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Enlarged perivascular spaces in brain MRI: Automated quantification in four regions
2019
NeuroImage
A B S T R A C T Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, are common in aging, and are considered a reflection of cerebral small vessel disease. ...
These scans were visually scored by an expert rater, who counted the number of PVS in each brain region. ...
Introduction This paper proposes and evaluates an algorithm for the automated quantification of enlarged perivascular spaces (PVS) in four brain regions. ...
doi:10.1016/j.neuroimage.2018.10.026
pmid:30326293
fatcat:yvlkoeeyw5cvlg63sxq6opltxy
3D Regression Neural Network for the Quantification of Enlarged Perivascular Spaces in Brain MRI
[article]
2018
arXiv
pre-print
Enlarged perivascular spaces (EPVS) in the brain are an emerging imaging marker for cerebral small vessel disease, and have been shown to be related to increased risk of various neurological diseases, ...
We propose a convolutional network regression method to quantify the extent of EPVS in the basal ganglia from 3D brain MRI. ...
Introduction This paper addresses the problem of automated quantification of enlarged perivascular spaces from MR images. ...
arXiv:1802.05914v2
fatcat:pysgwj6tframzhsfmk5oasrsxy
Automated Quantification of Enlarged Perivascular Spaces in Clinical Brain MRI across Sites
[article]
2019
bioRxiv
pre-print
Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, and are a marker of cerebral small vessel disease. ...
We evaluate and compare two recently published automated methods for the quantification of enlarged perivascular spaces in 76 clinical scans acquired from 9 different scanners. ...
Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, and are a marker of cerebral small vessel disease. ...
doi:10.1101/738955
fatcat:f53n7ljbnrghfjuw4r4yiyei7i
Direct Rating Estimation of Enlarged Perivascular Spaces (EPVS) in Brain MRI Using Deep Neural Network
2021
Applied Sciences
In this article, we propose a deep-learning-based estimation model for rating enlarged perivascular spaces (EPVS) in the brain's basal ganglia region using T2-weighted magnetic resonance imaging (MRI) ...
The model uses the cropped basal ganglia region on the T2-weighted MRI. We formulated the rating of EPVS as a multi-class classification problem. ...
Several studies on enlarged perivascular spaces (EPVS) in the brain indicate that their presence is an indication of neuronal dysfunctions and that they could serve as a biomarker to diagnose brain diseases ...
doi:10.3390/app11209398
fatcat:gw5mxhp27ff7lbrpmco545gm3q
The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study
2019
Clinical Interventions in Aging
EPVS in the CSO and BG may have distinct pathophysiology.Keywords: enlarged perivascular spaces, cerebral small vessel disease, blood–brain barrier, dynamic contrast-enhanced, DCE, magnetic res [...] ...
perivascular spaces (EPVS) have been widely considered as a feature of cerebral small vessel disease (cSVD) but the pathogenesis of EPVS remains unclear. ...
Keywords: enlarged perivascular spaces, cerebral small vessel disease, blood–brain barrier, dynamic contrast-enhanced, DCE, magnetic resonance imaging, MRI Introduction Enlarged perivascular spaces (EPVS ...
doaj:cf00e3256b5940feb209a61d7c73fccb
fatcat:onbk4rogpbcmhfrpiiuifpaefq
Image processing approaches to enhance perivascular space visibility and quantification using MRI
[article]
2019
bioRxiv
pre-print
Imaging the perivascular spaces (PVS), also known as Virchow-Robin space, has significant clinical value, but there remains a need for neuroimaging techniques to improve mapping and quantification of the ...
Current technique for PVS evaluation is a scoring system based on visual reading of visible PVS in regions of interest, and often limited to large caliber PVS. ...
The contrast ratio between perivascular spaces (PVS) and the adjacent white matter voxels from multiple manually selected regions. ...
doi:10.1101/609362
fatcat:zcm5uymiojeojdvc7mt53t6wkq
Perivascular spaces--MRI marker of inflammatory activity in the brain?
2008
Brain
The Virchow^Robin spaces (VRS), perivascular compartments surrounding small blood vessels as they penetrate the brain parenchyma, are increasingly recognized for their role in leucocyte trafficking as ...
In the present study, we investigated VRS numbers and volumes in different brain regions in 45 multiple sclerosis patients and 30 healthy controls of similar age and gender distribution, applying three ...
in multiple sclerosis Brain (2008) , 131, 2332^2340 ...
doi:10.1093/brain/awn171
pmid:18676439
fatcat:wcvf7q47avd2lbpmpccmatgirq
Automated quantification of small vessel disease brain changes on MRI predicts cognitive and functional decline
[article]
2019
bioRxiv
pre-print
measures of white matter hyperintensities (WMH), lacunes, cortical infarcts, enlarged perivascular spaces and regional brain atrophy. ...
