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Emphasizing Functional Relevance Over State Restoration in Post-silicon Signal Tracing
2018
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
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The state restoration ratio (SRR) has been a de facto standard for evaluating the quality of signals selected for postsilicon tracing and debug. ...
We present an algorithm, based on PageRank [PageRank on Netlist (PRoN)], for post-silicon trace signal selection. PageRank is not designed to maximize SRR and is applied to the circuit netlist. ...
The proposed work improves over above mentioned works in terms of scalability, functional relevance of the selected signals to comprehend post-silicon execution, and behavioral coverage of the selected ...
doi:10.1109/tcad.2018.2887047
fatcat:g655w2zr4jfaban5n7fge6rogm
Efficient Trace Signal Selection for Post Silicon Validation and Debug
2011
2011 24th Internatioal Conference on VLSI Design
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A major problem governing post-silicon debug is the observability of internal signals since the chip has already been manufactured. ...
Post-silicon validation is an essential part of modern integrated circuit design to capture bugs and design errors that escape pre-silicon validation phase. ...
Signal Reconstruction In Post-silicon debug, unknown signal states can be reconstructed from the traced states in 2 ways -forward and backward restoration. ...
doi:10.1109/vlsid.2011.14
dblp:conf/vlsid/BasuM11
fatcat:6ikf3djpw5gwrpnymiwbe5rizm
Dynamic Selection of Trace Signals for Post-Silicon Debug
2013
2013 14th International Workshop on Microprocessor Test and Verification
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These signal states are stored in an on-chip trace buffer during execution. ...
A major challenge in post-silicon debug is limited observability of the internal signals. Existing approaches address this issue by selecting a small set of useful signals. ...
These will be referred to as uart, one and slave, respectively for further discussion in this section. ...
doi:10.1109/mtv.2013.13
dblp:conf/mtv/BasuMPNA13
fatcat:e4mjrqvjmbajrcqhf76g4e3ody
Miniaturized Technologies for Enhancement of Motor Plasticity
2016
Frontiers in Bioengineering and Biotechnology
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Presentation of the right cues, applied in relevant spatiotemporal geometries, is required to awaken the dormant plastic forces essential for repair. ...
The focus of this review is to highlight some of the recent progress in neural interfaces designed to harness motor plasticity, and the role of miniaturization in development of strategies that engage ...
iNTRODUCTiON The idea that neuronal maps in the motor cortex are in a constant state of flux can be traced back to the early 1900s when Charles Sherrington conducted a series of motor-mapping experiments ...
doi:10.3389/fbioe.2016.00030
pmid:27148525
pmcid:PMC4834582
fatcat:ykov42qserhxrnsl5rfgovzqsu
A brain–spine interface alleviating gait deficits after spinal cord injury in primates
2016
Nature
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Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: ...
Theoretically, this strategy could also restore control over leg muscle activity for walking5. ...
Conventions are the same as in Figure 3 and Extended Data Figure 7 . This analysis emphasizes the graded modulation of stimulation at 7 days post-injury for monkey Q2. ...
doi:10.1038/nature20118
pmid:27830790
pmcid:PMC5108412
fatcat:fmc7z6b3u5c6xgiepi7eoscdrq
The Layer 7 Cortical Interface: A Scalable and Minimally Invasive Brain-Computer Interface Platform
[article]
2022
bioRxiv
pre-print
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Progress toward the development of brain-computer interfaces has signaled the potential to restore, replace, or augment lost or impaired neurological function in a variety of disease states. ...
We demonstrate the safety and feasibility of rapidly delivering reversible implants containing over 2,000 microelectrodes to multiple functional regions in both hemispheres of the Gottingen minipig brain ...
SSEPs are then computed as the averaged time-aligned signals over 50 stimuli. ...
doi:10.1101/2022.01.02.474656
fatcat:jmqgay4ffzgu3jmy6njjjnev5u
Mesh electronics: a new paradigm for tissue-like brain probes
2018
Current Opinion in Neurobiology
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Nevertheless, current neurotechnologies remain limited in their capability to cover large spatiotemporal range relevant to understanding the brain; that is, from the spatial scale of individual synapses ...
/neurons with millisecond time resolution to that of neural networks comprising different brain regions evolving over months to years. ...
neuroprostheses to restore vision and motor functions in models of retinal and muscular dystrophy [42, 56] . ...
doi:10.1016/j.conb.2017.11.007
pmid:29202327
pmcid:PMC5984112
fatcat:bszgjqgzcrhkzl3xc2czi526x4
Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation
[article]
2020
bioRxiv
pre-print
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Notably, upregulation of the NMDAR subunit GluN2B in SST interneurons corrects the excessive synaptic calcium signals and ameliorates learning deficits in R1117X mutants. ...
