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Emphasizing Functional Relevance Over State Restoration in Post-silicon Signal Tracing

Debjit Pal, Sai Ma, Shobha Vasudevan
2018 IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems  
The state restoration ratio (SRR) has been a de facto standard for evaluating the quality of signals selected for postsilicon tracing and debug.  ...  We present an algorithm, based on PageRank [PageRank on Netlist (PRoN)], for post-silicon trace signal selection. PageRank is not designed to maximize SRR and is applied to the circuit netlist.  ...  The proposed work improves over above mentioned works in terms of scalability, functional relevance of the selected signals to comprehend post-silicon execution, and behavioral coverage of the selected  ... 
doi:10.1109/tcad.2018.2887047 fatcat:g655w2zr4jfaban5n7fge6rogm

Efficient Trace Signal Selection for Post Silicon Validation and Debug

K Basu, P Mishra
2011 2011 24th Internatioal Conference on VLSI Design  
A major problem governing post-silicon debug is the observability of internal signals since the chip has already been manufactured.  ...  Post-silicon validation is an essential part of modern integrated circuit design to capture bugs and design errors that escape pre-silicon validation phase.  ...  Signal Reconstruction In Post-silicon debug, unknown signal states can be reconstructed from the traced states in 2 ways -forward and backward restoration.  ... 
doi:10.1109/vlsid.2011.14 dblp:conf/vlsid/BasuM11 fatcat:6ikf3djpw5gwrpnymiwbe5rizm

Dynamic Selection of Trace Signals for Post-Silicon Debug

Kanad Basu, Prabhat Mishra, Priyadarsan Patra, Amir Nahir, Alon Adir
2013 2013 14th International Workshop on Microprocessor Test and Verification  
These signal states are stored in an on-chip trace buffer during execution.  ...  A major challenge in post-silicon debug is limited observability of the internal signals. Existing approaches address this issue by selecting a small set of useful signals.  ...  These will be referred to as uart, one and slave, respectively for further discussion in this section.  ... 
doi:10.1109/mtv.2013.13 dblp:conf/mtv/BasuMPNA13 fatcat:e4mjrqvjmbajrcqhf76g4e3ody

Miniaturized Technologies for Enhancement of Motor Plasticity

Samira Moorjani
2016 Frontiers in Bioengineering and Biotechnology  
Presentation of the right cues, applied in relevant spatiotemporal geometries, is required to awaken the dormant plastic forces essential for repair.  ...  The focus of this review is to highlight some of the recent progress in neural interfaces designed to harness motor plasticity, and the role of miniaturization in development of strategies that engage  ...  iNTRODUCTiON The idea that neuronal maps in the motor cortex are in a constant state of flux can be traced back to the early 1900s when Charles Sherrington conducted a series of motor-mapping experiments  ... 
doi:10.3389/fbioe.2016.00030 pmid:27148525 pmcid:PMC4834582 fatcat:ykov42qserhxrnsl5rfgovzqsu

A brain–spine interface alleviating gait deficits after spinal cord injury in primates

Marco Capogrosso, Tomislav Milekovic, David Borton, Fabien Wagner, Eduardo Martin Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jerome Gandar, Quentin Barraud, David Xing, Elodie Rey, Simone Duis (+9 others)
2016 Nature  
Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:  ...  Theoretically, this strategy could also restore control over leg muscle activity for walking5.  ...  Conventions are the same as in Figure 3 and Extended Data Figure 7 . This analysis emphasizes the graded modulation of stimulation at 7 days post-injury for monkey Q2.  ... 
doi:10.1038/nature20118 pmid:27830790 pmcid:PMC5108412 fatcat:fmc7z6b3u5c6xgiepi7eoscdrq

The Layer 7 Cortical Interface: A Scalable and Minimally Invasive Brain-Computer Interface Platform [article]

Elton Ho, Mark Hettick, Demetrios Papageorgiou, Adam J Poole, Manuel Monge, Maria Vomero, Kate R Gelman, Timothy Hanson, Vanessa Tolosa, Michael Mager, Benjamin I Rapoport
2022 bioRxiv   pre-print
Progress toward the development of brain-computer interfaces has signaled the potential to restore, replace, or augment lost or impaired neurological function in a variety of disease states.  ...  We demonstrate the safety and feasibility of rapidly delivering reversible implants containing over 2,000 microelectrodes to multiple functional regions in both hemispheres of the Gottingen minipig brain  ...  SSEPs are then computed as the averaged time-aligned signals over 50 stimuli.  ... 
doi:10.1101/2022.01.02.474656 fatcat:jmqgay4ffzgu3jmy6njjjnev5u

Mesh electronics: a new paradigm for tissue-like brain probes

Guosong Hong, Xiao Yang, Tao Zhou, Charles M Lieber
2018 Current Opinion in Neurobiology  
Nevertheless, current neurotechnologies remain limited in their capability to cover large spatiotemporal range relevant to understanding the brain; that is, from the spatial scale of individual synapses  ...  /neurons with millisecond time resolution to that of neural networks comprising different brain regions evolving over months to years.  ...  neuroprostheses to restore vision and motor functions in models of retinal and muscular dystrophy [42, 56] .  ... 
doi:10.1016/j.conb.2017.11.007 pmid:29202327 pmcid:PMC5984112 fatcat:bszgjqgzcrhkzl3xc2czi526x4

Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation [article]

