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Enabling Longitudinal Exploratory Analysis of Clinical COVID Data [article]

David Borland, Irena Brain, Karamarie Fecho, Emily Pfaff, Hao Xu, James Champion, Chris Bizon, David Gotz
2021 arXiv   pre-print
sequence visual analytics technologies to a longitudinal clinical data from a cohort of 998 patients with high rates of COVID-19 infection.  ...  Recognizing the potential for visual analytics technologies to support exploratory analysis and hypothesis generation from longitudinal clinical data, a team of collaborators worked to apply existing event  ...  Partial support was also provided by the United States National Institutes of Health (NCATS OT2TR003430, NCATS UL1TR002489, NCATS UL1TR002489-03S4, and NCATS OT3TR002020).  ... 
arXiv:2108.11476v1 fatcat:bjgqx3h74nawfmizefprm4x52a

Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)

Jim M Wild, Joanna C Porter, Philip L Molyneaux, Peter M George, Iain Stewart, Richard James Allen, Raminder Aul, John Kenneth Baillie, Shaney L Barratt, Paul Beirne, Stephen M Bianchi, John F Blaikley (+42 others)
2021 BMJ Open Respiratory Research  
(UKILD) will undertake longitudinal observational studies of patients with suspected ILD following COVID-19.  ...  Early data suggest potentially severe long-term consequence of COVID-19 is development of long COVID-19-related interstitial lung disease (LC-ILD).Methods and analysisThe UK Interstitial Lung Disease Consortium  ...  longitudinal analysis of biomarkers and the undertaking of two substudies (figure 1B ). 1.  ... 
doi:10.1136/bmjresp-2021-001049 pmid:34556492 pmcid:PMC8461362 fatcat:twlnvk3ginfo5bh4zml3bkprie

National Early Warning Score 2 (NEWS2) to identify inpatient COVID-19 deterioration: a retrospective analysis

Kenneth F Baker, Aidan T Hanrath, Ina Schim van der Loeff, Lesley J Kay, Jonathan Back, Christopher JA Duncan
2021 Clinical medicine (London)  
We sought to provide the first report of the use of NEWS2 monitoring to pre-emptively identify clinical deterioration within hospitalised COVID-19 patients.  ...  We analysed all electronic clinical observations recorded within 28 days of admission until discharge or occurrence of a serious event, defined as any of the following: initiation of respiratory support  ...  15 Approval for local data collection and analysis of anonymised clinical data was approved by the NUTH Caldicott Guardian.  ... 
doi:10.7861/clinmed.2020-0688 pmid:33547065 pmcid:PMC8002770 fatcat:374rtiy4tfhmvbhdabcuck75gu

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection [article]

Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Sophia Brambs, Markus Joppich, Aleksandar Janjic, Oliver Popp, Vivien Polewka, Lucas E. Wange, Christoph Gold, Marieluise Kirchner, Maximilian Muenchhoff (+21 others)
2021 bioRxiv   pre-print
In conclusion, our data demonstrate a protective ISG phenotype in patients with successful containment of SARS-CoV-2 infection without progression to COVID-19.  ...  The immune system of most SARS-CoV-2 infected individuals limits viral spread to the upper airways without pulmonary involvement. This prevents the development of pneumonic COVID-19.  ...  Age in years of patients. n=7 pneumonic COVID-19, n=4 non-pneumonic for both. e: Qualitative longitudinal clinical laboratory values of CRP (mg/dl), LDH(U/l), IL-6 (pg/ml) and total leukocyte count (1000  ... 
doi:10.1101/2021.02.03.429351 fatcat:kevsypxu4faovij6ykcgai7z4i

Global Consortium Study of Neurological Dysfunction in COVID-19 (GCS-NeuroCOVID): Study Design and Rationale

Jennifer Frontera, the GCS-NeuroCOVID Study, Shraddha Mainali, Ericka L. Fink, Courtney L. Robertson, Michelle Schober, Wendy Ziai, David Menon, Patrick M. Kochanek, Jose I. Suarez, Raimund Helbok, Molly McNett (+1 others)
2020 Neurocritical Care  
Tier 2 consists of prospective functional and cognitive outcomes assessments with more detailed clinical, laboratory and radiographic data collection that would require informed consent.  ...  Study sites are eligible for participation if they provide clinical care to COVID-19 patients and are able to conduct patient-oriented research under approval of an internal or global ethics committee.  ...  Insight into Treatment Strategies Exploratory analysis of this planned observational study may also provide information on potential impact of empiric COVID-19 therapeutics on emerging neurological syndromes  ... 
doi:10.1007/s12028-020-00995-3 pmid:32445105 fatcat:v4m5pnvyh5cthimkbrpiu2jc5y

