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Envisioning the future of 'big data' biomedicine

Alex A.T. Bui, John Darrell Van Horn
2017 Journal of Biomedical Informatics  
We are in the midst of a revolution that is transforming the way we do biomedical research…we just have to devise creative ways to sift through this mountain of data and make sense of it" (7) .  ...  Working at the intersection of neuroimaging and genomics, the Enabling Neuroimaging Genetics through Meta-Analysis (ENIGMA) Center has performed some of the world's largest genetic studies of the brain  ... 
doi:10.1016/j.jbi.2017.03.017 pmid:28366789 pmcid:PMC5613673 fatcat:fgwbgtluhbhw3fngeksyjh2i2i

The new holism: P4 systems medicine and the medicalization of health and life itself

Henrik Vogt, Bjørn Hofmann, Linn Getz
2016 Medicine, Health care and Philosophy  
The emerging concept of systems medicine (or 'P4 medicine '-predictive, preventive, personalized and participatory) is at the vanguard of the post-genomic movement towards 'precision medicine'.  ...  It is directed at all levels of functioning, from the molecular to the social, continual throughout life and aimed at managing the whole continuum from cure of disease to optimization of health.  ...  , and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.  ... 
doi:10.1007/s11019-016-9683-8 pmid:26821201 pmcid:PMC4880637 fatcat:426gmnvuszgrho2zmdanml6tci

Big data in biomedicine

Fabricio F. Costa
2014 Drug Discovery Today  
I believe that we now stand at the brink of a potential digital revolution in data-centric healthcare, enabled by advances in computer technologies.  ...  This is just the start for the big data analytics and data-centric models in the digital revolution that researchers are starting to experience.  ... 
doi:10.1016/j.drudis.2013.10.012 pmid:24183925 fatcat:vtilwpmxmnfxtob7qhlpvhv5iu

Benefits of Big Data in Health Care: A Revolution

Dr. Ritushree Narayan
2019 International Journal of Trend in Scientific Research and Development  
Lifespan of a normal human is increasing with the world population and it produces new challenge in health care. big data change the method of data management ,leverage data and analyzing data.with the  ...  help of big data we can reduces the costs of treatment, reducing medication and provide better treatment with predictive analytics.  ...  With the advance in metabolomics, proteomics, genomics, and other types of omics know-hows through the previous eras, a remarkable volume of data associated to molecular biology has been formed.  ... 
doi:10.31142/ijtsrd22974 fatcat:n76yuik4yzbidapuiigdnm6qcq

Harnessing the Heart of Big Data

Sarah B. Scruggs, Karol Watson, Andrew I. Su, Henning Hermjakob, John R. Yates, Merry L. Lindsey, Peipei Ping
2015 Circulation Research  
Acknowledgments We thank Dr Ding Wang at UCLA for help in preparing the figures and Dr Edward Lau at UCLA for his critical input on the content.  ...  Sources of Funding This work was supported in part by the National Institutes of Health U54 GM114833 (to Dr Ping, Dr Watson, Dr Lindsey, Dr Su, H.  ...  Biomedicine, along with other fields, has been awakened and awed by the digital wave of major corporations such as Google and Amazon, who have revolutionized the Internet roadmap through developing and  ... 
doi:10.1161/circresaha.115.306013 pmid:25814682 pmcid:PMC4721634 fatcat:levyt7lpqvgxrpt6nccvcqqoiq

A Biomedical Open Knowledge Network Harnesses the Power of AI to Understand Deep Human Biology

Sergio Baranzini, Katy Börner, John Morris, Charlotte Nelson, Karthik Soman, Erica Schleimer, Michael Keiser, Mark Musen, Roger Pearce, Tahsin Reza, Brett Smith, Bruce Herr II (+8 others)
2022 The AI Magazine  
However, its application to biomedicine has been lagging in part due to the daunting complexity of molecular and cellular pathways that govern human physiology and pathology.  ...  In this article, we describe concrete uses of Scalable PrecisiOn Medicine Knowledge Engine (SPOKE), an open knowledge network that connects curated information from thirty-seven specialized and human-curated  ...  He completed the PhD degree in Electrical and Computer Engineering at The University of British Columbia, Vancouver. Brett  ... 
doi:10.1609/aimag.v43i1.19125 fatcat:cstlwsr2aretlcvl2j6xmx4w5y

Systems Medicine and the Emergence of Proactive P4 Medicine [chapter]

Leroy Hood, Mauricio A. Flores, Kristin R. Brogaard, Nathan D. Price
2013 Handbook of Systems Biology  
This will also provide the data to empower P4 medicine to revolutionize healthcare through consumer-driven social networks (Figure 23.1) .  ...  It revolutionized our understanding of molecular evolution. 10.  ... 
doi:10.1016/b978-0-12-385944-0.00023-x fatcat:eunnctdrpzeytf6zjlqcxi3csq

Mapping the new molecular landscape: social dimensions of epigenetics

Martyn Pickersgill, Jörg Niewöhner, Ruth Müller, Paul Martin, Sarah Cunningham-Burley
2013 New genetics and society (Print)  
Our discussion is situated within wider literatures on biomedicine and society, the politics of "interventionist STS", and on the problems of "caseness" within empirical social science.  ...  Epigenetics is the study of changes in gene expression caused by mechanisms other than changes in the DNA itself.  ...  It was made possible through the generous support of the Wellcome Trust, through the Strategic Award "The Human Body, its Scope, Limits and Future" (of which Cunningham-Burley is a co-investigator).  ... 
doi:10.1080/14636778.2013.861739 pmid:24482610 pmcid:PMC3898699 fatcat:g7lfjp7tkrfqdnig6d26fd47pe

