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Evaluating regional blood spinal cord barrier dysfunction following spinal cord injury using longitudinal dynamic contrast-enhanced MRI

Ilkan Tatar, Peter Cheng-te Chou, Mohamed Mokhtar Desouki, Hanaa El Sayed, Mehmet Bilgen
2009 BMC Medical Imaging  
This paper uses multimodal magnetic resonance imaging (MRI) to investigate neurovascular pathology and changes in blood spinal cord barrier (BSCB) permeability following SCI in a mouse model of SCI.  ...  Methods: C57BL/6 female mice (n = 5) were subjected to contusive injury at the thoracic T11 level and scanned on post injury days 1 and 3 using anatomical, dynamic contrast-enhanced (DCE-MRI) and diffusion  ...  Background Damage to blood-spinal cord barrier (BSCB) occurs as a consequence of mechanical insult to spinal cord (SC) [1] .  ... 
doi:10.1186/1471-2342-9-10 pmid:19519898 pmcid:PMC2714086 fatcat:dznnpe6ymjaixnpjam3bqbk2ie

Quantifying Blood-Spinal Cord Barrier Permeability after Peripheral Nerve Injury in the Living Mouse

Lindsay S Cahill, Christine L Laliberté, Xue Jun Liu, Jonathan Bishop, Brian J Nieman, Jeffrey S Mogil, Robert E Sorge, Catherine D Jones, Michael W Salter, R Mark Henkelman
2014 Molecular Pain  
Results: Here we used in vivo dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to establish a timecourse for BSCB permeability following PNI, produced by performing a spared nerve injury  ...  From this longitudinal study, we found that the SNI group had a significant increase in BSCB permeability over time throughout the entire spinal cord.  ...  Abbreviations B10: B10.D2-Hc o H2 d H2-T18 c /oSnJ; BSCB: Blood-spinal cord barrier; CD-1: Crl: CD1(ICR); CSF: Cerebrospinal fluid; DCE-MRI: Dynamic contrast-enhanced magnetic resonance imaging; EAE: Experimental  ... 
doi:10.1186/1744-8069-10-60 pmid:25216623 pmcid:PMC4190293 fatcat:zwqlyozzh5gqtmaw4raqz25yym

Comparison of Diagnostic Accuracy of MRI with and Without Contrast in Diagnosis of Traumatic Spinal Cord Injuries

Ahmad Ghasemi, Kaveh Haddadi, Ali Ahmadi Shad
2015 Medicine  
So given that is not significant differences between noncontrast and contrast-enhanced MRI in the diagnosis of major injuries (hematoma, edema, etc.) and contrast-enhanced MRI just better in soft tissues  ...  We recommend to the MRI with contrast only used in cases of suspected severe soft tissue injury, which have been ignored by detection MRI without contrast.  ...  ACKNOWLEDGMENTS The authors thank all the traumatic spinal patients who participated in this study.  ... 
doi:10.1097/md.0000000000001942 pmid:26512624 pmcid:PMC4985437 fatcat:teernikzwzhmbmkd45y7q5j2ca

Degenerative Cervical Myelopathy: Insights into Its Pathobiology and Molecular Mechanisms

Ji Tu, Jose Vargas Castillo, Abhirup Das, Ashish D. Diwan
2021 Journal of Clinical Medicine  
cord in the neck.  ...  In addition to describing different scoring and classification systems used by clinicians in diagnosing DCM, we also highlight how advanced imaging techniques are being used to study the disease process  ...  Lon-gitudinal dynamic contrast-enhanced MRI (DCE-MRI) studies revealed that the BSCB remained compromised even 56 days after moderately severe injury to the spinal cord in an animal model.  ... 
doi:10.3390/jcm10061214 pmid:33804008 pmcid:PMC8001572 fatcat:4632qu22dzc45frh7xmqsmxrm4

Advanced MRI strategies for assessing spinal cord injury [chapter]

