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Predicting Methylphenidate Response in ADHD Using Machine Learning Approaches

Jae-Won Kim, Vinod Sharma, Neal D. Ryan
2015 International Journal of Neuropsychopharmacology  
Acknowledgments Statement of Interest None.  ...  The predictor of the oppositional symptoms of DBD might also be related to impulse control functions of individuals with ADHD (King et al., 2003; Herrmann et al., 2010) .  ...  A more feasible opportunity for psychiatry, as with the rest of the medicine, is to utilize and combine the recent evidences in genetics, neuroimaging, and cognitive neuroscience to predict responses/nonresponses  ... 
doi:10.1093/ijnp/pyv052 pmid:25964505 pmcid:PMC4756719 fatcat:ctgxsa5hnfappfigm7qw2ovhgq

Placing Neuroanatomical Models of Executive Function in a Developmental Context

Karin Brocki, Jin Fan, John Fossella
2008 Annals of the New York Academy of Sciences  
One method of late is genetics, which is noninvasive and readily used in concert with neuroimaging.  ...  As much progress in this area continues to occur, we seek to evaluate the age dependency and manner in which certain aspects of EF and certain anatomical circuits show changes and interactions as children  ...  The current imaging genetics methods can be used to link individual differences in genotype to changes in brain structure or function.  ... 
doi:10.1196/annals.1417.025 pmid:18591485 pmcid:PMC2669085 fatcat:hvc2nqe5lvfdbdytlyi2qi4uqi

Neuroimaging of Nicotine Dependence: Key Findings and Application to the Study of Smoking–Mental Illness Co-morbidity

F. Joseph McClernon
2009 Journal of dual diagnosis  
To date, neuroimaging studies of nicotine dependence among individuals with mental illness have focused almost exclusively on schizophrenia.  ...  A conceptual/ methodological framework for studying dual diagnosis using neuroimaging measures is provided with the aim of spurring additional research in this area.  ...  Acknowledgments This work was supported by a grant to the author from the National Institutes of Health (K23 DA017261).  ... 
doi:10.1080/15504260902869204 pmid:19756221 pmcid:PMC2743422 fatcat:kravede3ejavxiyqaurijnqzha

Prediction of sleep side effects following methylphenidate treatment in ADHD youth

Jae Hyun Yoo, Vinod Sharma, Jae-Won Kim, Dana L. McMakin, Soon-Beom Hong, Andrew Zalesky, Bung-Nyun Kim, Neal D. Ryan
2019 NeuroImage: Clinical  
Our results provide preliminary support to the combination of multimodal classifier, in particular, neuroimaging features, as an informative method that can assist in predicting MPH side effects in ADHD  ...  Robustness of classifier model was validated in the independent dataset of 36 ADHD subjects.  ...  Wrapper subset evaluation method demonstrated the inattention symptoms of ADHD-RS, CPT response time variability, the DAT1, ADRA2A DraI, and SLC6A2 A-3081T polymorphisms, and the structural connectivities  ... 
doi:10.1016/j.nicl.2019.102030 pmid:31711956 pmcid:PMC7229354 fatcat:z3tkzyhhhbcuhnsr7npokw77vm

Cumulative Effects of Resting-state Connectivity Across All Brain Networks Significantly Correlate with ADHD Symptoms [article]

Michael A. Mooney, Robert J.M. Hermosillo, Eric Feczko, Oscar Miranda-Dominguez, Lucille A. Moore, Anders Perrone, Nora Byington, Gracie Grimsrud, Amanda Rueter, Elizabeth Nousen, Dylan Antovich, Sarah W. Feldstein Ewing (+3 others)
2021 medRxiv   pre-print
Methods Polyneuro scores (PNS) represent the cumulative effect of brain-wide measures—in the present case, resting-state functional connectivity (rs-fcMRI) associated with ADHD symptoms.  ...  Results The ADHD PNS was significantly associated with ADHD symptoms in both the ABCD and Oregon cohorts after accounting for relevant covariates (p-values < 0.001).  ...  Creation of genetic scores benefited from the collaboration of the OHSU Integrated Genomics Core (Chris Harrington, Ph.D., Director) and Kristina Vartanian.  ... 
doi:10.1101/2021.11.16.21266121 fatcat:aaydj2ukvzet7ibzkokeqs6sz4

