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Enhancing Human Spermine Synthase Activity by Engineered Mutations
2013
PLoS Computational Biology
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Spermine synthase (SMS) is an enzyme which function is to convert spermidine into spermine. ...
In contrast to these studies, here we report an artificial engineering of a more efficient SMS variant by transferring sequence information from another organism. ...
Negative folding energy change indicates that the mutant monomers are less stable compared with Enhancing Human Spermine Synthase Activity WT monomers, while positive energy change means increasing stability ...
doi:10.1371/journal.pcbi.1002924
pmid:23468611
pmcid:PMC3585406
fatcat:ng444mbe4re7botnts3m7s2hvy
Defining the role of polyamines in colon carcinogenesis using mouse models
2011
Journal of Carcinogenesis
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Genetically engineered mouse (GEM) models have made a significant contribution to the characterization of colorectal cancer risk factors. ...
Our work in this area has been primarily supported by USPHS grants from the National Cancer Institute (CA-72008, CA-95060, and CA-123065). ...
The hearing loss in Gy mice was reversed by breeding them with CAG/SmS mice, a transgenic line that ubiquitously expresses spermine synthase under the control of a composite cytomegalovirus-IE enhancer ...
doi:10.4103/1477-3163.79673
pmid:21712957
pmcid:PMC3122100
fatcat:wp4m3hsbebbb5nkxunz5cfy7pe
Characterization of transgenic mice with overexpression of spermidine synthase
2011
Amino Acids
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A composite cytomegalovirus-immediate early gene enhancer/chicken β-actin promoter (CAG) was utilized to generate transgenic mice that overexpress human spermidine synthase (SpdS) in order to determine ...
the impact of elevated spermidine synthase activity on murine development and physiology. ...
Supported by National Institutes of Health grants CA-018138 (DJF) and GM-26290 (AEP). ...
doi:10.1007/s00726-011-1028-6
pmid:21809077
pmcid:PMC3245749
fatcat:5mygsga3mvbj3dw5wexob7jn7e
Skin Carcinogenesis Studies Using Mouse Models with Altered Polyamines
2015
Cancer Growth and Metastasis
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Putrescine is converted to the higher polyamines spermidine and spermine by spermidine synthase (SpdS) and spermine synthase (SpmS), respectively. ...
It was originally hypothesized that genetic manipulations to enhance SSAT activity would decrease tumor susceptibility by depleting the higher polyamines spermidine and spermine. ...
doi:10.4137/cgm.s21219
pmid:26380554
pmcid:PMC4558889
fatcat:jipjaxmrinhmrlz5timh3guhai
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis
2012
Cancer Biology & Therapy
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(Spm) are produced from putrescine and the aminopropyl donor dcAdoMet by sequential action of the independent enzymes spermidine synthase (SpdS) and spermine synthase (SpmS). ...
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis human FAP syndrome and it has been utilized to identify genes ...
doi:10.4161/cbt.19241
pmid:22258329
pmcid:PMC3341213
fatcat:p47jeexybvdgpc2c67asqn4skq
Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases
2018
Medical Sciences
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The other Food and Drug Administration (FDA) approved application for DFMO is as an active ingredient in the hair removal cream Vaniqa. ...
Putrescine is further converted to spermidine and spermine by the sequential actions of spermidine synthase (SPDSYN) and spermine synthase (SPMSYN). ...
ARG: arginase; ODC: ornithine decarboxylase; SPDSYN: spermidine synthase; SPMSYN: spermine synthase; ADOMETDC: S-adenosylmethionine decarboxylase; SMO: spermine oxidase; SSAT: spermidine/spermine N1-acetyltransferase ...
doi:10.3390/medsci6010012
pmid:29419804
pmcid:PMC5872169
fatcat:rgnz55zvgffnpafelvmvx7nlgi
Polyamines: Small Molecules Triggering Pathways in Plant Growth and Development
1997
Plant Physiology
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Spain (A.F.T.) ity that provides the aminopropyl moiety that is used by spermidine and spermine synthases, respectively, to convert putrescine to spermidine and spermine. ...
In both of these studies only an increase in putrescine levels was observed, raising the issue of whether SAMDC, spermidine synthase, or spermine synthase activities are limiting in plants. ...
doi:10.1104/pp.113.4.1009
pmid:9112764
pmcid:PMC158223
fatcat:znrzfbpdqjft7dwivsia62hy2i
Reengineering the Oligosaccharide Specificity of CVN with BP_Dock
2013
Biophysical Journal
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Enhancing Human Spermine Synthase Activity by Site Directed Mutations Zhe Zhang 1,2 , Anthony Pegg 3 , Yoshihiko Ikeguchi 4 , Emil Alexov 1 . 1 Clemson University, Clemson, SC, USA, 2 University of Paris ...
