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Enlarged perivascular spaces in brain MRI: Automated quantification in four regions

Florian Dubost, Pinar Yilmaz, Hieab Adams, Gerda Bortsova, M. Arfan Ikram, Wiro Niessen, Meike Vernooij, Marleen de Bruijne
2019 NeuroImage  
A B S T R A C T Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, are common in aging, and are considered a reflection of cerebral small vessel disease.  ...  These scans were visually scored by an expert rater, who counted the number of PVS in each brain region.  ...  Introduction This paper proposes and evaluates an algorithm for the automated quantification of enlarged perivascular spaces (PVS) in four brain regions.  ... 
doi:10.1016/j.neuroimage.2018.10.026 pmid:30326293 fatcat:yvlkoeeyw5cvlg63sxq6opltxy

3D Regression Neural Network for the Quantification of Enlarged Perivascular Spaces in Brain MRI [article]

Florian Dubost, Hieab Adams, Gerda Bortsova, M. Arfan Ikram, Wiro Niessen, Meike Vernooij, Marleen de Bruijne
2018 arXiv   pre-print
Enlarged perivascular spaces (EPVS) in the brain are an emerging imaging marker for cerebral small vessel disease, and have been shown to be related to increased risk of various neurological diseases,  ...  We propose a convolutional network regression method to quantify the extent of EPVS in the basal ganglia from 3D brain MRI.  ...  Introduction This paper addresses the problem of automated quantification of enlarged perivascular spaces from MR images.  ... 
arXiv:1802.05914v2 fatcat:pysgwj6tframzhsfmk5oasrsxy

Automated Quantification of Enlarged Perivascular Spaces in Clinical Brain MRI across Sites [article]

Florian Dubost, Max Duennwald, Denver Huff, Vincent Scheumann, Frank Schreiber, Meike Vernooij, Wiro Niessen, Martin Skalej, Stefanie Schreiber, Steffen Oeltze-Jafra, Marleen de Bruijne
2019 bioRxiv   pre-print
Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, and are a marker of cerebral small vessel disease.  ...  We evaluate and compare two recently published automated methods for the quantification of enlarged perivascular spaces in 76 clinical scans acquired from 9 different scanners.  ...  Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, and are a marker of cerebral small vessel disease.  ... 
doi:10.1101/738955 fatcat:f53n7ljbnrghfjuw4r4yiyei7i

Direct Rating Estimation of Enlarged Perivascular Spaces (EPVS) in Brain MRI Using Deep Neural Network

Ehwa Yang, Venkateswarlu Gonuguntla, Won-Jin Moon, Yeonsil Moon, Hee-Jin Kim, Mina Park, Jae-Hun Kim
2021 Applied Sciences  
In this article, we propose a deep-learning-based estimation model for rating enlarged perivascular spaces (EPVS) in the brain's basal ganglia region using T2-weighted magnetic resonance imaging (MRI)  ...  The model uses the cropped basal ganglia region on the T2-weighted MRI. We formulated the rating of EPVS as a multi-class classification problem.  ...  Several studies on enlarged perivascular spaces (EPVS) in the brain indicate that their presence is an indication of neuronal dysfunctions and that they could serve as a biomarker to diagnose brain diseases  ... 
doi:10.3390/app11209398 fatcat:gw5mxhp27ff7lbrpmco545gm3q

The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study

Li Y, Li M, Yang L, Qin W, Yang S, Yuan J, Jiang T, Hu W
2019 Clinical Interventions in Aging  
EPVS in the CSO and BG may have distinct pathophysiology.Keywords: enlarged perivascular spaces, cerebral small vessel disease, blood–brain barrier, dynamic contrast-enhanced, DCE, magnetic res [...]  ...  perivascular spaces (EPVS) have been widely considered as a feature of cerebral small vessel disease (cSVD) but the pathogenesis of EPVS remains unclear.  ...  Keywords: enlarged perivascular spaces, cerebral small vessel disease, blood–brain barrier, dynamic contrast-enhanced, DCE, magnetic resonance imaging, MRI Introduction Enlarged perivascular spaces (EPVS  ... 
doaj:cf00e3256b5940feb209a61d7c73fccb fatcat:onbk4rogpbcmhfrpiiuifpaefq

Image processing approaches to enhance perivascular space visibility and quantification using MRI [article]