Farhan Ali, Ling-Xiao Shao, Danielle M Gerhard, Katherine Sweasy, Santosh Pothula, Christopher Pittenger, Ronald S Duman, Alex C Kwan
2020 bioRxiv   pre-print
Notably, upregulation of the NMDAR subunit GluN2B in SST interneurons corrects the excessive synaptic calcium signals and ameliorates learning deficits in R1117X mutants.  ...  Most studies of SHANK3 in the neocortex and hippocampus have focused on disturbances in pyramidal neurons.  ...  normalize synaptic calcium signals and restore prefrontal cortex-dependent learning in R1117X mutants.  ... 
doi:10.1101/2020.01.07.894832 fatcat:ynr7bhz6oza5fn4dkul4jnattu

An integrated brain-machine interface platform with thousands of channels [article]

Elon Musk, Neuralink
2019 bioRxiv   pre-print
Brain-machine interfaces (BMIs) hold promise for the restoration of sensory and motor function and the treatment of neurological disorders, but clinical BMIs have not yet been widely adopted, in part because  ...  Neuralink's approach to BMI has unprecedented packaging density and scalability in a clinically relevant package.  ...  When combined with rapidly improving spinal stimulation techniques [42] , in the future this approach could conceivably restore motor function.  ... 
doi:10.1101/703801 fatcat:lfo7loz4vrcx3kuimcalbskk7i

In vitro large-scale experimental and theoretical studies for the realization of bi-directional brain-prostheses

Paolo Bonifazi, Francesco Difato, Paolo Massobrio, Gian L. Breschi, Valentina Pasquale, Timothée Levi, Miri Goldin, Yannick Bornat, Mariateresa Tedesco, Marta Bisio, Sivan Kanner, Ronit Galron (+3 others)
2013 Frontiers in Neural Circuits  
Brain-machine interfaces (BMI) were born to control "actions from thoughts" in order to recover motor capability of patients with impaired functional connectivity between the central and peripheral nervous  ...  To reach this ambitious goal, we implemented a multidisciplinary "bottom-up" approach in which in vitro networks are the paradigm for the development of an in silico model to be incorporated into a neuromorphic  ...  The authors at TAU thank the help of Nitzan Herzog for calcium imaging set up, Mark Shein-Idelson for network patterning, Inna Brainis for cell culture and Moshe David-Pur for silicon wafer processing.  ... 
doi:10.3389/fncir.2013.00040 pmid:23503997 pmcid:PMC3596784 fatcat:oo225zxhprchfhf2gobo2most4

Progress towards biocompatible intracortical microelectrodes for neural interfacing applications

Mehdi Jorfi, John L Skousen, Christoph Weder, Jeffrey R Capadona
2014 Journal of Neural Engineering  
The increased emphasis stems from the improved understanding of the multifaceted role that inflammation may play in disrupting both biologic and abiologic components of the overall neural interface circuit  ...  In addition, a detailed overview of the current status of various materials-based approaches that have gained interest for neural interfacing applications is presented, and key challenges that remain to  ...  MPa in the wet state.  ... 
doi:10.1088/1741-2560/12/1/011001 pmid:25460808 pmcid:PMC4428498 fatcat:yk3auje62jhvzhyvnpq7yrd5si

The parents of neuroscience and the neuroscience of parents

Ilton Santos da SILVA, Katie Coren FREEMAN, Craig Howard KINSLEY
2012 Estudos de Biologia  
We will trace some of the fundamental roots of the field going back thousands of years, showing a logical connection between thinking of the past and ideas today.  ...  Finally, we will talk about what the future of the field may hold as more advancement in technology and apparatus lead us to new discoveries and insights into our inner universe.  ...  Neuroscientists are now developing implantable devices (like silicon chips) to transpose brain signals into a computer signal to help restore limb mobility in paralyzed subjects and enable prosthetic limbs  ... 
doi:10.7213/estud.biol.7324 fatcat:o6yqingi3vddxnoj5g7nzhn2vy

Colonic Motility and Jejunal Vagal Afferent Firing Rates Are Decreased in Aged Adult Male Mice and Can Be Restored by an Aminosterol

Christine L. West, Jessica Y. Amin, Sohana Farhin, Andrew M. Stanisz, Yu-Kang Mao, Wolfgang A. Kunze
2019 Frontiers in Neuroscience  
There is a general decline in gastrointestinal function in old age including decreased intestinal motility, sensory signaling, and afferent sensitivity.  ...  We hypothesized this may be linked to reduced colonic motility and alterations in vagal-gut-brain sensory signaling.  ...  Michael Zasloff, Georgetown University (Washington, DC, United States) for the donation of the squalamine used in this study and Dr.  ... 
doi:10.3389/fnins.2019.00955 pmid:31551703 pmcid:PMC6746984 fatcat:xqmleytyszhnjlzeabjqil3zvq

An Active Thin-Film Cochlear Electrode Array With Monolithic Backing and Curl

Angelique C. Johnson, Kensall D. Wise
2014 Journal of microelectromechanical systems  
The approach begins with the pre-emphasizing of the audio signal.  ...  functions for assessing the state of the high-density system.  ... 
doi:10.1109/jmems.2013.2288947 fatcat:vgdvzzg7ujcb7mzb7qvgl3gqyq

Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System

Barbara Sarter
2013 Journal of Nanomedicine & Nanotechnology  
; and (c) to discuss their potential relevance to novel, but safer than conventional dosing strategies for contemporary nanomedicines.  ...  Homeopathic manufacturing is "green", with mechanical grinding in lactose and agitation in ethanol-water as primary reagents.  ...  Acknowledgement This study was supported in part by National Center for Complementary and Alternative Medicine grant T32 AT01287 (PI: IRB).  ... 
doi:10.4172/2157-7439.1000179 fatcat:mputpznor5b3bpngayqtmxuece
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