Death Associated With Coronavirus (COVID-19) Infection in Individuals With Severe Mental Disorders in Sweden During the Early Months of the Outbreak—An Exploratory Cross-Sectional Analysis of a Population-Based Register Study

Martin Maripuu, Marie Bendix, Louise Öhlund, Micael Widerström, Ursula Werneke
2021 Frontiers in Psychiatry  
: Exploratory analysis with a cross-sectional design in the framework of a population-based register study covering the entire Swedish population.  ...  The Swedish Board for Health and Welfare (Socialstyrelsen) provided anonymized tabulated summary data for further analysis.  ...  As pointed out previously, for this exploratory analysis, we had to rely on summary data. Summary data are much less detailed than individual level data.  ... 
doi:10.3389/fpsyt.2020.609579 pmid:33488430 pmcid:PMC7819873 fatcat:66rqzzv26reefljrsnvuo3skai

Adapting the UK Biobank Brain Imaging Protocol and Analysis Pipeline for the C-MORE Multi-Organ Study of COVID-19 Survivors

Ludovica Griffanti, Betty Raman, Fidel Alfaro-Almagro, Nicola Filippini, Mark Philip Cassar, Fintan Sheerin, Thomas W. Okell, Flora A. Kennedy McConnell, Michael A. Chappell, Chaoyue Wang, Christoph Arthofer, Frederik J. Lange (+8 others)
2021 Frontiers in Neurology  
Our exploratory analysis tentatively revealed some group differences between recovered COVID-19 patients and controls, across severity groups, but not across anosmia groups.  ...  The protocol, pipeline code and data are openly available and will further contribute to the understanding of the medium to long-term effects of COVID-19.  ...  ACKNOWLEDGMENTS We thank our patients and their families who have sought to help others understand the effects of COVID-19.  ... 
doi:10.3389/fneur.2021.753284 pmid:34777224 pmcid:PMC8586081 fatcat:4budtjochrbwjkkobyu7sndi4u

Artificial intelligence mobile health platform for early detection of COVID-19 in quarantine subjects using a wearable biosensor: protocol for a randomised controlled trial

Chun Ka Wong, Deborah Tip Yin Ho, Anthony Raymond Tam, Mi Zhou, Yuk Ming LAU, Milky Oi Yan Tang, Raymond Cheuk Fung Tong, Kuldeep Singh Rajput, Gengbo Chen, Soon Chee Chan, Chung Wah SIU, Ivan Fan Ngai Hung
2020 BMJ Open  
IntroductionThere is an outbreak of COVID-19 worldwide.  ...  wearable biosensors to continuously monitor multidimensional physiological parameters for early detection of COVID-19 clinical progression.MethodThis randomised controlled open-labelled trial will involve  ...  To explore and estimate the effect of longitudinally measured clinical and physiological data on the time-to-event of primary and secondary outcomes, Open access joint modelling of longitudinal and  ... 
doi:10.1136/bmjopen-2020-038555 pmid:32699167 fatcat:mr5hq46wcvbyllpiuydaioni2a

Impact of COVID-19 Pandemic Burnout on Cardiovascular Risk in Healthcare Professionals Study Protocol: A Multicenter Exploratory Longitudinal Study

Hashel Al Tunaiji, Mai Al Qubaisi, Murat Dalkilinc, Luciana Aparecida Campos, Nnamdi Valbosco Ugwuoke, Eman Alefishat, Lujain Aloum, Ramzy Ross, Wael Almahmeed, Ovidiu Constantin Baltatu
2020 Frontiers in Medicine  
and Analysis: This is a STROBE compliant, blended, exploratory study involving online and onsite approaches that use wearable monitoring.  ...  Power BI and Tableau will be used for data visualization, while front-end data capture will be used for data collection using specific survey/questionnaires, which will enable data linkage between e-surveys  ...  ACKNOWLEDGMENTS The authors gratefully acknowledge Hariklia Kia Kornas, Manager Research Compliance and Training for her support and help for the development of an Effective Project Risk Management Process  ... 
doi:10.3389/fmed.2020.571057 pmid:33415114 pmcid:PMC7783289 fatcat:6tozalupgnaarl2aoipcoti2ge

Manifestations and impact of the COVID-19 pandemic in neuroinflammatory diseases

Seth N Levin, Shruthi Venkatesh, Katie E Nelson, Yi Li, Ines Aguerre, Wen Zhu, Karman Masown, Kathryn T Rimmer, Claudiu I Diaconu, Kaho B Onomichi, Victoria M Leavitt, Libby L Levine (+15 others)
2021 Annals of Clinical and Translational Neurology  
Overall, PwNID seem to have a risk of suspected COVID-19 similar to the reference population.  ...  criteria for suspected COVID-19, but only 4% of all participants received testing given testing shortages.  ...  Acknowledgment We thank all of our participants for taking the time to participate in this important study.  ... 
doi:10.1002/acn3.51314 pmid:33616290 pmcid:PMC8013889 fatcat:qtfubdbxe5et5gyc5tkvp2o6oe

