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The Role of Donor-Specific HLA Alloantibodies in Liver Transplantation

J. G. O'Leary, A. J. Demetris, L. S. Friedman, H. M. Gebel, P. F. Halloran, A. D. Kirk, S. J. Knechtle, S. V. McDiarmid, A. Shaked, P. I. Terasaki, K. J. Tinckam, S. J. Tomlanovich (+4 others)
2014 American Journal of Transplantation  
Several insights emerged. Acute antibody-mediated rejection (AMR), although rarely diagnosed, is increasingly understood to overlap with T cell-mediated rejection.  ...  Persons who undergo simultaneous liver-kidney transplantation are at risk of renal AMR when Class II DSA persist posttransplantation.  ...  with antibody class, subclass, MFI and specificity; (2) characteristics and timing of ADCC pathways; (3) endothelial physiologic consequences of antibody binding; and (4) potential novel therapeutic strategies  ... 
doi:10.1111/ajt.12667 pmid:24580828 pmcid:PMC4412601 fatcat:pb564exc7jbzfjtncv226jjkbq

Cell–cell signaling via Eph receptors and ephrins

Juha-Pekka Himanen, Nayanendu Saha, Dimitar B Nikolov
2007 Current Opinion in Cell Biology  
with promiscuous intra-subclass interactions, but rarely observed inter-subclass interactions.  ...  The interactions of the Ephs with their ephrin ligands are restricted to the sites of cell-cell contact since both molecules are membrane attached.  ...  In general, the A-subclass Eph receptors (EphA1-EphA9) bind promiscuously to the A-class ephrins (ephrin-A1 -ephrin-A6), while the EphB subclass receptors (EphB1 -EphB6) interact with the B-subclass ephrins  ... 
doi:10.1016/ pmid:17928214 pmcid:PMC3327877 fatcat:ksa5ud3ptvdhnb5qrlmppamxvi

Activity Recognition: Approaches, Practices and Trends [chapter]

Liming Chen, Ismail Khalil
2011 Activity Recognition in Pervasive Intelligent Environments  
Finally the chapter presents emerging research on activity recognition by outlining various issues and directions the field will take.  ...  This chapter aims to provide an overview on existing approaches, current practices and future trends on activity recognition.  ...  On the other hands ontology-based approach to activity recognition has only emerged recently with little published work.  ... 
doi:10.2991/978-94-91216-05-3_1 fatcat:jvu3pv3mivdm5aw4incyrcoy3q

The evolution of disease resistance genes [chapter]

Todd E. Richter, Pamela C. Ronald
2000 Plant Molecular Evolution  
In addition, domains believed to be involved in recognitional specificity, such as the leucine-rich repeat (LRR), are subject to adaptive selection.  ...  Recombination has also been implicated in the generation of novel resistance specificities. Resistance gene clusters appear to evolve more rapidly than other regions of the genome.  ...  Evidence of adaptive selection is rare but appears to be most common in gene regions that function in host and pathogen recognition [19] .  ... 
doi:10.1007/978-94-011-4221-2_10 fatcat:ae3wek6ydzfbhldclrnoujuzby

Mirtrons, an emerging class of atypical miRNA

Helen J. Curtis, Christopher R. Sibley, Matthew J. A. Wood
2012 Wiley Interdisciplinary Reviews - RNA  
One of these atypical pathways is the mirtron pathway, where short introns are excised by splicing to generate intermediates of the RNAi pathway, with no cleavage by the microprocessor.  ...  There is extensive evidence that mirtrons function as miRNAs, and while some are evolutionarily conserved across similar species, others appear to have emerged relatively recently.  ...  as to why these novel biogenesis pathways have emerged.  ... 
doi:10.1002/wrna.1122 pmid:22733569 fatcat:fr24pgehrnfa7fvd46vwo4bau4

Detecting the emergence of novel, zoonotic viruses pathogenic to humans

Ronald Rosenberg
2014 Cellular and Molecular Life Sciences (CMLS)  
RNA viruses, with their high potential for mutation and epidemic spread, are the most common class of pathogens found as new causes of human illness.  ...  Most emerging viruses are zoonoses; they have jumped from mammal or bird hosts to humans.  ...  The difference in the rates for the two classes highlights the important role that strategies for specimen collection play in the recognition of novel pathogens [19] . [22] .  ... 
doi:10.1007/s00018-014-1785-y pmid:25416679 pmcid:PMC4629502 fatcat:q5s2a46u6bgkdp5qicl66sz7zi

Cellular and molecular aspects of Goodpasture syndrome

Faris Q Alenzi, Mohamed L Salem, Fawwaz A Alenazi, Richard K Wyse
2012 Iranian Journal of Kidney Diseases  
Goodpasture syndrome, a rare human autoimmune disorder, is characterized by the presence of pathogenic autoantibodies that react with the components of the glomerular basement membrane.  ...  Notably, the Goodpasture antigen has been localized to the noncollagenous domain of the alpha3 chain of type IV collagen.  ...  ACKNOWLEDGMENTS The authors are grateful to Professors Mirgani Ahmad, Basil Al-Shaikh, and Abdulaziz Khawaja for their critical revision of this manuscript.  ... 
pmid:22218111 fatcat:lvjomrttfzadfkjbkcjvtgqcwy

