emily D. Moseley, Luigi Maccotta
2014 Journal of Neuroimaging  
and Purpose-To demonstrate the accuracy across different acquisition and analysis methods, we evaluated the variability in hippocampal volumetric and surface displacement measurements resulting from two  ...  This validates the robustness across MRI sequences of the HDM-LD technique for estimating volume and surface changes in subjects with epilepsy.  ...  Methods Subject selection Subjects were patients with a clinical diagnosis of temporal lobe epilepsy who underwent an MRI study for evaluation of their seizures.  ... 
doi:10.1111/jon.12135 pmid:24942549 pmcid:PMC4272329 fatcat:fkrezmo53fdabknlrddp23ipvm

Automated subfield volumetric analysis of hippocampus in temporal lobe epilepsy using high-resolution T2-weighed MR imaging

Daichi Sone, Noriko Sato, Norihide Maikusa, Miho Ota, Kaoru Sumida, Kota Yokoyama, Yukio Kimura, Etsuko Imabayashi, Yutaka Watanabe, Masako Watanabe, Mitsutoshi Okazaki, Teiichi Onuma (+1 others)
2016 NeuroImage: Clinical  
Automatic segmentation of hippocampal subfields (ASHS) and the new version of FreeSurfer software (ver.6.0) using high-resolution T2-weighted MR imaging are candidates for this volumetry.  ...  The aim of this study was to evaluate hippocampal subfields in TLE patients using ASHS as well as the old and new versions of FreeSurfer.  ...  Fig. 1 . 1 (A): Examples of automatic hippocampal segmentation results by FreeSurfer ver.5.3 on 3D T1-weighed MRI in a healthy subject (a) and a patient with right hippocampal sclerosis (b).  ... 
doi:10.1016/j.nicl.2016.06.008 pmid:27489767 pmcid:PMC4960104 fatcat:mv6wq76lkfdr7isvegqetstdcq

Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson's Disease

Jin-Woo Park, Chan-Nyoung Lee, Youngbo Sim, Hyung-Kyu Ham, Woo-Suk Tae, Byung-Jo Kim
2019 Parkinson's Disease  
In this study, we investigated the hippocampal subfield volume of patients with early-stage nondementia PD compared with normal healthy subjects using the ASHS method.  ...  Several studies used automated segmentation of hippocampal subfield (ASHS) for detailed measurements of anatomic subregions of the hippocampus, especially in the field of neurodegenerative disorders.  ...  Using the automated hippocampal subfield segmentation method of van Leemput et al.  ... 
doi:10.1155/2019/8254263 pmid:30854188 pmcid:PMC6378059 fatcat:sklpymdrt5cvxjnw2fsdckz3sm

Automated T2 relaxometry of the hippocampus for temporal lobe epilepsy

Gavin P. Winston, Sjoerd B. Vos, Jane L. Burdett, M. Jorge Cardoso, Sebastien Ourselin, John S. Duncan
2017 Epilepsia  
Although hippocampal segmentation for volumetry has been automated, T2 relaxometry currently involves subjective and time-consuming manual delineation of regions of interest.  ...  Significance: Automated hippocampal segmentation can be reliably extended to the determination of hippocampal T2 values, and a combination of hippocampal volumes and T2 values can separate subjects with  ...  Acknowledgments We are grateful to the Wolfson Foundation and the Epilepsy Society for supporting the Epilepsy Society MRI scanner.  ... 
doi:10.1111/epi.13843 pmid:28699215 pmcid:PMC5599984 fatcat:23wdwz3denfltjszj3ijtssffm

Robust Surface-Based Multi-template Automated Algorithm to Segment Healthy and Pathological Hippocampi [chapter]