Farshid Sepehrband, Giuseppe Barisano, Nasim Sheikh-Bahaei, Ryan P Cabeen, Jeiran Choupan, Meng Law, Arthur W Toga
2019 bioRxiv   pre-print
Imaging the perivascular spaces (PVS), also known as Virchow-Robin space, has significant clinical value, but there remains a need for neuroimaging techniques to improve mapping and quantification of the  ...  Current technique for PVS evaluation is a scoring system based on visual reading of visible PVS in regions of interest, and often limited to large caliber PVS.  ...  The contrast ratio between perivascular spaces (PVS) and the adjacent white matter voxels from multiple manually selected regions.  ... 
doi:10.1101/609362 fatcat:zcm5uymiojeojdvc7mt53t6wkq

Perivascular spaces--MRI marker of inflammatory activity in the brain?

J. Wuerfel, M. Haertle, H. Waiczies, E. Tysiak, I. Bechmann, K. D. Wernecke, F. Zipp, F. Paul
2008 Brain  
The Virchow^Robin spaces (VRS), perivascular compartments surrounding small blood vessels as they penetrate the brain parenchyma, are increasingly recognized for their role in leucocyte trafficking as  ...  In the present study, we investigated VRS numbers and volumes in different brain regions in 45 multiple sclerosis patients and 30 healthy controls of similar age and gender distribution, applying three  ...  in multiple sclerosis Brain (2008) , 131, 2332^2340  ... 
doi:10.1093/brain/awn171 pmid:18676439 fatcat:wcvf7q47avd2lbpmpccmatgirq

Automated quantification of small vessel disease brain changes on MRI predicts cognitive and functional decline [article]

Hanna Jokinen, Juha Koikkalainen, Hanna M Laakso, Susanna Melkas, Tuomas Nieminen, Antti Brander, Antti Korvenoja, Daniel Rueckert, Frederik Barkhof, Philip Scheltens, Reinhold Schmidt, Franz Fazekas (+12 others)
2019 bioRxiv   pre-print
measures of white matter hyperintensities (WMH), lacunes, cortical infarcts, enlarged perivascular spaces and regional brain atrophy.  ...  We used automated MRI segmentation to quantify multiple types of SVD brain changes and examined their individual and combined predictive value on cognitive and functional abilities.  ...  spaces were determined with automated MRI segmentation..  ... 
doi:10.1101/621888 fatcat:lcwl2sbyxbe6zbrjkyooyktcuu

Image processing approaches to enhance perivascular space visibility and quantification using MRI

Farshid Sepehrband, Giuseppe Barisano, Nasim Sheikh-Bahaei, Ryan P. Cabeen, Jeiran Choupan, Meng Law, Arthur W. Toga
2019 Scientific Reports  
Imaging the perivascular spaces (PVS), also known as Virchow-Robin space, has significant clinical value, but there remains a need for neuroimaging techniques to improve mapping and quantification of the  ...  Current technique for PVS evaluation is a scoring system based on visual reading of visible PVS in regions of interest, and often limited to large caliber PVS.  ...  Imperfection of the brain parcellation could affect the automated quantification (see an example in Supplementary Fig. 1 ).  ... 
doi:10.1038/s41598-019-48910-x pmid:31451792 pmcid:PMC6710285 fatcat:nxokg2litjcidnqk2lsqymddqq

MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

Gargi Banerjee, Hee Jin Kim, Zoe Fox, H. Rolf Jäger, Duncan Wilson, Andreas Charidimou, Han Kyu Na, Duk L. Na, Sang Won Seo, David J. Werring
2017 Brain  
We also hypothesised that MRI-visible perivascular spaces in the centrum semiovale would be associated with brain amyloid burden, as detected by amyloid-PET using subcortical vascular cognitive impairment  ...  MRI-visible perivascular space severity in either location did not predict amyloid-PET positivity.  ...  CMBs were counted in four lobar regions (frontal, temporal, parietal, occipital) and also in deep brain regions. A lobar region was defined as tissue ≤10 mm from the brain surface.  ... 
doi:10.1093/brain/awx003 pmid:28335021 fatcat:embfk55eqne7jfaqy4pnnlufcy

Ontario Neurodegenerative Disease Research Initiative (ONDRI): Structural MRI Methods and Outcome Measures

