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Paravascular spaces: entry to or exit from the brain?

Erik N. T. P. Bakker, Daphne M. P. Naessens, Ed VanBavel
2019 Experimental Physiology  
We recently recorded relatively large pressure oscillations in the cisterna magna of rats induced by ventilation, and smaller oscillations induced by the heart beat (Naessens, de Vos, VanBavel, & Bakker  ...  microsphere tracking, recent work from our group confirmed that at the brain surface, CSF flows along arteries in the direction of blood flow in a pulsatile manner (Bedussi, Almasian, de Vos, VanBavel, & Bakker  ...  ORCID Erik N. T. P. Bakker Daphne M. P. Naessens  ... 
doi:10.1113/ep087424 pmid:30582766 pmcid:PMC6618149 fatcat:swz53mo7b5g67pxoqebqdew5o4

MBEC special issue on microcirculation "engineering principles of vascular networks"

Axel R. Pries, Michael J. Mulvany, Erik N. T. P. Bakker
2008 Medical and Biological Engineering and Computing  
Acknowledgments Erik NTP Bakker is supported by the Netherlands Heart Foundation, grant 2001D038.  ...  The scheme shown would also represent the basic outline for suitable computational models of vascular adaptation Fig. 1 Fundamental physical stresses derived from blood flow which act on vessels (P T  ... 
doi:10.1007/s11517-008-0340-0 pmid:18414914 fatcat:kz3neic7hreojej6pcx63bg6k4

Components of acetylcholine-induced dilation in isolated rat arterioles

Erik N. T. P. Bakker, Pieter Sipkema
1997 American Journal of Physiology. Heart and Circulatory Physiology  
Bakker, Erik N. T. P., and Pieter Sipkema. Components of acetylcholine-induced dilation in isolated rat arterioles. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H1848-H1853, 1997.  ...  hyperpolarizing factor; cytochrome P-450; resistance vessels; potassium channels  ...  Data are means Ϯ SE, with n ϭ 5 for indomethacin and n ϭ 6 for all other compounds. * P Ͻ 0.01 for spontaneous tone vs. inhibitor.  ... 
doi:10.1152/ajpheart.1997.273.4.h1848 fatcat:bvzxtwk3xzforlp3ikhmqwctom

Mapping Solute Clearance From the Mouse Hippocampus Using a 3D Imaging Cryomicrotome

Daphne M. P. Naessens, Johannes G. G. Dobbe, Judith de Vos, Ed VanBavel, Erik N. T. P. Bakker
2021 Frontiers in Neuroscience  
the tracers for an additional 80 min (n = 7).  ...  A small subset of mice (n = 3) was sacrificed directly after an infusion period of 10 min to determine dispersion of the tracer due to the infusion, while another group was sacrificed after spreading of  ...  Fluorescein labeled dextran Texas Red labeled dextran Anatomical structure 10 min infusion (n = 3) 10 min infusion + 80 min additional spreading (n = 7) p = 0.057 10 min infusion (n = 3) 10  ... 
doi:10.3389/fnins.2021.631325 pmid:33867918 pmcid:PMC8044999 fatcat:irbi3bveund5hjkpwovwvaed2u

Blood–brain and blood–cerebrospinal fluid barrier permeability in spontaneously hypertensive rats

Daphne M. P. Naessens, Judith de Vos, Ed VanBavel, Erik N. T. P. Bakker
2018 Fluids and Barriers of the CNS  
*p ≤ 0.05, ***p ≤ 0.001. (unpaired Student's t-test or Mann-Whitney U test) of 1.02 ± 0.21 µl/min for WKY and 1.21 ± 0.10 µl/min for SHR (Fig. 1c) .  ...  WKY (unpaired Student's t-test) WKY SHR Na + 156.3 ± 0.31 (n = 4) 157.5 ± 0.25 (n = 4)* K + 2.76 ± 0.02 (n = 4) 2.77 ± 0.01 (n = 4) Cl − 130.1 ± 0.31 (n = 4) 131.3 ± 0.54 (n = 4) Ca 2+  ... 
doi:10.1186/s12987-018-0112-7 pmid:30244677 pmcid:PMC6151927 fatcat:xodazccv3na25jrkwrhwrr6mxu

Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats

Beatrice Bedussi, Daphne M. P. Naessens, Judith de Vos, Rik Olde Engberink, Micha M. M. Wilhelmus, Edo Richard, Malyssa ten Hove, Ed vanBavel, Erik N. T. P. Bakker
2017 Scientific Reports  
Data were analysed using Students' t-test or two-way ANOVA. A p value of <0.05 was considered statistically significant.  ...  Male normotensive Wistar Kyoto rats (WKY/NCrl) (n = 20) and male spontaneously hypertensive rats (SHR/NCrl) (n = 19) were obtained from Charles River at the age of 11 weeks.  ... 
doi:10.1038/s41598-017-00861-x pmid:28389645 pmcid:PMC5429689 fatcat:4pqw4qzayjaadgm3p6fmrgdenq

Altered brain fluid management in a rat model of arterial hypertension

Daphne M. P. Naessens, Bram F. Coolen, Judith de Vos, Ed VanBavel, Gustav J. Strijkers, Erik N. T. P. Bakker
2020 Fluids and Barriers of the CNS  
*p ≤ 0.05, ***p ≤ 0.001 (unpaired Student's t-test) WKY (n = 11) SHR (n = 10)  ...  The boxplots indicate the median and values of the 25th and 75th percentile of the data. * p ≤ 0.05, *** p ≤ 0.001 (unpaired Student's t-test) regions, the mean GFAP fluorescence intensity was quantified  ...  Cell nuclei are visualized using DAPI staining (blue). c The mean GFAP fluorescence intensity was not different between WKY (n=5) and SHR (n=5) in any of the anatomical brain structures (two-way ANOVA  ... 
doi:10.1186/s12987-020-00203-6 pmid:32590994 fatcat:4mxhxocrhbcwbb7mx2gzmtqpjm

Flow inhibits inward remodeling in cannulated porcine small coronary arteries

Adrian Pistea, Erik N. T. P. Bakker, Jos A. E. Spaan, Ed VanBavel
2005 American Journal of Physiology. Heart and Circulatory Physiology  
Vessels treated with N -nitro-L-arginine (L-NNA) to block NO production and untreated vessels were pressurized at 60 mmHg for 3 days with and without flow.  ...  N. T. P. Bakker was supported by The Netherlands Heart Foundation Grant NHS2001D038.  ...  In contrast, in the presence of L-NNA, all vessels returned to D 0.5 within 2 min [t D(0.5) ϭ 41.4 Ϯ 7.9 s, n ϭ 14], which is significantly faster than in the absence of L-NNA (P Ͻ 0.0001, unpaired t-test  ... 
doi:10.1152/ajpheart.00205.2005 pmid:16024578 fatcat:eqanakytbfdxjk6yk4uim7rr6e

Transglutaminase 2 is secreted from smooth muscle cells by transamidation-dependent microparticle formation

Jeroen van den Akker, Angela van Weert, Gijs Afink, Erik N. T. P. Bakker, Edwin van der Pol, Anita N. Böing, Rienk Nieuwland, Ed VanBavel
2011 Amino Acids  
As an example, we previously showed that TG2 plays a key role in vascular inward remodeling, a process occurring in hypertension and hypoperfusion (Bakker et al. 2005 (Bakker et al. , 2006 (Bakker et  ...  Both TG2 mutants were present in a smaller fraction of the MPs (TG2-W241A/eGFP: 18.2 ± 3.2%, P = 0.067 vs. TG2/eGFP; TG2-C277S: 14.8 ± 3.9%, P \ 0.05).  ... 
doi:10.1007/s00726-011-1010-3 pmid:21830119 pmcid:PMC3266506 fatcat:warwiw3aifheparud6ufvmmxjm

Role of cytochrome P-450 4A in oxygen sensing and NO production in rat cremaster resistance arteries

Cornel J. M. Kerkhof, Erik N. T. P. Bakker, Pieter Sipkema
1999 American Journal of Physiology. Heart and Circulatory Physiology  
., Erik N. T. P. Bakker, and Pieter Sipkema. Role of cytochrome P-450 4A in oxygen sensing and NO production in rat cremaster resistance arteries. Am. J. Physiol. 277 (Heart Circ.  ...  However, after partial blockade of cytochrome P-450 4A enzymes with 17-octadecynoic acid (17-ODYA), hypoxia increased the diameter by 65 Ϯ 6 µm (P Ͻ 0.05).  ...  Differences between two means were assessed by Student's t-test with a Bonferroni correction, if necessary. A probability value of P Ͻ 0.05 was considered significant for all tests.  ... 
doi:10.1152/ajpheart.1999.277.4.h1546 pmid:10516194 fatcat:d45nynldljbrjbln4wylapcpkm

Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway

Catarina Rippe, Baoyi Zhu, Katarzyna K. Krawczyk, Ed. Van Bavel, Sebastian Albinsson, Jonas Sjölund, Erik N. T. P. Bakker, Karl Swärd
2017 Scientific Reports  
Initial attempts to inhibit Notch signaling in cell culture using the γ-secretase inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-pheny lglycine t-butyl ester) were ineffective, possibly due  ...  Panel C shows correlations at the protein level between MAML2 and GUCY1A3 and between MAML2 and GUCY1B3. n = 6/group, *P < 0.05, **P < 0.01. NOTCH3 as well as NOTCH2, correlated with sGC expression.  ... 
doi:10.1038/s41598-017-01392-1 pmid:28465505 pmcid:PMC5430981 fatcat:36xrlc64rbfqjfysyz5y6a3fee

Decomposition cross-correlation for analysis of collagen matrix deformation by single smooth muscle cells

Jeroen van den Akker, Adrian Pistea, Erik N. T. P. Bakker, Ed VanBavel
2008 Medical and Biological Engineering and Computing  
First, gross displacement was defined at the point of maximal correlation between two parent images I 1 (at t = t 0 ) and I 2 (at t = t 0 + Dt), using a correlation threshold of 0.5 and a maximum tested  ...  The settings which were used for gel dynamics analysis and validation are given in bold of 15 min (n = 10 experiments).  ... 
doi:10.1007/s11517-008-0325-z pmid:18324432 pmcid:PMC2329731 fatcat:uvueazqolbgyfg2kzrvlrbfdcu

Organoid culture of cannulated rat resistance arteries: effect of serum factors on vasoactivity and remodeling

Erik N. T. P. Bakker, Esther T. van der Meulen, Jos A. E. Spaan, Ed VanBavel
2000 American Journal of Physiology. Heart and Circulatory Physiology  
Smooth muscle responses and substance P-induced endothelium-dependent dilation were maintained.  ...  Data are means Ϯ SE with n ϭ 6 vessels/group. Diameters at successive days were compared with day 1 with a post hoc Dunnett t-test.  ...  A repeated-measurement ANOVA followed by a post hoc Dunnett t-test was performed to determine the significance of differences between days. A paired t-test was used for all other comparisons.  ... 
doi:10.1152/ajpheart.2000.278.4.h1233 pmid:10749719 fatcat:fjisxjqdkredviabwwru32egui

Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system

Beatrice Bedussi, Monique G. J. T. B. van Lier, Jonas W. Bartstra, Judith de Vos, Maria Siebes, Ed VanBavel, Erik N. T. P. Bakker
2015 Fluids and Barriers of the CNS  
The mean distance is 64 ± 7 µm (N = 5) (Fig. 6d) , nor the parenchymal vessels close to the lateral ventricle (Fig. 6e) showed tracers.  ...  injected into the cisterna magna disperse over the subarachnoid space We next evaluated bulk flow using tracer infusion in the cisterna magna, using the same mix of tracers as injected into the striatum (n  ... 
doi:10.1186/s12987-015-0019-5 pmid:26435380 pmcid:PMC4593194 fatcat:j6klqhfvvbbunlfxo5ehf55q3i

Heterogeneity in Arterial Remodeling among Sublines of Spontaneously Hypertensive Rats

Erik N. T. P. Bakker, Gergely Groma, Léon J. A. Spijkers, Judith de Vos, Angela van Weert, Henk van Veen, Vincent Everts, Silvia M. Arribas, Ed VanBavel, Luis Eduardo M. Quintas
2014 PLoS ONE  
Data are mean 6 SEM, with WKY 6w: n = 15 and 5 mo: n = 17; SHR 6w: n = 16 and 5 mo: n = 16. # Indicates P,0.05, and ### P,0.001. doi:10.1371/journal.pone.0107998.g002 Figure 4 . 4 Endothelial function  ...  Data are mean 6 SEM with n$5 animals. { Indicates P,0.05 for SHR/NCrl vs. SHR/SP. ¥ Indicates P,0.05 for SHR/NHsd vs.  ... 
doi:10.1371/journal.pone.0107998 pmid:25251068 pmcid:PMC4175999 fatcat:ckplwlc7pray7o5ogjwocubpsq
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