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Empirical validation of directed functional connectivity [article]

Ravi D Mill, Anto Bagic, Walter Schneider, Michael W Cole
2016 bioRxiv   pre-print
However, a host of methodological uncertainties have impeded the application of directed connectivity methods, which have primarily been validated via 'ground truth' connectivity patterns embedded in simulated  ...  Mapping directions of influence in the human brain connectome represents the next phase in understanding its functional architecture.  ...  We then tested the empirical validity of MEG directed functional connectivity methods.  ... 
doi:10.1101/070979 fatcat:2pxqvzyyjzfklg6zsqxlj57jtu

Empirical validation of directed functional connectivity

Ravi D. Mill, Anto Bagic, Andreea Bostan, Walter Schneider, Michael W. Cole
2017 NeuroImage  
However, a host of methodological uncertainties have impeded the application of directed connectivity methods, which have primarily been validated via "ground truth" connectivity patterns embedded in simulated  ...  Mapping directions of influence in the human brain connectome represents the next phase in understanding its functional architecture.  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Science Foundation or National Institutes of Health.  ... 
doi:10.1016/j.neuroimage.2016.11.037 pmid:27856312 pmcid:PMC5321749 fatcat:l56jxk6g5fesbb4cczzzw7b3au

A posteriori model validation for the temporal order of directed functional connectivity maps

Adriene M. Beltz, Peter C. M. Molenaar
2015 Frontiers in Neuroscience  
A posteriori model validation for the temporal order of neural directed functional connectivity maps is rare.  ...  The aim of the current study was (a) to apply to directed functional connectivity maps of functional magnetic resonance imaging data an a posteriori model validation procedure (i.e., white noise tests  ...  Funding for collection of the empirical data sets presented in this paper was provided by National Institute on Drug Abuse grant R01 DA02463, National Institute on Alcohol Abuse and Alcoholism grant R01  ... 
doi:10.3389/fnins.2015.00304 pmid:26379489 pmcid:PMC4551081 fatcat:yq46edbmpvbupb2mjjg3ivx2u4

Anatomical and Functional Gradients Shape Dynamic Functional Connectivity in the Human Brain [article]

Xiaolu Kong, Ru Kong, Csaba Orban, Peng Wang, shaoshi zhang, Kevin Michael Anderson, Avram Holmes, John D Murray, Gustavo Deco, martijn van den heuvel, B.T. Thomas Yeo
2021 bioRxiv   pre-print
several minutes, i.e. static functional connectivity (FC).  ...  Furthermore, empirical and simulated FC dynamics demonstrated remarkably similar sharp transitions in FC patterns, suggesting the existence of multiple attractors.  ...  functional connectivity.  ... 
doi:10.1101/2021.03.15.435361 fatcat:zsuoci4ckzbg5dxwosfkqamrse

Causally informed activity flow models provide mechanistic insight into the emergence of cognitive processes from brain network interactions [article]

Ruben Sanchez-Romero, Takuya Ito, Ravi D. Mill, Stephen José Hanson, Michael W. Cole
2021 bioRxiv   pre-print
Brain activity flow models estimate the movement of task-evoked activity over brain connections to help explain the emergence of task-related functionality.  ...  empirical fMRI data.  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of any of the funding agencies. The authors also thank Joseph D.  ... 
doi:10.1101/2021.04.16.440226 fatcat:fjmy3bkow5h7rcdcrnwn447gee

A new computational approach to estimate whole-brain effective connectivity from functional and structural MRI, applied to language development

Gerald Hahn, Michael A. Skeide, Dante Mantini, Marco Ganzetti, Alain Destexhe, Angela D. Friederici, Gustavo Deco
2019 Scientific Reports  
Recently introduced effective connectivity methods allow for the in-vivo investigation of large-scale functional interactions between brain regions.  ...  However, dynamic causal modeling, the most widely used technique to date, typically captures only a few predefined regions of interest.  ...  (C) Correlation coefficient (similarity) between empirical and model FC of direct connections for all age groups shown for different values of ε.  ... 
doi:10.1038/s41598-019-44909-6 pmid:31186486 pmcid:PMC6559954 fatcat:d6x7o2ktijenpilefojpqth7pe

Bridging the Gap: Dynamic Causal Modeling and Granger Causality Analysis of Resting State Functional Magnetic Resonance Imaging

Sahil Bajaj, Bhim M. Adhikari, Karl J. Friston, Mukesh Dhamala
2016 Brain Connectivity  
These findings suggest that GC and DCM can be used to estimate directed functional and effective connectivity from fMRI measurements in a consistent manner.  ...  In this study, our objective was to establish construct validity between GC and DCM in the context of resting state functional magnetic resonance imaging (fMRI).  ...  GC: directed functional connectivity-empirical data In the analysis of the empirical data, the in-degree for each node (from the remaining three nodes) was calculated using Equation ( 3).  ... 
doi:10.1089/brain.2016.0422 pmid:27506256 fatcat:qfffrk3fj5g7pp5pjpqrmhzhga

Recurrent Structural Motifs Reflect Characteristics of Distinct Networks

Chen-Hsiang Yeang, Liang-Cheng Huang, Wei-Chung Liu
2012 2012 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining  
In directed networks, variations of feed-forward loops are over-represented in the networks of web document and political weblog hyperlinks as well as neuronal connections.  ...  These network motifs are the building blocks of large-scale networks and may confer functional/mechanistic implications of their underlying processes.  ...  The study is supported by the frontier project grant of Academia Sinica, grant number AS-100-TP2-C01.  ... 
doi:10.1109/asonam.2012.94 dblp:conf/asunam/YeangHL12 fatcat:nklfim23jzea5c7b3enutuyppy