Data Integration Challenges for Machine Learning in Precision Medicine

Mireya Martínez-García, Enrique Hernández-Lemus
2022 Frontiers in Medicine  
A main goal of Precision Medicine is that of incorporating and integrating the vast corpora on different databases about the molecular and environmental origins of disease, into analytic frameworks, allowing  ...  Efficient data integration and management is key to the successful application of computational intelligence approaches to medicine.  ...  FUNDING This work was supported by CONACYT (grant no. 285544/2016 Ciencia Bsica, and grant no. 2115 Fronteras de la Ciencia), as well as by federal funding from the National Institute of Genomic Medicine  ... 
doi:10.3389/fmed.2021.784455 pmid:35145977 pmcid:PMC8821900 fatcat:nxco4r4gsjdfnpbgoditxjptya

A vision and strategy for the virtual physiological human: 2012 update

P. Hunter, T. Chapman, P. V. Coveney, B. de Bono, V. Diaz, J. Fenner, A. F. Frangi, P. Harris, R. Hose, P. Kohl, P. Lawford, K. McCormack (+12 others)
2013 Interface Focus  
One contribution of 25 to a Theme Issue 'The virtual physiological human: integrative approaches to computational biomedicine'.  ...  The VPH Network of Excellence (NoE) has been set up to help develop common standards, open source software, freely accessible data and model repositories, and various training and dissemination activities  ...  The Digital Patient is intended to be a framework of information technologies that enable a more integrative, predictive, personalized, and patient-centric medicine, following the indications that will  ... 
doi:10.1098/rsfs.2013.0004 pmid:24427536 pmcid:PMC3638492 fatcat:2waldmlms5apzcfmujmchsntzq

Proceedings of the 2017 International Conference of Precision Health and Precision Nutrition

2018 Nutrition & Metabolism  
S2 Study for precision medicine of metabolic diseases Nutrition & Metabolism 2018, 15(Suppl 1):S2 The consistently increased morbidity of chronic non-communicable diseases, especially the metabolic diseases  ...  First, the drug development process takes too long (10-15 years/drug) and cost too much (~$1 billion/drug) with high failure rates (~80%) even for targets and compounds that survive through Phases II development  ...  Acknowledgements The study was supported by the Ministry of Science and Technology of China (2017YFC0909700, 2016YFC1304903) and Chinese Academy of Sciences (ZDBS-SSW-DQC-02).  ... 
doi:10.1186/s12986-018-0261-3 fatcat:55jat4kugfd53bczptg3bh5gbu

Principles of convergence in nature and society and their application: from nanoscale, digits, and logic steps to global progress

Mihail C. Roco
2020 Journal of nanoparticle research  
The affirmation of nanotechnology at the confluence of disciplines toward systematic control of matter at the nanoscale has been an enabling inspiration and foundation for other S&T fields, emerging industries  ...  Convergence offers a unifying strategy applicable to all systems that can be modeled as evolving neural-like networks.  ...  Disclaimer The content does not necessarily reflect the views of the National Science Foundation (NSF) or the US National Science and Technology Council's Subcommittee on Nanoscale Science, Engineering  ... 
doi:10.1007/s11051-020-05032-0 pmid:33106748 pmcid:PMC7577848 fatcat:axwr4pntpjcedp5ytfzaj33v7u

Introduction to Philosophy of Systems Biology [chapter]

Sara Green
2016 Philosophy of Systems Biology  
Ironically, perhaps, the culmination of the success of reductionist and gene-centric strategies in biology resulted in an increasing realization of the limitations of approaches investigating isolated  ...  Moreover, new questions are raised such as the implications of network modeling and large-scale simulations.  ...  Systems biology is expected to play a central part in future medicine, and projects under the labels of systems medicine, personalized medicine, P4 medicine and precision medicine indicate the directions  ... 
doi:10.1007/978-3-319-47000-9_1 fatcat:aax6bcvfrbds3kljms4djf4aje

D9.1 - GenoMed4All Impact Master Plan

Filippo Magrini, Diana López
2021 Zenodo  
Outline of the project's Dissemination, Communication and Exploitation strategies  ...  Expert networks GenoMed4All will seek to establish synergies with the reference expert networks in AI, HPC, eHealth, precision medicine and haematological diseases, among other realms.  ...  Group defines personalised medicine as "a medical model using characterization of individuals' phenotypes and genotypes (e.g. molecular profiling, medical imaging, lifestyle data) for tailoring the right  ... 
doi:10.5281/zenodo.5235225 fatcat:atqvpzzex5hvzgtckcmkoadbl4

A systems biology view of cancer

Reinhard Laubenbacher, Valerie Hower, Abdul Jarrah, Suzy V. Torti, Vladimir Shulaev, Pedro Mendes, Frank M. Torti, Steven Akman
2009 Biochimica et Biophysica Acta. CR. Reviews on Cancer  
After a discussion of recent progress using a network-centric approach, three case studies related to diagnostics, therapy, and drug development are presented in detail.  ...  Since the network is typically complex, with multiple connections between pathways and important feedback loops, it is crucial to represent it in the form of a computational model that can be used for  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.  ... 
doi:10.1016/j.bbcan.2009.06.001 pmid:19505535 pmcid:PMC2782452 fatcat:vqwiey67wzch5k2r2wxacdhptq
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