Seth A. Smith, James J. Pekar, Peter C.M. Van Zijl
2012 Handbook of Clinical Neurology  
New inflammatory lesions that have caused a breakdown in the blood-brain/spinal cord barrier show pronounced image signal enhancement after administration of gadolinium contrast agents, as well as chronic  ...  following traumatic injury.  ... 
doi:10.1016/b978-0-444-52137-8.00006-1 pmid:23098708 pmcid:PMC4482217 fatcat:d3klj3j4q5fw3dd6ms7d7d776u

Diagnosis and Management of Acute Myelopathies

Adam I. Kaplin, Chitra Krishnan, Deepa M. Deshpande, Carlos A. Pardo, Douglas A. Kerr
2005 The Neurologist  
Transverse myelitis (TM) is a prototype member of this group in which an immune-mediated process causes neural injury to the spinal cord, resulting in varying degrees of weakness, sensory alterations,  ...  and autonomic dysfunction.  ...  Gado-linium-enhanced spinal MRI and a lumbar puncture are mandatory in the evaluation of suspected TM, and we proposed that abnormal gadolinium enhancement of the spinal cord or CSF pleocytosis or elevated  ... 
doi:10.1097/01.nrl.0000149975.39201.0b pmid:15631640 fatcat:xyez2v5sorav7jjpiljx4rc5ge

Spinal vascular lesions: anatomy, imaging techniques and treatment

Valerio Da Ros, Eliseo Picchi, Valentina Ferrazzoli, Tommaso Schirinzi, Federico Sabuzi, Piergiorgio Grillo, Massimo Muto, Francesco Garaci, Mario Muto, Francesca Di Giuliano
2021 European Journal of Radiology Open  
Vascular lesions of the spinal cord are rare but potentially devastating conditions whose accurate recognition critically determines the clinical outcome.  ...  Several conditions lead to myelopathy due to either arterial ischemia, venous congestion or bleeding within the cord.  ...  The contrast enhanced MR of the spinal cord is mainly useful to evaluate the neoplastic and the inflammatory diseases; the use of Gadolinium based contrast agent with high relaxivity allows to obtain higher  ... 
doi:10.1016/j.ejro.2021.100369 pmid:34307789 pmcid:PMC8283341 fatcat:p4x4l4cjsje5fa6kjjrpaykszi

Transverse myelitis: pathogenesis, diagnosis and treatment

Chitra Krishnan
2004 Frontiers in Bioscience  
Gadolinium enhanced spinal MRI and a lumbar puncture are mandatory in the evaluation of suspected TM, and we proposed that abnormal gadolinium enhancement of the spinal cord or CSF pleocytosis or elevated  ...  In support of this mechanism, most patients have CSF pleocytosis and blood-brain barrier breakdown within a focal area of the spinal cord.  ... 
doi:10.2741/1351 pmid:14977560 fatcat:gymhrjwwbndhhjdep6itwwq6g4

Multiple sclerosis: the role of MR imaging

Y Ge
2006 American Journal of Neuroradiology  
With acute spinal cord lesions, enhancement is frequently seen.  ...  spinal cord.  ... 
pmid:16775258 pmcid:PMC8133908 fatcat:jcl5qfa77fegro2vuzmfab5c2e

18F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse model of multiple sclerosis

Sara Belloli, Lucia Zanotti, Valentina Murtaj, Cristina Mazzon, Giuseppe Di Grigoli, Cristina Monterisi, Valeria Masiello, Leonardo Iaccarino, Andrea Cappelli, Pietro Luigi Poliani, Letterio Salvatore Politi, Rosa Maria Moresco
2018 Journal of Neuroinflammation  
An average of 8-10 spinal cord sections for each mouse was evaluated.  ...  The only preclinical study associating TSPO-PET with MRI used T1-weighted sequences to focus on the longitudinal evaluation of ventricles volume enlargement, although not evaluating their relation with  ...  PET and MRI images of EAE mice at 14 days p.i. In vivo PET and MRI representative images of three of the four EAE mice used for the in vivo imaging evaluation at 14 days postimmunization.  ... 
doi:10.1186/s12974-017-1044-x pmid:29402285 pmcid:PMC5800080 fatcat:v2ukuujnqrd5hdynknrhuaeqbm

