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Comparison of glaucoma diagnostic accuracy of macular ganglion cell complex thickness based on nonhighly myopic and highly myopic normative database

Henry Shen-Lih Chen, Chun-Hsiu Liu, Da-Wen Lu
2016 Taiwan Journal of Ophthalmology  
We compared the difference of sensitivity, specificity, and diagnostic accuracy between the nonhighly myopic database and the highly myopic database for differentiating the early glaucomatous eyes from  ...  based on nonhighly myopic and highly myopic normal eyes.  ...  (B) Pattern deviation of the Humphrey perimeter showing an inferior glaucomatous defect in the visual field.  ... 
doi:10.1016/j.tjo.2016.01.001 pmid:29018704 pmcid:PMC5602119 fatcat:3kuy5byzkre4zizir4xz44bopm

Early Primary Open-Angle Glaucoma

Austin R. Lifferth
2018 Canadian Journal of Optometry  
optic neuropathy causes characteristic retinal nerve fiber layer damage that will eventually lead to associated glaucomatous visual field defects if left untreated.  ...  Unfortunately, these visual field defects are difficult for the patient to detect until more advanced stages and, as a result, early glaucoma is usually asymptomatic.2 This paper presents a case that is  ...  Because of this preferential pattern of neuroretinal rim loss, the ISNT Rule 35,36 mnemonic has been proven to be very effective in differentiating normal optic nerves from those with early glaucomatous  ... 
doi:10.15353/cjo.80.238 fatcat:3umx4jxzbfflnordddfztdxipe

Atlas-based shape analysis and classification of retinal optical coherence tomography images using the functional shape (fshape) framework

Sieun Lee, Nicolas Charon, Benjamin Charlier, Karteek Popuri, Evgeniy Lebed, Marinko V. Sarunic, Alain Trouvé, Mirza Faisal Beg
2017 Medical Image Analysis  
To demonstrate the clinical relevance and application of the framework, we generated atlases of the inner layer surface and layer thickness of the Retinal Nerve Fiber Layer (RNFL) of glaucomatous and normal  ...  subjects, visualizing detailed spatial pattern of RNFL loss in glaucoma.  ...  A bounded variation regularization method was used to reduce the effect of speckles and enhance retinal boundaries 125 for segmentation and visualization.  ... 
doi:10.1016/ pmid:27689896 fatcat:yxbipk3imfg4xko34jhjbnkzeu

Fourier Analysis of Scanning Laser Polarimetry Measurements with Variable Corneal Compensation in Glaucoma

Felipe A. Medeiros, Linda M. Zangwill, Christopher Bowd, Antje S. Bernd, Robert N. Weinreb
2003 Investigative Ophthalmology and Visual Science  
The combination of Fourier RNFL thickness measures in an LDF, obtained using SLP with variable corneal compensation, improved the ability to discriminate glaucomatous from healthy eyes, compared with the  ...  To apply Fourier analysis to the retinal nerve fiber layer (RNFL) thickness measurements obtained with scanning laser polarimetry (SLP), by using variable corneal compensation, and to evaluate the ability  ...  with glaucomatous visual field loss, compared with the GDx software-provided parameters.  ... 
doi:10.1167/iovs.02-0814 pmid:12766063 fatcat:yad4jg2qmbbdvglbrw2kfzfzfm

Sampling the Visual Field Based on Individual Retinal Nerve Fiber Layer Thickness Profile

Shonraj Ballae Ganeshrao, Andrew Turpin, Allison M. McKendrick
2018 Investigative Ophthalmology and Visual Science  
Current perimeters use fixed grid patterns. We test whether a grid based on an individual's retinal nerve fiber layer (RNFL) thickness profile would find more visual field (VF) defects. METHODS.  ...  We describe the defect-based method for choosing test locations. First, the 26 VF locations with the highest positive predictive value to detect glaucoma from the 24-2 pattern are chosen.  ...  Current perimeters use fixed grid patterns. We test whether a grid based on an individual's retinal nerve fiber layer (RNFL) thickness profile would find more visual field (VF) defects. METHODS.  ... 
doi:10.1167/iovs.17-21979 pmid:29490343 fatcat:4yzyd4sagvddpkcn2xisw4kifm

Additive Diagnostic Role of Imaging in Glaucoma: Optical Coherence Tomography and Retinal Nerve Fiber Layer Photography

