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New Updates of the Imaging Role in Diagnosis, Staging, and Response Treatment of Malignant Pleural Mesothelioma

Chiara Romei, Salvatore Claudio Fanni, Federica Volpi, Alessio Milazzo, Caterina Aida D'Amore, Leonardo Colligiani, Emanuele Neri, Annalisa De Liperi, Giulia Maria Stella, Chandra Bortolotto
2021 Cancers  
Malignant pleural mesothelioma is a rare neoplasm with poor prognosis. CT is the first imaging technique used for diagnosis, staging, and assessment of therapy response.  ...  Although, CT has intrinsic limitations due to low soft tissue contrast and the current staging system as well as criteria for evaluating response, it does not consider the complex growth pattern of this  ...  Both DWI and ADC could help in differentiating benign from malignant lesions and in distinguishing false positive PET/CT pleural disease as inflammation and talc pleurodesis [7] .  ... 
doi:10.3390/cancers13174377 pmid:34503186 fatcat:aohghhq56fbs7m2dv6e7z3ohbi

Factors associated with survival in a large series of patients with malignant pleural mesothelioma in New South Wales

A Linton, N Pavlakis, R O'Connell, M Soeberg, S Kao, S Clarke, J Vardy, N van Zandwijk
2014 British Journal of Cancer  
Studies, Japan Health effects of carbon nanotubes (CNT) have been gaining attentions of toxicologists, because the shape of CNT is similar to that of asbestos and the potency of CNT to cause mesothelioma  ...  Those results indicate that MARCO is probably important for the fast-phase uptake of MWCNT and there are other mechanisms (non-MARCO mediated) in the slow-phase cellular uptake of MWCNT.  ...  P10-5 Extent of the sarcomatoid component is an independent predictor of survival in malignant mesothelioma P10-3 The accuracy of pretreatment biopsy of pleural malignant mesothelioma in predicting  ... 
doi:10.1038/bjc.2014.478 pmid:25188323 pmcid:PMC4453733 fatcat:cvajfefqozcuxcvzv2z54d664e

The Third Italian Consensus Conference for Malignant Pleural Mesothelioma: State of the art and recommendations

S. Novello, C. Pinto, V. Torri, L. Porcu, M. Di Maio, M. Tiseo, G. Ceresoli, C. Magnani, S. Silvestri, A. Veltri, M. Papotti, G. Rossi (+7 others)
2016 Critical reviews in oncology/hematology  
radiation oncologists have taken part in the Third Italian Consensus Conference of Malignant Pleural Mesothelioma.  ...  In biopsies interpreted as reactive mesothelial proliferation, BAP1 loss was 100% predictive of malignancy, whereas only 3 out of 36 (8%) BAP1positive cases progressed to mesothelioma.  ... 
doi:10.1016/j.critrevonc.2016.05.004 pmid:27286698 fatcat:e5f5wkb7wzb3tolovfc4smz244

Recent Advances in Pulmonary Imaging

Daniel D. Maki, Warren B. Gefter, Abass Alavi
1999 Chest  
Positron emission tomography provides an important new approach to the accurate detection and staging of chest malignancies and to the evaluation of pulmonary nodules.  ...  Recent years have witnessed an explosion in imaging technology applicable to chest medicine.  ...  Recently, we reported preliminary data on the role of FDG-PET imaging in the management of malignant mesothelioma. 48 The uptake of FDG was sig-nificantly higher in malignant pleural lesions than in  ... 
doi:10.1378/chest.116.5.1388 pmid:10559104 fatcat:hdrrnikbmbdexfrnetucfp5fsa

Imaging-Based Tumor Treatment Response Evaluation: Review of Conventional, New, and Emerging Concepts

Hee Kang, Ho Yun Lee, Kyung Soo Lee, Jae-Hun Kim
2012 Korean Journal of Radiology  
This review elucidates morphologic and functional or metabolic approaches, and new concepts in the evaluation of tumor response in the era of personalized medicine (targeted chemotherapy).  ...  The state-of-the-art multidetector CT is still playing an important role, by showing high-quality, highresolution images that are appropriate enough to measure tumor size and its changes.  ...  The lower correlation between the primarily SSbased WHO criteria and the treatment response of bone metastasis might be a result of several factors including the high false positive rates of SS caused  ... 
doi:10.3348/kjr.2012.13.4.371 pmid:22778559 pmcid:PMC3384819 fatcat:f2sgxu6divb6xdwmzysrrtms2q


2010 Journal of Thoracic Oncology  
Serial MRIs of 30 metastatic brain tumors in 19 patients were reviewed. Tumor growth rate and volumetric doubling time were estimated after chemo-resistance developed.  ...  However, pleural fluid CEA was most sensitive marker for the diagnosis of malignant pleural effusion in this study.PD-019 Pretreatment FDG-PET Can Predict Survival Rates Following Definitive Radiotherapy  ...  However, we could estimate the accuracy rate (68%) of reporting cases of malignant mesothelioma after comparing the data of Health Insurance Institute.  ... 
doi:10.1097/jto.0b013e31820108f5 fatcat:6rgpehrk6bbfbpouhjmca4zg44


