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Empowering cortical thickness measures in clinical diagnosis of Alzheimer's disease with spherical sparse coding

Jie Zhang, Yonghui Fan, Qingyang Li, Paul M. Thompson, Jieping Ye, Yalin Wang
2017 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017)  
Cortical thickness estimation performed in vivo via magnetic resonance imaging (MRI) is an important technique for the diagnosis and understanding of the progression of Alzheimer's disease (AD).  ...  In this paper, a spherical sparse coding and dictionary learning method is proposed and it achieves relatively high classification results on publicly available data from the Alzheimer's Disease Neuroimaging  ...  [5] investigated the potential of fully automated measurements of cortical thickness to reproduce the clinical diagnosis in 19 AD and 17 cognitive unimpaired (CU) subjects.  ... 
doi:10.1109/isbi.2017.7950557 pmid:28959379 pmcid:PMC5613953 dblp:conf/isbi/ZhangFLTYW17 fatcat:niyechvjq5axjfje4augcjc7te

Predicting Brain Amyloid Using Multivariate Morphometry Statistics, Sparse Coding, and Correntropy: Validation in 1,101 Individuals From the ADNI and OASIS Databases

Jianfeng Wu, Qunxi Dong, Jie Gui, Jie Zhang, Yi Su, Kewei Chen, Paul M. Thompson, Richard J. Caselli, Eric M. Reiman, Jieping Ye, Yalin Wang
2021 Frontiers in Neuroscience  
Biomarker assisted preclinical/early detection and intervention in Alzheimer's disease (AD) may be the key to therapeutic breakthroughs.  ...  We test our method in two independent cohorts, 841 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and 260 subjects from the Open Access Series of Imaging Studies (OASIS).  ...  “Empowering cortical thickness measures in clinical diagnosis of Alzheimer’s disease with spherical sparse coding,” in Proceedings of the IEEE 14th International Symposium on Biomedical Imaging , (Melbourne  ... 
doi:10.3389/fnins.2021.669595 pmid:34421510 pmcid:PMC8377280 fatcat:kdizw3nygvf77f26qws5illw7i

Abstracts

2010 Dementia and Geriatric Cognitive Disorders  
Hyperphosphorylation of tau is prominent in frontotemporal dementia with mutations in the MAPT gene, as well as in Pick's disease, as it is in Alzheimer's disease.  ...  Efforts to develop treatments for tau pathology in Alzheimer's disease may thus prove to be useful in the treatment of the same pathology in other tauopathies.  ...  In these bvFTD patients we measured cortical thickness and compared the regions of thinning with the location of the cortical "FB network".  ... 
doi:10.1159/000320292 fatcat:3toxl2yk3ffc7kaw4gnbb362wy

Alzheimer's Disease Detection Through Whole-Brain 3D-CNN MRI

Guilherme Folego, Marina Weiler, Raphael F. Casseb, Ramon Pires, Anderson Rocha
2020 Frontiers in Bioengineering and Biotechnology  
In this context, our system represents a promising tool in finding biomarkers to help with the diagnosis of AD and, eventually, many other diseases.  ...  The projected burden of dementia by Alzheimer's disease (AD) represents a looming healthcare crisis as the population of most countries grows older.  ...  This research is part of the first author's master's thesis, through the Institute of Computing, University of Campinas, Campinas, Brazil (Folego, 2018  ... 
doi:10.3389/fbioe.2020.534592 pmid:33195111 pmcid:PMC7661929 fatcat:dug2lz6d2fh3paihgnajj72duq

Complete remissions in chemotherapy of lung cancer models induced in mice by asbestos

William E Smith, Doras D Hubert, Ebrahim Yazdi, Stephen M Holiat, Elizabeth Cutler Bissell, Laurel Melcher Watts, Raymond A Baylouny, Harold J Sobel
2005 The Mount Sinai journal of medicine  
In groups of 6 mice fed a retinoid (Ro 10-9359) and treated with PCNU, CRs of ASB XIII occurred in 3 animals in each of two trials and in none in a third trial.  ...  No CRs of ASB XIV occurred in 80 mice treated with eight other anticancer agents or in 50 controls injected with 0.9% NaCl solution.  ...  the Brodmann areas Results: MR images displayed the varying thicknesses of the cortex and individual cortical layers, and demonstrated well the presence and rel ative thicknesses of the bands of Baillarger  ... 
pmid:15682259 fatcat:hd5vku7ldnarfcmv4qmbizztl4

RE(ACT)® International Congress on Research on Rare and Orphan Diseases

2011 Molecular Syndromology  
The disease in various respects resembles Paget's disease and infantile cortical hyperostosis (Caffey's disease) of humans. We mapped CMO to a 1.8-Mb region on dog chromosome 5 by GWAS.  ...  To conclude, fine-tuning the use of promoters or promoter-like elements in combination with the codon-optimization of the RAG1 coding sequence has brought us closer to clinical application of lentivirus-based  ...  Half of the boys under 5 years of age are underweight with a probable diagnosis of failure to thrive; whereas adult duplication carriers have an 8.3-fold increased risk of being clinically underweight.  ... 
doi:10.1159/000336858 fatcat:q67z2gzqzvclvfy7p5gquzvnoa

RE(ACT)®: INTERNATIONAL CONGRESS ON RESEARCH ON RARE AND ORPHAN DISEASES

2012 Molecular Syndromology  
The disease in various respects resembles Paget's disease and infantile cortical hyperostosis (Caffey's disease) of humans. We mapped CMO to a 1.8-Mb region on dog chromosome 5 by GWAS.  ...  To conclude, fine-tuning the use of promoters or promoter-like elements in combination with the codon-optimization of the RAG1 coding sequence has brought us closer to clinical application of lentivirus-based  ...  Half of the boys under 5 years of age are underweight with a probable diagnosis of failure to thrive; whereas adult duplication carriers have an 8.3-fold increased risk of being clinically underweight.  ... 
pmid:22670144 pmcid:PMC3362213 fatcat:7x4vqttaxrhvjig37e56vknyre

