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MRI features in 17 patients with l2 hydroxyglutaric aciduria

Héla Fourati, Emna Ellouze, Mourad Ahmadi, Dhouha Chaari, Fatma Kamoun, Ines Hsairi, Chahnez Triki, Zeineb Mnif
2016 European Journal of Radiology Open  
E-mail addresses: fourati, (H. Fourati). Table 1 1 Patient's distribution by age group. Table 3 3 MR abnormalities reading gird.  ... 
doi:10.1016/j.ejro.2016.09.001 pmid:27709120 pmcid:PMC5043405 fatcat:arnbkznuebhytpurv3dwvonysi

Bilateral septic arthritis of the sternoclavicular joint complicating infective endocarditis: a case report

Karim Masmoudi, Emna Elleuch, Rim Akrout, Afef Feki, Mariam Ezzeddine, Hela Fourati, Dorra Lahiani, Mounir Ben Jemaâ, Sofiène Baklouti
2018 Journal of Medical Case Reports  
Septic arthritis is an infectious disease that commonly affects weight-bearing or proximal joints such as the knee and the hip. The sternoclavicular joint is an unusual site of this entity. It usually occurs in patients with diabetes mellitus, intravenous drug abusers, or those with rheumatoid arthritis. Analysis of the previous literature showed few articles and these described essentially cases of unilateral presentation. Case presentation: We report a rare case of a bilateral septic
more » ... of the sternoclavicular joint sustained by a 71-year-old Tunisian woman whose medical history was significant for methicillin-resistant Staphylococcus aureus infective endocarditis 6 months ago. Imaging investigations revealed destruction of the medial extremities of her two clavicles and bilateral collections in the soft tissues around her sternoclavicular joints. She was treated successfully by needle aspiration drainage combined with a 12-week antibiotherapy. Conclusions: Bilateral septic arthritis of the sternoclavicular joint is an extremely rare entity, with a paucity of literature. Only early diagnosis, which is obtained from the culture of the joint fluid using needle aspiration, allows satisfactory functional outcome and a good prognosis. Osteoarticular infections should be considered in patients with recent infective endocarditis in cases of fever recurrence.
doi:10.1186/s13256-018-1709-9 pmid:29973288 pmcid:PMC6033282 fatcat:lvfywxxmwzglbaac4ea7gbopsq

Cd and Ni transport and accumulation in the halophyte Sesuvium portulacastrum: implication of organic acids in these processes

Mejda Mnasri, Rim Ghabriche, Emna Fourati, Hanen Zaier, Kebba Sabally, Suzelle Barrington, Stanley Lutts, Chedly Abdelly, Tahar Ghnaya
2015 Frontiers in Plant Science  
The implication of organic acids in Cd and Ni translocation was studied in the halophyte species Sesuvium portulacastrum. Citric, fumaric, malic, and ascorbic acids were separated and quantified by HPLC technique in shoots, roots and xylem saps of plants grown on nutrient solutions added with 50 µM Cd, 100 µM Ni and the combination of 50 µM Cd + 100 µM Ni. Results showed that Cd had no significant impact on biomass production while Ni and the combination of both metals drastically affected
more » ... development. Cadmium and Ni concentrations in tissues and xylem sap were higher in plants subjected to individual metal application than those subjected to the combined effect of Cd and Ni suggesting a possible competition between these metals for absorption. Both metals applied separately or in combination induced an increase in citrate concentration in shoots and xylem sap but a decrease of this concentration in the roots. However, a minor relationship was observed between metal application and fumaric, malic, and ascorbic acids. Both observations suggest the implication of citric acid in Cd, Ni translocation and shoot accumulation in S. portulacastrum. The relatively high accumulation of citric acid in xylem sap and shoot of S. portulacastrum could be involved in metal chelation and thus contributes to heavy metal tolerance in this species.
doi:10.3389/fpls.2015.00156 pmid:25821455 pmcid:PMC4358066 fatcat:3utnf3tcv5g53htgontyelfwu4

An interethnic variability and a functional prediction of DNA repair gene polymorphisms: the example of XRCC3 (p.Thr241>Met) and XPD (p.Lys751>Gln) in a healthy Tunisian population