2012 Journal of Thoracic Oncology  
chest physicians, thoracic surgeons, and radiation oncologists are principally dealing with patients with primary lung carcinoma of usual histologies in their daily practice. they are mostly adenocarcinoma  ...  females, and the causes of MPE were breast or ovarian cancer, non-small cell lung carcinoma, and malignant pleural mesothelioma in 14, 12, and 9 cases, respectively. the relationship of factors to survival  ...  Conclusions: Our results show that the prognosis of patients with MPE who underwent palliative talc pleurodesis is independent of age, gender, type of malignancy, and amount of pleural effusion, suggesting  ... 
doi:10.1097/jto.0b013e318253d2ff fatcat:gk4cuwksgnct3camgbii5vfqaq


1998 Acta Cytologica  
All positive diagnoses were confirmed by histology (false positive rate = 0%).  ...  The false negative rate was 8% and false positive rate 1% CONCLUSION: By combining mammography and US-FNA, it is feasible to avoid surgery on the majority of benign diagnoses.  ... 
doi:10.1159/000332117 fatcat:rmpmtc6nanbcxnet63pjkd4hku


2015 Journal of Thoracic Oncology  
in the management of patients with synchronous nodules.  ...  Backgrounds: The prognostic significance of additional lung nodules in the setting of lung cancer is important as the impact on survival is often considered for the justification of surgical selection  ...  In the overall patient population, investigator-assessed disease control rate (DCR) was 77.1% and median duration of response (DOR) 9.7 months. (Figure) .  ... 
doi:10.1016/s1556-0864(16)30011-9 fatcat:nlhtgbimt5fu5dx4syerr2hjmu


2014 Journal of Thoracic Oncology  
Twenty-three out of 24 ALK FISH positive NSCLC (95.8%) were ALK IHC-positive. Only one ALK FISH positive NSCLC (3.2%) was false negative by IHC.  ...  Rate of EGFR m. was minor than reported previously in our center due to the small number of patients tested in this series.  ...  The complication rate, adequacy of samples as defined by BTS guidelines, false negative and positive rates, sensitivity (lesions >2cm) and the success of tumour sub-typing and analysis of predictive  ... 
doi:10.1097/jto.0000000000000131 fatcat:q4acxaqedndzjjtpcekgjdzwh4

Experimental and Data Analysis Considerations for Three-Dimensional Mass Spectrometry Imaging in Biomedical Research

D. R. N. Vos, S. R. Ellis, B. Balluff, R. M. A. Heeren
2020 Molecular Imaging and Biology  
The benefit of investigating volumetric data has led to a quick rise in the application of single-sample 3D-MSI investigations.  ...  Most of the MSI studies are conducted in a 2D fashion where only a single slice of the full sample volume is investigated.  ...  The work was performed in the M4I research program and was financially supported by the Dutch Province of Limburg as part of the "LINK" program.  ... 
doi:10.1007/s11307-020-01541-5 pmid:33025328 pmcid:PMC7910367 fatcat:gat2r33jknecdfo6y2ampj5z2u


2015 Journal of Thoracic Oncology  
However, despite this high rate of false-positives, validated models are available to allow for accurate prediction of malignancy risk.  ...  However, these biomarkers are competing with serial CT -based volumetric analyses which appears on initial studies to considerably reduce the false positive rate (discriminate benign from malignant based  ...  The risk of death is particularly high in the first year of hemodialysis, with rates reported up to 25%.  ... 
doi:10.1016/s1556-0864(16)30009-0 fatcat:dp7nw6kfnnekjimnadoi5bexpa


2010 Journal of Thoracic Oncology  
Results: The median survival, 1-and 2-year survival rates were 17 months, 68% and 34%, respectively.  ...  The interval between the date of initial surgery and the date of recurrence diagnosis (disease free interval) was median 15 months.  ...  A major drawback of current screen regimens is, however, that they lead to a high rate of false positive test results and to low positive predictive values.  ... 
doi:10.1097/01.jto.0000372622.81561.0e fatcat:yeedmnacvzegvon22pk6g2cdsu

B - Scientific Sessions

2010 Insights into Imaging  
After intravenous contrast media injection (8 ml/s, 350 mg iodine/ml) and dynamic density measurements in the right ventricle, dynamic scanning was initiated manually. 15 low-dose 16 cm volume scans were  ...  Conclusion: Perfusion imaging of the whole pancreas allows for discrimination between changes in pancreatic oedema and necrosis in early phase of severe acute pancreatitis.  ...  The common external rotation of the knee in OPI may lead to higher, possible false positive measurements of the TTTG.  ... 
doi:10.1007/s13244-010-0011-1 pmid:23099631 pmcid:PMC3534347 fatcat:yfnq3lgteja2lfjl66ivdfnoum

Proceedings of the International Cancer Imaging Society (ICIS) 18th Annual Teaching Course

2018 Cancer Imaging  
Our studies indicate that deep learning approaches can significantly reduce the false positive rate in lung cancer screening and have the potential to produce a fully automated screening assay.  ...  Quantitative image analysis coupled with deep learning techniques hold the potential to reduce this false positive rate.  ...  The aim of this study is to determine whether DWI can differentiate pleural dissemination of lung cancer from malignant pleural mesothelioma (MPM), empyema or pleural thickness, or pleural effusion.  ... 
doi:10.1186/s40644-018-0160-x fatcat:l3fdy44aunejnfamsnka5hfiwu
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