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Understanding the disease genome: gene essentiality and the interplay of selection, recombination and mutation
2017
Briefings in Bioinformatics
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Increasing understanding of the interplay between genetic recombination, selection and mutation and their relationship to gene essentiality suggests that gene-specific information may be useful for the ...
Considered alongside additional distinctive properties of the disease genome, such as the timing of the evolutionary emergence of genes and the roles of their products in protein networks, the case for ...
Gene essentiality and the disease genome Essential genes are critical for cell viability. ...
doi:10.1093/bib/bbx110
pmid:28968721
fatcat:trzatwxqabhg5dntdgs7r6y73m
Combined use of feature engineering and machine-learning to predict essential genes in Drosophila melanogaster
2020
NAR Genomics and Bioinformatics
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Here, we harnessed comprehensive genomic-phenomic datasets publicly available for D. melanogaster and a machine-learning-based workflow to predict essential genes of this fly. ...
We discovered strong predictors of such genes, paving the way for computational predictions of essentiality in less-studied arthropod pests and vectors of infectious diseases. ...
For D. melanogaster, studies have sought to infer essential genes computationally using features based 2 NAR Genomics and Bioinformatics, 2020, Vol. 2, No. 3 on gene homology/orthology/ontology, PPI/ ...
doi:10.1093/nargab/lqaa051
pmid:33575603
pmcid:PMC7671374
fatcat:x5sixw7yxvae7hqt2jdtx7izpm
1P232 Feasibility of the essential maps derived from the microbial genomes(Bioinformatics-structural, functional, and comparative genomics,Oral Presentations)
1P232 微生物ゲノムから同定された必須マップに関する実現性の検証(生命情報科学(構造・機能・比較ゲノミクス),口頭発表,第45回日本生物物理学会年会)
2007
Seibutsu Butsuri
1P232 微生物ゲノムから同定された必須マップに関する実現性の検証(生命情報科学(構造・機能・比較ゲノミクス),口頭発表,第45回日本生物物理学会年会)
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丘id as 蜘 ents め genome sequenoes and SCOPEC ;adataba5e ot ' catalytic domain ofenzymes , 、 、 ・ eb 岨 しan en 甲 11a血 data 呂et . ...
lebyex ustiv 鰯 q 風 λ eRcecompurisonbut actUtiUy , noL W 白 pre 日 t a hsUc app ch to compare genomes a5 a whde and pmvide 凱 a 丘Ule・ um ・ 峨 ・ fdata abcu 匸曲 曲 ue . ...
． ・ 生命 t 青報
PhyiogeneticAnalysesefEssendal Genes by Using OR レGENE
Himoshi Kaw 目 皿 o ω ， ｝ 五deaki Mixuno 〔 2)and Ak 血 Dri Sarai ω ． ( 1： Dep 匸 of
thoscience日 nd Bioinformatics ， Graduate翫hool Df Computer ...
doi:10.2142/biophys.47.s81_3
fatcat:y5eyqgg5fvfmvppu23ozkwdqk4
1P230 Phylogenetic Analyses of Essential Genes by Using ORI-GENE(Bioinformatics-comparative genomics and molecular evolution,Poster Presentations)
1P230 ORI-GENEを用いた必須遺伝子の進化系統解析(生命情報科学(比較ゲノミクス・分子進化),ポスター発表,第45回日本生物物理学会年会)
2007
Seibutsu Butsuri
1P230 ORI-GENEを用いた必須遺伝子の進化系統解析(生命情報科学(比較ゲノミクス・分子進化),ポスター発表,第45回日本生物物理学会年会)
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丘id as 蜘 ents め genome sequenoes and SCOPEC ;adataba5e ot ' catalytic domain ofenzymes , 、 、 ・ eb 岨 しan en 甲 11a血 data 呂et . ...
lebyex ustiv 鰯 q 風 λ eRcecompurisonbut actUtiUy , noL W 白 pre 日 t a hsUc app ch to compare genomes a5 a whde and pmvide 凱 a 丘Ule・ um ・ 峨 ・ fdata abcu 匸曲 曲 ue . ...
． ・ 生命 t 青報
PhyiogeneticAnalysesefEssendal Genes by Using OR レGENE
Himoshi Kaw 目 皿 o ω ， ｝ 五deaki Mixuno 〔 2)and Ak 血 Dri Sarai ω ． ( 1： Dep 匸 of
thoscience日 nd Bioinformatics ， Graduate翫hool Df Computer ...
doi:10.2142/biophys.47.s81_1
fatcat:2humu4dhybapdjdafrfwcf5z6q
Index
[chapter]
Essentials of Genomics and Bioinformatics
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project 32ff, 48
-maps 32
-number ofgenes 34
188
167
202ff
177
-telomeres 34
drug discovery, and bioinformatics 105ff
-gene-centric-107
-target-centric -107
drug targets, identification ...
Turner syndrome 75 twin studies 80 two-dimensional gel electrophoresis see 2D gel two-locus analysis 151 Genome and Human Rights 385 working draft of human genome sequence 48 Web-based database intergration ...
doi:10.1002/9783527612642.index
fatcat:u5eldwcccjfm5og25lj4moi7ai
Introduction to minitrack: computational issues in bioinformatics
2003
36th Annual Hawaii International Conference on System Sciences, 2003. Proceedings of the
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Employing algorithmic approaches are expected to be essential to the development and advancement of many fields in biosciences. ...
A true multidisciplinary field of study, Bioinformatics deals with the development and use of mathematical and computational methods to assist in modeling and solving problems in biosciences. ...