Ghada Ben Salah, Nourhene Fendri-Kriaa, Hassen Kamoun, Fakhri Kallabi, Emna Mkaouar-Rebai, Amine Fourati, Hammadi Ayadi, Faiza Fakhfakh
2012 Molecular Biology Reports  
Genetic polymorphisms in DNA repair genes might influence the repair activities of the enzymes predisposing individuals to cancer risk. Owing to the presence of these genetic variants, interethnic differences in DNA repair capacity have been observed in various populations. The present study was undertaken to determine the allele and genotype frequencies of two common non-synony- ) in a healthy Tunisian population and to compare them with HapMap ( populations. Also, we
more » ... dicted their eventual functional effect based on bioinformatics tools. The genotypes of 154 healthy and unrelated individuals were determined by PCR-RFLP procedure. Our findings showed a close relatedness with Caucasians from European ancestry which might be explained by the strategic geographic location of Tunisia in the Mediterranean, thus allowing exchanges with Europeans countries. The in silico predictions showed that p.Thr241[Met substitution in XRCC3 protein was predicted as possibly damaging, indicating that it is likely to have functional consequences as well. To the best of our knowledge, this is the first study in this regard in Tunisia. So, these data could provide baseline database and help us to explore the relationship of XRCC3 and XPD polymorphisms with both cancer risk and DNA repair variability in our population.
doi:10.1007/s11033-012-1829-z pmid:22740138 fatcat:77ejkszxg5cm3pf5yi3bdbzatm

Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency

Nadia Charfi, Mahdi Kamoun, Mouna Feki Mnif, Neila Mseddi, Fatma Mnif, Nozha Kallel, Basma Ben Naceur, Nabila Rekik, Hela Fourati, Emna Daoud, Zainab Mnif, Mourad Hadj Sliman (+2 others)
2012 Case Reports in Urology  
Congenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may result in hyperplasia of ACTH-sensitive tissues in adrenal glands and other sites such as the testes, causing testicular masses known as testicular adrenal rest tumors (TARTs). Leydig cell tumors
more » ... s) are make up a very small number of all testicular tumors and can be difficult to distinguish from TARTs. This distinction is interesting because LCTs and TARTs require different therapeutic approaches. Hereby, we present an unusual case of a 19-year-old patient with CAH due to 11β-hydroxylase deficiency, who presented with TARTs and an epididymal Leydig cell tumor.
doi:10.1155/2012/648643 pmid:22606635 pmcid:PMC3350130 fatcat:zbfdqr2nbvbsdnkhe2l4ozzrje

Whole and Purified Aqueous Extracts of Nigella sativa L. Seeds Attenuate Apoptosis and the Overproduction of Reactive Oxygen Species Triggered by p53 Over-Expression in the Yeast Saccharomyces cerevisiae

Wafa Mihoubi, Emna Sahli, Fatma Rezgui, Najeh Dabebi, Rabiaa Sayehi, Hajer Hassairi, Najla Masmoudi-Fourati, Kamel Walha, Khalifa ben Khadhra, Mohamed Baklouti, Imen Ghzaiel, Sami Fattouch (+4 others)
2022 Cells  
Plants are an important source of pharmacologically active compounds. In the present work, we characterize the impact of black cumin (Nigella sativa L.) aqueous extracts on a yeast model of p53-dependent apoptosis. To this end, the Saccharomyces cerevisiae recombinant strain over-expressing p53 was used. The over-expression of p53 triggers the expression of apoptotic markers: the externalization of phosphatidylserine, mitochondrial defect associated with cytochrome-c release and the induction
more » ... DNA strand breaks. These different effects were attenuated by Nigella sativa L. aqueous extracts, whereas these extracts have no effect on the level of p53 expression. Thus, we focus on the anti-apoptotic molecules present in the aqueous extract of Nigella sativa L. These extracts were purified and characterized by complementary chromatographic methods. Specific fluorescent probes were used to determine the effect of the extracts on yeast apoptosis. Yeast cells over-expressing p53 decrease in relative size and have lower mitochondrial content. The decrease in cell size was proportional to the decrease in mitochondrial content and of mitochondrial membrane potential (ΔΨm). These effects were prevented by the purified aqueous fraction obtained by fractionation with different columns, named C4 fraction. Yeast cell death was also characterized by reactive oxygen species (ROS) overproduction. In the presence of the C4 fraction, ROS overproduction was strongly reduced. We also noted that the C4 fraction promotes the cell growth of control yeast cells, which do not express p53, supporting the fact that this purified extract acts on cellular mediators activating cell proliferation independently of p53. Altogether, our data obtained on yeast cells over-expressing p53 demonstrate that anti-apoptotic molecules targeting p53-induced apoptosis associated with mitochondrial dysfunction and ROS overproduction are present in the aqueous extracts of Nigella seeds and in the purified aqueous C4 fraction.
doi:10.3390/cells11050869 pmid:35269491 pmcid:PMC8909299 fatcat:jchc4kcs4vgslguuqksgugziea