Hosung Kim, Tommaso Mansi, Neda Bernasconi, Andrea Bernasconi
2011 Lecture Notes in Computer Science  
To account for inter-subject variability, including shape variants, we used a multi-template library derived from a large database of controls and patients.  ...  We propose a novel segmentation method (SurfMulti) to statistically estimate locoregional texture and shape using a surface-based approach that guarantees shapeinherent point-wise correspondences.  ...  High time requirement, rater-bias, and the demand to study large cohorts of healthy and diseased populations, however, have motivated the automation of hippocampal volumetry.  ... 
doi:10.1007/978-3-642-23626-6_55 fatcat:afuabkhmnnbkzbdmozjmqdkbcu

Differential Atrophy of Hippocampal Subfields: A Comparative Study of Dementia with Lewy Bodies and Alzheimer Disease

Elijah Mak, Li Su, Guy B. Williams, Rosie Watson, Michael Firbank, Andrew Blamire, John O'Brien
2016 The American journal of geriatric psychiatry  
Methods: 104 participants (35 DLBs, 36 ADs, and 35 healthy comparison subjects (HC)) underwent clinical assessment and 3 Tesla T1-weighted imaging.  ...  We aim to investigate hippocampal subfield differences in vivo in a clinical cohort of DLB and AD subjects.  ...  data for patients and healthy comparison subjects are summarized in Table 1 Hippocampal subfields Hippocampal subfield atrophy in DLB and AD 11 The volumetric comparisons of the hippocampal subfields  ... 
doi:10.1016/j.jagp.2015.06.006 pmid:26324541 fatcat:i2ja7uo66vhghijslxjzenxmsm

Evaluation of atlas-based segmentation of hippocampi in healthy humans

Roman Rodionov, Marie Chupin, Elaine Williams, Alexander Hammers, Chandrasekharan Kesavadas, Louis Lemieux
2009 Magnetic Resonance Imaging  
Materials & Methods Data Eighteen healthy subjects (five females; mean age 34.7 years and range: 25 -56 years) were included.  ...  Data processing and analysis Individual ROIs for both hippocampi of each subject were segmented from the MR images using SACHA.  ...  Acknowledgements This work was undertaken at UCLH/UCL who received a proportion of funding from the UK  ... 
doi:10.1016/j.mri.2009.01.008 pmid:19261422 fatcat:wc67hoxtyzerhoygixtivblfna

Clinical validation of automated hippocampal segmentation in temporal lobe epilepsy

Peter N. Hadar, Lohith G. Kini, Carlos Coto, Virginie Piskin, Lauren E. Callans, Stephanie H. Chen, Joel M. Stein, Sandhitsu R. Das, Paul A. Yushkevich, Kathryn A. Davis
2018 NeuroImage: Clinical  
While a neuroradiologist's interpretation of MR imaging is a key, albeit imperfect, diagnostic tool for seizure localization in medically-refractory TLE patients, automated hippocampal segmentation may  ...  These promising findings demonstrate the clinical utility of automated segmentation in the TLE MR imaging pipeline prior to surgical resection, and suggest that further investigation into JLF/CL-assisted  ...  The authors would like to thank the Thornton Foundation and staff and members of the Center for Neuroengineering and Therapeutics (CNT) at the University of Pennsylvania and the Penn Epilepsy Center for  ... 
doi:10.1016/j.nicl.2018.09.032 pmid:30380521 pmcid:PMC6205355 fatcat:hzfjhrhyybcsth2jei7l2pb4li

Is There a Negative Correlation between Explicit Memory and Hippocampal Volume?

