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Ethics and Privacy Considerations for Systems Biology Applications in Predictive and Personalized Medicine
[chapter]
Handbook of Research on Computational and Systems Biology
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Integrative analysis and modeling of the omics data using systems biology have led to growing interests in the development of predictive and personalized medicine. ...
This chapter shares technological, ethical, and social perspectives on emerging personalized medicine applications. ...
In this paper, we provide a historical perspective on the emergence of predictive and personalized medicine, its relationship with systems biology, bioethics concerns when developing biobanks, and privacy ...
doi:10.4018/978-1-60960-491-2.ch001
fatcat:psb67vzuunhvtdhuguzcwxj4w4
Autonomous Systems and Artificial Intelligence – Hype or Prerequisite for P5 Medicine?
[chapter]
2021
Studies in Health Technology and Informatics
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care processes, health and social care systems around the globe undergo an organizational, methodological and technological transformation towards personalized, preventive, predictive, participative precision ...
This paper addresses chances, challenges and risks of specific disruptive methodologies and technologies for the transformation of health and social care systems, especially focusing on the deployment ...
Acknowledgement The authors are indebted to thank their colleagues from HL7, ISO TC 215 and CEN TC 251 for their kind and constructive support and cooperation. ...
doi:10.3233/shti210567
pmid:34734847
fatcat:5buoj34g2nfejekink3tc4rsba
What Is Trust? Ethics and Risk Governance in Precision Medicine and Predictive Analytics
2017
Omics
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as trust, and what factors might establish and sustain trust in precision medicine, predictive analytics, and large-scale biology. ...
Moving forward, we propose a "points to consider" on how best to enhance trust in precision medicine and predictive analytics. ...
This article was developed as a background document for an expert workshop on Trust in Precision Medicine-A Risk Governance Perspective (Geneva, Switzerland, November 23-24, 2017) organized by IRGC in ...
doi:10.1089/omi.2017.0156
pmid:29257733
pmcid:PMC5737145
fatcat:hnuckbffqjaz5fmal4g5glclju
Artificial Intelligence in Healthcare and Medicine: Promises, Ethical Challenges, and Governance
2019
Chinese Medical Sciences Journal
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To ensure "trustworthy" AI applications in healthcare and medicine, the creation of an ethical global governance framework and system as well as special guidelines for frontier AI applications in medicine ...
In this article, the author investigates and discusses three aspects of AI in medicine and healthcare: the application and promises of AI, special ethical concerns pertaining to AI in some frontier fields ...
Ethical challenges of AI application in healthcare and medicine It is the author's viewpoint that ethical issues pertaining to AI in medicine should be considered at two levels: for humanity as a whole ...
doi:10.24920/003611
pmid:31315747
fatcat:7doxviegifcy7f5udid5wdsrx4
Ethical priority of the most actionable system of biomolecules: the metabolome
2019
American Journal of Physical Anthropology
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Given the current mechanisms to fund research, ELSI beyond human DNA is stifled and in need of considerable attention. ...
The metabolome is a system of small biomolecules (metabolites) and a direct result of human bioculture. ...
Given the key role of small molecules at the intersection of cultural, biological, and environmental systems, metabolomics has a unique potential in a personalized medicine framework; the metabolome is ...
doi:10.1002/ajpa.23943
pmid:31643083
pmcid:PMC7003909
fatcat:7tfwlsi3avacjobmqco2qalxlm
Opportunities and Challenges in Interpreting and Sharing Personal Genomes
2019
Genes
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and ethical sharing of personal genome data while protecting the privacy of individuals. ...
The talks at the conference focused on two main topic areas: (1) Technologies and Applications, with emphasis on personal genomics in the context of healthcare. ...
Conflicts of Interest: G.G. holds a provisional patent application on the genome fingerprinting method referred to in this report. The authors declare no other conflicts of interest. ...
doi:10.3390/genes10090643
pmid:31450660
pmcid:PMC6770764
fatcat:hm3jveriuvg7bgdhisi2x6mc4e
Theoretical and Practical Principles on Nanoethics: A Narrative Review Article
2019
Iranian Journal of Public Health
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nanoproducts and particles and unpredictable side effects of such nanoparticles; and secondly, the application of developed nanoparticles in areas such as justice, privacy protection, patient-physician ...
Interests in nanotechnology and its application in medical research, diagnosis, and treatment of diseases continuously grow. ...
Hereby, the authors would like to express their gratitude for the sincere cooperation and assistance of the professors and colleagues at the Research Center and Department of Medical Ethics of Shahid Beheshti ...
pmid:31850252
pmcid:PMC6908913
fatcat:vhsi7kekl5fkvak6gf4hzajyxa
Theoretical and Practical Principles on Nanoethics: A Narrative Review Article
2020
Iranian Journal of Public Health
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nanoproducts and particles and unpredictable side effects of such nanoparticles; and secondly, the application of developed nanoparticles in areas such as justice, privacy protection, patient-physician ...