Clustering Arabic Tweets for Sentiment Analysis

Diab Abuaiadah, Dileep Rajendran, Mustafa Jarrar
2017 2017 IEEE/ACS 14th International Conference on Computer Systems and Applications (AICCSA)  
 Maroua Abdelhafidh, Lamia Chaari Fourati, Mohamed Fourati and Amor Abidi.  ...  .  Sana Hamdi, Emna Bouazizi and Sami Faiz.  ... 
doi:10.1109/aiccsa.2017.162 dblp:conf/aiccsa/AbuaiadahRJ17 fatcat:t63au2drvrbo3fulnxkunb7kvy

Unrepaired persistent truncus arteriosus in a 38-year-old woman with an uneventful pregnancy

a Abid, e Daoud, SB Kahla, s Mallek, L Abid, H Fourati, Z Mnif, S Kammoun
2015 Cardiovascular Journal of Africa  
Daoud, MD Hela Fourati, MD Zeineb Mnif, MD AFRICA e7 biventricular hypertrophy.  ...  hedi Chaker hospital, sfax, tunisia Dorra Abid, MD, Sahar Ben Kahla, MD Souad Mallek, MD Leila Abid, MD Samir Kammoun, MD department of radiology, hedi Chaker hospital, sfax, tunisia Emna  ... 
doi:10.5830/cvja-2015-005 pmid:26407331 pmcid:PMC4683288 fatcat:uqzfs6dy2nc67mj4wkxrg3leze

Provisional technical program

2013 2013 ACS International Conference on Computer Systems and Applications (AICCSA)  
Identifying Temporal Relations between Main Events in News Articles Sana Hamdi, Malek Ben Salem, Emna Bouazizi and Rafik Bouaziz.  ...  A simple text/graphic separation method for document image segmentation Hazar Mliki, Nesrine Fourati, Souhaïl Smaoui and Mohamed Hammami.  ... 
doi:10.1109/aiccsa.2013.6616410 fatcat:jcfvb62oavf2nhbwh437gp2hxi

ATSIP 2020 Front Matters

2020 2020 5th International Conference on Advanced Technologies for Signal and Image Processing (ATSIP)  
detection Bochra Jaafar, Hela Mahersia and Zied Lachiri USIP-96 15:40-16:00 Performance Evaluation of Various Denoising Filters and segmentation methods for OCT images Abir Chaari, Khouloud Kammoun, Imen Fourati  ...  NETWORKS (SCN) Chairmen's: Lotfi KAMMOUN (ENIS, TUN) & Mohamed GHORBEL (ENET'COM, TUN) SCN-80 15:00-15:20 Deep learning for internet of things in fog computing: Survey and Open Issues Jihene Tmamna, Emna  ... 
doi:10.1109/atsip49331.2020.9231837 fatcat:ey7hgky7gzg7vf3itasckyxdqm


Olivier Badot, Patrick Joffre, Aline Scouarnec
2018 Management & Avenir  
Pour leur part, Nour Ben Lakhal et Emna Gara Bach Ouerdian proposent une recherche qui porte sur l'impact du soutien perçu du supérieur sur le transfert des acquis de la formation.  ...  Mona Fourati Ennouri et Jamil Chaabouni signalent que bien que les usages bancaires en ligne soient en pleine évolution, peu de recherches s'intéressent à ces usages et à leurs impacts sur les entreprises  ... 
doi:10.3917/mav.103.0009 fatcat:7x7wji6nd5eivi6ng5ncjlo7ii

Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016

Imen Bouzouita, Andrea Maurizio Cabibbe, Alberto Trovato, Henda Draoui, Asma Ghariani, Basma Midouni, Leila Essalah, Emna Mehiri, Daniela Maria Cirillo, Leila Slim Saidi
2019 Emerging Infectious Diseases  
Acknowledgments We thank Ibtissem Blanco, Rachid Fourati, and Dhikrayet Gamara for their contribution to this study. About the Author Ms.  ... 
doi:10.3201/eid2503.181370 pmid:30789128 pmcid:PMC6390739 fatcat:4w5bcitrgbd4bfsiywaxb3tgbq

