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Enabling Longitudinal Exploratory Analysis of Clinical COVID Data
[article]
2021
arXiv
pre-print
sequence visual analytics technologies to a longitudinal clinical data from a cohort of 998 patients with high rates of COVID-19 infection. ...
Recognizing the potential for visual analytics technologies to support exploratory analysis and hypothesis generation from longitudinal clinical data, a team of collaborators worked to apply existing event ...
Partial support was also provided by the United States National Institutes of Health (NCATS OT2TR003430, NCATS UL1TR002489, NCATS UL1TR002489-03S4, and NCATS OT3TR002020). ...
arXiv:2108.11476v1
fatcat:bjgqx3h74nawfmizefprm4x52a
Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)
2021
BMJ Open Respiratory Research
(UKILD) will undertake longitudinal observational studies of patients with suspected ILD following COVID-19. ...
Early data suggest potentially severe long-term consequence of COVID-19 is development of long COVID-19-related interstitial lung disease (LC-ILD).Methods and analysisThe UK Interstitial Lung Disease Consortium ...
longitudinal analysis of biomarkers and the undertaking of two substudies (figure 1B ). 1. ...
doi:10.1136/bmjresp-2021-001049
pmid:34556492
pmcid:PMC8461362
fatcat:twlnvk3ginfo5bh4zml3bkprie
National Early Warning Score 2 (NEWS2) to identify inpatient COVID-19 deterioration: a retrospective analysis
2021
Clinical medicine (London)
We sought to provide the first report of the use of NEWS2 monitoring to pre-emptively identify clinical deterioration within hospitalised COVID-19 patients. ...
We analysed all electronic clinical observations recorded within 28 days of admission until discharge or occurrence of a serious event, defined as any of the following: initiation of respiratory support ...
15 Approval for local data collection and analysis of anonymised clinical data was approved by the NUTH Caldicott Guardian. ...
doi:10.7861/clinmed.2020-0688
pmid:33547065
pmcid:PMC8002770
fatcat:374rtiy4tfhmvbhdabcuck75gu
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
[article]
2021
bioRxiv
pre-print
In conclusion, our data demonstrate a protective ISG phenotype in patients with successful containment of SARS-CoV-2 infection without progression to COVID-19. ...
The immune system of most SARS-CoV-2 infected individuals limits viral spread to the upper airways without pulmonary involvement. This prevents the development of pneumonic COVID-19. ...
Age in years of patients. n=7 pneumonic COVID-19, n=4 non-pneumonic for both. e: Qualitative longitudinal clinical laboratory values of CRP (mg/dl), LDH(U/l), IL-6 (pg/ml) and total leukocyte count (1000 ...
doi:10.1101/2021.02.03.429351
fatcat:kevsypxu4faovij6ykcgai7z4i
Global Consortium Study of Neurological Dysfunction in COVID-19 (GCS-NeuroCOVID): Study Design and Rationale
2020
Neurocritical Care
Tier 2 consists of prospective functional and cognitive outcomes assessments with more detailed clinical, laboratory and radiographic data collection that would require informed consent. ...
Study sites are eligible for participation if they provide clinical care to COVID-19 patients and are able to conduct patient-oriented research under approval of an internal or global ethics committee. ...
Insight into Treatment Strategies Exploratory analysis of this planned observational study may also provide information on potential impact of empiric COVID-19 therapeutics on emerging neurological syndromes ...
doi:10.1007/s12028-020-00995-3
pmid:32445105
fatcat:v4m5pnvyh5cthimkbrpiu2jc5y
Death Associated With Coronavirus (COVID-19) Infection in Individuals With Severe Mental Disorders in Sweden During the Early Months of the Outbreak—An Exploratory Cross-Sectional Analysis of a Population-Based Register Study
2021
Frontiers in Psychiatry
: Exploratory analysis with a cross-sectional design in the framework of a population-based register study covering the entire Swedish population. ...
The Swedish Board for Health and Welfare (Socialstyrelsen) provided anonymized tabulated summary data for further analysis. ...
As pointed out previously, for this exploratory analysis, we had to rely on summary data. Summary data are much less detailed than individual level data. ...
doi:10.3389/fpsyt.2020.609579
pmid:33488430
pmcid:PMC7819873
fatcat:66rqzzv26reefljrsnvuo3skai
Adapting the UK Biobank Brain Imaging Protocol and Analysis Pipeline for the C-MORE Multi-Organ Study of COVID-19 Survivors
2021
Frontiers in Neurology
Our exploratory analysis tentatively revealed some group differences between recovered COVID-19 patients and controls, across severity groups, but not across anosmia groups. ...
The protocol, pipeline code and data are openly available and will further contribute to the understanding of the medium to long-term effects of COVID-19. ...
ACKNOWLEDGMENTS We thank our patients and their families who have sought to help others understand the effects of COVID-19. ...
doi:10.3389/fneur.2021.753284
pmid:34777224
pmcid:PMC8586081
fatcat:4budtjochrbwjkkobyu7sndi4u
Artificial intelligence mobile health platform for early detection of COVID-19 in quarantine subjects using a wearable biosensor: protocol for a randomised controlled trial
2020
BMJ Open
IntroductionThere is an outbreak of COVID-19 worldwide. ...
wearable biosensors to continuously monitor multidimensional physiological parameters for early detection of COVID-19 clinical progression.MethodThis randomised controlled open-labelled trial will involve ...