Joel Ramirez, Melissa F. Holmes, Christopher J. M. Scott, Miracle Ozzoude, Sabrina Adamo, Gregory M. Szilagyi, Maged Goubran, Fuqiang Gao, Stephen R. Arnott, Jane M. Lawrence-Dewar, Derek Beaton, Stephen C. Strother (+7 others)
2020 Frontiers in Neurology  
To effectively quantify regional measures of normal and pathological brain tissue volumes, the ONDRI neuroimaging platform implemented a semi-automated MRI processing pipeline that was able to address  ...  The purpose of this paper is to serve as a reference and conceptual overview of the comprehensive neuroimaging pipeline used to generate regional brain tissue volumes and neurovascular marker data that  ...  ACKNOWLEDGMENTS We would like to thank the ONDRI participants for the time, consent, and participation in our study. Thank you to the L.C.  ... 
doi:10.3389/fneur.2020.00847 pmid:32849254 pmcid:PMC7431907 fatcat:pqfbaq5skzax3iezfqs5i42squ

DEEPMIR: A DEEP neural network for differential detection of cerebral Microbleeds and IRon deposits in MRI [article]

Tanweer Rashid, Ahmed Abdulkadir, Ilya M. Nasrallah, Jeffrey B. Ware, Hangfan Liu, Pascal Spincemaille, J. Rafael Romero, R. Nick Bryan, Susan R. Heckbert, Mohamad Habes
2021 arXiv   pre-print
Lobar cerebral microbleeds (CMBs) and localized non-hemorrhage iron deposits in the basal ganglia have been associated with brain aging, vascular disease and neurodegenerative disorders.  ...  Quantitative susceptibility mapping (QSM) derived from in vivo magnetic resonance imaging (MRI) is necessary to differentiate between iron content and mineralization.  ...  Mimics such as enlarged perivascular spaces (EPVS) and calcifications have an appearance on SWI that is similar to that of CMBs.  ... 
arXiv:2010.00148v3 fatcat:qfoxkor7prehfo6747wmirslvm

Role of MRI in multiple sclerosis I: inflammation and lesions

Robert Zivadinov
2004 Frontiers in Bioscience  
All observers also agreed that 4 T images subjectively enhanced the perception of normal perivascular spaces and small perivascular lesions.  ...  Quantification 3.4. Prognostic value 4. Role of enhanced MRI scans in detecting inflammation 4.1. Evidence of blood brain barrier breakdown 4.2.  ... 
doi:10.2741/1251 pmid:14766399 fatcat:be5nm4fsore3llnriijlr67weq

Brain morphometry and longitudinal relaxation time of spontaneously hypertensive rats (SHR) in early and intermediate stages of hypertension investigated by 3D VFA-SPGR MRI

Sunil Koundal, Xiaodan Liu, Simon Sanggaard, Kristian Mortensen, Joanna Wardlaw, Maiken Nedergaard, Helene Benveniste, Hedok Lee
2019 Neuroscience  
The diagnostic features by which SVD manifests in brain includes white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and atrophy.  ...  In the present study, we use in vivo magnetic resonance imaging (MRI) to characterize brain morphometry and longitudinal relaxation time (T1) of spontaneously hypertensive rats (SHRs) to study the contribution  ...  Author manuscript; available in PMC 2020 April 15. Author Manuscript Author Manuscript Author Manuscript Author Manuscript  ... 
doi:10.1016/j.neuroscience.2019.01.030 pmid:30690138 pmcid:PMC6450758 fatcat:z5v4kph4yna7jow6tm4i55q324

Enlarged perivascular spaces in multiple sclerosis on magnetic resonance imaging: a systematic review and meta-analysis

Tobias Granberg, Thomas Moridi, Judith S Brand, Susanne Neumann, Martin Hlavica, Fredrik Piehl, Benjamin V Ineichen
2020 Journal of Neurology  
Perivascular spaces can become detectable on magnetic resonance imaging (MRI) upon enlargement, referred to as enlarged perivascular spaces (EPVS) or Virchow-Robin spaces.  ...  In MS, EPVS have been associated with cognitive decline, contrast-enhancing MRI lesions, and brain atrophy. Yet, these associations were not consistent between studies.  ...  We are grateful for funding from the Swiss National Science Foundation (to BVI) and Region Stockholm (to TG). We thank Leo Ornstein for help with data analysis.  ... 
doi:10.1007/s00415-020-09971-5 pmid:32535680 pmcid:PMC7577911 fatcat:cp5ygshkinbthm6ekolqjsrz5i
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