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Poster Session I

2013 Neuropsychopharmacology  
Results: Thirty-five subjects with a mean age of 50±9 years and 70% Caucasian.  ...  Cognitive deficits (attention, working memory, and cognitive flexibility) are considered a core symptom cluster in schizophrenia (SZ); predictive of functional outcome yet not alleviated by current drug  ...  Slifstein, A. Abi-Dargham, and S. Kapur, Arch Gen Psychiatry 69, 776 (2012). 2  ... 
doi:10.1038/npp.2013.279 fatcat:54ipecxjarcvljrvn5fgtgif5u

Poster Session II

2010 Neuropsychopharmacology  
Methods: The study included 20 deficit and 36 nondeficit outpatients with schizophrenia and 28 individuals in a healthy comparison group.  ...  (DLPFC) in postmortem brain samples from persons with schizophrenia and a comparison group.  ...  Results: Here we report the characterization of VU0152100 in several preclinical models predictive of antipsychotic-like activity, negative symptoms of schizophrenia and enhancement of learning and memory  ... 
doi:10.1038/npp.2010.217 fatcat:gbcgyi35jbdndlwhlgwio7ts7y

Saturday Abstracts

2008 Biological Psychiatry  
She studies how our early experiences change brain circuits during critical periods of learning and development.  ...  She has served as the President of the 38,000 member Society for Neuroscience, and has received many honors and awards, including being elected a member of the Development then served as Group Director  ...  Conclusions: Diverse psychopathology is common in families of FEP patients.  ... 
doi:10.1016/j.biopsych.2008.02.013 fatcat:nwato7lql5f6fix5m7nxejlaey

Poster Session III

2006 Neuropsychopharmacology  
Effects of GHB on learning and memory in animals remain unknown. Methods: In this study the effects of GHB exposure on spatial learning and memory was tested using the Morris water maze.  ...  with Alzheimer's disease, schizophrenia and other CNS disorders.  ...  A "Virtual" Comparison of Paliperidone ER and Oral Risperidone in Patients with Schizophrenia Nina R.  ... 
doi:10.1038/sj.npp.1301268 fatcat:rl22v3qzwfh4hcr2c4z3b2daoi

ACNP 56th Annual Meeting: Poster Session I, December 4, 2017

2017 Neuropsychopharmacology  
A fasting blood sample was collected and a study physician performed a general medical assessment for each participant.  ...  Results: Women with current PTSD had significantly higher levels of HbA1c (p = 0.006) and AEG (p = 0.008) compared to women without PTSD.  ...  Methods: Here we used voxel-based morphometry (VBM) to study the differences in gray matter (GM) volumes between female and male iCUD.  ... 
doi:10.1038/npp.2017.264 pmid:29192265 fatcat:psc2w4azgrbfhjtxe6oxrnsdaq

ACNP 59th Annual Meeting: Poster Session I

2020 Neuropsychopharmacology  
In the light-dark box, a main effect of stress was observed (p<0.05), with posthoc comparisons revealing elevated PTSD-like phenotype in stressed KO mice compared to non-stressed KO mice (p<0.05).  ...  30-50% comorbidity with substance use disorder (SUDs).  ...  Here we present the results of the efficacy and safety of KarXT in a phase 2 study of acute psychosis in subjects with schizophrenia.  ... 
doi:10.1038/s41386-020-00890-7 pmid:33279934 pmcid:PMC7735198 fatcat:mqfz5f66vfbuvdbnrj7b2jt334

Poster Session I

2010 Neuropsychopharmacology  
Results: We found a significant effect of 6-OHDA treatment in both place preferences for cocaine and impulsivity that interacted with sex. 6-OHDA-treated males had a greater preference for the cocaineassociated  ...  One measure of impulsive choice is delayed discounting and occurs in 26.8% of children with ADHD.  ...  Results: There was a direct association between increased HDRS score and viral load elevation in the untreated cells (po0.05).  ... 
doi:10.1038/npp.2010.216 fatcat:v3q2xjxc45b2hckv33pzz7mtee

Abstracts Presented at the Thirty–Fourth Annual International Neuropsychological Society Conference, February 1–4, 2006, Boston, Massachussetts, USA

2006 Journal of the International Neuropsychological Society  
Effort and Cognition in Persistently Psychiatrically Disabled Patients. Objective: Recent research suggests poor mental effort is a core feature of schizophrenia.  ...  Sixty-four of these patients were diagnosed with a schizophrenia spectrum disorder (SCZ), and 51 were diagnosed with a nonpsychotic persistent mental illness (PMI).  ...  GM volume was examined using voxel-based morphometry (VBM), which assesses local tissue volume on a voxel-by-voxel basis throughout the whole brain.  ... 
doi:10.1017/s1355617706069918 fatcat:cy3cbwlgrvccfnn6w7inplceni