Martine Chantôme, Pierre Perruchet, Dominique Hasboun, Didier Dormont, Mokhran Sahel, Nader Sourour, Abderrezak Zouaoui, Claude Marsault, Michel Duyme
1999 NeuroImage  
The aim of this research was to study the relationship between explicit memory and hippocampal volume.  ...  This finding is not consistent with pathologic findings, which tend to show a relationship between decrease in memory performance and hippocampal atrophy. This discrepancy is discussed.  ...  , Christiane Charlemaine, and Sabine Clément for their assistance in the translation.  ... 
doi:10.1006/nimg.1999.0486 pmid:10547336 fatcat:qf3vjfnoy5eormolctnvgz6up4

Alzheimer's Disease: Initial Clinical Implementation of Automated Volumetry

Diego A. Herrera, Julio Vargas, John Fredy Ochoa, Jon Edinson Duque, Sergio A. Vargas, Francisco Lopera, Mauricio Castillo
2014 Canadian Journal of Neurological Sciences  
The authors certify that no actual or potential conflict of interest exists in relation to this article. This material has not been presented at any meeting.  ...  High consistency and reproducibility of the method suggest it could be implemented in clinical practice to diagnose those pathologies.  ...  automatic hippocampus segmentation tools, which some studies have validated. 5 In two studies, FreeSurfer slightly overestimated hippocampal volume in healthy and depressed subjects; however, correlation  ... 
doi:10.1017/cjn.2014.23 pmid:25373817 fatcat:ljqakojy6jas3oqdzvz4frgsmy

Detection of Alzheimer's disease signature in MR images seven years before conversion to dementia: Toward an early individual prognosis

Pierrick Coupé, Vladimir S. Fonov, Charlotte Bernard, Azar Zandifar, Simon F. Eskildsen, Catherine Helmer, José V. Manjón, Hélène Amieva, Jean-François Dartigues, Michèle Allard, Gwenaelle Catheline, D. Louis Collins
2015 Human Brain Mapping  
Hippocampal grading was evaluated on subjects from the Three-City cohort, with a follow-up period of 12 years.  ...  subjects and patients with AD.  ...  Disclosure statement Hippocampal grading method is the subject of a US provisional patent application (US 61/535,720 / P1310USPR). D.L.  ... 
doi:10.1002/hbm.22926 pmid:26454259 fatcat:spmhzi6lvnd5vkzhprgdgnwugm

Automatic multispectral MRI segmentation of human hippocampal subfields: an evaluation of multicentric test–retest reproducibility

Andrea Chiappiniello, Roberto Tarducci, Cristina Muscio, Maria Grazia Bruzzone, Marco Bozzali, Pietro Tiraboschi, Anna Nigri, Claudia Ambrosi, Elena Chipi, Stefania Ferraro, Cristina Festari, Roberto Gasparotti (+11 others)
2020 Brain Structure and Function  
Here, we assessed test–retest reproducibility of FreeSurfer 6.0 hippocampal subfield segmentations using multispectral MRI analysis pipelines (22 healthy subjects scanned twice, a week apart, at four 3T  ...  AbstractAccurate and reproducible automated segmentation of human hippocampal subfields is of interest to study their roles in cognitive functions and disease processes.  ...  The current literature presents very few test-retest 3T studies evaluating FreeSurfer hippocampal subfield segmentations in healthy subjects, as outlined in Table 1 .  ... 
doi:10.1007/s00429-020-02172-w pmid:33231744 fatcat:lgbumqbh5zdhzoojj76qqoicn4

Hippocampal subfield volumetry in patients with subcortical vascular mild cognitive impairment

Xinwei Li, Deyu Li, Qiongling Li, Yuxia Li, Kuncheng Li, Shuyu Li, Ying Han
2016 Scientific Reports  
We utilized an automated hippocampal subfield segmentation method provided by FreeSurfer to estimate the volume of several hippocampal subfields, including the cornu ammonis (CA) areas, the dentate gyrus  ...  Hippocampal atrophy has been found in patients with aMCI/AD and is widely considered a neuroimaging hallmark for the early diagnosis of AD 9 .  ...  However, the hippocampal subfield segmentation method provided by FreeSurfer was validated against manual segmentation and achieved reasonable Dice index values (approximately 0.7) for all large hippocampal  ... 
doi:10.1038/srep20873 pmid:26876151 pmcid:PMC4753487 fatcat:q3uydqtwfzdrvas3sygcsvvig4
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