Neuroimaging-Based Deep Learning in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder

Jae-Won Song, Na-Rae Yoon, Soo-Min Jang, Ga-Young Lee, Bung-Nyun Kim
2020 Journal of korean Academy of Child and Adolescent Psychiatry  
In the field of neuroimaging of neurodevelopmental disorders, various biomarkers for diagnosis, classification, prognosis prediction, and treatment response prediction have been examined; however, they  ...  Here, we review studies that combine neurodevelopmental disorder neuroimaging and DL techniques to explore the strengths, limitations, and future directions of this research area.  ...  This review summarizes the latest papers that use DL in the field of neuroimaging in ASD and ADHD research (Table 1) .  ... 
doi:10.5765/jkacap.200021 pmid:32665754 pmcid:PMC7350542 fatcat:hams6rtmfvgqjmv6mxnik25h6u

Structural MRI of Pediatric Brain Development: What Have We Learned and Where Are We Going?

Jay N. Giedd, Judith L. Rapoport
2010 Neuron  
Over the past two decades, thousands of brain MRI scans from healthy youth and those with neuropsychiatric illness have been acquired and analyzed with respect to diagnosis, sex, genetics, and/or psychological  ...  Magnetic resonance imaging (MRI) allows unprecedented access to the anatomy and physiology of the developing brain without the use of ionizing radiation.  ...  in using neuroimaging to make predictions about behavior or ability in a particular individual.  ... 
doi:10.1016/j.neuron.2010.08.040 pmid:20826305 pmcid:PMC3285464 fatcat:kkkd5rcwajbdjooamisvibkaku

Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder

Santosh K. Yadav, Ajaz A. Bhat, Sheema Hashem, Sabah Nisar, Madeeha Kamal, Najeeb Syed, Mohamed-Ramzi Temanni, Rakesh K. Gupta, Saddat Kamran, Muhammad Waqar Azeem, Amit K. Srivastava, Puneet Bagga (+5 others)
2021 Translational Psychiatry  
In this review, we discuss the neurobiology of ADHD with particular emphasis on structural and functional changes in the ADHD brain and their interactions with complex genomic variations utilizing imaging  ...  Recently, neuroimaging genomic studies observed a significant association of brain imaging phenotypes with genetic susceptibility in ADHD.  ...  Acknowledgements This work was supported by the Qatar Foundation, National Priorities Research Program (NPRP10-0202-170320), and the Sidra Medicine Precision Program (SDR #200048).  ... 
doi:10.1038/s41398-021-01473-w pmid:34091591 fatcat:iegcts2oevgb5eatussrlkurey

Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan

Barbara Franke, Giorgia Michelini, Philip Asherson, Tobias Banaschewski, Andrea Bilbow, Jan K. Buitelaar, Bru Cormand, Stephen V. Faraone, Ylva Ginsberg, Jan Haavik, Jonna Kuntsi, Henrik Larsson (+5 others)
2018 European Neuropsychopharmacology  
However, course and symptoms of the disorder and the comorbidities may fluctuate and change over time, and even age of onset in childhood has recently been questioned.  ...  In this selective review, we summarise current knowledge of the long-term course of ADHD, with an emphasis on clinical symptom and cognitive trajectories, treatment effects over the lifespan, and the development  ...  In addition, we summarise knowledge on cognitive and neuroimaging changes during life with the disorder and touch on lifespan aspects in the study of genetic and environmental risk factors for the disorder  ... 
doi:10.1016/j.euroneuro.2018.08.001 pmid:30195575 fatcat:pxgqkle6vzd5jjpias2zcxzwyu

Neuroimaging of Attention-Deficit/Hyperactivity Disorder: Current Neuroscience-Informed Perspectives for Clinicians

Samuele Cortese, F. Xavier Castellanos
2012 Current Psychiatry Reports  
The neuroimaging literature of Attention-Deficit/Hyperactivity Disorder (ADHD) is growing rapidly.  ...  Finally, imaging studies with a developmental perspective are revealing the brain correlates of ADHD over the lifespan, complementing clinical observations on the phenotypic continuity and discontinuity  ...  They found disruption of the brain dopamine reward pathway in 45 adults with ADHD relative to 41 controls, which was related to symptoms of inattention in participants with ADHD, thus linking core symptoms  ... 
doi:10.1007/s11920-012-0310-y pmid:22851201 pmcid:PMC3876939 fatcat:zmz2zup5zzdfnkd3t32oybarle

Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients

Atsunori Sugimoto, Yutaro Suzuki, Kiyohiro Yoshinaga, Naoki Orime, Taketsugu Hayashi, Jun Egawa, Shin Ono, Takuro Sugai, Toshiyuki Someya
2021 Frontiers in Human Neuroscience  
In clinical settings, individuals with severe symptoms are often observed to perform more difficultly when performing the tasks which individuals with mild symptoms can perform easily.  ...  before treatment but not in the responder group, suggesting that non-responders can activate the prefrontal cortex without atomoxetine.Conclusions: Individuals with increased ADHD symptoms appear to recruit  ...  Neuroimaging-aided prediction of the effect of methylphenidate in children with attention-deficit hyperactivity disorder: a randomized controlled trial.  ... 
doi:10.3389/fnhum.2021.755025 pmid:34899218 pmcid:PMC8663632 fatcat:ypghh4n6zbhwtmwad7fblhwyye

Novel approach to evaluate central autonomic regulation in attention deficit/hyperactivity disorder (ADHD)

N. Sekaninová, M. Mestanik, A. Mestanikova, A. Hamrakova, I. Tonhajzerova
2019 Physiological Research  
Although the exact cause has not yet been known, the crucial role in the development of this disease plays the interaction of genetic, neurobiological and epigenetic factors.  ...  According to current knowledge, ADHD is defined as a biological dysfunction of central nervous system with genetically or organically defined deficits in noradrenergic and dopaminergic neurotransmission  ...  (EU) sources and the project "European Centre of Excellence for Perinatological Research" no. 26220120036.  ... 
doi:10.33549/physiolres.934160 pmid:31177787 fatcat:66yhcruxlre5fksexihpo4ns2i

nnnnnEmotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence

Tammo Viering, Pieter J. Hoekstra, Alexandra Philipsen, Jilly Naaijen, Andrea Dietrich, Catharina A. Hartman, Barbara Franke, Jan K. Buitelaar, Andrea Hildebrandt, Christiane M. Thiel, Carsten Gießing
2021 NeuroImage  
The course of attention deficit hyperactivity disorder (ADHD) from adolescence into adulthood shows large variations between individuals; nonetheless determinants of interindividual differences in the  ...  ADHD severity and resting state neuroimaging data were measured in ADHD and unaffected individuals at two points during adolescence and young adulthood.  ...  This work reflects only the authors' views and the European Union is not liable for any use that may be made of the infor-  ... 
doi:10.1016/j.neuroimage.2021.118729 pmid:34813971 fatcat:5pg37gijzzh6lg2kj63dewhxsy

Prediction complements explanation in understanding the developing brain

Monica D. Rosenberg, B. J. Casey, Avram J. Holmes
2018 Nature Communications  
Together with large-scale developmental neuroimaging datasets and complementary analytic approaches, predictive modeling affords us the opportunity and obligation to identify novel treatment targets and  ...  for the facts that neural phenotypes and behavior vary widely across the population and change over time within individuals [15] [16] [17] [18] .  ...  External validation with data from the ADHD-200 Consortium 108 revealed that the same functional networks that index attention task performance in adulthood predict ADHD symptoms in childhood.  ... 
doi:10.1038/s41467-018-02887-9 pmid:29467408 pmcid:PMC5821815 fatcat:7jmnwbzqt5b3vbfghnrih5h75q

The neurobiology and genetics of Attention-Deficit/Hyperactivity Disorder (ADHD): What every clinician should know

Samuele Cortese
2012 European journal of paediatric neurology  
Genetic studies showing a heritability of w60e75% suggest that a plethora of genes, each one with a small but significant effect, interact with environmental factors to increase the susceptibility to ADHD  ...  and genetics of Attention-Deficit/ Hyperactivity Disorder (ADHD).  ...  The key points of the present review are summarised in Table 1 . Neuroimaging Several imaging techniques have been used to explore brain structure and function in individuals with ADHD.  ... 
doi:10.1016/j.ejpn.2012.01.009 pmid:22306277 fatcat:u5s2crihr5hbngrjy5a27job3m
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