Most studies of SHANK3 in the neocortex and hippocampus have focused on disturbances in pyramidal neurons. ...
normalize synaptic calcium signals and restore prefrontal cortex-dependent learning in R1117X mutants. ...
doi:10.1101/2020.01.07.894832
fatcat:ynr7bhz6oza5fn4dkul4jnattu
An integrated brain-machine interface platform with thousands of channels
[article]
2019
bioRxiv
pre-print
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Brain-machine interfaces (BMIs) hold promise for the restoration of sensory and motor function and the treatment of neurological disorders, but clinical BMIs have not yet been widely adopted, in part because ...
Neuralink's approach to BMI has unprecedented packaging density and scalability in a clinically relevant package. ...
When combined with rapidly improving spinal stimulation techniques [42] , in the future this approach could conceivably restore motor function. ...
doi:10.1101/703801
fatcat:lfo7loz4vrcx3kuimcalbskk7i
In vitro large-scale experimental and theoretical studies for the realization of bi-directional brain-prostheses
2013
Frontiers in Neural Circuits
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Brain-machine interfaces (BMI) were born to control "actions from thoughts" in order to recover motor capability of patients with impaired functional connectivity between the central and peripheral nervous ...
To reach this ambitious goal, we implemented a multidisciplinary "bottom-up" approach in which in vitro networks are the paradigm for the development of an in silico model to be incorporated into a neuromorphic ...
The authors at TAU thank the help of Nitzan Herzog for calcium imaging set up, Mark Shein-Idelson for network patterning, Inna Brainis for cell culture and Moshe David-Pur for silicon wafer processing. ...
doi:10.3389/fncir.2013.00040
pmid:23503997
pmcid:PMC3596784
fatcat:oo225zxhprchfhf2gobo2most4
Progress towards biocompatible intracortical microelectrodes for neural interfacing applications
2014
Journal of Neural Engineering
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The increased emphasis stems from the improved understanding of the multifaceted role that inflammation may play in disrupting both biologic and abiologic components of the overall neural interface circuit ...
In addition, a detailed overview of the current status of various materials-based approaches that have gained interest for neural interfacing applications is presented, and key challenges that remain to ...
MPa in the wet state. ...
doi:10.1088/1741-2560/12/1/011001
pmid:25460808
pmcid:PMC4428498
fatcat:yk3auje62jhvzhyvnpq7yrd5si
The parents of neuroscience and the neuroscience of parents
2012
Estudos de Biologia
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We will trace some of the fundamental roots of the field going back thousands of years, showing a logical connection between thinking of the past and ideas today. ...
Finally, we will talk about what the future of the field may hold as more advancement in technology and apparatus lead us to new discoveries and insights into our inner universe. ...
Neuroscientists are now developing implantable devices (like silicon chips) to transpose brain signals into a computer signal to help restore limb mobility in paralyzed subjects and enable prosthetic limbs ...
doi:10.7213/estud.biol.7324
fatcat:o6yqingi3vddxnoj5g7nzhn2vy
Colonic Motility and Jejunal Vagal Afferent Firing Rates Are Decreased in Aged Adult Male Mice and Can Be Restored by an Aminosterol
2019
Frontiers in Neuroscience
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There is a general decline in gastrointestinal function in old age including decreased intestinal motility, sensory signaling, and afferent sensitivity. ...
We hypothesized this may be linked to reduced colonic motility and alterations in vagal-gut-brain sensory signaling. ...
Michael Zasloff, Georgetown University (Washington, DC, United States) for the donation of the squalamine used in this study and Dr. ...
doi:10.3389/fnins.2019.00955
pmid:31551703
pmcid:PMC6746984
fatcat:xqmleytyszhnjlzeabjqil3zvq
An Active Thin-Film Cochlear Electrode Array With Monolithic Backing and Curl
2014
Journal of microelectromechanical systems
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The approach begins with the pre-emphasizing of the audio signal. ...
functions for assessing the state of the high-density system. ...
doi:10.1109/jmems.2013.2288947
fatcat:vgdvzzg7ujcb7mzb7qvgl3gqyq
Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System
2013
Journal of Nanomedicine & Nanotechnology
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; and (c) to discuss their potential relevance to novel, but safer than conventional dosing strategies for contemporary nanomedicines. ...
Homeopathic manufacturing is "green", with mechanical grinding in lactose and agitation in ethanol-water as primary reagents. ...
Acknowledgement This study was supported in part by National Center for Complementary and Alternative Medicine grant T32 AT01287 (PI: IRB). ...
doi:10.4172/2157-7439.1000179
fatcat:mputpznor5b3bpngayqtmxuece
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