We used automated MRI segmentation to quantify multiple types of SVD brain changes and examined their individual and combined predictive value on cognitive and functional abilities. ...
spaces were determined with automated MRI segmentation.. ...
doi:10.1101/621888
fatcat:lcwl2sbyxbe6zbrjkyooyktcuu
Image processing approaches to enhance perivascular space visibility and quantification using MRI
2019
Scientific Reports
Imaging the perivascular spaces (PVS), also known as Virchow-Robin space, has significant clinical value, but there remains a need for neuroimaging techniques to improve mapping and quantification of the ...
Current technique for PVS evaluation is a scoring system based on visual reading of visible PVS in regions of interest, and often limited to large caliber PVS. ...
Imperfection of the brain parcellation could affect the automated quantification (see an example in Supplementary Fig. 1 ). ...
doi:10.1038/s41598-019-48910-x
pmid:31451792
pmcid:PMC6710285
fatcat:nxokg2litjcidnqk2lsqymddqq
MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden
2017
Brain
We also hypothesised that MRI-visible perivascular spaces in the centrum semiovale would be associated with brain amyloid burden, as detected by amyloid-PET using subcortical vascular cognitive impairment ...
MRI-visible perivascular space severity in either location did not predict amyloid-PET positivity. ...
CMBs were counted in four lobar regions (frontal, temporal, parietal, occipital) and also in deep brain regions. A lobar region was defined as tissue ≤10 mm from the brain surface. ...
doi:10.1093/brain/awx003
pmid:28335021
fatcat:embfk55eqne7jfaqy4pnnlufcy
Ontario Neurodegenerative Disease Research Initiative (ONDRI): Structural MRI Methods and Outcome Measures
2020
Frontiers in Neurology
To effectively quantify regional measures of normal and pathological brain tissue volumes, the ONDRI neuroimaging platform implemented a semi-automated MRI processing pipeline that was able to address ...
The purpose of this paper is to serve as a reference and conceptual overview of the comprehensive neuroimaging pipeline used to generate regional brain tissue volumes and neurovascular marker data that ...
ACKNOWLEDGMENTS We would like to thank the ONDRI participants for the time, consent, and participation in our study. Thank you to the L.C. ...
doi:10.3389/fneur.2020.00847
pmid:32849254
pmcid:PMC7431907
fatcat:pqfbaq5skzax3iezfqs5i42squ
DEEPMIR: A DEEP neural network for differential detection of cerebral Microbleeds and IRon deposits in MRI
[article]
2021
arXiv
pre-print
Lobar cerebral microbleeds (CMBs) and localized non-hemorrhage iron deposits in the basal ganglia have been associated with brain aging, vascular disease and neurodegenerative disorders. ...
Quantitative susceptibility mapping (QSM) derived from in vivo magnetic resonance imaging (MRI) is necessary to differentiate between iron content and mineralization. ...
Mimics such as enlarged perivascular spaces (EPVS) and calcifications have an appearance on SWI that is similar to that of CMBs. ...
arXiv:2010.00148v3
fatcat:qfoxkor7prehfo6747wmirslvm
Role of MRI in multiple sclerosis I: inflammation and lesions
2004
Frontiers in Bioscience
All observers also agreed that 4 T images subjectively enhanced the perception of normal perivascular spaces and small perivascular lesions. ...
Quantification
3.4. Prognostic value
4. Role of enhanced MRI scans in detecting inflammation
4.1. Evidence of blood brain barrier breakdown
4.2. ...
doi:10.2741/1251
pmid:14766399
fatcat:be5nm4fsore3llnriijlr67weq
Brain morphometry and longitudinal relaxation time of spontaneously hypertensive rats (SHR) in early and intermediate stages of hypertension investigated by 3D VFA-SPGR MRI
2019
Neuroscience
The diagnostic features by which SVD manifests in brain includes white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and atrophy. ...
In the present study, we use in vivo magnetic resonance imaging (MRI) to characterize brain morphometry and longitudinal relaxation time (T1) of spontaneously hypertensive rats (SHRs) to study the contribution ...
Author manuscript; available in PMC 2020 April 15.
Author Manuscript Author Manuscript
Author Manuscript Author Manuscript ...
doi:10.1016/j.neuroscience.2019.01.030
pmid:30690138
pmcid:PMC6450758
fatcat:z5v4kph4yna7jow6tm4i55q324
Enlarged perivascular spaces in multiple sclerosis on magnetic resonance imaging: a systematic review and meta-analysis
2020
Journal of Neurology
Perivascular spaces can become detectable on magnetic resonance imaging (MRI) upon enlargement, referred to as enlarged perivascular spaces (EPVS) or Virchow-Robin spaces. ...
In MS, EPVS have been associated with cognitive decline, contrast-enhancing MRI lesions, and brain atrophy. Yet, these associations were not consistent between studies. ...
We are grateful for funding from the Swiss National Science Foundation (to BVI) and Region Stockholm (to TG). We thank Leo Ornstein for help with data analysis. ...
doi:10.1007/s00415-020-09971-5
pmid:32535680
pmcid:PMC7577911
fatcat:cp5ygshkinbthm6ekolqjsrz5i
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