K. E. Kim, S. H. Kim, S. Oh, J. W. Jeoung, M. H. Suh, J. H. Seo, M. Kim, K. H. Park, D. M. Kim
2014 Investigative Ophthalmology and Visual Science  
Additive diagnostic role of imaging in glaucoma: optical coherence tomography and retinal nerve fiber layer photography. Invest Ophthalmol Vis Sci. 2014;55:8024-8030.  ...  Glaucomatous visual field defect was defined as presence of a cluster of three or more non-edge points with P less than 5% probability of being normal, one with P less than 1% on pattern deviation plot  ...  Qualitative examination of RNFLP enables direct visual confirmation of the whole RNFL defect's shape and pattern and, at the same time, of the associated glaucomatous disc change.  ... 
doi:10.1167/iovs.14-15237 pmid:25414196 fatcat:mapw3vepljffnkpem47qya7tiy

Rule Extraction for Glaucoma Detection with Summary Data from StratusOCT

Mei-Ling Huang, Hsin-Yi Chen, Jian-Cheng Lin
2007 Investigative Ophthalmology and Visual Science  
Measurements of glaucoma variables (retinal nerve fiber layer thickness and optic nerve head analysis results) were obtained with the StratusOCT.  ...  To extract and induce rules of association for differentiating between normal and glaucomatous eyes based on the quantitative assessment of summary data reports from the StratusOCT (optical coherence tomography  ...  The evaluation of glaucomatous visual field defects was made based on the following liberal criteria: two or more contiguous points with a pattern deviation sensitivity loss of P Ͻ 0.01, or three or more  ... 
doi:10.1167/iovs.06-0320 pmid:17197539 fatcat:wuslqdez7rgbjjqkbgfwohz6fy

Estimation of the central 10-degree visual field using en-face images obtained by optical coherence tomography

Ryu Iikawa, Tetsuya Togano, Yuta Sakaue, Aki Suetake, Ryoko Igarashi, Daiki Miyamoto, Kiyoshi Yaoeda, Masaaki Seki, Takeo Fukuchi, Sanjoy Bhattacharya
2020 PLoS ONE  
Actual HFA10-2 data and estimated visual fields based on en-face images were well matched: when the test points of <5%, <2%, and <1% of the probability plot in total deviation (TD) and pattern deviation  ...  Estimated visual fields were created based on the presence/absence of NFBs and compared to actual HFA10-2 data. κ coefficients were calculated between probability plots of visual fields and NFBs in en-face  ...  [30] estimated the central 10-degree visual field from macular OCT using the correlation between RNFL thickness and visual field sensitivity in the 68 test points; they reported a high correlation with  ... 
doi:10.1371/journal.pone.0229867 pmid:32134980 fatcat:zf3rdlqwpbfhrhyyk6cikbarvu

Detection of Glaucoma Progression by Assessment of Segmented Macular Thickness Data Obtained Using Spectral Domain Optical Coherence Tomography

Jung Hwa Na, Kyung Rim Sung, Seunghee Baek, Yoon Jeon Kim, Mary K. Durbin, Hye Jin Lee, Hwang Ki Kim, Yong Ho Sohn
2012 Investigative Ophthalmology and Visual Science  
The sensitivity and specificity of these parameters in terms of glaucoma progression detection were determined, with reference to assessment of optic disc/retinal nerve fiber layer (RNFL) photographs/visual  ...  retinal nerve fiber layer (cRNFLT) and total macular thickness (TMT) measurements.  ...  Therefore, circumpapillary retinal nerve fiber layer (cRNFL) thickness has been used to assess the extent of glaucomatous damage. cRNFL thickness is determined with the aid of optical coherence tomography  ... 
doi:10.1167/iovs.11-9369 pmid:22562510 fatcat:b65p7ceujrdu3bva7wj3syi7su

Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

Chieh-Li Chen, Karine D. Bojikian, Divakar Gupta, Joanne C. Wen, Qinqin Zhang, Chen Xin, Rei Kono, Raghu C. Mudumbai, Murray A. Johnstone, Philip P. Chen, Ruikang K. Wang
2016 Quantitative Imaging in Medicine and Surgery  
Methods: One eye from each subject was scanned with a 68 kHz Cirrus 5000 HD-OCT-based OMAG prototype system centered at the ONH (Carl Zeiss Meditec Inc, Dublin, CA, USA).  ...  Conclusions: ONH perfusion detected by OMAG showed significant differences between glaucoma and normal controls and was significantly correlated with disease severity and structural defects in glaucomatous  ...  normalized flux) and other functional [visual field (VF) mean deviation (MD) and pattern standard deviation (PSD)] and structural clinical measurements [retinal nerve fiber layer (RNFL) thickness, cup-to-disc  ... 
doi:10.21037/qims.2016.03.05 pmid:27190764 pmcid:PMC4858460 fatcat:rologzwe7nhutoiky6dokvwgmy

Optimizing Structure–Function Relationship by Maximizing Correspondence Between Glaucomatous Visual Fields and Mathematical Retinal Nerve Fiber Models

