Filters








3,814 Hits in 2.0 sec

ToppMiR: ranking microRNAs and their mRNA targets based on biological functions and context

Chao Wu, Eric E. Bardes, Anil G. Jegga, Bruce J. Aronow
2014 Nucleic Acids Research  
Identifying functionally significant microRNAs (miRs) and their correspondingly most important messenger RNA targets (mRNAs) in specific biological contexts is a critical task to improve our understanding of molecular mechanisms underlying organismal development, physiology and disease. However, current miR-mRNA target prediction platforms rank miR targets based on estimated strength of physical interactions and lack the ability to rank interactants as a function of their potential to impact a
more » ... iven biological system. To address this, we have developed ToppMiR (http://toppmir.cchmc.org), a web-based analytical workbench that allows miRs and mRNAs to be co-analyzed via biologically centered approaches in which gene function associated annotations are used to train a machine learning-based analysis engine. ToppMiR learns about biological contexts based on gene associated information from expression data or from a userspecified set of genes that relate to context-relevant knowledge or hypotheses. Within the biological framework established by the genes in the training set, its associated information content is then used to calculate a features association matrix composed of biological functions, protein interactions and other features. This scoring matrix is then used to jointly rank both the test/candidate miRs and mRNAs. Results of these analyses are provided as downloadable tables or network file formats usable in Cytoscape.
doi:10.1093/nar/gku409 pmid:24829448 pmcid:PMC4086116 fatcat:xfiekqshmne4roqwleqep3bc6y

Conditional Deletion of Shp2 in the Mammary Gland Leads to Impaired Lobulo-alveolar Outgrowth and Attenuated Stat5 Activation

Yuehai Ke, Jacqueline Lesperance, Eric E. Zhang, Emilie A. Bard-Chapeau, Robert G. Oshima, William J. Muller, Gen-Sheng Feng
2006 Journal of Biological Chemistry  
Tel.: 858-795-5265; Fax: 858-713-6274; E-mail: gfeng@burnham.org.  ...  E, litter size from control and mutant females was determined on the delivery and weaning days.  ... 
doi:10.1074/jbc.m607325200 pmid:16959766 pmcid:PMC1761121 fatcat:ectexw2pa5gz5d6fgvqvjv75ba

Cross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived NRXN1-Mutant Neurons [article]

ChangHui Pak, Tamas Danko, Vincent R Mirabella, Jinzhao Wang, Xianglong Zhang, Thomas Ward, Sarah Grieder, Madhuri Vangipuram, Yu-Wen Alvin Huang, Yingfei Liu, Kang Jin, Phillip Dexheimer (+13 others)
2020 bioRxiv   pre-print
E.  ...  . ; https://doi.org/10.1101/2020.11.03.366617 doi: bioRxiv preprint E & F.  ... 
doi:10.1101/2020.11.03.366617 fatcat:g4hmp25winciteikhasuaac254

Clinical Sensitivity and Interpretation of PCR and Serological COVID-19 Diagnostics for Patients Presenting to the Hospital [article]

Tyler E Miller, Wilfredo F. Garcia Beltran, Adam Z. Bard, Tasos Gogakos, Melis N Anahtar, Michael G. Astudillo, Diane Yang, Julia Thierauf, Adam S. Fisch, Grace K. Mahowald, Megan J. Fitzpatrick, Valentina Nardi (+24 others)
2020 medRxiv   pre-print
genes, and the Xpert Xpress SARS-CoV-2 assay run on the 99 GeneXpert Infinity targets regions of the N and E genes.  ...  96 the Centers for Disease Control and Prevention primers targeting regions of the N gene of 97 SARS-CoV-22, the cobas SARS-CoV-2 Test performed on the cobas 6800 targets 98 regions of the ORF1a and E  ... 
doi:10.1101/2020.06.19.20135723 fatcat:4saearb2crghvnet2vswdultye

Clinical sensitivity and interpretation of PCR and serological COVID‐19 diagnostics for patients presenting to the hospital

Tyler E. Miller, Wilfredo F. Garcia Beltran, Adam Z. Bard, Tasos Gogakos, Melis N. Anahtar, Michael Gerino Astudillo, Diane Yang, Julia Thierauf, Adam S. Fisch, Grace K. Mahowald, Megan J. Fitzpatrick, Valentina Nardi (+24 others)
2020 The FASEB Journal  
T A B L E 1 Demographics of cohorts used in analysis F I G U R E 1 Sensitivity by assay modality over time.  ...  genes, and the Xpert Xpress SARS-CoV-2 assay run on the GeneXpert Infinity (Cepheid) targets regions of the N and E genes.  ...  Bard, T. Gogakos, E.S. Rosenberg, and J.K. Lennerz conceived and designed the study. T.E. Miller, W.F. Garcia Beltran, A.Z. Bard, T. Gogakos, M.N. Anahtar, M.G. Astudillo, D. Yang, J. Thierauf, A.S.  ... 
doi:10.1096/fj.202001700rr pmid:32856766 pmcid:PMC7461169 fatcat:dhfkionogfbpfczr7jxkh4n5qe

Page 25 of None Vol. 6, Issue 31 [page]

1828 None  
E  ...  -—Call EricEric the bard,” he added, as with loud acclamations all drained their goblets to the bottom—‘“ he who made the song of triumph what time I ravaged the wide seas of Britain.”  ... 