In the first paper, "Comparative Genome Anotation for Mapping, Prediction and discovery of Genes," by Kappen and Salbaum, the analysis of specific chromosomes in two genomes, the human genome and the muse ...
doi:10.1109/hicss.2003.1174801
fatcat:hxybzz4dengnho3y4khop6rska
An adaptive landscape for training in the essentials of next gen sequencing data acquisition and bioinformatic analysis
2014
BMC Bioinformatics
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P O S T E R P R E S E N T A T I O N Open Access An adaptive landscape for training in the essentials of next gen sequencing data acquisition and bioinformatic analysis Mark Farman 1,2 , Patrick Calie 3 ...
RNASeq data to a reference genome, construction of in silico gene models, and populating a genome browser, to name a few. ...
doi:10.1186/1471-2105-15-s10-p25
pmcid:PMC4196053
fatcat:r5do5f5mrnhijaqfywzydjk7rm
Page 650 of Journal of Clinical Oncology Vol. 30, Issue 6
[page]
2012
Journal of Clinical Oncology
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The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
As detailed in Table 2, these bioinformatic functions are an essential component of cancer genomics. ...
Role of Bioinformatics in Cancer Genomics
Bioinformatics
Function Background
Genome alignment Alignment and reconstruction requires reads and sufficiently long enough to be mapped accurately reconstruction ...
Bioinformatics in cancer therapeutics—hype or hope?
2005
Nature Clinical Practice Oncology
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Development and use of bioinformatics is essential for the future of cancer therapeutics. ...
Development and application of bioinformatics by multidisciplinary teams conducting focused translational research is essential for all steps of this process. ...
doi:10.1038/ncponc0176
pmid:16264939
fatcat:33t6jfuf55g7xmnpmsme6pll7a
Response to Hertz-Fowler and Berriman: Continuing tsetse and Trypanosoma genome sequencing projects
2004
Trends in Parasitology
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The recent genome initiatives of the neglected parasites Trypanosoma vivax and Trypanosoma congolense, and the vector tsetse [1,2] are promising with regards to the Corresponding author: Alberto M.R. ...
Acknowledgements A.M.R.D. and E.C.G. are recipients of research productivity fellowships, in addition to bioinformatics research grants from the Brazilian Council for Research and Development. ...
We stated [1] that both bioinformatics and research are becoming more necessary and essential in DECs. ...
doi:10.1016/j.pt.2004.04.014
fatcat:w35jn2nzprfgdoa7vkjxd5hdua
In silico identification and characterization of novel drug targets and outer membrane proteins in the fish pathogen Edwardsiella tarda
2011
Open Access Bioinformatics
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The complete genome of the fish pathogen Edwardsiella tarda and the host Danio rerio (zebrafish) was subjected to subtractive genome analysis with the objective of identifying potential drug targets and ...
The nonparalogous proteins were analyzed for sequence homology with the Database of Essential Genes to determine the essentiality of the proteins for the bacteria. ...
Acknowledgments The Bioinformatics Sub-distributed Information Centre, Department of Biotechnology (DBT), Government of India and DBT Indo-Norwegian project on fish and shell fish vaccine are gratefully ...
doi:10.2147/oab.s15581
fatcat:eongownihnfvfaeorodtij4vke
Bioinformatics: Essential Infrastructure for Global Biology1
1996
Journal of Computational Biology
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(Data supplied by MichaelCinkosky and Dennis Benson.)
): A...major...goal of genome informatics should be the integration of genome and genome-related databases. ...
Despite this, the advance of bioinformatics is essential for much of biology. ⇒ Needed: Coordinated, international efforts to develop better means for supporting worthy bioinformatics activities. ...
doi:10.1089/cmb.1996.3.465
pmid:8891960
fatcat:twxmdwnczrcjfjtnzn6q2lqkoy
Editorial
2009
Bioinformatics
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BIOINFORMATICS FOR NEXT GENERATION SEQUENCING The transforming aspect of the Human Genome Project was not the completion of the genome sequence itself, but rather the technologies that enabled, and were ...
tools to effectively analyze the data are essential to successful application of the technology. ...
doi:10.1093/bioinformatics/btp037
pmid:19202193
fatcat:kfyfcy7jaje2jhq4z42zw7z4yq
Think Outside of the Box—Think Genomic
2003
Cell Biology Education
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Discovering Genomics, Proteomics, and Bioinformatics, a book by A. ...
The book begins by introducing us to basic biological issues and relates this to the sequencing of whole genomes and the questions that the genome sequences can answer. ...
Discovering Genomics, Proteomics, and Bioinformatics, a book by A. ...
doi:10.1187/cbe.03-06-0028
pmcid:PMC256978
fatcat:uv4rrgkbcvgp3evikyyi7wmf5a
Genomics research at Bioinformatics of Genome Regulation and Structure\ Systems Biology (BGRS\SB) conferences in Novosibirsk
2019
BMC Genomics
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In this Special Issue of BMC Genomics we present the studies on computational genomics discussed at BGRS\SB-2018 (Bioinformatics of Genome Regulation and Structure\Systems Biology) multi-conference (http ...
Parallel special issues of BioMed Central journals after the BGRS conference series include manuscripts in the fields of plant biology, genomics, bioinformatics and genetics, and collated as ...
The BGRS\SB-2018 conference organization and computer genomics session were supported by the Russian Foundation of Basic Research, Russian-German and Sino-Russian Virtual Bioinformatics Network. ...
doi:10.1186/s12864-019-5707-0
pmid:32039700
fatcat:kfidr6jaercq7iguvhsmc2hsr4
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