Interests in nanotechnology and its application in medical research, diagnosis, and treatment of diseases continuously grow. ...
Hereby, the authors would like to express their gratitude for the sincere cooperation and assistance of the professors and colleagues at the Research Center and Department of Medical Ethics of Shahid Beheshti ...
doi:10.18502/ijph.v48i10.3481
fatcat:jgpvhdzxpzf4lchzuxf4rh4rlm
Ethical Issues of Artificial Biomedical Applications
[chapter]
2011
IFIP Advances in Information and Communication Technology
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While the plethora of artificial biomedical applications is enriched and combined with the possibilities of artificial intelligence, bioinformatics and nanotechnology, the variability in the ideological ...
The convergence of bioethics and computer ethics, attempts to illustrate and approach problems, occurring by the fusion of human and machine or even through the replacement of human determination by super ...
Additionally, nanotechnology is having a great impact on the fields of biology, biotechnology and medicine. ...
doi:10.1007/978-3-642-23960-1_36
fatcat:mwhlm7jomjdhhnviewbulseiky
Impact of the human genome assignment on biology and generation
2020
Journal of Shifa Tameer-e-Millat University
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Physicians approach to practice medicine is changing and becoming more personalized as a result of this project. ...
Diseases prognosis and risk can be now more accurately predicted through the advancements in HGP. ...
cloud and use it for personalized medicine in future that will change the practice of medicine and greatly contribute to the next generation of health systems. ...
doi:10.32593/jstmu/vol3.iss1.78
fatcat:x6ey4q7ykvftxhnkdq6ucdsquy
Exploring the Landscape, Hot Topics, and Trends of Electronic Health Records Literature with Topics Detection and Evolution Analysis
2021
International Journal of Computational Intelligence Systems
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, and engagement; (iv) information systems application and impact. ...
The EHRs research mainly included four topics: (i) population health, disease risk prediction, and primary care; (ii) technology, ethics, and privacy security; (iii) quality improvement, user acceptance ...
AUTHORS' CONTRIBUTIONS Yuxing Qian and Zhenni Ni contributed equally to this work. ...
doi:10.2991/ijcis.d.210203.006
fatcat:vykcp2vfgnc2plq5bz3zip2l7e
The Ethical Dimensions of Nanomedicine
2007
The Medical clinics of North America
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Moreover, ensuring privacy and confidentiality in such a system would be of utmost importance; a system without adequate safeguards presents serious ethical problems. ...
This report predicts that the greatest short-term impact of nanomedicine will be in therapies and diagnostics for cancer and central nervous system disorders. ...
doi:10.1016/j.mcna.2007.05.007
pmid:17826108
fatcat:q76gt6bwrzarngs2gay2btfu3u
Clinical decision-making and secondary findings in systems medicine
2016
BMC Medical Ethics
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Systems medicine is the name for an assemblage of scientific strategies and practices that include bioinformatics approaches to human biology (especially systems biology); "big data" statistical analysis ...
Given this distinction, the clinical translation of systems medicine poses a number of important ethical and epistemological challenges for researchers working to generate systems medicine knowledge and ...
Funding This publication originates from within the framework of the research network MENON -medical theoretical, ethical and economical evaluation of System Medicine. ...
doi:10.1186/s12910-016-0113-5
pmid:27209083
pmcid:PMC4875611
fatcat:wyjblgqhirffvbhifj5pi6e5xy
Personalized medicine: challenges and opportunities for translational bioinformatics
2013
Personalized Medicine
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Personalized medicine can be defined broadly as a model of healthcare that is predictive, personalized, preventive and participatory. ...
medicine and provides example areas for translational bioinformatics research inquiry. ...
P Tarczy-Hornoch was supported in part by CTSA (NIH NCRR 1 UL1 RR 025014), WA State Life Sciences Discover Fund grant 'Northwest Institute for Genetic Medicine' and CSER (NIH NHGRI U01 HG006507). ...
doi:10.2217/pme.13.30
pmid:24039624
pmcid:PMC3770190
fatcat:6bafa4ln6jcdtdnjirdipstyui
Design of Biomedical Informatics Framework for Personalized Medicine in Healthcare Organizations
2019
Studies in Health Technology and Informatics
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and to explore how this patient's data can be leveraged by informatics tools to achieve the goal of personalized medicine. ...
To implement personalized medicine effectively at organizational level, it is vital to identify, organize, integrate and leverage multi-dimensional patient data from heterogeneous and distributed resources ...
The consideration of ethical aspects [9] , such as security, privacy and confidentiality related to the use of multi-dimensional patient's data is a sine qua non; moreover social and legal questions ...
doi:10.3233/shti190560
pmid:31438257
fatcat:s3x3phegyfdgvkb2kimw5pvwt4
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