ACCF/AHA Consensus Conference Report on Professionalism and Ethics: Participants/authors

2004 Journal of the American College of Cardiology  
E.  ...  Eric N. Prystowsky • Bard Medical • Guidant • Guidant • Guidant • Bard Medical • Astra Zeneca None • CardioNet • King Pharmaceuticals, Inc.  ... 
doi:10.1016/j.jacc.2004.09.002 fatcat:3xnx7agc2rfdjhkqwjsrdo4moq

GREAT3 results – I. Systematic errors in shear estimation and the impact of real galaxy morphology

Rachel Mandelbaum, Barnaby Rowe, Robert Armstrong, Deborah Bard, Emmanuel Bertin, James Bosch, Dominique Boutigny, Frederic Courbin, William A. Dawson, Annamaria Donnarumma, Ian Fenech Conti, Raphaël Gavazzi (+31 others)
2015 Monthly notices of the Royal Astronomical Society  
) ) 2 as e 2[1 − (e (s) ) 2 ]g.  ...  A PCA decomposition was then performed on a vector with first component | e| = (e 1,out − e 1,in ) 2 + (e 2,out − e 2,in ) 2 .  ... 
doi:10.1093/mnras/stv781 fatcat:eqavquyi5zfdfb2qmri4zaer7i

Page 551 of British Librarian 1737 Vol. 1, Issue [page]

1760 British Librarian 1737  
4 yo ‘ Farexp «0 laid it al E ng pace, walks o’er the ks around him feed. 1 cool refrefhing gale, charm is center’d in the inflation of Eric- an Archb--p. cool Epictetus hat doétrine to a maid, to tranflate  ...  fup with you : bards fay feldom true, . \ bard faid he wou ; naries 5st Answer te theR EB US in our laft.  ... 

Preface [chapter]

2020 The Intellectual Origins of the Global Financial Crisis  
Th e rise of economic thinking is central to  ...  Th e second main section of Arendt's exploration of twentieth-century totalitarianism is called "Imperialism."  ...  Th e ensuing conference, "Th e Burden of Our Times: Th e Intellectual Origins of the Global Financial Crisis," took place in October 2009 at Bard College.  ... 
doi:10.1515/9780823249633-001 fatcat:tptzwh5fufh4rikqoapyeezwdi

Page 350 of Neural Computation Vol. 6, Issue 2 [page]

1994 Neural Computation  
Cugliandolo Letters Learning of Phase Lags in Coupled Neural Oscillators Bard Ermentrout and Nancy Kopell A Mechanism for Neuronal Gain Control by Descending Pathways Mark E.  ...  Backpropagation Algorithm and Resistance to Local Minima William Finnoff Relating Real-Time Backpropagation and Backpropagation-Through-Time: An Application of Flow Graph Interreciprocity Francoise Beaufays and Eric  ... 

Page 150 of Church History Vol. 12, Issue 2 [page]

1943 Church History  
W., Prof. 619 E. Washington St. Greencastle, Ind. Hirsch, Elizabeth F., Dr. Bard College Annandale-on-Hudson, N. Y. Hoffman, Milton J., Prof. New Brunswick Theological Seminary New Brunswick, N. J.  ...  Harbison, E. Harris, Prof. 9 Aiken Ave. Princeton, N. J. Hardy, E. R., Jr., Dr. 175 Ninth Ave. New York, N. Y. Harkness, R. E. E., Prof. Crozer Theological Seminary Chester, Penna.  ... 

Page 168 of Church History Vol. 11, Issue 2 [page]

1942 Church History  
W., Prof. 619 E. Washington St. Greencastle, Ind. Hirsch, Elizabeth F., Dr. Bard College Annandale-on-Hudson, N. Y. Hoffman, Milton J., Prof. New Brunswick Theological Seminary New Brunswick, N. J.  ...  Harbison, E. Harris, Prof. 9 Aiken Ave. Princeton, N. J. Hardy, E. R., Jr., Dr. 175 Ninth Ave. New York, N. Y. Harkness, R. E. E., Prof. Crozer Theological Seminary Chester, Penna.  ... 

Page 150 of Church History Vol. 13, Issue 2 [page]

1944 Church History  
W., Prof. 619 E. Washington St. Greencastle, Ind. Hirsch, Elizabeth F., Dr. Bard College Annandale-on-Hudson, N. Y. Hoffman, Milton J., Prof. New Brunswick Theological Seminary New Brunswick, N. J.  ...  Harbison, E. Harris, Prof. 9 Aiken Ave. Princeton, N. J. Hardy, E. R., Jr., Dr. 175 Ninth Ave. New York 11, N. Y. Harkness, R. E. E., Prof. Crozer Theological Seminary Chester, Penna.  ... 

Page 388 of Overland Monthly and Out West Magazine Vol. 85, Issue 12 [page]

1927 Overland Monthly and Out West Magazine  
STERLING, GEORGE STEWART, IRENE TAGGARD, GENEVIEVE TAYLOR, ERIC THOMPSON, JESSE THORSELL, ESTHER TYRELL, DOROTHY ULMAN, DOROTHY VALENTINE, UFFINGTON WAITE, EDGAR WARDEMAN, WATKINS, MARY E WHITE, TOM ..  ...  FIELD, SARA BARD FITCH, W. T. FLANNAGAN, DOROTHY GIDLOW, ELSA GORDON, DON .. GROSS, ANTON GROSS, CARL W GREENWOOD, MAY . HAGEMEYER, JOHAN HAMPTON, EDGAR LLOYD HANIFIN, ADA.. HARRIS, JOSEPH ...  ... 
« Previous Showing results 1 — 15 out of 3,814 results