ECR 2015 Book of Abstracts - A - Postgraduate Educational Programme

2015 Insights into Imaging  
data, coded terminology, technical parameters, measurements, annotations and key images.  ...  CAA is also associated with cSS. CMBs occur in the normal ageing population and are seen with increasing frequency in patients with Alzheimer's disease, ischemic stroke and intracerebral haemorrhage.  ...  Decline in episodic long-term memory and also some other forms of cognition is one of several biomarkers in an Alzheimer's disease pathological cascade model.  ... 
doi:10.1007/s13244-015-0386-0 pmid:25708993 pmcid:PMC4349897 fatcat:m7eyvqcwojfpvf3lr5hy6dwjb4

ECR 2011 Book of Abstracts - A - Postgraduate Educational Programme

2011 Insights into Imaging  
data, coded terminology, technical parameters, measurements, annotations and key images.  ...  CAA is also associated with cSS. CMBs occur in the normal ageing population and are seen with increasing frequency in patients with Alzheimer's disease, ischemic stroke and intracerebral haemorrhage.  ...  Decline in episodic long-term memory and also some other forms of cognition is one of several biomarkers in an Alzheimer's disease pathological cascade model.  ... 
doi:10.1007/s13244-011-0078-3 pmid:23100070 pmcid:PMC3533621 fatcat:qa3ln4hhvve2hhumgwwnmykgoe

ECR 2016 Book of Abstracts - A - Postgraduate Educational Programme

2016 Insights into Imaging  
data, coded terminology, technical parameters, measurements, annotations and key images.  ...  CAA is also associated with cSS. CMBs occur in the normal ageing population and are seen with increasing frequency in patients with Alzheimer's disease, ischemic stroke and intracerebral haemorrhage.  ...  Decline in episodic long-term memory and also some other forms of cognition is one of several biomarkers in an Alzheimer's disease pathological cascade model.  ... 
doi:10.1007/s13244-016-0474-9 pmid:26873353 pmcid:PMC4762839 fatcat:itxslbcacjhh3kixfkcwmdbt44

ECR 2013 Book of Abstracts - A - Postgraduate Educational Programme

2013 Insights into Imaging  
data, coded terminology, technical parameters, measurements, annotations and key images.  ...  CAA is also associated with cSS. CMBs occur in the normal ageing population and are seen with increasing frequency in patients with Alzheimer's disease, ischemic stroke and intracerebral haemorrhage.  ...  Decline in episodic long-term memory and also some other forms of cognition is one of several biomarkers in an Alzheimer's disease pathological cascade model.  ... 
doi:10.1007/s13244-013-0227-y pmid:23468009 pmcid:PMC3666656 fatcat:yitsk227mba2pl7wcypouf6tz4

28th Annual Computational Neuroscience Meeting: CNS*2019

2019 BMC Neuroscience  
A BQ Zum BT-328 board was used, programmed with Arduino code, with three TG9e microservomotors.  ...  Some efforts use neurons with intrinsic rich dynamics as observed in several experimental works of CPGs [2, 3].  ...  packing of spherical cells with given radii.  ... 
doi:10.1186/s12868-019-0538-0 fatcat:3pt5qvsh45awzbpwhqwbzrg4su

ACRT-SCTS Scholar Abstracts

2010 Clinical and Translational Science  
Subject cohorts will be identified using a combination of physician diagnosis codes and pharmacy claims. The serious infection outcome will be defined by physician hospital discharge diagnosis codes.  ...  Patients with both diseases, or with coexisting diagnoses of other autoimmune diseases, were excluded.  ...  symptoms in older adults with Alzheimer's disease (AD), the most common form of dementia.  ... 
doi:10.1111/j.1752-8062.2010.00181_2.x fatcat:lwvd6nteozgezazejeqpjupawu

5th International Symposium on Focused Ultrasound

Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger, Jonathon Parker, Vinod Ravikumar, Pejman Ghanouni, Sherman Stein, Casey Halpern, Vibhor Krishna (+1008 others)
2016 Journal of Therapeutic Ultrasound  
A5 Focused ultrasound facilitated gene delivery for neuro-restoration in Parkinson's disease mice  ...  Journal of Therapeutic Ultrasound 2016, 4(Suppl 1):A2 Objectives Essential Tremor (ET) is one of the most common neurologic conditions, and conservative measures are frequently suboptimal.  ...  of Alzheimer's disease (Götz et al., Science 2001).  ... 
doi:10.1186/s40349-016-0076-5 fatcat:4vm7i5mt6vheni3hflxd3pwl2i

Human fetal ventral midbrain in standard culture versus organoids

Marcella Birtele, Alessandro Fiorenzano, Jenny Nelander, Malin Parmar
2019 Zenodo  
Parkinson disease (PD) is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc).  ...  We used immunocytochemistry to study the presence of ventral midbrain markers in 2D versus 3D condition together with single cell RNA sequencing to transcriptionally compare fetal VM tissue in standard  ...  DIRECT GENERATION OF HUMAN NAÏVE INDUCED PLURIPOTENT STEM CELLS FROM SOMATIC CELLS IN MICROFLUIDICS  ... 
doi:10.5281/zenodo.3358629 fatcat:svr6h5ghyzc4bdmzasks2lzgma
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