Spermine Synthase (SMS) is an enzyme converting spermidine into spermine, both of which are polyamines controlling normal cell growth and development. ...
doi:10.1016/j.bpj.2012.11.2114
fatcat:xm2masde65bmviy3udstk3ccrm
Interferons: Reprogramming the Metabolic Network against Viral Infection
2018
Viruses
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Recent studies have started to illuminate on the specific role of interferon in rewiring cellular metabolism to activate immune cells and limit viral infection. ...
Interferons are cytokines that enhances the transcription of hundreds of interferon-stimulated genes (ISGs) whose products are key players in the innate immune response to viral infection. ...
Acknowledgments: This work was supported by funding from Canadian Institutes of Health Research to Chen Liang. Author Contributions: Kavita Raniga and Chen Liang prepared the manuscript. ...
doi:10.3390/v10010036
pmid:29342871
pmcid:PMC5795449
fatcat:x3o5f4w4kfgqjl6q5hbc732vyq
Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism
2018
Science Advances
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In contrast to the view of metabolites as fuel (anabolic intermediates) for cancer cells, polyamines are better defined as the oil that lubricates the cancer engine because they affect the activity of ...
In this review, we enumerate and discuss current views of the regulation and activity of polyamine metabolism in tumor cell biology. ...
Spermidine can react with a second dcSAM molecule through the action of spermine synthase to produce spermine and an additional MTA molecule. ...
doi:10.1126/sciadv.aar2606
pmid:29376126
pmcid:PMC5783676
fatcat:wpubsrgihbhedezxnhqasxg4re
Targeting Polyamines and Inflammation for Cancer Prevention
[chapter]
2010
Recent Results in Cancer Research
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These include reactions catalyzed by the biosynthetic enzymes, ornithine decarboxylase (ODC), Sadenosylmethionine decarboxylase (SAMDC), and the spermidine and spermine synthases. ...
Targeting polyamine metabolism (by use of polyamine synthesis inhibitors or polyamine catabolism activators) and inflammation (by use of nonsteroidal anti-inflammatory drugs) has been studied for many ...
As shown in this figure, the activity of the surface transporter to import aiginine can be enhanced by increasing polyamine synthesis and/or export, as occurs in human prostate carcinogenesis (Bettuzzi ...
doi:10.1007/978-3-642-10858-7_4
pmid:21253788
pmcid:PMC3587145
fatcat:r6c5oel5tzawtasydgeyvcisry
Citrus Polyamines: Structure, Biosynthesis, and Physiological Functions
2020
Plants
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We believe that the molecular and biochemical understanding of PAs metabolism and their physiological roles in citrus plants will help citrus breeding programs to enhance tolerance to biotic and abiotic ...
genetic engineering. ...
SAMS: S-Adenosyl-methionine synthase, SPDS: Spermidine synthase, SPMS: Spermine synthase, and TSS: Thermospermine synthase encoded by ACAULIS5 (ACL5). ...
doi:10.3390/plants9040426
pmid:32244406
fatcat:s7roriuakfdbvojdcqyygpgfn4
Novel Chimeric Spermidine Synthase-Saccharopine Dehydrogenase Gene (SPE3-LYS9) in the Human PathogenCryptococcus neoformans
2004
Eukaryotic Cell
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In contrast toSaccharomyces cerevisiae spe3mutants, the polyamine auxotrophy ofC. neoformans spe3-LYS9mutants was not satisfied by spermine. ...
Thus,SPE3-LYS9encodes functional spermidine synthase and saccharopine dehydrogenase gene products. ...
This work was supported by a Public Health Service grant from NIAID (PO1-AI44975). ...
doi:10.1128/ec.3.3.752-763.2004
pmid:15189996
pmcid:PMC420128
fatcat:juqy5rf3wrgaxnlvafwaqog6du
Polyamines and transglutaminases: biological, clinical, and biotechnological perspectives
2014
Amino Acids
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The mechanisms which lead to enhanced proliferation are unknown. Modification of eIF-5A involves two catalytic steps by deoxyhypusine synthase (DHS) and deoxhypusine hydroxylase (DOHH). ...
BSAO and spermine association in multidrug resistant cells, sensitized to spermine metabolites by an increased mitochondrial activity, and mammals spermine oxidase are differentially activated in tissues ...
doi:10.1007/s00726-014-1688-0
pmid:24553826
fatcat:yudjhpfqevbnpkwgqsugt3dvqm
Combination Chemoprevention for Colon Cancer Targeting Polyamine Synthesis and Inflammation
2009
Clinical Cancer Research
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Increased polyamine synthesis and inflammation have long been associated with colon carcinogenesis in both preclinical models and in humans. ...
synthesis and inflammation can be an effective strategy for preventing the occurrence of the advanced and/or multiple adenomas that are most closely associated with the development of colon cancers in humans ...
This bile acid -induced inflammatory response is suppressed by loss of nitric oxide synthase 2 alleles in genetically engineered mice (18) , which imply a role for the nitric oxide synthase 2 substrate ...
doi:10.1158/1078-0432.ccr-08-2235
pmid:19188144
pmcid:PMC2666541
fatcat:xmuvbiajirbd5dnfozoswqvwya
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