Introduction to JINS Special Issue on Human Brain Connectivity in the Modern Era: Relevance to Understanding Health and Disease

Deanna M. Barch, Mieke Verfaellie, Stephen M. Rao
2016 Journal of the International Neuropsychological Society  
JINS Vo l u m e 2 2 , N u m b e r 2 F e b r u a r y 2 0 1 6 I S S N 1 3 5 5 -6 1 7 7  ...  Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function.  ...  Mapping human whole-brain structural networks with diffusion MRI. PLoS One, 2(7), e597.  ... 
doi:10.1017/s1355617716000047 fatcat:f2preenihbes5ftkrxbo7tgt64

ACNP 59th Annual Meeting: Poster Session II

2020 Neuropsychopharmacology  
Following quality control and removal of participants missing scan modalities, n = 248 participants were included in a multimodal data fusion analysis with n = 54 scanned at both timepoints.  ...  In the current analysis, an initial dataset of 363 participants completed MRI scans within a)~2-weeks, b)~6-months, or c) both~2-weeks and~6-months post-trauma.  ...  850 ms, multiband factor = 6, 2 mm isotropic voxels = 7 min and 32 s per run).  ... 
doi:10.1038/s41386-020-00891-6 pmid:33279935 pmcid:PMC7735200 fatcat:5nfeakhcfnhpnjyuvli34vyxxq

Poster Session III

2004 Neuropsychopharmacology  
This cortical region is difficult to image in the single-voxel mode and may be a site of early pathology in cases of HIV-alcoholism comorbidity, given the known frontoparietal circuitry that can be disrupted  ...  Consistent with our studies of a neurotensin receptor agonist and contrary to studies with a neurotensin receptor antagonist, mice lacking NTS1 showed sensitization to D-amphetamine, which was enhanced  ...  voxel-based morphometry (VBM), a sophisticated fully automated morphological imaging technique, which allows a statistical comparison of gray matter volume on a voxel-byvoxel basis.  ... 
doi:10.1038/sj.npp.1300648 fatcat:vw22deytbbeyrpwv7zwkwotqgm

Final Program, Thirty-Sixth Annual Meeting International Neuropsychological Society, February 6-9, 2008, Waikoloa, Hawaii, USA

2008 Journal of the International Neuropsychological Society  
Post-hoc voxel based morphometry comparisons were also conducted using SPM5 software to identify any volume differences in areas not examined with manual methods.  ...  C Co on nc cl lu us si io on ns s: : Results of this study do not support the idea that the presence of comorbid PTSD results in increased cognitive impairment in schizophrenia.  ...  Motor Speed in Children and Adolescents with Nonverbal Learning Disabilities.  ... 
doi:10.1017/s1355617708080429 fatcat:7cinmclodjdjdfwakkdssx2iiy

ACNP 55th Annual Meeting: Poster Session III

2016 Neuropsychopharmacology  
Based on studies in peripheral organs, COX-1 is typically present at baseline (i.e., constitutively expressed) but not induced (i.e., upregulated) by inflammation.  ...  In our presentation last year at the ACNP, we reported a) the pharmacological characterization of the COX-1 and COX-2 radioligands using in vitro enzymatic assays in monkey and human blood, and b) initial  ...  Methods: MRI was performed ex-vivo and the resulting images images were analyzed using Voxel-Based Morphometry for T1-weighted sequences and tract-based spatial statistics for DTI data sets.  ... 
doi:10.1038/npp.2016.242 fatcat:4efd43swjbboranfrcs3pp32h4

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
The kinetics of dynorphin signal activation, duration and spread were characterized in striatum using a combination of photorelease, sensor imaging and electrophysiology.  ...  Recent progress has been made on probes to study interactions between the opioid neuropeptide dynorphin and the kappa opioid receptor, which are implicated in the negative aversive states associated with  ...  A subsample of 50 patients was studied with multimodal MRI imaging before/after treatment: diffusion tensor imaging (DTI) for white matter (WM) microstructure, voxel-based morphometry (VBM) and cortical  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y

ACNP 57th Annual Meeting: Poster Session III

2018 Neuropsychopharmacology  
In a previous study, we developed the SASP (Senescence-Associated Secretory Phenotype) index, which is a composite measure of biomarkers related to senescence processes and can be viewed as an indicator  ...  This study aims to evaluate the association between SASP index with structural brain changes and cognitive performance in older adults with major depression.  ...  We used whole-brain voxel-based morphometry (VBM) within a general linear model to characterize unique effects of maltreatment and presence of psychopathology (n = 71 with and n = 98 without), and the  ... 
doi:10.1038/s41386-018-0268-5 fatcat:wiooxnisvfhovadauljiso4ie4
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