Epidemiologic features and management of hypertension in Tunisia, the results from the Hypertension National Registry (NaTuRe HTN)

Leila Abid, Rania Hammami, Ikram Chamtouri, Meriam Drissa, Selim Boudiche, MohamedAmine Bahloul, Hedi BenSlima, Khaled Sayahi, Selma Charfeddine, Emna Allouche, Lamia Rais, Badr Kaab (+112 others)
Hypertension is the leading cause of morbi-mortality in our country. Thus, we conducted this national survey on hypertension to analyze the profile of the Tunisian hypertensive patient and to assess the level of blood pressure control. Nature HTN is an observational multicentric survey, including hypertensive individuals and consulting their doctors during the period of the study. Blood pressure measurements were conducted during consultation, using a standardized auscultatory or oscillometric
more » ... phygmomanometer after at least 15 min of rest. The diagnosis of new hypertension is based on the 2018 ESC/ESH criteria. The primary endpoint of our study was uncontrolled hypertension defined by a systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg. Three hundred twenty-one investigators participated in the study. We enrolled 25,890 patients with a female predominance (Sex ratio, 1.21) and an average age of 64.4 ± 12.2 years. Most individuals were treated in the public sector (74%), 39.4% of patients were diabetic, 25.8% were obese, 44.6% were overweight and 14% were smokers. Hypertension was controlled in 51.7% of cases if we consider 140/90 as a BP target, and only in 18.6% if we consider 130/80 as a target. The independent predictors of uncontrolled blood pressure were male sex (OR = 1.09, 95%CI [1.02-1.16]), age > 65 year-old (OR = 1.07, 95% CI[1.01-1.13], diabetes (OR = 1.18, 95% CI [1.11-1.25], Smoking (OR = 1.15, 95% CI [1.05-1.25]), Obesity (OR = 1.14, 95% CI[1.07-1.21]), management in public sector (OR = 1.25, 95% CI [1.16-1.34]), and Heart rate > 80 bpm (OR = 1.59, 95% CI [1.48-1.71]). Contrarily, high educational level (OR = 0.9, 95% CI [0.84-0.97], absence of history of coronary disease (OR = 0.86, 95% CI [0.8-0.93]), salt restriction (OR = 0.48, 95% CI [0.45-0.51]), drug compliance (OR = 0.57, 95% CI[0.52-0.61]), and regular physical activity (OR = 0.77, 95% CI[0.71-0.84]) are strong predictors of blood pressure control. NaTuRe HTN showed that blood pressure control was reached in more than half of the Tunisian people. The control remains low in patients with high cardiovascular profiles and in those treated in the public sector. A national health program based on therapeutic education, regular control and continuous support to the public institutions is needed to decrease the burden of hypertension incidence rate.
doi:10.1186/s12872-022-02584-y pmid:35351007 pmcid:PMC8966189 fatcat:edovesbjzfdvvi67su2ybadgxe

Des fissures dans la « Maison Tunisie » ? Le régime de Ben Ali face aux mobilisations protestataires

Vincent Geisser, Éric Gobe
2007 L Année du Maghreb  
On citera plus particulièrement cette année deux autres victimes de harcèlements : Mohamed Fourati et Sihem Bensedrine.  ...  On y trouve des journalistes aux ordres du Ben Ali comme Ridha Mellouli et Emna Soula (AJT), des hommes d'affaires comme Mohamed Aziz Miled (PDG de la Tunisian Travel Service), des intellectuels comme  ... 
doi:10.4000/anneemaghreb.140 fatcat:w6nfff63brd3dhw274cgqik4tq

Proceedings of Réanimation 2017, the French Intensive Care Society International Congress

Chtara Kamilia, Kais Regaieg, Najeh Baccouch, Hedi Chelly, Mabrouk Bahloul, Mounir Bouaziz, Ali Jendoubi, Ahmed Abbes, Houda Belhaouane, Oussama Nasri, Layla Jenzri, Salma Ghedira (+1089 others)
2017 Annals of Intensive Care  
doi:10.1186/s13613-016-0224-7 fatcat:2iumv76ivzdszafcy6hbqkd7um