To explore and estimate the effect of longitudinally measured clinical and physiological data on the time-to-event of primary and secondary outcomes, Open access joint modelling of longitudinal and ...
doi:10.1136/bmjopen-2020-038555
pmid:32699167
fatcat:mr5hq46wcvbyllpiuydaioni2a
Impact of COVID-19 Pandemic Burnout on Cardiovascular Risk in Healthcare Professionals Study Protocol: A Multicenter Exploratory Longitudinal Study
2020
Frontiers in Medicine
and Analysis: This is a STROBE compliant, blended, exploratory study involving online and onsite approaches that use wearable monitoring. ...
Power BI and Tableau will be used for data visualization, while front-end data capture will be used for data collection using specific survey/questionnaires, which will enable data linkage between e-surveys ...
ACKNOWLEDGMENTS The authors gratefully acknowledge Hariklia Kia Kornas, Manager Research Compliance and Training for her support and help for the development of an Effective Project Risk Management Process ...
doi:10.3389/fmed.2020.571057
pmid:33415114
pmcid:PMC7783289
fatcat:6tozalupgnaarl2aoipcoti2ge
Manifestations and impact of the COVID-19 pandemic in neuroinflammatory diseases
2021
Annals of Clinical and Translational Neurology
Overall, PwNID seem to have a risk of suspected COVID-19 similar to the reference population. ...
criteria for suspected COVID-19, but only 4% of all participants received testing given testing shortages. ...
Acknowledgment We thank all of our participants for taking the time to participate in this important study. ...
doi:10.1002/acn3.51314
pmid:33616290
pmcid:PMC8013889
fatcat:qtfubdbxe5et5gyc5tkvp2o6oe
Survey protocol for exploring video and phone use in Aotearoa New Zealand general practice: considerations for future telehealth
2021
BMJ Health & Care Informatics
IntroductionTelehealth became the most practical option for general practice consultations in Aotearoa New Zealand (NZ) as a result of the national lockdowns in response to the COVID-19 pandemic. ...
The data will be statistically analysed to create a foundation for in-depth research on the use of telehealth services in NZ general practice services, with a specific focus on consumer experiences and ...
Acknowledgements The authors acknowledge the endorsement of this research ...
doi:10.1136/bmjhci-2020-100309
pmid:33753326
pmcid:PMC7986763
fatcat:ff3dhmd6arcz7fk6eq6qv4rh2a
Prognostic Factors for Post-COVID-19 Syndrome: A Systematic Review and Meta-Analysis
2022
Journal of Clinical Medicine
We conducted a systematic review and meta-analysis to identify factors present during COVID-19 hospitalization associated with an increased risk of exhibiting new or persisting symptoms (Post-COVID-19 ...
To summarize the prognostic effect of each factor (or group of factors), odds ratios were estimated using raw data. Overall, 20 articles met the inclusion criteria, involving 13,340 patients. ...
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/jcm11061541
pmid:35329867
pmcid:PMC8948827
fatcat:xcytd6autbcjtpjuezqilpqzpa
Looking in the medicine cabinet: methods for using real-world data to assess the impact of measles, mumps and rubella (MMR) and recombinant adjuvanted varicella-zoster vaccines on coronavirus disease 2019 (COVID-19) prevention and case fatality
2021
Gates Open Research
Analysis of real-world data can be used to identify promising leads and dead ends among products being repurposed for clinical practice for coronavirus disease 2019 (COVID-19). ...
Applying these methods to the impact of live viral vaccines on COVID-19 case fatalities yields actionable findings for further analysis. ...
bias and heterogeneity sufficiently to enable reliable analysis. ...
doi:10.12688/gatesopenres.13329.1
fatcat:xao2q3djtfgfnhbi2kycslo3iq
Leveraging a health information exchange for analyses of COVID-19 outcomes including an example application using smoking history and mortality
2021
PLoS ONE
These HIE capabilities enable clinical specialists and epidemiologists to conduct outcomes analyses during the current COVID-19 pandemic and beyond. ...
We gathered demographic, lifestyle, laboratory, and clinical data from patient's encounters across the healthcare system. ...
Identifying and characterizing predictors of adverse and positive outcomes requires large sample sizes with rich demographic, lifestyle and clinical data, ethnic and social diversity, and longitudinal ...
doi:10.1371/journal.pone.0247235
pmid:34081724
fatcat:u7fgzsnhurglhiodr66i5mvwym
Impact On Clinical Practice Of The Preoperative Screening Of Covid-19 Infection In Surgical Oncological Patients. Prospective Cohort Study
2020
International Journal of Surgery Open
The aim of this study was to describe the impact on clinical practice of sequential preoperative screening for COVID-19-infection in deciding whether to proceed or postpone surgery. ...
The prevalence of preoperative COVID-19-infection was 4.5%, 95%CI:2.3-8.6% (8 patients). Of the operated patients (171), all had a negative medical history, PCR and chest CT. ...
The guarantor accepts full responsibility for the work and/or the conduct of the study, had access to the data, and controlled the decision to publish. ...
doi:10.1016/j.ijso.2020.08.003
pmid:34568610
pmcid:PMC7417291
fatcat:yvvasdyeujh25mm5ky2qpm4qly
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