Refining the Common Model of Cognition Through Large Neuroscience Data

Zoe Steine-Hanson, Natalie Koh, Andrea Stocco
2018 Procedia Computer Science  
The Common Model of Cognition (CMC) is an effort to highlight the commonalities between multiple studies of human-like intelligent minds and cognition, and bring these architectures and functions together  ...  Abstract The Common Model of Cognition (CMC) is an effort to highlight the commonalities between multiple studies of human-like intelligent minds and cognition, and bring these architectures and functions  ...  This provided the first piece of empirical evidence for the validity of the CMC, at least in human minds.  ... 
doi:10.1016/j.procs.2018.11.026 fatcat:fafkcjo3ejd6zez45mxgrhyeia

MULAN: Evaluation and ensemble statistical inference for functional connectivity

Huifang E. Wang, Karl J. Friston, Christian G. Bénar, Marmaduke M. Woodman, Patrick Chauvel, Viktor Jirsa, Christophe Bernard
2018 NeuroImage  
The final step cross-validates experimental subsets of data and provides a direct estimate of the most likely graph and our confidence in the proposed connectivity.  ...  Many analysis methods exist to extract graphs of functional connectivity from neuronal networks.  ...  We also suggest using at least two classes of BMs (that would usually report instantaneous or undirected functional connectivity and directed functional connectivity based on temporal dependencies).  ... 
doi:10.1016/j.neuroimage.2017.10.036 pmid:29111409 fatcat:mywublbp7vbgncmyfktr7dopmi

Free Vibration Analysis of a Rectangular Duct with Different Axial Boundary Conditions

Pruthviraj Namdeo Chavan, B. Venkatesham
2015 International Journal of Acoustics and Vibration  
These basis functions are the static solutions of a point-supported beam under a series of sinusoidal loads.  ...  This paper describes the free vibration analysis of a rectangular duct by using the Rayleigh-Ritz method. Static beam functions are used as admissible functions in the Rayleigh-Ritz method.  ...  In the Rayleigh-Ritz method, validity and accuracy are entirely dependent on the choice of the admissible functions. 8 These static beam functions are the static solutions of the point-supported beams  ... 
doi:10.20855/ijav.2015.20.1363 fatcat:ajmzgbqqibhglcjinc2klslqv4

Page 28 of The Philosophical Review Vol. 58, Issue 1 [page]

1949 The Philosophical Review  
Again, does Nelson believe that by assuming ontological connections for which the laws of logic are to be viewed as “surrogates,” he can “account” for the validity of the latter or explain their regulative  ...  Does Nelson believe that if the category of causality is objective, knowledge of this fact con- tributes anything to validating any particular empirical generaliza- tion? Consider an example.  ... 

Inference of Brain Networks with Approximate Bayesian Computation – assessing face validity with an example application in Parkinsonism

Timothy O. West, Luc Berthouze, Simon F. Farmer, Hayriye Cagnan, Vladimir Litvak
2021 NeuroImage  
We provide a proof of principle, first pass validation of this framework using a set of neural mass models of the cortico-basal ganglia thalamic circuit inverted upon spectral features from experimental  ...  In this first paper, we establish a face validation of the optimization procedures in terms of: (i) the ability to approximate posterior densities over parameters that are plausible given the known causes  ...  We thank all authors of the publicly available toolboxes used in this paper (listed in the supplementary information VI). We thank Eugene P. Duff, Benoit Duchet, and Karl J.  ... 
doi:10.1016/j.neuroimage.2021.118020 pmid:33839264 fatcat:rtzbmswf4zhlzordavyg4o3tji

A cognitive state transformation model for task-general and task-specific subsystems of the brain connectome [article]

Kwangsun Yoo, Monica D. Rosenberg, Young Hye Kwon, Dustin Scheinost, Robert T Constable, Marvin M. Chun
2020 bioRxiv   pre-print
Much progress has been made to reveal task-induced modulations in the whole-brain functional connectome, but we still lack a way to model changes in the brain's functional organization.  ...  connectome with a high degree of specificity across seven different cognitive states.  ...  component 8 and 9 with the opposite direction in Figure 6 ).  ... 
doi:10.1101/2020.12.23.424176 fatcat:etyf6sfgfndxhox53xsvftwhri

Linking Entropy at Rest with the Underlying Structural Connectivity in the Healthy and Lesioned Brain

Victor M Saenger, Adrián Ponce-Alvarez, Mohit Adhikari, Patric Hagmann, Gustavo Deco, Maurizio Corbetta
2017 Cerebral Cortex  
Here we measured the entropy of brain regions (nodes) in empirical and modeled functional networks reconstructed from resting state fMRI to address the connection of entropy at rest with the underlying  ...  This is the first study showing that artificial lesions affect local and global network aspects in very similar ways compared to empirical strokes, shedding new light into the functional nature of stroke  ...  S3) validating the specificity and sensitivity of our method.  ... 
doi:10.1093/cercor/bhx176 pmid:28981635 fatcat:yhvdngmaobhcpgzwof7syys7la
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