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G2S3: A gene graph-based imputation method for single-cell RNA sequencing data

Weimiao Wu, Yunqing Liu, Qile Dai, Xiting Yan, Zuoheng Wang, Qing Nie
2021 PLoS Computational Biology  
However, prevalent dropout events result in high data sparsity and noise that may obscure downstream analyses in single-cell transcriptomic studies.  ...  Single-cell RNA sequencing technology provides an opportunity to study gene expression at single-cell resolution.  ...  In our experiments, G2S3 had comparable performance to EnImpute, an ensemble learning method that combines results from multiple imputation methods.  ... 
doi:10.1371/journal.pcbi.1009029 pmid:34003861 fatcat:f4gjthqvjnaxjnznlss4bhbdfy