Visual Object RecognitionCan a Single Mechanism Suffice? [chapter]

Michael J. Tarr
2006 Perception of Faces, Objects, and ScenesAnalytic and Holistic Processes  
Future studies will continue to investigate this issue, for example using far more sophisticated classes of novel objects (Figure 1f is one such creation).  ...  To that end, we created 4 sets of novel 3D objects based on "paperclip" objects used in studies by Bülthoff and Shimon Edelman (1992) : objects comprised of 5 "tubes" connected end to end; objects comprised  ... 
doi:10.1093/acprof:oso/9780195313659.003.0008 fatcat:u7luuwaq65c63eyjaodn3c3fim

Pulmonary arterial hypertension: the most devastating vascular complication of systemic sclerosis

V. McLaughlin, M. Humbert, G. Coghlan, P. Nash, V. Steen
2009 Rheumatology  
Exercise capacity (6MWD) NYHA FC Class I-no limitation of usual activity Class II-mild limitation of physical activity Class III-marked limitation of physical activity Class IV-unable to perform any  ...  The potential to use novel, targeted therapies in combination may offer further improvements in survival.  ... 
doi:10.1093/rheumatology/kep107 pmid:19487219 fatcat:v6h67wl4kvduvpjahqd7ilduqy

Structure and evolution of plant disease resistance genes

Przemysław Lehmann
2002 Journal of Applied Genetics  
Plant resistance genes are highly polymorphic and have diverse recognition specificities.  ...  These genes appear to evolve more rapidly than other regions of the genome, and domains such as the leucine-rich repeat, are subject to adaptive selection  ...  Adaptive evolution in the LRR is consistent with an evolutionary arms race in this respect that pathogens should impose selection to continually alter recognition specificity.  ... 
pmid:12441626 fatcat:iycthant7ve5tokwud2mdxtchm

Vive la différence: biogenesis and evolution of microRNAs in plants and animals

Michael J Axtell, Jakub O Westholm, Eric C Lai
2011 Genome Biology  
The lengths of pre-miRNAs are more consistent in animals than in plants, with most in the 55-to 70-nucleotide range; however, select Drosophila pre-miRNAs can approach 200 nucleotides [34] .  ...  All animals use the Drosha RNase III enzyme, which partners with the double-stranded RNA-binding domain protein DGCR8 (known as Pasha in invertebrates), to liberate pre-miRNA hairpins from pri-miRNA transcripts  ...  Therefore, these classes of plant miRNAs are expected to emerge and disappear with distinct dynamics [106, 107, 120, 121] . Does the genomic location of miRNA hairpins influence their emergence?  ... 
doi:10.1186/gb-2011-12-4-221 pmid:21554756 pmcid:PMC3218855 fatcat:ikvbw2owlvhybkwkds2f2zegxu

Gas Turbine Condition Monitoring and Diagnostics [chapter]

Igor Loboda
2010 Gas Turbines  
To perform the monitoring, the subclasses DM1 1 , DM1 2 , …, DM1 q compose a healthy engine class M 1 , while the subclasses DM2 1 , DM2 2 , …, DM2 q make up a faulty engine class M 2 .  ...  Each former class D j is divided into two subclasses DM1 j and DM2 j by the healthy class boundary.  ... 
doi:10.5772/10210 fatcat:e5bvz6es7jck3efm7unotbps5y

Mapping mutable genres in structurally complex volumes

Ted Underwood, Michael L. Black, Loretta Auvil, Boris Capitanu
2013 2013 IEEE International Conference on Big Data  
We note that narrative points of view seem to have strong associations with particular themes and genres.  ...  gradually across the time axis. 2) Because volumes are much longer than articles, they tend to be internally heterogeneous, and the classification task needs to begin with segmentation.  ...  The collections we used were drawn from HathiTrust Digital Library, with assistance from HathiTrust Research Center.  ... 
doi:10.1109/bigdata.2013.6691676 dblp:conf/bigdataconf/UnderwoodBAC13 fatcat:xk6g6g7fk5fmxlgkbrh4wdok6u

Introductory Chapter: B-Cells [chapter]

Mourad Aribi
2020 Normal and Malignant B-Cell  
The B-cell progenitors continue to develop in the bone marrow [21] .  ...  at their 3 0 ends.  ... 
doi:10.5772/intechopen.90636 fatcat:yfer3rwomzfyfe7sb3l6zytr5a

Plant Glycine-Rich Proteins in Stress Response: An Emerging, Still Prospective Story

Magdalena Czolpinska, Michal Rurek
2018 Frontiers in Plant Science  
Consequently, isolation, cloning, characterization, and functional validation of novel GRPs expressed in response to the diverse stress conditions are expected to be growing areas of research in the coming  ...  The general structure of this superfamily facilitates division of GRPs into five main subclasses.  ...  Both authors have accepted the final version of the manuscript and agreed to be accountable for all aspects of the work.  ... 
doi:10.3389/fpls.2018.00302 pmid:29568308 pmcid:PMC5852109 fatcat:s6kpmtzu2vdkfab7jnksr64gwu
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