The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials

Kedar R. Mahajan, Daniel Ontaneda
2017 Neurotherapeutics  
Imaging techniques of the brain and spinal cord have rapidly evolved in the last decade to permit in vivo characterization of tissue microstructural changes, connectivity, metabolic changes, neuronal loss  ...  RD and MD increases also have been noted 10 months prior to GdE, suggesting tissue injury prior to breakdown of the blood-brain barrier [46] .  ...  DTI has been extensively applied to the spinal cord in normal-appearing and lesional regions, correlates with demyelination histologically [248] , and can be used to track recovery longitudinally [249  ... 
doi:10.1007/s13311-017-0561-8 pmid:28770481 fatcat:nwefozrjtjafngwma3aibamu3a

Spinal Arteriovenous Fistulas and Arteriovenous Malformations – Complicated Vasculature and Surgical Imaging [chapter]

Shinji Yamamoto, Phyo Kim
2013 Arteriovenous Fistulas - Diagnosis and Management  
Following contrast administration, diffuse intramedullary enhancement may be seen as a sign of chronic venous congestion with a breakdown of the blood-spinal cord barrier.  ...  Left: Spinal contrast-enhanced dynamic MRA of fistulous-type spinal cord AV malformation (type III).  ... 
doi:10.5772/56367 fatcat:gq4wvbyr2vcrjfzzapia27oyu4

Spinal Cord Injury: How Can We Improve the Classification and Quantification of Its Severity and Prognosis?

Vibhor Krishna, Hampton Andrews, Abhay Varma, Jacobo Mintzer, Mark S. Kindy, James Guest
2014 Journal of Neurotrauma  
The preservation of functional neural tissue after spinal cord injury (SCI) is the basis for spontaneous neurological recovery.  ...  Quantitative methods to evaluate residual tissue sparing after severe acute SCI have not entered widespread clinical use.  ...  The development of accurate responsive physiologic monitoring devices that could evaluate spinal cord tissue oxygen levels and blood flow is needed.  ... 
doi:10.1089/neu.2013.2982 pmid:23895105 pmcid:PMC3904531 fatcat:5cy7eqdmgnhopgdn6tm4247jfy

Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases

Jun Yang, Qinqing Li
2020 Frontiers in Neurology  
In this article, we provide a brief review of MEMRI use in CNS diseases ranging from neurodegenerative diseases to brain injury and spinal cord injury.  ...  Based on these properties, MEMRI is used to describe neuroanatomical structures, monitor neural activity, and evaluate axonal transport rates.  ...  Spinal Cord Injury Spinal cord injury (SCI) is another serious CNS disease with high mortality and disability rates. MRI has important application value in SCI.  ... 
doi:10.3389/fneur.2020.00143 pmid:32161572 pmcid:PMC7052353 fatcat:hypuo4utcfhufdmqi5ovdhhs5y

Magnetic Resonance Imaging of Blood Brain/Nerve Barrier Dysfunction and Leukocyte Infiltration: Closely Related or Discordant?

Gesa Weise, Guido Stoll
2012 Frontiers in Neurology  
We here review contrast-enhanced magnetic resonance imaging (MRI) as a non-invasive tool to depict barrier dysfunction and its relation to macrophage infiltration in the central and peripheral nervous  ...  Novel experimental contrast agents like Gadofluorine M (Gf) allow more sensitive assessment of BBB dysfunction than conventional Gadolinium (Gd)-DTPA enhanced MRI.  ...  Moreover, macrophage invasion spread from the upper spinal cord and brainstem to the cerebellum and subcortical regions during disease progression.  ... 
doi:10.3389/fneur.2012.00178 pmid:23267343 pmcid:PMC3527731 fatcat:7bazxvnlondhvkcnc7gfybt2xq
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