Nicole S. Erler, Susan R. Bryan, Paul H. C. Eilers, Emmanuel M. E. H. Lesaffre, Hans G. Lemij, Koenraad A. Vermeer
2014 Investigative Ophthalmology and Visual Science  
The resulting fields were compared with visual fields that were smoothed based on the regular testing grid. RESULTS.  ...  To introduce a method to optimize structural retinal nerve fiber layer (RNFL) models based on glaucomatous visual field data and to show how such an optimized model can be used to reduce noise in visual  ...  commonly called retinal sensitivity), it produces an estimate of the visual field.  ... 
doi:10.1167/iovs.13-12492 pmid:24644052 fatcat:npvcri2pl5gjbdfr46262zyize

Glaucoma Progression Detection by Retinal Nerve Fiber Layer Measurement Using Scanning Laser Polarimetry: Event and Trend Analysis

Byung Gil Moon, Kyung Rim Sung, Jung Woo Cho, Sung Yong Kang, Sung-Cheol Yun, Jung Hwa Na, Youngrok Lee, Michael S. Kook
2012 Korean Journal of Ophthalmology  
Event analysis Trend analysis Visual field 22 (14.5) 16 (10.5) Scanning laser polarimetry 37 (24.3) 19 (12.5) Table 5 . 5 Sensitivity and specificity (%) with 95% CI based on SLP EA and SLP  ...  Fig. 2 . 2 Clinical example showing visual field (VF) data and scanning laser polarimetry (SLP) retinal nerve fiber layer (RNFL) information in a 54-year old woman with glaucomatous eyes.  ... 
doi:10.3341/kjo.2012.26.3.174 pmid:22670073 pmcid:PMC3364428 fatcat:m3xdjfojubbolbswupmksekzou

The Structure and Function Relationship in Glaucoma: Implications for Detection of Progression and Measurement of Rates of Change

Felipe A. Medeiros, Linda M. Zangwill, Christopher Bowd, Kaweh Mansouri, Robert N. Weinreb
2012 Investigative Ophthalmology and Visual Science  
Estimates of retinal ganglion cell (RGC) counts were obtained from SAP and SD-OCT using a previously derived algorithm.  ...  studies, we proposed a method for estimating the amount of RGC loss from a combination of retinal nerve fiber layer (RNFL) assessment with optical coherence tomography and SAP. 16, 17 The estimates of  ...  Glaucomatous visual field losses were based on presence of repeatable abnormal SAP with pattern standard deviation (PSD) outside of the 95% normal confidence limits or a Glaucoma Hemifield Test result  ... 
doi:10.1167/iovs.12-10345 pmid:22893677 pmcid:PMC3466074 fatcat:ilkghpp2sjfnbbq7lyv7q7khd4

Peripapillary Retinal Nerve Fiber Layer Vascular Microcirculation in Glaucoma Using Optical Coherence Tomography–Based Microangiography

Chieh-Li Chen, Anqi Zhang, Karine D. Bojikian, Joanne C. Wen, Qinqin Zhang, Chen Xin, Raghu C. Mudumbai, Murray A. Johnstone, Philip P. Chen, Ruikang K. Wang
2016 Investigative Ophthalmology and Visual Science  
Retinal nerve fiber layer blood flow metrics showed significant correlations with visual field indices and structural changes in glaucomatous eyes (P 0.0123).  ...  One eye from each subject was scanned with a Cirrus HD-OCT 5000-based OMAG prototype system montage scanning protocol centered at the optic nerve head (ONH).  ...  The diagnosis of OAG was based on characteristic optic disc findings and an abnormal RNFL thickness on FD-OCT irrespective of glaucomatous visual field (VF) loss.  ... 
doi:10.1167/iovs.15-18909 pmid:27442341 pmcid:PMC4968914 fatcat:3wqwcv5uqrautfiujeu5lcgry4

Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects

Uchechukwu Osuagwu, Feryal Zereid
2013 Clinical Ophthalmology  
To assess the difference in retinal nerve fiber layer (RNFL) and optic disc algorithms between glaucomatous and normal Arab subjects using optical coherence tomography (OCT).  ...  The mean RNFL thickness around the disc and at all quadrants was significantly thinner in glaucomatous eyes than in normal eyes (P < 0.01).  ...  Acknowledgment The authors acknowledge the assistance rendered by Ebtesam H AlQhtany during data collection, and Dr Uchegbu O Frank during graphical analysis.  ... 
doi:10.2147/opth.s50992 pmid:24109175 pmcid:PMC3792954 fatcat:w3n2h6lvi5f57ey5egmgli4oxa
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