Survey protocol for exploring video and phone use in Aotearoa New Zealand general practice: considerations for future telehealth

Karen Day, Inga Hunter, Vasudha Rao, Greig Russell, Rachel Roskvist, Fiona Moir, Emily Gill, Bert van der Werf
2021 BMJ Health & Care Informatics  
IntroductionTelehealth became the most practical option for general practice consultations in Aotearoa New Zealand (NZ) as a result of the national lockdowns in response to the COVID-19 pandemic.  ...  The data will be statistically analysed to create a foundation for in-depth research on the use of telehealth services in NZ general practice services, with a specific focus on consumer experiences and  ...  Acknowledgements The authors acknowledge the endorsement of this research  ... 
doi:10.1136/bmjhci-2020-100309 pmid:33753326 pmcid:PMC7986763 fatcat:ff3dhmd6arcz7fk6eq6qv4rh2a

Prognostic Factors for Post-COVID-19 Syndrome: A Systematic Review and Meta-Analysis

Giuseppe Maglietta, Francesca Diodati, Matteo Puntoni, Silvia Lazzarelli, Barbara Marcomini, Laura Patrizi, Caterina Caminiti
2022 Journal of Clinical Medicine  
We conducted a systematic review and meta-analysis to identify factors present during COVID-19 hospitalization associated with an increased risk of exhibiting new or persisting symptoms (Post-COVID-19  ...  To summarize the prognostic effect of each factor (or group of factors), odds ratios were estimated using raw data. Overall, 20 articles met the inclusion criteria, involving 13,340 patients.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/jcm11061541 pmid:35329867 pmcid:PMC8948827 fatcat:xcytd6autbcjtpjuezqilpqzpa

Looking in the medicine cabinet: methods for using real-world data to assess the impact of measles, mumps and rubella (MMR) and recombinant adjuvanted varicella-zoster vaccines on coronavirus disease 2019 (COVID-19) prevention and case fatality

Douglas McNair, Hao Hu, Casey Selwyn
2021 Gates Open Research  
Analysis of real-world data can be used to identify promising leads and dead ends among products being repurposed for clinical practice for coronavirus disease 2019 (COVID-19).  ...  Applying these methods to the impact of live viral vaccines on COVID-19 case fatalities yields actionable findings for further analysis.  ...  bias and heterogeneity sufficiently to enable reliable analysis.  ... 
doi:10.12688/gatesopenres.13329.1 fatcat:xao2q3djtfgfnhbi2kycslo3iq

Leveraging a health information exchange for analyses of COVID-19 outcomes including an example application using smoking history and mortality

Guillermo A. Tortolero, Michael R. Brown, Shreela V. Sharma, Marcia C. de Oliveira Otto, Jose-Miguel Yamal, David Aguilar, Matt D. Gunther, Dania I. Mofleh, Rachel D. Harris, Jemima C. John, Paul S. de Vries, Ryan Ramphul (+14 others)
2021 PLoS ONE  
These HIE capabilities enable clinical specialists and epidemiologists to conduct outcomes analyses during the current COVID-19 pandemic and beyond.  ...  We gathered demographic, lifestyle, laboratory, and clinical data from patient's encounters across the healthcare system.  ...  Identifying and characterizing predictors of adverse and positive outcomes requires large sample sizes with rich demographic, lifestyle and clinical data, ethnic and social diversity, and longitudinal  ... 
doi:10.1371/journal.pone.0247235 pmid:34081724 fatcat:u7fgzsnhurglhiodr66i5mvwym

Impact On Clinical Practice Of The Preoperative Screening Of Covid-19 Infection In Surgical Oncological Patients. Prospective Cohort Study

J. Castellvi, C. Jerico, A. DeMiguel, D. Camacho, J.M. Mullerat, J. Catala, R. Cliville, S. Videla
2020 International Journal of Surgery Open  
The aim of this study was to describe the impact on clinical practice of sequential preoperative screening for COVID-19-infection in deciding whether to proceed or postpone surgery.  ...  The prevalence of preoperative COVID-19-infection was 4.5%, 95%CI:2.3-8.6% (8 patients). Of the operated patients (171), all had a negative medical history, PCR and chest CT.  ...  The guarantor accepts full responsibility for the work and/or the conduct of the study, had access to the data, and controlled the decision to publish.  ... 
doi:10.1016/j.ijso.2020.08.003 pmid:34568610 pmcid:PMC7417291 fatcat:yvvasdyeujh25mm5ky2qpm4qly
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